{"id":"https://openalex.org/W188245501","doi":null,"title":"Ischemia and reperfusion: the endothelial perspective. A radical view.","display_name":"Ischemia and reperfusion: the endothelial perspective. A radical view.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W188245501","mag":"188245501","pmid":"https://pubmed.ncbi.nlm.nih.gov/16899903"},"language":"en","primary_location":{"id":"pmid:16899903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16899903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088608614","display_name":"Tommaso Gori","orcid":"https://orcid.org/0000-0003-2917-6707","observed_orcids":["https://orcid.org/0000-0003-2917-6707"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tommaso Gori","raw_affiliation_strings":["Dipartimento di Medicina Interna, Cardiovascolare e Geriatrica, Universit\u00e0 degli Studi di Siena, Italy. tommaso.gori@utoronto.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna, Cardiovascolare e Geriatrica, Universit\u00e0 degli Studi di Siena, Italy. tommaso.gori@utoronto.ca","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103452417","display_name":"Monica Lisi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Lisi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109894395","display_name":"Sandro Forconi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandro Forconi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3661,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.777277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"35","issue":"1-2","first_page":"31","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.36959999799728394,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.9760000109672546},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.6230000257492065},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.8299999833106995},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.7260000109672546},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8180000185966492},{"id":"https://openalex.org/keywords/ischemic-preconditioning","display_name":"ischemic preconditioning","score":0.9210000038146973},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tissue-necrosis","display_name":"tissue necrosis","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7458406686782837},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7167375683784485},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6953402757644653},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6766952276229858},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5406640768051147},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5142685770988464},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.4370138645172119},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4153469204902649},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38801005482673645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3780309557914734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.368660032749176},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35497182607650757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2448449432849884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23759615421295166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21108993887901306},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15086022019386292}],"mesh":[{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019194","descriptor_name":"Ischemic Preconditioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16899903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16899903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},{"id":"mag:188245501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16899903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W89430380","https://openalex.org/W960047494","https://openalex.org/W1954329710","https://openalex.org/W2001044397","https://openalex.org/W2001322138","https://openalex.org/W2008931703","https://openalex.org/W2027100787","https://openalex.org/W2037121432","https://openalex.org/W2055063453","https://openalex.org/W2070212734","https://openalex.org/W2084408440","https://openalex.org/W2088940818","https://openalex.org/W2097867305","https://openalex.org/W2105140175","https://openalex.org/W2110204147","https://openalex.org/W2113586520","https://openalex.org/W2113842550","https://openalex.org/W2119416582","https://openalex.org/W2126090002","https://openalex.org/W2146217294","https://openalex.org/W2154283765","https://openalex.org/W2155034650","https://openalex.org/W2161074774","https://openalex.org/W2412856908","https://openalex.org/W2471911827"],"related_works":["https://openalex.org/W192634407","https://openalex.org/W1995409772","https://openalex.org/W1736321361","https://openalex.org/W1630686923","https://openalex.org/W1990398731","https://openalex.org/W2427897949","https://openalex.org/W2004754488","https://openalex.org/W2129117422","https://openalex.org/W7095888995","https://openalex.org/W2413835485"],"abstract_inverted_index":{"Ischemia":[0],"and":[1,100,142,170],"reperfusion":[2],"(IR)":[3],"injury":[4,151,169],"causes":[5],"a":[6,59,105,112,115,123],"variety":[7],"of":[8,30,93,122,132,139,149,162,174],"changes":[9],"in":[10,62,77,79,104,135,166,171],"tissue":[11,124],"homeostasis":[12],"that":[13],"lead":[14],"to":[15,22,38,50,125],"necrosis":[16],"and/or":[17],"programmed":[18],"cell":[19],"death.":[20],"Due":[21],"its":[23],"strategic":[24],"location":[25],"at":[26],"the":[27,32,54,90,120,130,133,137,144,147,160,172],"luminal":[28],"surface":[29],"vessels,":[31],"vascular":[33],"endothelium":[34,134],"is":[35],"particularly":[36],"sensitive":[37],"IR.":[39],"In":[40,155],"particular,":[41,156],"endothelial":[42,71,153,167],"biosynthetic":[43],"activities":[44],"(and":[45],"their":[46],"protective":[47,106],"effects)":[48],"appear":[49],"be":[51,74],"impaired":[52],"by":[53,58,81],"oxidative":[55],"burst":[56],"induced":[57],"sudden":[60],"increase":[61,119],"oxygen":[63,97],"free":[64,94,98,164],"radical":[65],"species":[66],"upon":[67],"reperfusion.":[68],"Importantly,":[69],"this":[70],"damage":[72],"can":[73,118],"easily":[75],"assessed":[76],"vivo":[78],"humans":[80],"measuring":[82],"endothelium-dependent":[83],"vasorelaxation.":[84],"Paradoxically,":[85],"recent":[86],"studies":[87],"have":[88],"emphasized":[89],"central":[91],"role":[92,131,161],"radicals":[95,99,165],"(including":[96],"nitric":[101],"oxide)":[102],"also":[103],"process,":[107],"denominated":[108],"ischemic":[109,175],"preconditioning,":[110],"i.e.":[111],"condition":[113],"whereby":[114],"given":[116],"stimulus":[117],"tolerance":[121],"IR":[126,140,150,168],"damage.":[127],"We":[128],"discuss":[129],"determining":[136],"mechanism":[138],"injury,":[141],"on":[143,152,159],"other":[145],"side,":[146],"effect":[148],"function.":[154],"we":[157],"focus":[158],"reactive":[163],"development":[173],"preconditioning.":[176]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
