{"id":"https://openalex.org/W188276756","doi":null,"title":"Cell-mediated immunity in systemic lupus erythematosus.","display_name":"Cell-mediated immunity in systemic lupus erythematosus.","publication_year":1977,"publication_date":"1977-10-01","ids":{"openalex":"https://openalex.org/W188276756","mag":"188276756","pmid":"https://pubmed.ncbi.nlm.nih.gov/606439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1541176"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1541176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1541176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1541176","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069064151","display_name":"Alexandros Andrianakos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A A Andrianakos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090059379","display_name":"Philip N. Tsichlis","orcid":"https://orcid.org/0000-0002-5300-0448","observed_orcids":["https://orcid.org/0000-0002-5300-0448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P N Tsichlis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108477447","display_name":"Emmanuel Merikas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E G Merikas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623134","display_name":"Spyros G. Marketos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S G Marketos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038322725","display_name":"John Turner Sharp","orcid":"https://orcid.org/0000-0002-7429-9047","observed_orcids":["https://orcid.org/0000-0002-7429-9047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J T Sharp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019437917","display_name":"George Merikas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G E Merikas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9495,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.92513863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"30","issue":"1","first_page":"89","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/leukocyte-migration-inhibition","display_name":"leukocyte migration inhibition","score":0.8289999961853027},{"id":"https://openalex.org/keywords/streptokinase-streptodornase","display_name":"streptokinase-streptodornase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/skin-testing","display_name":"skin testing","score":0.7879999876022339},{"id":"https://openalex.org/keywords/purified-protein-derivative","display_name":"purified protein derivative","score":0.9490000009536743},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocyte-count","display_name":"peripheral blood lymphocyte count","score":0.8769999742507935},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2777990475","wikidata":"https://www.wikidata.org/wiki/Q485831","display_name":"Lymphocytopenia","level":3,"score":0.9291441440582275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.8229525685310364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6525582075119019},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6438450813293457},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5309103727340698},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.506341814994812},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4448852837085724},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.421236515045166},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.4185945689678192},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15876510739326477}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002464","descriptor_name":"Cell Migration Inhibition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1541176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1541176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:606439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/606439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:188276756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/606439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1541176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1541176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W15590002","https://openalex.org/W155520168","https://openalex.org/W1568239005","https://openalex.org/W1986720974","https://openalex.org/W2007264933","https://openalex.org/W2010694381","https://openalex.org/W2013882917","https://openalex.org/W2018342969","https://openalex.org/W2021973599","https://openalex.org/W2027639920","https://openalex.org/W2043529307","https://openalex.org/W2049395357","https://openalex.org/W2053654911","https://openalex.org/W2059726724","https://openalex.org/W2069024709","https://openalex.org/W2073060011","https://openalex.org/W2074784999","https://openalex.org/W2078660666","https://openalex.org/W2080987814","https://openalex.org/W2102308411","https://openalex.org/W2123257538","https://openalex.org/W2153036417","https://openalex.org/W2159301932","https://openalex.org/W2170126019","https://openalex.org/W2312877120","https://openalex.org/W2317299924","https://openalex.org/W2399257801","https://openalex.org/W2409778087"],"related_works":["https://openalex.org/W1568239005","https://openalex.org/W2010694381","https://openalex.org/W2093995287","https://openalex.org/W2047071772","https://openalex.org/W2018342969","https://openalex.org/W2134781523","https://openalex.org/W7112221447","https://openalex.org/W2069135123","https://openalex.org/W2170126019","https://openalex.org/W2133532605"],"abstract_inverted_index":{"Cell-mediated":[0],"immunity":[1],"in":[2,24,64,121,156,162,209,214,233],"systemic":[3],"lupus":[4],"erythematosus":[5],"(SLE)":[6],"was":[7,61,131],"assessed":[8],"by":[9,17,110,125,237],"skin":[10,112,148,174],"testing":[11,113],"with":[12,33,39,46,80,96,114,164],"six":[13],"common":[14,115],"antigens":[15,116],"and":[16,31,55,117,142,161,177,240],"streptokinase-streptodornase":[18],"(SK\u2013SD)":[19],"induced":[20],"leucocyte":[21,118,202],"migration":[22,57,119,203],"inhibition":[23,120,204],"twenty-four":[25,34],"SLE":[26,51,85,101,140,159,211,234],"patients,":[27,212],"who":[28],"were":[29,53,73,153],"age-":[30],"sex-matched":[32],"healthy":[35],"subjects":[36],"or":[37,82],"patients":[38,52,141,160],"diseases":[40],"not":[41,62],"known":[42],"to":[43,76,89,98,123,166,206],"be":[44],"associated":[45],"immunological":[47],"abnormalities.":[48],"25%":[49],"of":[50,58,67,105,138,145,186,200,221,229],"anergic,":[54],"the":[56,65,139,143,157,184,187,191,198,201,210,227],"their":[59,146],"leucocytes":[60],"inhibited":[63],"presence":[66],"SK\u2013SD.":[68,126],"Depressed":[69],"cell-mediated":[70,106,230],"immune":[71,188,231],"responses":[72,232],"significantly":[74,154],"related":[75],"disease":[77,168],"activity.":[78,169],"Patients":[79],"inactive":[81],"mildly":[83],"active":[84,100],"exhibited":[86],"selective":[87],"hyporeactivity":[88],"purified":[90],"protein":[91],"derivative":[92],"(PPD),":[93],"while":[94],"those":[95,163],"moderately":[97],"severely":[99],"had":[102],"marked":[103],"depression":[104,199,228],"immunity,":[107],"as":[108,183],"manifested":[109],"both":[111,238],"response":[122,205],"stimulation":[124],"A":[127],"significant":[128],"positive":[129,147],"correlation":[130,171],"found":[132,172],"between":[133,173],"absolute":[134,178],"peripheral":[135],"lymphocyte":[136,151,179,241],"counts":[137,152],"number":[144,220],"tests.":[149],"Peripheral":[150],"decreased":[155],"anergic":[158],"moderate":[165],"severe":[167],"The":[170],"test":[175],"reactivity":[176],"count":[180],"suggests":[181],"lymphocytopenia":[182,194,239],"mechanism":[185],"suppression.":[189],"On":[190],"other":[192],"hand,":[193],"alone":[195],"cannot":[196],"explain":[197],"SK\u2013SD":[207],"observed":[208],"because":[213],"this":[215],"system":[216],"a":[217],"relatively":[218],"constant":[219],"lymphocytes":[222],"is":[223,235],"employed.":[224],"In":[225],"conclusion,":[226],"caused":[236],"hyporeactivity.":[242]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}