{"id":"https://openalex.org/W1879408402","doi":"https://doi.org/10.1242/dev.111.4.1045","title":"Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis","display_name":"Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W1879408402","doi":"https://doi.org/10.1242/dev.111.4.1045","mag":"1879408402","pmid":"https://pubmed.ncbi.nlm.nih.gov/1879349"},"language":"en","primary_location":{"id":"doi:10.1242/dev.111.4.1045","doi":"https://doi.org/10.1242/dev.111.4.1045","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.111.4.1045","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082917536","display_name":"Jan L. Christian","orcid":"https://orcid.org/0000-0003-3812-3658","observed_orcids":["https://orcid.org/0000-0003-3812-3658"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan L. Christian","raw_affiliation_strings":["University of Washington School of Medicine 1 Department of Pharmacology , , Seattle, Washington 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington School of Medicine 1 Department of Pharmacology , , Seattle, Washington 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104507222","display_name":"Jill A. McMahon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill A. Mcmahon","raw_affiliation_strings":["2 Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nudey, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nudey, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003394161","display_name":"Andrew P. McMahon","orcid":"https://orcid.org/0000-0002-3779-1729","observed_orcids":["https://orcid.org/0000-0002-3779-1729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew P. Mcmahon","raw_affiliation_strings":["2 Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nudey, New Jersey 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nudey, New Jersey 07110, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024528673","display_name":"Randall T. Moon","orcid":"https://orcid.org/0000-0002-9352-1408","observed_orcids":["https://orcid.org/0000-0002-9352-1408"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall T. Moon","raw_affiliation_strings":["University of Washington School of Medicine 1 Department of Pharmacology , , Seattle, Washington 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington School of Medicine 1 Department of Pharmacology , , Seattle, Washington 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.0114,"has_fulltext":false,"cited_by_count":377,"citation_normalized_percentile":{"value":0.9881725,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"111","issue":"4","first_page":"1045","last_page":"1055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesoderm-induction","display_name":"mesoderm induction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/xenopus","display_name":"Xenopus","score":0.4519999921321869},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.921999990940094},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.4449999928474426},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.92556232213974},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.8821145296096802},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.8348196744918823},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.6569176912307739},{"id":"https://openalex.org/C66332042","wikidata":"https://www.wikidata.org/wiki/Q5425488","display_name":"FGF and mesoderm formation","level":5,"score":0.6541606783866882},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6474495530128479},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5346089601516724},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5194158554077148},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49948644638061523},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.49947452545166016},{"id":"https://openalex.org/C122428330","wikidata":"https://www.wikidata.org/wiki/Q3816207","display_name":"Paraxial mesoderm","level":5,"score":0.49855637550354004},{"id":"https://openalex.org/C18155467","wikidata":"https://www.wikidata.org/wiki/Q660498","display_name":"Germ layer","level":5,"score":0.47521287202835083},{"id":"https://openalex.org/C6047887","wikidata":"https://www.wikidata.org/wiki/Q420811","display_name":"Blastula","level":5,"score":0.4733949899673462},{"id":"https://openalex.org/C83330619","wikidata":"https://www.wikidata.org/wiki/Q21124872","display_name":"NODAL","level":2,"score":0.45895299315452576},{"id":"https://openalex.org/C46122727","wikidata":"https://www.wikidata.org/wiki/Q14885879","display_name":"Brachyury","level":5,"score":0.45838919281959534},{"id":"https://openalex.org/C205583638","wikidata":"https://www.wikidata.org/wiki/Q7046607","display_name":"Nodal signaling","level":5,"score":0.4267277121543884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32918214797973633},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3128019869327545},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2435438632965088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2151714265346527},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17635053396224976},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004627","descriptor_name":"Embryonic Induction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.111.4.1045","doi":"https://doi.org/10.1242/dev.111.4.1045","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.111.4.1045","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:1879349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1879349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:develop:111/4/1045","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/111/4/1045","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5765432358","display_name":"Training in Cellular and Molecular Biology","funder_award_id":"T32GM007270","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8504702650","display_name":"INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA","funder_award_id":"K04AR001837","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8656842855","display_name":"INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA","funder_award_id":"R01AR040089","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W179583434","https://openalex.org/W194137483","https://openalex.org/W625308339","https://openalex.org/W638406814","https://openalex.org/W1602639889","https://openalex.org/W1826524642","https://openalex.org/W1830541558","https://openalex.org/W1859128757","https://openalex.org/W1927305112","https://openalex.org/W1945116336","https://openalex.org/W1965918354","https://openalex.org/W1970341768","https://openalex.org/W1974005072","https://openalex.org/W1975301960","https://openalex.org/W1977025966","https://openalex.org/W1978411854","https://openalex.org/W1986925729","https://openalex.org/W1989194294","https://openalex.org/W1997368786","https://openalex.org/W2001199318","https://openalex.org/W2012083927","https://openalex.org/W2012477673","https://openalex.org/W2013548303","https://openalex.org/W2016552656","https://openalex.org/W2033291406","https://openalex.org/W2034351801","https://openalex.org/W2042415724","https://openalex.org/W2047555442","https://openalex.org/W2055830220","https://openalex.org/W2058838132","https://openalex.org/W2061199905","https://openalex.org/W2064185923","https://openalex.org/W2064864270","https://openalex.org/W2069456480","https://openalex.org/W2069816854","https://openalex.org/W2079200533","https://openalex.org/W2084771679","https://openalex.org/W2086028819","https://openalex.org/W2086807339","https://openalex.org/W2091630371","https://openalex.org/W2091637225","https://openalex.org/W2091668130","https://openalex.org/W2094038781","https://openalex.org/W2103665693","https://openalex.org/W2104000274","https://openalex.org/W2107332774","https://openalex.org/W2135312009","https://openalex.org/W2138270253","https://openalex.org/W2138978169","https://openalex.org/W2144634347","https://openalex.org/W2150068899","https://openalex.org/W2157416798","https://openalex.org/W2165781463","https://openalex.org/W2265750209","https://openalex.org/W2333851779","https://openalex.org/W2342402144","https://openalex.org/W2390784421","https://openalex.org/W2399009859","https://openalex.org/W2412608594","https://openalex.org/W2417037728","https://openalex.org/W2418240748","https://openalex.org/W2423917277","https://openalex.org/W2462880666","https://openalex.org/W4239927990","https://openalex.org/W4302403715","https://openalex.org/W6638225704","https://openalex.org/W6675322106"],"related_works":["https://openalex.org/W2001835391","https://openalex.org/W23956445","https://openalex.org/W2027255572","https://openalex.org/W7073683908","https://openalex.org/W2067874905","https://openalex.org/W1848134006","https://openalex.org/W2040003312","https://openalex.org/W2094413951","https://openalex.org/W2008999766","https://openalex.org/W2279944031"],"abstract_inverted_index":{"In":[0],"amphibian":[1],"embryos,":[2],"formation":[3],"of":[4,91,109,143],"the":[5,14,140],"basic":[6],"body":[7],"plan":[8],"depends":[9],"on":[10],"positional":[11],"differences":[12],"in":[13,21,35,54,111,131,139],"mesoderm.":[15],"Although":[16],"peptide":[17],"growth":[18,58],"factors":[19,135],"involved":[20,138],"mesoderm":[22],"induction":[23],"have":[24,39],"tentatively":[25],"been":[26],"identified,":[27],"additional":[28],"signals":[29],"are":[30,62],"required":[31],"to":[32,56,77,85,133],"generate":[33],"pattern":[34],"this":[36],"tissue.":[37],"We":[38],"isolated":[40],"a":[41,45,95,101,114,124],"Xenopus":[42],"cDNA":[43],"for":[44],"Wnt-1":[46],"related":[47],"gene,":[48],"designated":[49],"Xwnt-8,":[50],"which":[51,71,128],"is":[52,74,129,137],"activated":[53],"response":[55,132],"mesoderm-inducing":[57,134],"factors.":[59],"Xwnt-8":[60,92,98,110,121],"transcripts":[61],"transiently":[63],"expressed,":[64],"being":[65],"most":[66],"abundant":[67],"during":[68],"gastrulation":[69],"at":[70],"time":[72],"expression":[73,99,108],"confined":[75],"primarily":[76],"ventral":[78,102],"mesodermal":[79,103,144],"cells.":[80],"Embryos":[81],"dorsoanteriorized":[82],"by":[83],"exposure":[84],"lithium":[86],"exhibit":[87],"greatly":[88],"reduced":[89],"levels":[90],"mRNA,":[93],"supporting":[94],"correlation":[96],"between":[97],"and":[100,136],"cell":[104],"fate.":[105],"Surprisingly,":[106],"ectopic":[107],"embryos":[112],"causes":[113],"dorsoanterior-enhanced":[115],"phenotype.":[116],"These":[117],"findings":[118],"suggest":[119],"that":[120],"may":[122],"be":[123],"secondary":[125],"signalling":[126],"agent":[127],"produced":[130],"early":[141],"steps":[142],"patterning.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}