{"id":"https://openalex.org/W188348100","doi":null,"title":"Activity of glutathione S-transferases in the urine of kidney transplant recipients during the first week after transplantation.","display_name":"Activity of glutathione S-transferases in the urine of kidney transplant recipients during the first week after transplantation.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W188348100","mag":"188348100","pmid":"https://pubmed.ncbi.nlm.nih.gov/10850600"},"language":"en","primary_location":{"id":"pmid:10850600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of transplantation","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103704890","display_name":"WG Polak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"W P Polak","raw_affiliation_strings":["Department of General and Transplantation Surgery, Medical University of Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Transplantation Surgery, Medical University of Warsaw, Poland","institution_ids":["https://openalex.org/I268303160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053296004","display_name":"Maciej Kosieradzki","orcid":"https://orcid.org/0000-0003-2889-1311","observed_orcids":["https://orcid.org/0000-0003-2889-1311","https://orcid.org/0000-0003-1344-5001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kosieradzki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110006644","display_name":"A. Kwiatkowski","orcid":"https://orcid.org/0009-0006-5587-8306","observed_orcids":["https://orcid.org/0009-0006-5587-8306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kwiatkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009105445","display_name":"R. Danielewicz","orcid":"https://orcid.org/0000-0001-9263-6038","observed_orcids":["https://orcid.org/0000-0001-9263-6038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Danielewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025456500","display_name":"Wojciech Lisik","orcid":"https://orcid.org/0000-0003-3020-3979","observed_orcids":["https://orcid.org/0000-0003-3020-3979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Lisik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082810909","display_name":"G Michalak","orcid":"https://orcid.org/0000-0002-4402-3824","observed_orcids":["https://orcid.org/0000-0002-4402-3824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Michalak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052485914","display_name":"Leszek P\u0105czek","orcid":"https://orcid.org/0000-0003-0160-3009","observed_orcids":["https://orcid.org/0000-0003-0160-3009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Paczek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109332264","display_name":"Mieczys\u0142aw Lao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Lao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109306013","display_name":"Janusz Wa\u0142aszewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wa\u0142aszewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023954720","display_name":"Wojciech A. Rowinski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W A Rowi\u0144ski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.00892438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"1","first_page":"42","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/delayed-graft-function","display_name":"delayed graft function","score":0.9470000267028809},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/acute-tubular-necrosis","display_name":"acute tubular necrosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/proximal-tubule-injury","display_name":"proximal tubule injury","score":0.6549999713897705},{"id":"https://openalex.org/keywords/graft-function","display_name":"graft function","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8465140461921692},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6805840730667114},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6743026971817017},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6618725061416626},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6148256659507751},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5889009237289429},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.49471279978752136},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4782670736312866},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.463886559009552},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.44701966643333435},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.4110342264175415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4099680185317993},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3412792980670929},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24226412177085876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10868614912033081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09652730822563171}],"mesh":[{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D007683","descriptor_name":"Kidney Tubular Necrosis, Acute","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007683","descriptor_name":"Kidney Tubular Necrosis, Acute","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007683","descriptor_name":"Kidney Tubular Necrosis, Acute","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D051549","descriptor_name":"Glutathione S-Transferase pi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10850600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of transplantation","raw_type":"Journal Article"},{"id":"mag:188348100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028273729","https://openalex.org/W2774092591","https://openalex.org/W2494831335","https://openalex.org/W2126722020","https://openalex.org/W947332963","https://openalex.org/W2047354299","https://openalex.org/W2983014931","https://openalex.org/W2587115274","https://openalex.org/W2024805430","https://openalex.org/W2111499314"],"abstract_inverted_index":{"UNLABELLED:":[0],"Glutathione":[1],"S-Tranferases":[2],"(GST)":[3],"are":[4,8,25],"the":[5,15,21,28,53,64,71,80,83,136,144,180,207,221],"enzymes":[6,24],"which":[7],"strictly":[9],"specific":[10],"for":[11],"epithelial":[12],"cells":[13],"of":[14,47,55,66,82,87,138,169,238],"proximal":[16],"and":[17,60,135,140,150,179,185,194,216,228],"distal":[18],"tubules":[19],"in":[20,27,63,143,161,165,200,220,231],"kidney.":[22,89],"These":[23],"detected":[26],"urine":[29,40,65,145,222],"when":[30],"some":[31],"tubular":[32],"damage":[33],"process":[34],"is":[35,42],"found.":[36],"In":[37],"healthy":[38],"people":[39],"GST":[41,62,142,196,215,219,230],"hardly":[43],"detected.":[44],"The":[45],"goal":[46],"this":[48],"study":[49],"was":[50,126,159],"to":[51,78,118],"evaluate":[52],"release":[54,137],"two":[56],"isoenzymes":[57],"--":[58],"alpha":[59,139,193,218,227],"pi":[61,141,195,214,229],"kidney":[67,75],"graft":[68,204,239],"recipients":[69],"during":[70,206],"first":[72,208],"week":[73],"after":[74,153,211],"transplantation,":[76],"aiming":[77],"differentiate":[79],"cause":[81],"delayed":[84],"function":[85,134,157,205],"(DF)":[86],"transplanted":[88,117],"MATERIAL":[90],"AND":[91],"METHODS:":[92],"50":[93,119],"cadaveric":[94],"kidneys":[95,109,115],"were":[96,110,116,146,198],"procured":[97],"using":[98,105],"standard":[99],"technique":[100],"with":[101,202,233],"\"in":[102],"situ\"":[103],"cooling":[104],"UW":[106],"solution.":[107],"All":[108],"machine":[111],"perfused.":[112],"After":[113],"preservation":[114],"ERSD":[120],"patients.":[121],"Standard":[122],"triple":[123],"drug":[124],"immunosuppression":[125],"applied":[127],"(steroids,":[128],"CsA,":[129],"Cell-Cept":[130],"or":[131],"Aza.).":[132],"Graft":[133],"measured":[147],"1,":[148],"3":[149],"7":[151,209],"days":[152,210],"transplantation.":[154],"RESULTS:":[155],"immediate":[156],"(IF)":[158],"found":[160,199],"72%":[162],"(36pts),":[163],"DF":[164,170,203,234],"28%":[166],"(14pts).":[167],"5":[168,182],"patients":[171],"had":[172,175,183],"ATN,":[173],"4":[174],"acute":[176,186,224],"rejection":[177,187],"(REJ)":[178],"remaining":[181],"ATN":[184],"(see":[188],"table":[189],"below).":[190],"CONCLUSIONS:":[191],"High":[192,226],"concentrations":[197],"pts":[201,232],"Tx.":[212],"Elevated":[213],"low":[217],"indicates":[223],"rejection.":[225,240],"should":[235],"raise":[236],"suspicion":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}