{"id":"https://openalex.org/W1882882011","doi":null,"title":"Immuno-allergic reactions to antituberculosis treatment","display_name":"Immuno-allergic reactions to antituberculosis treatment","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W1882882011","mag":"1882882011"},"language":"en","primary_location":{"id":"mag:1882882011","doi":null,"is_oa":false,"landing_page_url":"https://erj.ersjournals.com/content/erj/42/Suppl_57/P4458.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090860108","display_name":"S. Habib\u00e8ch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167348","display_name":"Abderrahmane Mami Hospital","ror":"https://ror.org/04w40b524","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167348"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"S. Habib\u00e8ch","raw_affiliation_strings":["Respiratory Department, A Mami Hospital, Ariana, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, A Mami Hospital, Ariana, Tunisia","institution_ids":["https://openalex.org/I4210167348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109527477","display_name":"Hajer Racil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167348","display_name":"Abderrahmane Mami Hospital","ror":"https://ror.org/04w40b524","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167348"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hajer Racil","raw_affiliation_strings":["Respiratory Department, A Mami Hospital, Ariana, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, A Mami Hospital, Ariana, Tunisia","institution_ids":["https://openalex.org/I4210167348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060583138","display_name":"Safa Hfaidh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167348","display_name":"Abderrahmane Mami Hospital","ror":"https://ror.org/04w40b524","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167348"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Safa Hfaidh","raw_affiliation_strings":["Respiratory Department, A Mami Hospital, Ariana, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, A Mami Hospital, Ariana, Tunisia","institution_ids":["https://openalex.org/I4210167348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089070486","display_name":"Sana Cheikhrouhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167348","display_name":"Abderrahmane Mami Hospital","ror":"https://ror.org/04w40b524","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167348"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"S. Cheikhrouhou","raw_affiliation_strings":["Respiratory Department, A Mami Hospital, Ariana, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, A Mami Hospital, Ariana, Tunisia","institution_ids":["https://openalex.org/I4210167348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058052261","display_name":"Naouel Chaouch","orcid":"https://orcid.org/0000-0001-5323-3025","observed_orcids":["https://orcid.org/0000-0001-5323-3025"]},"institutions":[{"id":"https://openalex.org/I4210167348","display_name":"Abderrahmane Mami Hospital","ror":"https://ror.org/04w40b524","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167348"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"N. Chaouch","raw_affiliation_strings":["Respiratory Department, A Mami Hospital, Ariana, Tunisia"],"raw_orcid":"https://orcid.org/0000-0001-5323-3025","affiliations":[{"raw_affiliation_string":"Respiratory Department, A Mami Hospital, Ariana, Tunisia","institution_ids":["https://openalex.org/I4210167348"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002822318","display_name":"Abdellatif Chabbou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167348","display_name":"Abderrahmane Mami Hospital","ror":"https://ror.org/04w40b524","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167348"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"A. Chabbou","raw_affiliation_strings":["Respiratory Department, A Mami Hospital, Ariana, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, A Mami Hospital, Ariana, Tunisia","institution_ids":["https://openalex.org/I4210167348"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210167348"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07750253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"42","issue":null,"first_page":"4458","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.8640000224113464},{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"pyrazinamide","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-induced-skin-reaction","display_name":"drug-induced skin reaction","score":0.6909999847412109},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.7070000171661377},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.6710000038146973},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9816319346427917},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.6324921250343323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5338899493217468},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.48178550601005554},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.46032702922821045},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38449588418006897},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3764151632785797},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.34320521354675293}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1882882011","doi":null,"is_oa":false,"landing_page_url":"https://erj.ersjournals.com/content/erj/42/Suppl_57/P4458.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1913791334","https://openalex.org/W4406954720","https://openalex.org/W2905616498","https://openalex.org/W4387982055","https://openalex.org/W4408038209","https://openalex.org/W68892123","https://openalex.org/W3006173792","https://openalex.org/W2012952638","https://openalex.org/W3165003111","https://openalex.org/W2003093831"],"abstract_inverted_index":{"Introduction:":[0],"\n\nPulmonary":[1],"Tuberculosis":[2],"(PTB)":[3],"is":[4,21,34,63,236,239,248,259,271],"a":[5,22,35,196,219,240,251],"major":[6,252],"public":[7],"health":[8],"problem":[9,24,242],"in":[10,47,83,92,103,141,164,215,221,229,266,273],"Tunisia.":[11],"Immunoallergic":[12],"reactions":[13,126,166],"(IAR)":[14],"to":[15,59,180],"antiTB":[16,137],"treatment":[17,171,190,204],"are":[18],"rare.":[19],"It":[20],"real":[23,241],"of":[25,71,80,105,124,133,136,173,203,210,233,257,269],"management":[26],"and":[27,31,52,76,110,155,176,218,261],"may":[28],"involve":[29],"life-threatening.\n\nMaterials":[30],"methods:":[32],"\n\nIt":[33,62],"retrospective":[36],"study.":[37],"Among":[38],"315":[39],"non":[40],"HIV":[41],"confirmed":[42,225],"PTB":[43,86],"patients":[44,187,258],"(P)":[45],"hospitalized":[46],"our":[48],"department":[49],"between":[50],"2001":[51],"2012,":[53],"19":[54,64,93],"P":[55,66,96,169,217],"(6%)":[56],"developed":[57],"IAR":[58,101,235],"anti-TB":[60],"treatment.\n\nResults:":[61],"male":[65],"with":[67,195],"an":[68,227],"average":[69,130,201],"age":[70],"42":[72],"years":[73],"(between":[74],"18":[75],"71":[77],"years).":[78],"Five":[79,186],"them":[81],"had":[82,97],"their":[84],"history":[85],"correctly":[87],"treated.":[88],"Smoking":[89],"was":[90,127,139,184,205,213,224],"observed":[91,128],"P.":[94],"17":[95,131],"sequential":[98],"TB":[99,193,253],"treatment.":[100,254],"reported":[102],"order":[104],"frequency":[106],"are:":[107],"cutaneous":[108],"pruritus":[109],"or":[111],"urticaria":[112],"(9":[113],"cases),":[114,117,145,148,151],"hematological":[115],"(6":[116],"renal":[118,142,182],"failure":[119,143,183],"(4":[120,150],"cases).":[121],"The":[122,200],"occurrence":[123,232],"these":[125],"on":[129],"day":[132],"the":[134,267],"introduction":[135],"treatment.\n\nRifadine":[138],"incriminated":[140],"(3":[144,167],"thrombocytopenia":[146],"(2":[147,153],"anemia":[149],"leukoneutropenia":[152],"cases)":[154],"skin":[156,165],"rash":[157],"(1":[158],"case).":[159],"Piazoline":[160],"has":[161],"been":[162],"implicated":[163],"cases).\n\nFive":[168],"stopped":[170],"because":[172],"adverse":[174],"events":[175],"1":[177],"death":[178],"related":[179],"immune-allergic":[181],"noted.":[185],"received":[188],"symptomatic":[189],"without":[191],"stopping":[192],"drugs":[194],"good":[197],"clinical":[198],"outcome.":[199],"duration":[202],"8":[206,216],"months.":[207],"A":[208],"delay":[209],"smear":[211],"negativity":[212],"noted":[214],"relapse":[220],"3.":[222],"Resistance":[223],"by":[226,250],"antibiogram":[228],"3P.\n\nConclusion:":[230],"\n\nThe":[231],"severe":[234],"unpredictable.":[237],"This":[238],"when":[243],"this":[244],"therapeutic":[245],"side":[246,264],"effect":[247],"caused":[249],"Careful":[255],"monitoring":[256],"necessary":[260],"reporting":[262],"any":[263],"effects":[265],"service":[268],"pharmacovigilance":[270],"needed":[272],"all":[274],"cases.":[275]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}