{"id":"https://openalex.org/W1879653471","doi":"https://doi.org/10.1128/mcb.6.12.4268","title":"Multidrug-Resistant Phenotype Cosegregates with an Amplified Gene in Somatic Cell Hybrids of Drug-Resistant Chinese Hamster Ovary Cells and Drug-Sensitive Murine Cells","display_name":"Multidrug-Resistant Phenotype Cosegregates with an Amplified Gene in Somatic Cell Hybrids of Drug-Resistant Chinese Hamster Ovary Cells and Drug-Sensitive Murine Cells","publication_year":1986,"publication_date":"1986-12-01","ids":{"openalex":"https://openalex.org/W1879653471","doi":"https://doi.org/10.1128/mcb.6.12.4268","mag":"1879653471","pmid":"https://pubmed.ncbi.nlm.nih.gov/3796603","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/367208"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.6.12.4268","doi":"https://doi.org/10.1128/mcb.6.12.4268","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.6.12.4268","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/367208","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061430399","display_name":"Larry D. Teeter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L D Teeter","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009040984","display_name":"Julie A. Sanford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Sanford","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039200530","display_name":"Subrata Sen","orcid":"https://orcid.org/0000-0001-6884-6246","observed_orcids":["https://orcid.org/0000-0001-6884-6246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sen","raw_affiliation_strings":["Translational Molecular Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Molecular Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109866643","display_name":"Raymond L. Stallings","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Stallings","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111577004","display_name":"Michael J. Siciliano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Siciliano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109421846","display_name":"M. Tien Kuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T Kuo","raw_affiliation_strings":["Translational Molecular Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Molecular Pathology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4193,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63937149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":"12","first_page":"4268","last_page":"4273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.9750000238418579},{"id":"https://openalex.org/keywords/somatic-hybrids","display_name":"somatic cell hybrids","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vincristine-resistance","display_name":"vincristine resistance","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.734000027179718},{"id":"https://openalex.org/keywords/incomplete-dominance","display_name":"incomplete dominance","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/drug-resistance-phenotype","display_name":"drug resistance phenotype","score":0.4970000088214874},{"id":"https://openalex.org/keywords/chromosome-2","display_name":"chromosome 2","score":0.49799999594688416},{"id":"https://openalex.org/keywords/chromosome-8","display_name":"chromosome 8","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.8907489776611328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8828927278518677},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.6178222894668579},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6139933466911316},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5600454211235046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5365360379219055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49608930945396423},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4837043881416321},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.415368914604187},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3965587317943573},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3093339502811432}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003703","descriptor_name":"Demecolcine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.6.12.4268","doi":"https://doi.org/10.1128/mcb.6.12.4268","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.6.12.4268","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.6.12.4268-4273.1986","doi":"https://doi.org/10.1128/mcb.6.12.4268-4273.1986","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.6.12.4268-4273.1986","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:367208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/367208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:3796603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3796603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:367208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/367208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1460750418","display_name":null,"funder_award_id":"CA-34936","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G964351976","display_name":null,"funder_award_id":"GM28573","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1567849582","https://openalex.org/W1588249304","https://openalex.org/W1595352454","https://openalex.org/W1968513798","https://openalex.org/W1971950332","https://openalex.org/W1978496767","https://openalex.org/W1988667160","https://openalex.org/W1989012593","https://openalex.org/W1996328138","https://openalex.org/W2007931369","https://openalex.org/W2012766451","https://openalex.org/W2014966854","https://openalex.org/W2042377464","https://openalex.org/W2049772927","https://openalex.org/W2060330767","https://openalex.org/W2060333964","https://openalex.org/W2064089281","https://openalex.org/W2066943324","https://openalex.org/W2072388933","https://openalex.org/W2075057208","https://openalex.org/W2075749214","https://openalex.org/W2111486924","https://openalex.org/W2495451609"],"related_works":["https://openalex.org/W1550152223","https://openalex.org/W2044314043","https://openalex.org/W80818464","https://openalex.org/W2142452421","https://openalex.org/W1988667160","https://openalex.org/W2425179254","https://openalex.org/W2397173437","https://openalex.org/W2066943324","https://openalex.org/W1970638030","https://openalex.org/W277311296"],"abstract_inverted_index":{"Gene":[0],"amplification":[1],"has":[2],"been":[3],"associated":[4,45],"with":[5,46,148,198],"multidrug":[6],"resistance":[7,104,188],"(MDR)":[8],"in":[9,36,64,107,139,171],"several":[10],"drug-resistant":[11],"Chinese":[12],"hamster":[13],"ovary":[14],"(CHO)":[15],"cell":[16,71],"lines":[17],"which":[18,165],"exhibit":[19],"cross-resistance":[20],"to":[21,84],"other":[22],"unrelated,":[23],"cytotoxic":[24],"drugs.":[25],"In":[26,67],"situ":[27],"hybridization":[28],"studies":[29],"(Teeter":[30],"et":[31],"al.,":[32],"J.":[33],"Cell":[34],"Biol.,":[35],"press)":[37],"suggested":[38],"the":[39,47,51,57,86,90,93,97,124,127,130,136,149,161,169,186,199],"presence":[40,128],"of":[41,54,56,129,135,160,177],"an":[42,108,154],"amplified":[43,94,132,155],"gene":[44,137,156],"MDR":[48,98,106,125,170,200],"phenotype":[49,189],"on":[50,157],"long":[52],"arm":[53],"either":[55],"largest":[58],"CHO":[59,78,117,143,163,180],"chromosomes":[60,181,193],"(1":[61],"or":[62],"Z1)":[63],"vincristine-resistant":[65,77,162],"cells.":[66,173],"this":[68],"study,":[69],"somatic":[70],"hybrids":[72],"were":[73],"constructed":[74],"between":[75,89,121,179],"these":[76,172,192],"cells":[79,83,164],"and":[80,96,105,114,142,183,185],"drug-sensitive":[81],"murine":[82],"determine":[85],"functional":[87],"relationship":[88],"chromosome":[91,144,158],"bearing":[92],"sequences":[95],"phenotype.":[99,201],"Hybrids":[100],"exhibited":[101],"primary":[102],"drug":[103,187],"incomplete":[109],"dominant":[110],"fashion.":[111],"Hybrid":[112],"clones":[113],"subclones":[115],"segregated":[116],"chromosomes.":[118],"Concordant":[119],"segregation":[120],"vincristine":[122],"resistance,":[123],"phenotype,":[126],"MDR-associated":[131],"sequences,":[133,141],"overexpression":[134],"located":[138],"those":[140],"Z1":[145,159],"was":[146],"consistent":[147],"hypothesis":[150],"that":[151,191],"there":[152],"is":[153,166],"responsible":[167],"for":[168],"A":[174],"low":[175],"level":[176],"discordance":[178],"Z8":[182],"2":[184],"suggests":[190],"may":[194],"contain":[195],"genes":[196],"involved":[197]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}