{"id":"https://openalex.org/W18814673","doi":"https://doi.org/10.1023/a:1008999622117","title":"Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep","display_name":"Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W18814673","doi":"https://doi.org/10.1023/a:1008999622117","mag":"18814673","pmid":"https://pubmed.ncbi.nlm.nih.gov/10478493"},"language":"en","primary_location":{"id":"doi:10.1023/a:1008999622117","doi":"https://doi.org/10.1023/a:1008999622117","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1008999622117","pdf_url":null,"source":{"id":"https://openalex.org/S190862277","display_name":"Transgenic Research","issn_l":"0962-8819","issn":["0962-8819","1573-9368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transgenic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041594856","display_name":"Heiner Niemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heiner Niemann","raw_affiliation_strings":["Department of Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL), Neustadt, Germany. niemann@tzv.fal.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL), Neustadt, Germany. niemann@tzv.fal.de","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087576541","display_name":"Roman Halter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman Halter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088491928","display_name":"Joseph W. Carnwath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph W. Carnwath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109382722","display_name":"Doris Herrmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doris Herrmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Erika Lemme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Lemme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110024681","display_name":"Dieter Paul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dieter Paul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":2.495,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.8859559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"237","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-factor-viii","display_name":"human factor VIII","score":0.7760000228881836},{"id":"https://openalex.org/keywords/transgenic-sheep","display_name":"transgenic sheep","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mammary-gland-bioreactor","display_name":"mammary gland bioreactor","score":0.859000027179718},{"id":"https://openalex.org/keywords/milk-clotting-activity","display_name":"milk-clotting activity","score":0.6209999918937683},{"id":"https://openalex.org/keywords/transgene-transmission","display_name":"transgene transmission","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8273972272872925},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7523348331451416},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.7229371070861816},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6966832876205444},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6291313171386719},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5057380199432373},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49715688824653625},{"id":"https://openalex.org/C166342232","wikidata":"https://www.wikidata.org/wiki/Q11936831","display_name":"Minigene","level":5,"score":0.4779129922389984},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4550233781337738},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4523996114730835},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.44185811281204224},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.43726304173469543},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.4132179021835327},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4045708477497101},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.33147066831588745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2205137014389038},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1906774938106537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1288733184337616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08433634042739868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007782","descriptor_name":"Lactoglobulins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007782","descriptor_name":"Lactoglobulins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1023/a:1008999622117","doi":"https://doi.org/10.1023/a:1008999622117","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1008999622117","pdf_url":null,"source":{"id":"https://openalex.org/S190862277","display_name":"Transgenic Research","issn_l":"0962-8819","issn":["0962-8819","1573-9368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transgenic Research","raw_type":"journal-article"},{"id":"pmid:10478493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10478493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transgenic research","raw_type":"Journal Article"},{"id":"pmh:oai:fraunhofer.de:B-63870","doi":null,"is_oa":false,"landing_page_url":"http://publica.fraunhofer.de/documents/B-63870.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer ITA","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/195798","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/195798","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:www.openagrar.de:timport_mods_00032898","doi":null,"is_oa":false,"landing_page_url":"https://www.openagrar.de/receive/timport_mods_00032898","pdf_url":null,"source":{"id":"https://openalex.org/S7407055137","display_name":"OpenAgrar","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1529386582","https://openalex.org/W1540151595","https://openalex.org/W1564397880","https://openalex.org/W1581671952","https://openalex.org/W1671211416","https://openalex.org/W1860470769","https://openalex.org/W1964725146","https://openalex.org/W1967104104","https://openalex.org/W1969542542","https://openalex.org/W1973862215","https://openalex.org/W1975126507","https://openalex.org/W1982247017","https://openalex.org/W1986705405","https://openalex.org/W1986993620","https://openalex.org/W1989133204","https://openalex.org/W1991298002","https://openalex.org/W2012565460","https://openalex.org/W2012896303","https://openalex.org/W2018289835","https://openalex.org/W2021283345","https://openalex.org/W2025161006","https://openalex.org/W2031213896","https://openalex.org/W2031311971","https://openalex.org/W2036098607","https://openalex.org/W2040804173","https://openalex.org/W2041076733","https://openalex.org/W2044070655","https://openalex.org/W2047819219","https://openalex.org/W2049858733","https://openalex.org/W2058682758","https://openalex.org/W2062321149","https://openalex.org/W2071011190","https://openalex.org/W2074434853","https://openalex.org/W2074611792","https://openalex.org/W2075397960","https://openalex.org/W2084773650","https://openalex.org/W2090122012","https://openalex.org/W2094905506","https://openalex.org/W2096643836","https://openalex.org/W2100837269","https://openalex.org/W2130261067","https://openalex.org/W2134812217","https://openalex.org/W2138009608","https://openalex.org/W2169318769","https://openalex.org/W2400075822","https://openalex.org/W2406062167","https://openalex.org/W2412788806","https://openalex.org/W2416764111"],"related_works":["https://openalex.org/W2094905506","https://openalex.org/W2094880053","https://openalex.org/W2075929350","https://openalex.org/W2142927299","https://openalex.org/W7164458653","https://openalex.org/W298123129","https://openalex.org/W3000673739","https://openalex.org/W7071981304","https://openalex.org/W7131996534","https://openalex.org/W121123561"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
