{"id":"https://openalex.org/W1878620955","doi":null,"title":"Current and future regenerative medicine - principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine.","display_name":"Current and future regenerative medicine - principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine.","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W1878620955","mag":"1878620955","pmid":"https://pubmed.ncbi.nlm.nih.gov/19412395","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2629419"},"language":"en","primary_location":{"id":"pmid:19412395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19412395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian veterinary journal = La revue veterinaire canadienne","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2629419/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103445132","display_name":"Thomas G. Koch","orcid":"https://orcid.org/0009-0008-9094-9186","observed_orcids":["https://orcid.org/0009-0008-9094-9186"]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas G Koch","raw_affiliation_strings":["Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada. tkoch@uoguelph.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada. tkoch@uoguelph.ca","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040375477","display_name":"Lise Charlotte Berg","orcid":"https://orcid.org/0000-0002-8752-2885","observed_orcids":["https://orcid.org/0000-0002-8752-2885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lise C Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071432046","display_name":"Dean Harvey Betts","orcid":"https://orcid.org/0000-0002-5528-9142","observed_orcids":["https://orcid.org/0000-0002-5528-9142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dean H Betts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8475,"has_fulltext":true,"cited_by_count":134,"citation_normalized_percentile":{"value":0.63066538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"50","issue":"2","first_page":"155","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.2797999978065491,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10872","display_name":"Veterinary Equine Medical Research","score":0.09749999642372131,"subfield":{"id":"https://openalex.org/subfields/3402","display_name":"Equine"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8149999976158142},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.9929999709129333},{"id":"https://openalex.org/keywords/horses","display_name":"horses","score":0.7450000047683716},{"id":"https://openalex.org/keywords/equine-medicine","display_name":"equine medicine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/multipotent-mesenchymal-stromal-cells","display_name":"multipotent mesenchymal stromal cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/scaffolds","display_name":"scaffolds","score":0.722000002861023},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.8140000104904175},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.718999981880188},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8479999899864197},{"id":"https://openalex.org/keywords/clinical-trial-evidence","display_name":"clinical trial evidence","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5700073838233948},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.44174522161483765},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32168281078338623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18932929635047913}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006734","descriptor_name":"Horse Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014730","descriptor_name":"Veterinary Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:19412395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19412395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian veterinary journal = La revue veterinaire canadienne","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2629419","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2629419/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can Vet J","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/0c865690-54e8-11de-87b8-000ea68e967b","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2629419","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2629419/pdf/cvj_02_155.pdf","source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Koch, T G, Berg, L C & Betts, D H 2009, 'Current and future regenerative medicine - principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine', Canadian Veterinary Journal, vol. 50, no. 2, pp. 155-165. < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629419/ >","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1878620955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19412395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2629419","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2629419/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can Vet J","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333601","display_name":"Ontario Veterinary College, University of Guelph","ror":"https://ror.org/04frvgs13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1878620955.pdf","grobid_xml":"https://content.openalex.org/works/W1878620955.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W77107632","https://openalex.org/W99630384","https://openalex.org/W110185725","https://openalex.org/W1508614962","https://openalex.org/W1546331692","https://openalex.org/W1739491659","https://openalex.org/W1783122597","https://openalex.org/W1966991920","https://openalex.org/W1968529931","https://openalex.org/W1969390542","https://openalex.org/W1976960856","https://openalex.org/W1977454262","https://openalex.org/W1978047468","https://openalex.org/W1981478725","https://openalex.org/W1981565019","https://openalex.org/W1981764614","https://openalex.org/W1982132497","https://openalex.org/W1984733212","https://openalex.org/W1986164634","https://openalex.org/W1991565515","https://openalex.org/W1991906978","https://openalex.org/W1992339081","https://openalex.org/W1993314665","https://openalex.org/W1996867474","https://openalex.org/W1998566647","https://openalex.org/W1999074559","https://openalex.org/W2002222421","https://openalex.org/W2005588642","https://openalex.org/W2006429928","https://openalex.org/W2010388612","https://openalex.org/W2011555773","https://openalex.org/W2013632655","https://openalex.org/W2014885564","https://openalex.org/W2015095160","https://openalex.org/W2017986522","https://openalex.org/W2021371517","https://openalex.org/W2024326908","https://openalex.org/W2024667212","https://openalex.org/W2025371271","https://openalex.org/W2026963578","https://openalex.org/W2031849770","https://openalex.org/W2034659824","https://openalex.org/W2035040282","https://openalex.org/W2036345374","https://openalex.org/W2036348189","https://openalex.org/W2037660784","https://openalex.org/W2038270895","https://openalex.org/W2040782956","https://openalex.org/W2040875954","https://openalex.org/W2041207935","https://openalex.org/W2045475354","https://openalex.org/W2047560789","https://openalex.org/W2048065392","https://openalex.org/W2051297632","https://openalex.org/W2051298158","https://openalex.org/W2056392359","https://openalex.org/W2056510698","https://openalex.org/W2056942201","https://openalex.org/W2056972350","https://openalex.org/W2058195651","https://openalex.org/W2059328928","https://openalex.org/W2060134459","https://openalex.org/W2062408180","https://openalex.org/W2062541215","https://openalex.org/W2064721251","https://openalex.org/W2067308846","https://openalex.org/W2067703873","https://openalex.org/W2070435400","https://openalex.org/W2071650138","https://openalex.org/W2074509558","https://openalex.org/W2075153089","https://openalex.org/W2077182018","https://openalex.org/W2078126231","https://openalex.org/W2080726151","https://openalex.org/W2083056729","https://openalex.org/W2084304606","https://openalex.org/W2085216114","https://openalex.org/W2086943348","https://openalex.org/W2089878334","https://openalex.org/W2090502291","https://openalex.org/W2093003772","https://openalex.org/W2096510429","https://openalex.org/W2101437484","https://openalex.org/W2101578040","https://openalex.org/W2105668403","https://openalex.org/W2107545291","https://openalex.org/W2108908219","https://openalex.org/W2109538121","https://openalex.org/W2109670212","https://openalex.org/W2112540399","https://openalex.org/W2114331080","https://openalex.org/W2124504432","https://openalex.org/W2129922015","https://openalex.org/W2130036102","https://openalex.org/W2130806884","https://openalex.org/W2131115331","https://openalex.org/W2132590692","https://openalex.org/W2132594520","https://openalex.org/W2136221233","https://openalex.org/W2138307488","https://openalex.org/W2139223251","https://openalex.org/W2139942447","https://openalex.org/W2139987563","https://openalex.org/W2140013481","https://openalex.org/W2142527986","https://openalex.org/W2148407693","https://openalex.org/W2149099863","https://openalex.org/W2150753734","https://openalex.org/W2151838922","https://openalex.org/W2151946493","https://openalex.org/W2152379015","https://openalex.org/W2159720934","https://openalex.org/W2159851383","https://openalex.org/W2159999899","https://openalex.org/W2160666689","https://openalex.org/W2168800437","https://openalex.org/W2169037052","https://openalex.org/W2177625381","https://openalex.org/W2179920390","https://openalex.org/W2182839735","https://openalex.org/W2256572980","https://openalex.org/W2262096323","https://openalex.org/W2404007759","https://openalex.org/W2410120643"],"related_works":["https://openalex.org/W2898122766","https://openalex.org/W1783122597","https://openalex.org/W2058373439","https://openalex.org/W4211114747","https://openalex.org/W1980248118","https://openalex.org/W2101686580","https://openalex.org/W4410904161","https://openalex.org/W1759582908","https://openalex.org/W2187221328","https://openalex.org/W7036933880"],"abstract_inverted_index":{"This":[0],"paper":[1],"provides":[2],"a":[3],"bird's-eye":[4],"perspective":[5],"of":[6,10,29,34,73,81,106,131,155,162,203,249],"the":[7,24,65,71,74,101,109,190,192,201,208,233,247],"general":[8],"principles":[9],"stem-cell":[11],"therapy":[12],"and":[13,26,40,42,108,138,152,158,166,200,214,216,220,225,228,238,251],"tissue":[14,132,168,229],"engineering;":[15],"it":[16],"relates":[17],"comparative":[18,237],"knowledge":[19],"in":[20,47,64,103,126,145,176,180,207,232],"this":[21,260],"area":[22],"to":[23,88,111,183,258],"current":[25],"future":[27],"status":[28],"equine":[30,35,62,146,181,239,262],"regenerative":[31],"medicine.The":[32],"understanding":[33,154],"stem":[36,54,163,204],"cell":[37,55,159,227],"biology,":[38],"biofactors,":[39],"scaffolds,":[41],"their":[43],"potential":[44],"therapeutic":[45,124],"use":[46,125],"horses":[48,250],"are":[49,84,141,256],"rudimentary":[50],"at":[51],"present.":[52],"Mesenchymal":[53],"isolation":[56],"has":[57,171,235],"been":[58,173],"proclaimed":[59],"from":[60,117],"several":[61],"tissues":[63,119],"past":[66],"few":[67],"years.":[68],"Based":[69],"on":[70],"criteria":[72],"International":[75],"Society":[76],"for":[77,123],"Cellular":[78],"Therapy,":[79],"most":[80,167,243],"these":[82,115],"cells":[83,116],"more":[85],"correctly":[86],"referred":[87],"as":[89,186],"multipotent":[90],"mesenchymal":[91],"stromal":[92],"cells,":[93,135],"unless":[94],"there":[95],"is":[96],"proof":[97],"that":[98,242],"they":[99],"exhibit":[100],"fundamental":[102],"vivo":[104],"characteristics":[105],"pluripotency":[107],"ability":[110],"self-renew.":[112],"That":[113],"said,":[114],"various":[118],"hold":[120],"great":[121],"promise":[122],"horses.":[127],"The":[128],"3":[129],"components":[130],"engineering":[133,169,230],"-":[134,140],"biological":[136],"factors,":[137],"biomaterials":[139],"increasingly":[142],"being":[143],"applied":[144],"medicine,":[147],"fuelled":[148],"by":[149],"better":[150],"scaffolds":[151],"increased":[153],"individual":[156],"biofactors":[157],"sources.The":[160],"effectiveness":[161],"cell-based":[164,205],"therapies":[165,206],"concepts":[170],"not":[172],"demonstrated":[174],"sufficiently":[175],"controlled":[177],"clinical":[178],"trials":[179],"patients":[182],"be":[184,211,223],"regarded":[185],"evidence-based":[187],"medicine.":[188],"In":[189],"meantime,":[191],"medical":[193],"mantra":[194],"\"do":[195],"no":[196],"harm\"":[197],"should":[198,210,222],"prevail,":[199],"application":[202],"horse":[209,234],"done":[212],"critically":[213],"cautiously,":[215],"treatment":[217],"outcomes":[218],"(good":[219],"bad)":[221],"recorded":[224],"reported.Stem":[226],"research":[231,263],"exciting":[236],"specific":[240],"perspectives":[241],"likely":[244],"will":[245],"benefit":[246],"health":[248],"humans.":[252],"Controlled,":[253],"well-designed":[254],"studies":[255],"needed":[257],"move":[259],"new":[261],"field":[264],"forward.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
