{"id":"https://openalex.org/W1881186243","doi":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","title":"Novel Benzimidazole Analogs as Inhibitors of EGFR Tyrosine Kinase","display_name":"Novel Benzimidazole Analogs as Inhibitors of EGFR Tyrosine Kinase","publication_year":2012,"publication_date":"2012-05-05","ids":{"openalex":"https://openalex.org/W1881186243","doi":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","mag":"1881186243","pmid":"https://pubmed.ncbi.nlm.nih.gov/22564276"},"language":"en","primary_location":{"id":"doi:10.1111/j.1747-0285.2012.01407.x","doi":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1747-0285.2012.01407.x","source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology &amp; Drug Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1747-0285.2012.01407.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Soni Yadav","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soni Yadav","raw_affiliation_strings":["Department of Applied Sciences, Institute of Engineering and Technology, Lucknow 226021, India","Department of Chemistry, DrKNMIET, Modinagar, Meerut 201204, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Sciences, Institute of Engineering and Technology, Lucknow 226021, India","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, DrKNMIET, Modinagar, Meerut 201204, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023436635","display_name":"Deepa Sinha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105454292","display_name":"Guru Gobind Singh Indraprastha University","ror":"https://ror.org/034q1za58","country_code":"IN","type":"education","lineage":["https://openalex.org/I105454292"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepa Sinha","raw_affiliation_strings":["Department of Applied Sciences, HMRITM (Affiliated to GGSIP University), Delhi 110036, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Sciences, HMRITM (Affiliated to GGSIP University), Delhi 110036, India","institution_ids":["https://openalex.org/I105454292"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sanjay K. Singh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjay K. Singh","raw_affiliation_strings":["Department of Applied Sciences, Institute of Engineering and Technology, Lucknow 226021, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Sciences, Institute of Engineering and Technology, Lucknow 226021, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100668386","display_name":"Vinay Kumar Singh","orcid":"https://orcid.org/0000-0002-5572-0000","observed_orcids":["https://orcid.org/0000-0002-5572-0000"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vinay K. Singh","raw_affiliation_strings":["Department of Chemistry, DrKNMIET, Modinagar, Meerut 201204, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, DrKNMIET, Modinagar, Meerut 201204, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100668386"],"corresponding_institution_ids":[],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":0.4207,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.54904545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"80","issue":"4","first_page":"625","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6439999938011169},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2778484023","wikidata":"https://www.wikidata.org/wiki/Q415190","display_name":"Benzimidazole","level":2,"score":0.9514994621276855},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6353965401649475},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6345055103302002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5925498604774475},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4842061996459961},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4323170781135559},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3948850929737091},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36835333704948425},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33211809396743774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3274945914745331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24372804164886475},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12303543090820312},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0959392786026001},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07756674289703369},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1747-0285.2012.01407.x","doi":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1747-0285.2012.01407.x","source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology &amp; Drug Design","raw_type":"journal-article"},{"id":"pmid:22564276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22564276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical biology & drug design","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1111/j.1747-0285.2012.01407.x","doi":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1747-0285.2012.01407.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1747-0285.2012.01407.x","source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology &amp; Drug Design","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1881186243.pdf"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W13726717","https://openalex.org/W1940555273","https://openalex.org/W1966834726","https://openalex.org/W1976975528","https://openalex.org/W1979587158","https://openalex.org/W1981860982","https://openalex.org/W1990523720","https://openalex.org/W2005725046","https://openalex.org/W2010115581","https://openalex.org/W2027875213","https://openalex.org/W2028681252","https://openalex.org/W2038466121","https://openalex.org/W2057458801","https://openalex.org/W2075882809","https://openalex.org/W2076777729","https://openalex.org/W2077358087","https://openalex.org/W2094538647","https://openalex.org/W2148032818","https://openalex.org/W2157647593","https://openalex.org/W2172864711","https://openalex.org/W2316432008","https://openalex.org/W2319672847","https://openalex.org/W2949540093","https://openalex.org/W2950023757","https://openalex.org/W2952285196","https://openalex.org/W4244846039","https://openalex.org/W4250114130","https://openalex.org/W4256331492"],"related_works":["https://openalex.org/W4414574862","https://openalex.org/W4200001153","https://openalex.org/W4200203564","https://openalex.org/W4306399260","https://openalex.org/W7159934603","https://openalex.org/W4385448500","https://openalex.org/W2792036853","https://openalex.org/W7221856661","https://openalex.org/W4413835243","https://openalex.org/W2899740919"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,16,61],"new":[3],"benzimidazole":[4],"congeners":[5],"were":[6,11,43],"synthesized,":[7],"and":[8,19,25],"their":[9],"structures":[10],"elucidated":[12],"on":[13,47],"the":[14,62,72],"basis":[15],"elemental":[17],"analyses":[18],"spectral":[20],"studies":[21,29],"(\u00b9H":[22],"NMR,":[23],"FT-IR":[24],"EI-MS).":[26],"Preliminary":[27],"pharmacokinetic":[28],"showed":[30],"a":[31],"promising":[32],"outlook":[33],"for":[34],"further":[35],"in":[36,45,54,71],"vivo":[37],"evaluation.":[38],"The":[39],"newly":[40],"synthesized":[41],"compounds":[42,64],"tested":[44,63],"vitro":[46],"human":[48],"breast":[49],"carcinoma":[50],"cell":[51],"line":[52],"(MCF-7)":[53],"which":[55],"EGFR":[56],"is":[57],"highly":[58],"expressed.":[59],"Most":[60],"exhibited":[65],"antitumor":[66],"activity":[67],"with":[68],"IC\u2085\u2080":[69],"values":[70],"micro":[73],"to":[74],"nano":[75],"molar":[76],"range.":[77]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
