{"id":"https://openalex.org/W18826162","doi":"https://doi.org/10.4172/2329-9029.1000107","title":"Tobacco Ntomt2 Revisited: Multiple O-Methylation of Quercetin is Catalyzed by a Single Gene Product","display_name":"Tobacco Ntomt2 Revisited: Multiple O-Methylation of Quercetin is Catalyzed by a Single Gene Product","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W18826162","doi":"https://doi.org/10.4172/2329-9029.1000107","mag":"18826162"},"language":"en","primary_location":{"id":"doi:10.4172/2329-9029.1000107","doi":"https://doi.org/10.4172/2329-9029.1000107","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2329-9029.1000107","pdf_url":null,"source":{"id":"https://openalex.org/S2765075125","display_name":"Journal of Plant Biochemistry & Physiology","issn_l":"2329-9029","issn":["2329-9029"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Plant Biochemistry &amp; Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109904253","display_name":"Jian Min Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Min Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012624580","display_name":"Amira Moheb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amira Moheb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o-methyltransferase","display_name":"O-methyltransferase","score":0.7310000061988831},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5360000133514404},{"id":"https://openalex.org/keywords/binding-pocket","display_name":"binding pocket","score":0.4690000116825104},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/general-base-catalysis","display_name":"general base catalysis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nicotiana-tabacum","display_name":"tobacco","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5647460222244263},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5111384987831116},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.4507916569709778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42874160408973694},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.4186040759086609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38221192359924316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3364775478839874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17141470313072205},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16297757625579834},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4172/2329-9029.1000107","doi":"https://doi.org/10.4172/2329-9029.1000107","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2329-9029.1000107","pdf_url":null,"source":{"id":"https://openalex.org/S2765075125","display_name":"Journal of Plant Biochemistry & Physiology","issn_l":"2329-9029","issn":["2329-9029"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Plant Biochemistry &amp; Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1515889059","https://openalex.org/W1528122668","https://openalex.org/W1548774217","https://openalex.org/W1592197664","https://openalex.org/W1600507024","https://openalex.org/W1965771291","https://openalex.org/W1978341535","https://openalex.org/W1982127102","https://openalex.org/W1982155071","https://openalex.org/W1984923138","https://openalex.org/W1986645535","https://openalex.org/W1990178667","https://openalex.org/W1993923229","https://openalex.org/W2001350940","https://openalex.org/W2001628109","https://openalex.org/W2002505397","https://openalex.org/W2006612458","https://openalex.org/W2013263299","https://openalex.org/W2016207843","https://openalex.org/W2037516643","https://openalex.org/W2055020674","https://openalex.org/W2058428472","https://openalex.org/W2062158062","https://openalex.org/W2064078155","https://openalex.org/W2068395196","https://openalex.org/W2078154234","https://openalex.org/W2087843541","https://openalex.org/W2095565753","https://openalex.org/W2100608205","https://openalex.org/W2106882534","https://openalex.org/W2107834654","https://openalex.org/W2117892897","https://openalex.org/W2123859926","https://openalex.org/W2146396346","https://openalex.org/W2147421370","https://openalex.org/W2158534713","https://openalex.org/W2163249738","https://openalex.org/W2163378870","https://openalex.org/W2175564726","https://openalex.org/W2278940270","https://openalex.org/W2477142511"],"related_works":["https://openalex.org/W2029329209","https://openalex.org/W2001350940","https://openalex.org/W7221120729","https://openalex.org/W4235214095","https://openalex.org/W2006612458","https://openalex.org/W2062158062","https://openalex.org/W2028420723","https://openalex.org/W4393933086","https://openalex.org/W2072776220","https://openalex.org/W2793011681"],"abstract_inverted_index":{"Tobacco":[0],"NtOMT2":[1,32,100,106,130,152],"was":[2],"previously":[3],"reported":[4],"as":[5,20,154],"an":[6],"inducible,":[7],"o-diphenol":[8],"O-methyltransferase":[9],"(OMT)":[10],"that":[11,44,50,116,178],"exhibits":[12],"\r\n\r\n\r\n\r\nsimilar":[13],"preferences":[14],"towards":[15],"quercetin":[16,57,70],"and":[17,39,64,75,125,157],"caffeic":[18],"acid":[19],"substrates.":[21],"In":[22],"this":[23],"report,":[24],"we":[25],"further":[26],"examine":[27],"the":[28,55,72,85,99,108,117,121,126,162,173],"substrate":[29],"\r\n\r\n\r\n\r\nspecificity":[30],"of\u00a0":[31],"based":[33],"on":[34,71],"enzyme":[35],"assays,":[36],"kinetic":[37],"data":[38],"phylogenetic":[40],"analysis.":[41],"We":[42],"demonstrate":[43],"\r\n\r\n\r\n\r\nNtOMT2":[45],"is":[46,172,182],"a":[47,113,133,148,155,185],"flavonol":[48,56],"OMT":[49],"catalyzes":[51],"multiple":[52,150,167,180],"O-methylation":[53],"of":[54,69,88,105,135,169],"giving":[58],"rise":[59],"to":[60,84,131,176],"its":[61],"mono-,":[62],"\r\n\r\n\r\n\r\ndi-":[63],"trimethyl":[65],"ether":[66],"derivatives.":[67],"Mono-methylation":[68],"3-,":[73],"3\u2032-/4\u2032-":[74],"7-hydroxyl":[76],"groups":[77,124],"occurs":[78],"in":[79,98,147,160],"\r\n\r\n\r\n\r\na":[80],"random":[81,149],"fashion":[82],"according":[83],"physio-chemical":[86],"properties":[87],"their":[89,94],"hydroxyl":[90,123],"groups,":[91],"together":[92],"with":[93,107,140],"similar":[95,137],"\r\n\r\n\r\n\r\nbinding":[96,143],"energies":[97],"binding":[101,138],"pocket.":[102],"Homology":[103],"modeling":[104],"Medicago":[109],"sativa":[110],"COMT":[111],"\r\n\r\n\r\n\r\nas":[112],"template":[114],"indicates":[115],"H-bonding":[118],"network":[119],"between":[120],"functional":[122],"neighboring":[127],"\r\n\r\n\r\n\r\nresidues":[128],"allowed":[129],"establish":[132],"number":[134],"energetically":[136],"arrangements":[139],"slightly":[141],"different":[142],"modes;":[144],"thus":[145],"resulting":[146],"methylation.":[151],"functions":[153],"proximity":[156],"orientation":[158],"\r\n\r\n\r\n\r\nagent":[159],"using":[161],"general":[163],"base":[164],"catalysis":[165],"for":[166],"methylation":[168,181],"quercetin.":[170],"This":[171],"first":[174],"report":[175],"indicate":[177],"\r\n\r\n\r\n\r\nquercetin":[179],"catalyzed":[183],"by":[184],"single":[186],"gene":[187],"product.":[188]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}
