{"id":"https://openalex.org/W188055868","doi":null,"title":"Cellular Roles of the Inhibitor of Apoptosis Protein c-IAP1.","display_name":"Cellular Roles of the Inhibitor of Apoptosis Protein c-IAP1.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W188055868","mag":"188055868"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/61726","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/61726","pdf_url":"https://hdl.handle.net/2027.42/61726","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/61726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035874244","display_name":"Rebecca A. Csomos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rebecca A. Csomos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035874244"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciap1","display_name":"cIAP1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inhibitor-of-apoptosis-proteins","display_name":"inhibitor of apoptosis proteins","score":0.9620000123977661},{"id":"https://openalex.org/keywords/apoptosis-regulation","display_name":"apoptosis regulation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/caspase-independent-apoptosis","display_name":"caspase-independent apoptosis","score":0.6489999890327454},{"id":"https://openalex.org/keywords/smac","display_name":"Smac/DIABLO","score":0.6470000147819519},{"id":"https://openalex.org/keywords/traf2","display_name":"TRAF2","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tnf-receptor-signaling","display_name":"TNF receptor signaling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cd30","display_name":"CD30","score":0.8149999976158142},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.6359999775886536},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.46000000834465027},{"id":"https://openalex.org/keywords/autoubiquitination","display_name":"autoubiquitination","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mitochondrial-membrane-permeabilization","display_name":"mitochondrial membrane permeabilization","score":0.5559999942779541},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.32499998807907104},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3540000021457672},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6738379597663879},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.6641719937324524},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4174238443374634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3537438213825226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22516462206840515},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.1894320547580719}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/61726","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/61726","pdf_url":"https://hdl.handle.net/2027.42/61726","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:188055868","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/61726","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/61726","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/61726","pdf_url":"https://hdl.handle.net/2027.42/61726","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W188055868.pdf","grobid_xml":"https://content.openalex.org/works/W188055868.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073961089","https://openalex.org/W2120492514","https://openalex.org/W2738332138","https://openalex.org/W2061561620","https://openalex.org/W2069407758","https://openalex.org/W7098157858","https://openalex.org/W1984229970","https://openalex.org/W4244813735","https://openalex.org/W1557686543","https://openalex.org/W1990683719"],"abstract_inverted_index":{"Since":[0,255],"the":[1,23,51,64,88,97,187,209,264,280,286,308],"discovery":[2],"that":[3,83,95,147,160,306,329,340],"conserved":[4,43],"mechanisms":[5,291],"of":[6,13,36,67,91,100,153,182,189,228,248,266,285,310],"cell":[7,80,253],"death":[8,81],"contribute":[9],"to":[10,21,112,204,224,292,316],"homeostatic":[11],"maintenance":[12],"multicellular":[14],"organisms,":[15],"much":[16,105],"effort":[17],"has":[18],"been":[19,61,70],"devoted":[20],"identifying":[22],"effectors":[24],"and":[25,63,86,122,125,135,151,250,277,337],"regulatory":[26],"proteins":[27],"involved":[28],"in":[29,33,186,268],"apoptosis.":[30],"Originally":[31],"identified":[32],"1993,":[34],"inhibitor":[35,82],"apoptosis":[37,164],"(iap)":[38],"genes":[39],"are":[40,96],"an":[41,231],"evolutionarily":[42],"family":[44,117],"defined":[45],"by":[46,165,173,219,259,303,343],"a":[47,78,138,166,304,320,332],"unique":[48],"structural":[49],"motif,":[50],"baculoviral":[52],"IAP":[53,75,116,120,232],"repeat":[54],"(BIR)":[55],"domain.":[56],"Eight":[57],"mammalian":[58],"IAPs":[59,68,103],"have":[60,69,104,127],"identified,":[62],"functional":[65],"properties":[66],"studied":[71],"extensively.":[72],"While":[73],"X-linked":[74],"(XIAP)":[76],"is":[77,331,341],"potent":[79],"directly":[84],"binds":[85],"inhibits":[87],"enzymatic":[89],"activities":[90],"caspases,":[92],"cysteine":[93],"proteases":[94],"central":[98],"executioners":[99],"apoptosis,":[101],"some":[102],"less":[106],"effective":[107],"apoptotic":[108,336],"inhibitory":[109],"properties.":[110],"Relative":[111],"XIAP,":[113,249],"two":[114],"related":[115],"members,":[118],"cellular":[119],"1":[121],"2":[123],"(c-IAP1":[124],"c-IAP2)":[126],"significantly":[128],"weaker":[129],"affinity":[130],"for":[131,295,335],"caspases.":[132],"Additionally,":[133],"c-IAP1":[134,215,222,256,267,294,301,317,330],"c-IAP2":[136],"contain":[137],"RING":[139,309,321],"domain":[140],"with":[141,206],"intrinsic":[142],"E3":[143],"ubiquitin":[144],"ligase":[145],"activity":[146],"can":[148],"catalyze":[149],"autoubiquitination":[150],"degradation":[152,296,302,318],"target":[154,293],"proteins.":[155],"Therefore,":[156],"it":[157],"was":[158,184,216,257,271],"hypothesized":[159],"c-IAPs":[161,183,201],"might":[162],"inhibit":[163],"caspase-independent":[167],"mechanism,":[168],"which":[169],"could":[170],"be":[171],"mediated":[172],"their":[174],"ubiquitination":[175],"status":[176],"or":[177],"binding":[178,233,243],"partners.":[179],"The":[180],"stability":[181],"evaluated":[185],"presence":[188],"adaptor":[190],"molecules,":[191],"tumor":[192],"necrosis":[193],"factor":[194],"(TNF)":[195],"receptor":[196,212],"associated":[197],"factors":[198],"(TRAFs),":[199],"since":[200],"were":[202,297],"shown":[203],"associate":[205],"TRAFs":[207],"at":[208,261],"type-2":[210],"TNF":[211,262,273],"(TNFR2).":[213],"Surprisingly,":[214],"selectively":[217],"stabilized":[218,258],"TRAF2.":[220],"Stabilized":[221],"bound":[223],"second":[225],"mitochondrial-derived":[226],"activator":[227],"caspase":[229],"(Smac),":[230],"protein":[234],"released":[235],"from":[236],"mitochondria":[237],"following":[238],"mitochondrial":[239],"membrane":[240],"perturbation.":[241],"This":[242],"event":[244],"prevented":[245],"Smac":[246,299],"antagonism":[247],"potently":[251],"inhibited":[252],"death.":[254],"TRAF2":[260],"receptors,":[263,274],"regulation":[265],"TNF-mediated":[269],"signaling":[270],"evaluated.":[272],"including":[275],"CD30":[276,313],"TNFR2,":[278],"regulate":[279],"inflammatory":[281],"response":[282],"through":[283,319],"activation":[284,314],"NF-\u03baB":[287],"pathways.":[288],"Two":[289],"distinct":[290,345],"identified.":[298],"mediates":[300],"mechanism":[305],"utilizes":[307],"c-IAP1,":[311],"while":[312],"leads":[315],"independent":[322],"mechanism.":[323],"Taken":[324],"together,":[325],"these":[326],"data":[327],"suggest":[328],"molecule":[333],"critical":[334],"non-apoptotic":[338],"processes":[339],"regulated":[342],"multiple":[344],"mechanisms.":[346]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}