{"id":"https://openalex.org/W1878410949","doi":"https://doi.org/10.1016/s0065-230x(08)60678-8","title":"5-Methylcytosine, Gene Regulation, and Cancer","display_name":"5-Methylcytosine, Gene Regulation, and Cancer","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W1878410949","doi":"https://doi.org/10.1016/s0065-230x(08)60678-8","mag":"1878410949","pmid":"https://pubmed.ncbi.nlm.nih.gov/6197868"},"language":"en","primary_location":{"id":"doi:10.1016/s0065-230x(08)60678-8","doi":"https://doi.org/10.1016/s0065-230x(08)60678-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0065-230x(08)60678-8","pdf_url":null,"source":{"id":"https://openalex.org/S169378627","display_name":"Advances in cancer research","issn_l":"0065-230X","issn":["0065-230X","2162-5557"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Cancer Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4234027726","display_name":null},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024542312","display_name":"Arthur D. Riggs","orcid":"https://orcid.org/0000-0002-8184-5288","observed_orcids":["https://orcid.org/0000-0002-8184-5288"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur D. Riggs","raw_affiliation_strings":["Division of Biology, City of Hope Research Institute, Duarte. California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, City of Hope Research Institute, Duarte. California","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088347458","display_name":"Peter A. Jones","orcid":"https://orcid.org/0000-0001-8309-4767","observed_orcids":["https://orcid.org/0000-0001-8309-4767"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Jones","raw_affiliation_strings":["Departments of Pediatrics and Biochemistry, Childrens Hospital of Los Angeles, USC School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Biochemistry, Childrens Hospital of Los Angeles, USC School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":34.6804,"has_fulltext":false,"cited_by_count":420,"citation_normalized_percentile":{"value":0.99780782,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"40","issue":null,"first_page":"1","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mammalian-gene-expression","display_name":"mammalian gene expression","score":0.8130000233650208},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.765999972820282},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/modified-dna-bases","display_name":"modified DNA bases","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6794379949569702},{"id":"https://openalex.org/C2775926025","wikidata":"https://www.wikidata.org/wiki/Q238563","display_name":"5-Methylcytosine","level":5,"score":0.5818287134170532},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5818166732788086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5598543882369995},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5597460269927979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46240976452827454},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43123891949653625},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4223019778728485},{"id":"https://openalex.org/C106285112","wikidata":"https://www.wikidata.org/wiki/Q7556570","display_name":"Therapeutic gene modulation","level":5,"score":0.4211077094078064},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3969819247722626},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.19835060834884644}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0065-230x(08)60678-8","doi":"https://doi.org/10.1016/s0065-230x(08)60678-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0065-230x(08)60678-8","pdf_url":null,"source":{"id":"https://openalex.org/S169378627","display_name":"Advances in cancer research","issn_l":"0065-230X","issn":["0065-230X","2162-5557"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Cancer Research","raw_type":"book-chapter"},{"id":"pmid:6197868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6197868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":168,"referenced_works":["https://openalex.org/W181865417","https://openalex.org/W597384269","https://openalex.org/W966774311","https://openalex.org/W1478898356","https://openalex.org/W1498462216","https://openalex.org/W1519629411","https://openalex.org/W1525972653","https://openalex.org/W1528346173","https://openalex.org/W1530969865","https://openalex.org/W1532928035","https://openalex.org/W1541931550","https://openalex.org/W1559481667","https://openalex.org/W1582507827","https://openalex.org/W1591592032","https://openalex.org/W1595950962","https://openalex.org/W1602222199","https://openalex.org/W1607145333","https://openalex.org/W1838928116","https://openalex.org/W1865658459","https://openalex.org/W1869695314","https://openalex.org/W1963910789","https://openalex.org/W1964556049","https://openalex.org/W1964899178","https://openalex.org/W1965060050","https://openalex.org/W1965087547","https://openalex.org/W1966468838","https://openalex.org/W1968807484","https://openalex.org/W1968913698","https://openalex.org/W1969774671","https://openalex.org/W1969883059","https://openalex.org/W1970078675","https://openalex.org/W1971408353","https://openalex.org/W1972941987","https://openalex.org/W1974173158","https://openalex.org/W1974359182","https://openalex.org/W1974747095","https://openalex.org/W1975545922","https://openalex.org/W1975831985","https://openalex.org/W1979453497","https://openalex.org/W1979601741","https://openalex.org/W1980451107","https://openalex.org/W1982128154","https://openalex.org/W1982491292","https://openalex.org/W1983543728","https://openalex.org/W1984924023","https://openalex.org/W1987155442","https://openalex.org/W1987793414","https://openalex.org/W1989200134","https://openalex.org/W1990125516","https://openalex.org/W1990707190","https://openalex.org/W1990933742","https://openalex.org/W1991466548","https://openalex.org/W1992288855","https://openalex.org/W1994087362","https://openalex.org/W1995339904","https://openalex.org/W1995463262","https://openalex.org/W1996043889","https://openalex.org/W1996729627","https://openalex.org/W1997827286","https://openalex.org/W1998517881","https://openalex.org/W1999696587","https://openalex.org/W2000838016","https://openalex.org/W2001855651","https://openalex.org/W2002194892","https://openalex.org/W2002241901","https://openalex.org/W2005684293","https://openalex.org/W2006488092","https://openalex.org/W2007653337","https://openalex.org/W2009726024","https://openalex.org/W2011857798","https://openalex.org/W2013506096","https://openalex.org/W2013973825","https://openalex.org/W2015872074","https://openalex.org/W2016197401","https://openalex.org/W2016696208","https://openalex.org/W2017360343","https://openalex.org/W2017595171","https://openalex.org/W2018111224","https://openalex.org/W2019172827","https://openalex.org/W2020844796","https://openalex.org/W2021060566","https://openalex.org/W2022346440","https://openalex.org/W2022915138","https://openalex.org/W2025421534","https://openalex.org/W2026863696","https://openalex.org/W2027409002","https://openalex.org/W2027411626","https://openalex.org/W2027782583","https://openalex.org/W2031131841","https://openalex.org/W2031526147","https://openalex.org/W2032506756","https://openalex.org/W2032799016","https://openalex.org/W2033328319","https://openalex.org/W2033819427","https://openalex.org/W2034101991","https://openalex.org/W2034394847","https://openalex.org/W2035707671","https://openalex.org/W2036290882","https://openalex.org/W2036566832","https://openalex.org/W2036853135","https://openalex.org/W2039279930","https://openalex.org/W2039440857","https://openalex.org/W2040479932","https://openalex.org/W2040730335","https://openalex.org/W2043449207","https://openalex.org/W2044041971","https://openalex.org/W2046399641","https://openalex.org/W2047551991","https://openalex.org/W2049053982","https://openalex.org/W2051406511","https://openalex.org/W2051677114","https://openalex.org/W2054217735","https://openalex.org/W2054382677","https://openalex.org/W2054518372","https://openalex.org/W2056314801","https://openalex.org/W2056733416","https://openalex.org/W2057267447","https://openalex.org/W2057456910","https://openalex.org/W2058487126","https://openalex.org/W2059944708","https://openalex.org/W2060262724","https://openalex.org/W2063141151","https://openalex.org/W2065967652","https://openalex.org/W2066678272","https://openalex.org/W2066766542","https://openalex.org/W2068567381","https://openalex.org/W2070743361","https://openalex.org/W2072627259","https://openalex.org/W2073857478","https://openalex.org/W2074508501","https://openalex.org/W2081137670","https://openalex.org/W2081812924","https://openalex.org/W2083150665","https://openalex.org/W2084926826","https://openalex.org/W2087909223","https://openalex.org/W2089446809","https://openalex.org/W2091070405","https://openalex.org/W2091602444","https://openalex.org/W2093896423","https://openalex.org/W2093908800","https://openalex.org/W2095619460","https://openalex.org/W2098852247","https://openalex.org/W2102149360","https://openalex.org/W2104457577","https://openalex.org/W2110458663","https://openalex.org/W2116017139","https://openalex.org/W2120890729","https://openalex.org/W2124246239","https://openalex.org/W2140908643","https://openalex.org/W2141394967","https://openalex.org/W2141414940","https://openalex.org/W2145750252","https://openalex.org/W2149417050","https://openalex.org/W2153090288","https://openalex.org/W2153753459","https://openalex.org/W2155302928","https://openalex.org/W2156621023","https://openalex.org/W2159884726","https://openalex.org/W2162938473","https://openalex.org/W2165446716","https://openalex.org/W2171812209","https://openalex.org/W2267250549","https://openalex.org/W2318281771","https://openalex.org/W2412274067","https://openalex.org/W2419598166","https://openalex.org/W2443900741","https://openalex.org/W2473254733","https://openalex.org/W7164838080"],"related_works":["https://openalex.org/W2468478394","https://openalex.org/W2067815493","https://openalex.org/W4387117201","https://openalex.org/W2034445530","https://openalex.org/W7161801441","https://openalex.org/W2952124633","https://openalex.org/W4280554968","https://openalex.org/W30761779","https://openalex.org/W1791265846","https://openalex.org/W4256535121"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}