{"id":"https://openalex.org/W18848488","doi":null,"title":"Application of calcium phosphate coating as drug delivery system for orthopedic implants","display_name":"Application of calcium phosphate coating as drug delivery system for orthopedic implants","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W18848488","mag":"18848488"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-5852","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3476640","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058966019","display_name":"Xiaohua Yu","orcid":"https://orcid.org/0000-0002-0233-0121","observed_orcids":["https://orcid.org/0000-0002-0233-0121","https://orcid.org/0000-0002-9088-3235"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiaohua Yu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0233-0121","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058966019"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-phosphate-coatings","display_name":"calcium phosphate coatings","score":0.9380000233650208},{"id":"https://openalex.org/keywords/biomimetic-coatings","display_name":"biomimetic coatings","score":0.734000027179718},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6029999852180481},{"id":"https://openalex.org/keywords/orthopedic-implants","display_name":"orthopedic implants","score":0.968999981880188},{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.8190000057220459},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9559999704360962},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/protein-incorporation","display_name":"protein incorporation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/release-kinetics","display_name":"release kinetics","score":0.6859999895095825},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/simulated-body-fluid","display_name":"simulated body fluid","score":0.8029999732971191},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6311403512954712},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6106840372085571},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.565321683883667},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5516659617424011},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.477749764919281},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4326796531677246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4059704542160034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2827759087085724},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2602001428604126},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22535336017608643},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.18577274680137634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1765425205230713},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.14390501379966736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10231459140777588}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-5852","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3476640","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:opencommons.uconn.edu:dissertations-5852","doi":null,"is_oa":false,"landing_page_url":"http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3476640","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:18848488","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/AAI3476640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983214371","https://openalex.org/W2505677108","https://openalex.org/W2617755407","https://openalex.org/W4417148518","https://openalex.org/W2409283436","https://openalex.org/W3027817253","https://openalex.org/W1987184477","https://openalex.org/W2146739805","https://openalex.org/W2539380352","https://openalex.org/W1993340654"],"abstract_inverted_index":{"Musculoskeletal":[0],"disorders":[1],"are":[2],"one":[3],"of":[4,85,115,139,161,195,263,270,277,300,318],"the":[5,16,20,35,38,59,83,106,116,137,140,159,177,189,201,206,229,261,288,297,315,344,349,375,398],"most":[6],"severe":[7],"human":[8],"health":[9],"issues":[10],"we":[11],"have":[12,55],"to":[13,19,104,121,135,157,181,221,259,286,390],"face":[14],"in":[15,23,34,374],"future":[17],"due":[18],"population":[21],"aging":[22],"many":[24],"countries.":[25],"More":[26],"than":[27],"1.1":[28],"million":[29],"surgical":[30],"procedures":[31],"were":[32,197,245,256],"performed":[33],"USA":[36],"and":[37,52,74,88,192,243,354,396],"estimated":[39],"medical":[40],"treatment":[41],"for":[42,62,95],"these":[43],"patients":[44],"is":[45,100,120,213,293,338],"over":[46],"5":[47],"billion":[48],"dollars.":[49],"Although":[50],"titanium":[51,110,131,141,271,392],"its":[53,328,352],"alloys":[54],"been":[56,172],"used":[57,258],"as":[58,91,228],"dominant":[60],"materials":[61],"orthopedic":[63,86],"implants,":[64],"they":[65],"still":[66],"suffer":[67],"from":[68,302,321,348],"shortcomings":[69],"like":[70],"limited":[71],"life":[72],"span":[73],"poor":[75],"osseointegration.":[76],"Biomimetic":[77],"calcium":[78],"phosphate":[79],"(CaP)":[80],"coatings":[81],"improve":[82,136,371,391],"osteoconductivity":[84],"implants":[87],"show":[89],"promise":[90],"slow":[92],"delivery":[93],"systems":[94],"therapeutic":[96,330],"proteins,":[97],"therefore":[98,314],"it":[99,284],"a":[101,123,151,214,387],"promising":[102,388],"approach":[103,389],"address":[105],"problems":[107],"associated":[108],"with":[109,335],"based":[111,132,142,393],"implants.":[112,272],"The":[113,167,232,274,332,378],"objective":[114],"proposed":[117],"research":[118],"plan":[119],"fabricate":[122],"biomimetic":[124,225,303,379],"CaP":[125,165,226,237,266,304,322,368,380],"coating":[126,207,227,238,267,305,323,350,369,381],"incorporating":[127],"osteogenic":[128,230,289,319,383],"agent":[129,290,320,384],"on":[130,239,268,358],"implant":[133,372],"surface":[134,179],"osseointegration":[138,269,373,395],"implant.":[143],"A":[144,251],"systematical":[145],"study":[146,362],"was":[147,219,279],"carried":[148],"out":[149],"using":[150,247],"model":[152,255,336],"protein-bovine":[153],"serum":[154],"albumin":[155],"(BSA)":[156],"reveal":[158],"mechanism":[160],"protein":[162],"incorporation":[163,169,235,275,342,366],"into":[164,224,236,327,343,367],"coating.":[166,345],"BSA":[168,196,202,278,301,311,337],"efficiency":[170,194,276],"has":[171],"improved":[173,281],"by":[174,199,309,340],"carefully":[175],"adjusting":[176,310],"substrate":[178],"area":[180],"simulated":[182],"body":[183],"fluid":[184],"(SBF)":[185],"volume":[186],"ratio.":[187],"Then,":[188],"release":[190,193,298,316],"kinetics":[191,299],"optimized":[198],"changing":[200],"adding":[203,312],"time":[204],"during":[205],"process.":[208,401],"Parathyroid":[209],"hormone":[210],"(PTH),":[211],"which":[212,282],"potential":[215],"bone":[216,399],"growth":[217],"stimulator,":[218],"chosen":[220],"be":[222,307,325,386],"incorporated":[223,265],"agent.":[231],"effect":[233,262],"PTH":[234,264,341,346,365],"osteoblast":[240,359],"adhesion,":[241],"proliferation,":[242],"differentiation":[244],"evaluated":[246],"MC3T3-E1":[248],"cell":[249],"culture.":[250],"mouse":[252,376],"tibia":[253],"insert":[254],"further":[257],"investigate":[260],"^":[273,402],"substantially":[280],"makes":[283],"possible":[285],"lower":[287],"cost.":[291],"It":[292],"also":[294],"demonstrated":[295,334],"that":[296,364],"can":[306,324,370],"tailored":[308],"time,":[313],"profile":[317],"fit":[326],"best":[329],"effectiveness.":[331],"concept":[333],"evident":[339],"liberated":[347],"remained":[351],"bioactivity":[353],"showed":[355],"favorable":[356],"influence":[357],"proliferation.":[360],"Animal":[361],"indicates":[363],"tibia.":[377],"bearing":[382],"could":[385],"implants'":[394],"accelerate":[397],"healing":[400]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}