{"id":"https://openalex.org/W188246712","doi":null,"title":"Engineered Materials to Measure and Regulate Cell Mechanotransduction","display_name":"Engineered Materials to Measure and Regulate Cell Mechanotransduction","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W188246712","mag":"188246712"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:20.500.14332/28000","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/28000","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017675944","display_name":"Brandon L. Blakely","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brandon L. Blakely","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017675944"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-mechanotransduction","display_name":"cell mechanotransduction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dna-hairpin","display_name":"DNA hairpins","score":0.8149999976158142},{"id":"https://openalex.org/keywords/fluorophore-quencher-pair","display_name":"fluorophore-quencher pair","score":0.7910000085830688},{"id":"https://openalex.org/keywords/traction-force-measurement","display_name":"traction force measurement","score":0.8040000200271606},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.7799999713897705},{"id":"https://openalex.org/keywords/poly-ethylene-glycol-hydrogels","display_name":"poly(ethylene glycol) hydrogels","score":0.8009999990463257},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/angiogenic-sprouting","display_name":"angiogenic sprouting","score":0.8980000019073486},{"id":"https://openalex.org/keywords/micromolding","display_name":"micromolding","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tissue-explants","display_name":"tissue explants","score":0.6000000238418579},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5886249542236328},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.5246241688728333},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4890376031398773},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.48606541752815247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47422337532043457},{"id":"https://openalex.org/C32520587","wikidata":"https://www.wikidata.org/wiki/Q2142522","display_name":"Tractive force","level":2,"score":0.4621473252773285},{"id":"https://openalex.org/C527607","wikidata":"https://www.wikidata.org/wiki/Q175538","display_name":"Microfabrication","level":4,"score":0.4349222779273987},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3969497084617615},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36073029041290283},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.27906519174575806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16314440965652466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11694243550300598},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:20.500.14332/28000","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/28000","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-12215","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3623799","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:edissertations-3022","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=3022&context=edissertations","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"mag:188246712","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=12215&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":206,"referenced_works":["https://openalex.org/W100715757","https://openalex.org/W1525292585","https://openalex.org/W1562490776","https://openalex.org/W1584346353","https://openalex.org/W1597787921","https://openalex.org/W1598962581","https://openalex.org/W1607200676","https://openalex.org/W1655034548","https://openalex.org/W1875913653","https://openalex.org/W1967265143","https://openalex.org/W1967895130","https://openalex.org/W1967912612","https://openalex.org/W1969689864","https://openalex.org/W1969964831","https://openalex.org/W1970525947","https://openalex.org/W1970863842","https://openalex.org/W1973089587","https://openalex.org/W1973757009","https://openalex.org/W1974008634","https://openalex.org/W1974672813","https://openalex.org/W1976401919","https://openalex.org/W1979038578","https://openalex.org/W1979169277","https://openalex.org/W1981734818","https://openalex.org/W1981951648","https://openalex.org/W1982486040","https://openalex.org/W1982949730","https://openalex.org/W1983844422","https://openalex.org/W1983986887","https://openalex.org/W1986225001","https://openalex.org/W1986411839","https://openalex.org/W1986475577","https://openalex.org/W1986540698","https://openalex.org/W1986933463","https://openalex.org/W1987628024","https://openalex.org/W1987817703","https://openalex.org/W1990718621","https://openalex.org/W1992166637","https://openalex.org/W1993006648","https://openalex.org/W1993274199","https://openalex.org/W1994076220","https://openalex.org/W1998276013","https://openalex.org/W1999765951","https://openalex.org/W1999959517","https://openalex.org/W2000176833","https://openalex.org/W2000402725","https://openalex.org/W2001129308","https://openalex.org/W2002223490","https://openalex.org/W2005451208","https://openalex.org/W2005472501","https://openalex.org/W2005532545","https://openalex.org/W2008081243","https://openalex.org/W2008577210","https://openalex.org/W2010320204","https://openalex.org/W2010446343","https://openalex.org/W2011437850","https://openalex.org/W2013205720","https://openalex.org/W2013827506","https://openalex.org/W2014077602","https://openalex.org/W2014090427","https://openalex.org/W2015640138","https://openalex.org/W2017120550","https://openalex.org/W2017536526","https://openalex.org/W2018889278","https://openalex.org/W2021340446","https://openalex.org/W2023862597","https://openalex.org/W2024885580","https://openalex.org/W2025041673","https://openalex.org/W2025735516","https://openalex.org/W2026322027","https://openalex.org/W2026632078","https://openalex.org/W2026652581","https://openalex.org/W2026710381","https://openalex.org/W2029847157","https://openalex.org/W2030261975","https://openalex.org/W2030601421","https://openalex.org/W2034309840","https://openalex.org/W2034758576","https://openalex.org/W2035108361","https://openalex.org/W2037810763","https://openalex.org/W2039317622","https://openalex.org/W2040903350","https://openalex.org/W2042257864","https://openalex.org/W2045161614","https://openalex.org/W2048305477","https://openalex.org/W2048832515","https://openalex.org/W2049387285","https://openalex.org/W2049636186","https://openalex.org/W2051504714","https://openalex.org/W2051772872","https://openalex.org/W2053001031","https://openalex.org/W2053331432","https://openalex.org/W2054371293","https://openalex.org/W2054971583","https://openalex.org/W2055940657","https://openalex.org/W2056010224","https://openalex.org/W2057116920","https://openalex.org/W2057566851","https://openalex.org/W2058096164","https://openalex.org/W2058310958","https://openalex.org/W2060090720","https://openalex.org/W2060661444","https://openalex.org/W2061223357","https://openalex.org/W2061464631","https://openalex.org/W2061519659","https://openalex.org/W2061889278","https://openalex.org/W2062279417","https://openalex.org/W2063753069","https://openalex.org/W2067897176","https://openalex.org/W2067947421","https://openalex.org/W2068092779","https://openalex.org/W2068888445","https://openalex.org/W2069636792","https://openalex.org/W2069775076","https://openalex.org/W2069820450","https://openalex.org/W2072889522","https://openalex.org/W2074183516","https://openalex.org/W2074437338","https://openalex.org/W2074631701","https://openalex.org/W2074801137","https://openalex.org/W2076987005","https://openalex.org/W2078393006","https://openalex.org/W2079042914","https://openalex.org/W2079595896","https://openalex.org/W2080452175","https://openalex.org/W2081407528","https://openalex.org/W2081789842","https://openalex.org/W2082182581","https://openalex.org/W2082753131","https://openalex.org/W2084400115","https://openalex.org/W2085320707","https://openalex.org/W2085767196","https://openalex.org/W2090409777","https://openalex.org/W2091119718","https://openalex.org/W2091592906","https://openalex.org/W2091844468","https://openalex.org/W2092415206","https://openalex.org/W2092832320","https://openalex.org/W2093126111","https://openalex.org/W2093171685","https://openalex.org/W2095859689","https://openalex.org/W2096595594","https://openalex.org/W2100122781","https://openalex.org/W2100303404","https://openalex.org/W2103963843","https://openalex.org/W2104916769","https://openalex.org/W2109707676","https://openalex.org/W2110148884","https://openalex.org/W2111412288","https://openalex.org/W2111719518","https://openalex.org/W2111811045","https://openalex.org/W2112719371","https://openalex.org/W2112805595","https://openalex.org/W2113220609","https://openalex.org/W2113324173","https://openalex.org/W2114989145","https://openalex.org/W2115146410","https://openalex.org/W2116527577","https://openalex.org/W2119063295","https://openalex.org/W2120346794","https://openalex.org/W2121484578","https://openalex.org/W2122243862","https://openalex.org/W2122708630","https://openalex.org/W2123046057","https://openalex.org/W2124751176","https://openalex.org/W2125238692","https://openalex.org/W2125644189","https://openalex.org/W2126087366","https://openalex.org/W2126496496","https://openalex.org/W2128884401","https://openalex.org/W2130119800","https://openalex.org/W2135165925","https://openalex.org/W2136273784","https://openalex.org/W2137278952","https://openalex.org/W2140506935","https://openalex.org/W2140835123","https://openalex.org/W2141141508","https://openalex.org/W2141634848","https://openalex.org/W2141738357","https://openalex.org/W2144023435","https://openalex.org/W2145009320","https://openalex.org/W2145288435","https://openalex.org/W2145392559","https://openalex.org/W2145731759","https://openalex.org/W2145963323","https://openalex.org/W2147000598","https://openalex.org/W2150712021","https://openalex.org/W2154475799","https://openalex.org/W2157317755","https://openalex.org/W2157537726","https://openalex.org/W2158931259","https://openalex.org/W2160657827","https://openalex.org/W2161350623","https://openalex.org/W2162310257","https://openalex.org/W2163187600","https://openalex.org/W2167460696","https://openalex.org/W2167956058","https://openalex.org/W2168454062","https://openalex.org/W2168955823","https://openalex.org/W2168986165","https://openalex.org/W2171190768","https://openalex.org/W2314244008","https://openalex.org/W2328878629","https://openalex.org/W2395585051","https://openalex.org/W2484038213","https://openalex.org/W3103649439"],"related_works":["https://openalex.org/W4383302263","https://openalex.org/W1968940890","https://openalex.org/W7118174298","https://openalex.org/W3083376442","https://openalex.org/W2750562350","https://openalex.org/W7125506533","https://openalex.org/W2334459477","https://openalex.org/W4399323195","https://openalex.org/W2258644868","https://openalex.org/W1505297706"],"abstract_inverted_index":{"The":[0,156],"extracellular":[1],"environment":[2],"plays":[3],"a":[4,8,26,34,211,227],"key":[5],"role":[6],"in":[7,168],"wide":[9],"array":[10],"of":[11,25,51,71,76,92,117,133,136,173,177,203],"cellular":[12,31,153,195],"functions":[13],"including":[14],"migration,":[15],"tissue":[16,241],"formation,":[17],"and":[18,33,65,85,114,223],"differentiation.":[19],"This":[20,219],"thesis":[21],"overviews":[22],"the":[23,99,112,124,134,171,175,200],"design":[24],"molecular":[27,43],"sensor":[28],"to":[29,37,61,80,89,102,144,148,151,159,163,180,216,230,234],"measure":[30,152],"forces":[32,50],"hydrogel":[35,215],"system":[36],"engineer":[38],"angiogenic":[39,236],"sprouting.":[40],"We":[41,109,189,225],"developed":[42],"force":[44,181],"probes":[45],"(FPs)":[46],"that":[47,83,123,194],"report":[48],"traction":[49,154],"adherent":[52],"cells":[53],"with":[54,186],"high":[55],"spatial":[56],"resolution,":[57],"can":[58,126],"be":[59,127],"linked":[60],"virtually":[62],"any":[63],"surface,":[64],"do":[66],"not":[67],"require":[68],"monitoring":[69],"deformations":[70],"elastic":[72],"substrates.":[73],"FPs":[74,105,125,147,162,179],"consist":[75],"DNA":[77,137],"hairpins":[78],"conjugated":[79],"fluorophore-quencher":[81],"pairs":[82],"unfold":[84],"fluoresce":[86],"when":[87],"subjected":[88],"specific":[90],"amounts":[91],"force.":[93],"In":[94,206],"chapter":[95,207],"two":[96],"we":[97,209],"overview":[98],"synthetic":[100],"strategies":[101],"produce":[103],"these":[104,118,146,161,178,232],"from":[106,130,238],"solid-state":[107],"synthesis.":[108],"then":[110],"demonstrate":[111],"chemical":[113],"physical":[115],"characterization":[116],"FPs.":[119],"These":[120],"data":[121],"show":[122,226],"designed":[128],"rationally":[129],"existing":[131],"knowledge":[132],"force-responsiveness":[135],"hairpins.":[138],"Chapter":[139],"three":[140],"summarizes":[141],"our":[142],"methods":[143],"affix":[145],"solid":[149],"substrates":[150],"forces.":[155],"silane":[157],"chemistry":[158],"conjugate":[160],"glass":[164],"coverslips":[165],"is":[166,183,221],"reported":[167],"detail.":[169],"Then,":[170],"results":[172],"converting":[174],"fluorescence":[176],"values":[182],"given":[184],"along":[185],"biological":[187],"validation.":[188],"find":[190],"using":[191],"this":[192],"method":[193],"tractions":[196],"are":[197],"exerted":[198],"at":[199],"distal":[201],"ends":[202],"focal":[204],"adhesions.":[205],"four":[208],"present":[210],"versatile":[212],"bioactive":[213],"PEG":[214],"study":[217],"angiogenesis.":[218],"material":[220],"MMP-degradable":[222],"cell-adhesive.":[224],"microfabrication":[228],"strategy":[229],"micromold":[231],"gels":[233],"pattern":[235],"sprouting":[237],"ex":[239],"vivo":[240],"explants.":[242]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}