{"id":"https://openalex.org/W1877247523","doi":"https://doi.org/10.1093/ajh/5.10.727","title":"A Randomized, Placebo-Controlled, Double-Blind Comparison of Amlodipine and Atenolol in Patients With Essential Hypertension","display_name":"A Randomized, Placebo-Controlled, Double-Blind Comparison of Amlodipine and Atenolol in Patients With Essential Hypertension","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W1877247523","doi":"https://doi.org/10.1093/ajh/5.10.727","mag":"1877247523","pmid":"https://pubmed.ncbi.nlm.nih.gov/1418836"},"language":"en","primary_location":{"id":"doi:10.1093/ajh/5.10.727","doi":"https://doi.org/10.1093/ajh/5.10.727","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/5.10.727","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Brian F. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian F. Johnson","raw_affiliation_strings":["University of Massachusetts Medical School, Worcester 01655","University of Massachusetts Medical School, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Medical School, Worcester 01655","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"University of Massachusetts Medical School, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020544805","display_name":"William H. Frishman","orcid":"https://orcid.org/0000-0002-2458-4480","observed_orcids":["https://orcid.org/0000-0002-2458-4480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William K. Frishman","raw_affiliation_strings":["Medical Tower, Norfolk, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Tower, Norfolk, Virginia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089634084","display_name":"Richard D. Brobyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210160141","display_name":"Virginia Mason Bainbridge Island Medical Center","ror":"https://ror.org/05658wt11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4210160141"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Brobyn","raw_affiliation_strings":["Bainbridge Medical Center, Bainbridge Island, Washington","Hospital of the Albert Einstein College of Medicine, New York","Medical Tower, Norfolk, Virginia","Puget Sound Medical Investigators Ltd., Olympia, Washington","University of Oklahoma Health Sciences Center, Oklahoma City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bainbridge Medical Center, Bainbridge Island, Washington","institution_ids":["https://openalex.org/I4210160141"]},{"raw_affiliation_string":"Hospital of the Albert Einstein College of Medicine, New York","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Medical Tower, Norfolk, Virginia","institution_ids":[]},{"raw_affiliation_string":"Puget Sound Medical Investigators Ltd., Olympia, Washington","institution_ids":[]},{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113604832","display_name":"Ronald D. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald D. Brown","raw_affiliation_strings":["Medical Tower, Norfolk, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Tower, Norfolk, Virginia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103418260","display_name":"Robert L. Reeves","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Reeves","raw_affiliation_strings":["Medical Tower, Norfolk, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Tower, Norfolk, Virginia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026694473","display_name":"Duane G. Wombolt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duane G. Wombolt","raw_affiliation_strings":["Medical Tower, Norfolk, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Tower, Norfolk, Virginia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":0.6778,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68608585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"10","first_page":"727","last_page":"732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":1.0},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.7570000290870667},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.7559999823570251},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.9419999718666077},{"id":"https://openalex.org/keywords/24-hour-ambulatory-blood-pressure","display_name":"24-hour ambulatory blood pressure","score":0.7960000038146973},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.8659999966621399},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antihypertensive-efficacy","display_name":"antihypertensive efficacy","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.9715056419372559},{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.8681144714355469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8654296398162842},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.7654989957809448},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7587568759918213},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7424468994140625},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.5709612965583801},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.532741367816925},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5009560585021973},{"id":"https://openalex.org/C2777482430","wikidata":"https://www.wikidata.org/wiki/Q7168709","display_name":"Peripheral edema","level":3,"score":0.43749678134918213},{"id":"https://openalex.org/C2992203999","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean blood pressure","level":4,"score":0.42116492986679077},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32125991582870483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2783215343952179},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.24395889043807983},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajh/5.10.727","doi":"https://doi.org/10.1093/ajh/5.10.727","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/5.10.727","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:1418836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1418836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004622457","https://openalex.org/W1275975961","https://openalex.org/W2107982961","https://openalex.org/W2080857212","https://openalex.org/W3140411628","https://openalex.org/W137999545","https://openalex.org/W2004748196","https://openalex.org/W2073159030","https://openalex.org/W2988983674","https://openalex.org/W2057112229"],"abstract_inverted_index":{"The":[0,75,144],"efficacy":[1],"and":[2,41,99,125,150,155,171,215,232,254],"safety":[3],"of":[4,50,189,225,228,244],"amlodipine":[5,62,87,170,214,245],"(2.5":[6],"mg,":[7,9],"5":[8],"or":[10,70,181,246],"10":[11],"mg)":[12,23,92,116],"once":[13,24],"daily":[14,25,89,113],"was":[15,199,207,222,252],"compared":[16],"with":[17,28,61,236],"atenolol":[18,66,111,172,211,216,247],"(50":[19],"mg":[20],"to":[21,56,248],"100":[22],"in":[26,32,80,201],"patients":[27,43,251],"mild-to-moderate":[29,249],"essential":[30],"hypertension":[31],"a":[33,51],"randomized,":[34],"double-blind,":[35],"parallel,":[36],"placebo-controlled":[37],"study.":[38],"One":[39],"hundred":[40],"twenty-five":[42],"were":[44,93,119,137,152,217],"randomly":[45],"allocated":[46],"at":[47,164,180],"the":[48,117,161,165,174,187,191,196,202,226,261],"end":[49],"4-week":[52],"run-in":[53],"placebo":[54,71,151,197],"period":[55,163,188],"8":[57],"weeks'":[58],"double-blind":[59],"treatment":[60,235],"(n":[63,67,72],"=":[64,68,73],"41),":[65],"43),":[69],"41).":[74],"mean":[76,176],"changes":[77,118],"from":[78],"baseline":[79],"blood":[81,105,131,178,257],"pressure":[82,106,132,179,258],"24":[83],"h":[84],"postdose":[85],"for":[86,97,103,123,129,147,195],"(mean":[88,112],"dose":[90,114],"8.8":[91],"-12.8/-10.1":[94],"mm":[95,101,121,127,184],"Hg":[96,102,122,128,185],"supine":[98,124,177],"-11.5/-9.8":[100],"standing":[104,130],"(P":[107,133],"<":[108,134],".001).":[109,135],"For":[110],"83.7":[115],"-11.3/-11.7":[120],"-13.3/-12.3":[126],"There":[136],"no":[138],"statistically":[139],"significant":[140],"differences":[141],"between":[142],"treatments.":[143],"responder":[145],"rates":[146],"amlodipine,":[148],"atenolol,":[149],"61.1%,":[153],"64.9%,":[154],"11.1%,":[156],"respectively.":[157],"Determinations":[158],"taken":[159],"over":[160],"24-h":[162,262],"final":[166],"visit":[167],"revealed":[168],"that":[169,241],"maintained":[173],"group":[175,198],"below":[182],"140/90":[183],"throughout":[186,260],"observation;":[190],"corresponding":[192],"time-effect":[193],"curve":[194],"clearly":[200],"hypertensive":[203,250],"range.":[204],"Heart":[205],"rate":[206],"significantly":[208],"lowered":[209],"by":[210],"only.":[212],"Both":[213],"well-tolerated.":[218],"Only":[219],"one":[220],"patient":[221],"withdrawn":[223],"because":[224],"development":[227],"peripheral":[229],"edema,":[230],"arthralgia,":[231],"fatigue":[233],"after":[234],"amlodipine.":[237],"This":[238],"study":[239],"demonstrates":[240],"once-daily":[242],"administration":[243],"well-tolerated":[253],"provided":[255],"adequate":[256],"control":[259],"dosing":[263],"interval.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
