{"id":"https://openalex.org/W187592144","doi":null,"title":"Neuroblastoma as a target for effector mechanisms of the immune system","display_name":"Neuroblastoma as a target for effector mechanisms of the immune system","publication_year":2007,"publication_date":"2007-05-24","ids":{"openalex":"https://openalex.org/W187592144","mag":"187592144"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26916673","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Neuroblastoma_as_a_target_for_effector_mechanisms_of_the_immune_system/26916673","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/39578","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058163888","display_name":"Anna De Geer","orcid":"https://orcid.org/0000-0002-5327-3198","observed_orcids":["https://orcid.org/0000-0002-5327-3198"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna De Geer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5327-3198","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058163888"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.42579999566078186,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immunoproteasome","display_name":"immunoproteasome","score":0.949999988079071},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7490000128746033},{"id":"https://openalex.org/keywords/antigen-processing-machinery","display_name":"antigen processing machinery","score":0.7049999833106995},{"id":"https://openalex.org/keywords/death-receptor-signaling","display_name":"death receptor signaling","score":0.6520000100135803},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bystander-activation","display_name":"bystander activation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.375},{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7612961530685425},{"id":"https://openalex.org/C183193105","wikidata":"https://www.wikidata.org/wiki/Q425068","display_name":"Granzyme","level":5,"score":0.6891632080078125},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.5638531446456909},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5514510869979858},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.49921250343322754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49584874510765076},{"id":"https://openalex.org/C2780380082","wikidata":"https://www.wikidata.org/wiki/Q12646460","display_name":"Granzyme B","level":4,"score":0.46659043431282043},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4617611765861511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4351475238800049},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4349607229232788},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4289677143096924},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.4216713607311249},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3616408109664917},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3422711491584778},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22760796546936035},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.11762872338294983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26916673","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Neuroblastoma_as_a_target_for_effector_mechanisms_of_the_immune_system/26916673","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/39578","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39578","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:187592144","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/39578/thesis.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/39578","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39578","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":650,"referenced_works":["https://openalex.org/W13371306","https://openalex.org/W25988025","https://openalex.org/W32707354","https://openalex.org/W39575425","https://openalex.org/W49395982","https://openalex.org/W62176468","https://openalex.org/W74626608","https://openalex.org/W100794221","https://openalex.org/W131994123","https://openalex.org/W134119395","https://openalex.org/W150366755","https://openalex.org/W193748226","https://openalex.org/W272579771","https://openalex.org/W1483194800","https://openalex.org/W1484166075","https://openalex.org/W1484817497","https://openalex.org/W1487106910","https://openalex.org/W1488330478","https://openalex.org/W1493114553","https://openalex.org/W1493511814","https://openalex.org/W1493702629","https://openalex.org/W1495717648","https://openalex.org/W1496047440","https://openalex.org/W1498187417","https://openalex.org/W1510387626","https://openalex.org/W1515490675","https://openalex.org/W1515564094","https://openalex.org/W1518790306","https://openalex.org/W1519609954","https://openalex.org/W1525810933","https://openalex.org/W1527985047","https://openalex.org/W1527997848","https://openalex.org/W1528349069","https://openalex.org/W1532737852","https://openalex.org/W1534035172","https://openalex.org/W1534491890","https://openalex.org/W1539052865","https://openalex.org/W1539353750","https://openalex.org/W1542886054","https://openalex.org/W1544100339","https://openalex.org/W1545789736","https://openalex.org/W1546871754","https://openalex.org/W1550301398","https://openalex.org/W1551972473","https://openalex.org/W1556867369","https://openalex.org/W1561153455","https://openalex.org/W1561587838","https://openalex.org/W1564470573","https://openalex.org/W1568276869","https://openalex.org/W1571612306","https://openalex.org/W1572252257","https://openalex.org/W1572267688","https://openalex.org/W1573445282","https://openalex.org/W1583511232","https://openalex.org/W1591100935","https://openalex.org/W1595168222","https://openalex.org/W1598843567","https://openalex.org/W1601314558","https://openalex.org/W1605088744","https://openalex.org/W1608209530","https://openalex.org/W1622240035","https://openalex.org/W1625007357","https://openalex.org/W1642763135","https://openalex.org/W1642873092","https://openalex.org/W1655756854","https://openalex.org/W1657044925","https://openalex.org/W1662819364","https://openalex.org/W1665436044","https://openalex.org/W1667620412","https://openalex.org/W1669828090","https://openalex.org/W1730863938","https://openalex.org/W1745634660","https://openalex.org/W1765237838","https://openalex.org/W1778509032","https://openalex.org/W1782287000","https://openalex.org/W1792651937","https://openalex.org/W1793388556","https://openalex.org/W1824767477","https://openalex.org/W1838901836","https://openalex.org/W1863050266","https://openalex.org/W1868595314","https://openalex.org/W1873259379","https://openalex.org/W1877245175","https://openalex.org/W1892022085","https://openalex.org/W1892975056","https://openalex.org/W1896731228","https://openalex.org/W1909200755","https://openalex.org/W1915556294","https://openalex.org/W1921382807","https://openalex.org/W1925735392","https://openalex.org/W1926885922","https://openalex.org/W1935879860","https://openalex.org/W1936567301","https://openalex.org/W1940650862","https://openalex.org/W1941973176","https://openalex.org/W1943002254","https://openalex.org/W1943059672","https://openalex.org/W1947177866","https://openalex.org/W1949656029","https://openalex.org/W1951128322","https://openalex.org/W1951179504","https://openalex.org/W1952554789","https://openalex.org/W1959376412","https://openalex.org/W1960538598","https://openalex.org/W1960710326","https://openalex.org/W1964420304","https://openalex.org/W1964653209","https://openalex.org/W1964661396","https://openalex.org/W1965605868","https://openalex.org/W1966474027","https://openalex.org/W1966861659","https://openalex.org/W1967007700","https://openalex.org/W1967769371","https://openalex.org/W1967975669","https://openalex.org/W1968948384","https://openalex.org/W1969053864","https://openalex.org/W1969464492","https://openalex.org/W1969478743","https://openalex.org/W1969863577","https://openalex.org/W1969965954","https://openalex.org/W1970096377","https://openalex.org/W1971302107","https://openalex.org/W1971563492","https://openalex.org/W1972304655","https://openalex.org/W1972593680","https://openalex.org/W1972636570","https://openalex.org/W1972748556","https://openalex.org/W1972814015","https://openalex.org/W1973251492","https://openalex.org/W1973954319","https://openalex.org/W1974368804","https://openalex.org/W1974490245","https://openalex.org/W1975122345","https://openalex.org/W1975193662","https://openalex.org/W1975291295","https://openalex.org/W1975336660","https://openalex.org/W1976048604","https://openalex.org/W1976510602","https://openalex.org/W1976601347","https://openalex.org/W1976952965","https://openalex.org/W1977292784","https://openalex.org/W1978161821","https://openalex.org/W1978607161","https://openalex.org/W1979014817","https://openalex.org/W1979494660","https://openalex.org/W1980391116","https://openalex.org/W1980780108","https://openalex.org/W1981182552","https://openalex.org/W1981324292","https://openalex.org/W1981376684","https://openalex.org/W1982186676","https://openalex.org/W1982732144","https://openalex.org/W1983114913","https://openalex.org/W1983645982","https://openalex.org/W1984655584","https://openalex.org/W1984791807","https://openalex.org/W1984972276","https://openalex.org/W1986126868","https://openalex.org/W1986672594","https://openalex.org/W1988183917","https://openalex.org/W1988199023","https://openalex.org/W1988791313","https://openalex.org/W1989150855","https://openalex.org/W1990390456","https://openalex.org/W1990863976","https://openalex.org/W1991238840","https://openalex.org/W1992761610","https://openalex.org/W1993199753","https://openalex.org/W1993331127","https://openalex.org/W1993339180","https://openalex.org/W1993514351","https://openalex.org/W1993786192","https://openalex.org/W1994255893","https://openalex.org/W1994269871","https://openalex.org/W1994937010","https://openalex.org/W1995515383","https://openalex.org/W1996892700","https://openalex.org/W1997215036","https://openalex.org/W1998347916","https://openalex.org/W1998548282","https://openalex.org/W1999231499","https://openalex.org/W1999341606","https://openalex.org/W1999468766","https://openalex.org/W1999551050","https://openalex.org/W2000070744","https://openalex.org/W2000215602","https://openalex.org/W2000281764","https://openalex.org/W2000812565","https://openalex.org/W2000836105","https://openalex.org/W2001124389","https://openalex.org/W2001708793","https://openalex.org/W2002295135","https://openalex.org/W2002447029","https://openalex.org/W2002801575","https://openalex.org/W2002855877","https://openalex.org/W2003398703","https://openalex.org/W2003670729","https://openalex.org/W2003965210","https://openalex.org/W2004266769","https://openalex.org/W2004645606","https://openalex.org/W2004746400","https://openalex.org/W2005420125","https://openalex.org/W2005433274","https://openalex.org/W2005448550","https://openalex.org/W2005640704","https://openalex.org/W2005668958","https://openalex.org/W2005749687","https://openalex.org/W2006080840","https://openalex.org/W2006184289","https://openalex.org/W2007084896","https://openalex.org/W2007129827","https://openalex.org/W2007509103","https://openalex.org/W2007512513","https://openalex.org/W2007691725","https://openalex.org/W2007824068","https://openalex.org/W2008267385","https://openalex.org/W2009003919","https://openalex.org/W2009371357","https://openalex.org/W2009538319","https://openalex.org/W2009778714","https://openalex.org/W2009801524","https://openalex.org/W2010457947","https://openalex.org/W2011795445","https://openalex.org/W2012546917","https://openalex.org/W2012741316","https://openalex.org/W2013981904","https://openalex.org/W2014244864","https://openalex.org/W2014349052","https://openalex.org/W2014864356","https://openalex.org/W2015751514","https://openalex.org/W2016198585","https://openalex.org/W2016612145","https://openalex.org/W2016671320","https://openalex.org/W2017462408","https://openalex.org/W2017619889","https://openalex.org/W2017728303","https://openalex.org/W2018091905","https://openalex.org/W2018227907","https://openalex.org/W2018229773","https://openalex.org/W2018309349","https://openalex.org/W2018327543","https://openalex.org/W2018474002","https://openalex.org/W2018653121","https://openalex.org/W2019558740","https://openalex.org/W2019681593","https://openalex.org/W2019735646","https://openalex.org/W2019993505","https://openalex.org/W2020413347","https://openalex.org/W2020746301","https://openalex.org/W2021137172","https://openalex.org/W2021268612","https://openalex.org/W2021289499","https://openalex.org/W2022000183","https://openalex.org/W2022054181","https://openalex.org/W2022427651","https://openalex.org/W2022839186","https://openalex.org/W2022842834","https://openalex.org/W2023219357","https://openalex.org/W2023389612","https://openalex.org/W2023548208","https://openalex.org/W2023598484","https://openalex.org/W2024023167","https://openalex.org/W2024083984","https://openalex.org/W2024120152","https://openalex.org/W2024280594","https://openalex.org/W2024515744","https://openalex.org/W2024997807","https://openalex.org/W2025488459","https://openalex.org/W2026318599","https://openalex.org/W2026383080","https://openalex.org/W2026422112","https://openalex.org/W2026632566","https://openalex.org/W2026760238","https://openalex.org/W2026885876","https://openalex.org/W2027465204","https://openalex.org/W2027884825","https://openalex.org/W2028318264","https://openalex.org/W2028460943","https://openalex.org/W2028713816","https://openalex.org/W2029488286","https://openalex.org/W2029506306","https://openalex.org/W2029832884","https://openalex.org/W2031286097","https://openalex.org/W2032558585","https://openalex.org/W2032879846","https://openalex.org/W2033981370","https://openalex.org/W2034269086","https://openalex.org/W2034815057","https://openalex.org/W2034894737","https://openalex.org/W2034915619","https://openalex.org/W2035051866","https://openalex.org/W2036031859","https://openalex.org/W2036274051","https://openalex.org/W2036355263","https://openalex.org/W2036571548","https://openalex.org/W2037313669","https://openalex.org/W2038118195","https://openalex.org/W2038253447","https://openalex.org/W2038333016","https://openalex.org/W2038639621","https://openalex.org/W2039068075","https://openalex.org/W2039267077","https://openalex.org/W2040074251","https://openalex.org/W2041426680","https://openalex.org/W2041547446","https://openalex.org/W2041664926","https://openalex.org/W2042687451","https://openalex.org/W2042946852","https://openalex.org/W2043115106","https://openalex.org/W2043287922","https://openalex.org/W2044016592","https://openalex.org/W2044178006","https://openalex.org/W2044663539","https://openalex.org/W2045068005","https://openalex.org/W2045166569","https://openalex.org/W2045246330","https://openalex.org/W2046451544","https://openalex.org/W2046972425","https://openalex.org/W2047153387","https://openalex.org/W2047528991","https://openalex.org/W2047567416","https://openalex.org/W2047819297","https://openalex.org/W2049750942","https://openalex.org/W2049850873","https://openalex.org/W2049956305","https://openalex.org/W2050672174","https://openalex.org/W2051258100","https://openalex.org/W2051440419","https://openalex.org/W2052069700","https://openalex.org/W2052667644","https://openalex.org/W2052688181","https://openalex.org/W2052997893","https://openalex.org/W2053178768","https://openalex.org/W2054231931","https://openalex.org/W2054375447","https://openalex.org/W2054698233","https://openalex.org/W2054717287","https://openalex.org/W2054946477","https://openalex.org/W2055192493","https://openalex.org/W2055231699","https://openalex.org/W2056924500","https://openalex.org/W2057698452","https://openalex.org/W2057838963","https://openalex.org/W2059577109","https://openalex.org/W2059586806","https://openalex.org/W2059762191","https://openalex.org/W2060409876","https://openalex.org/W2061163173","https://openalex.org/W2061613881","https://openalex.org/W2062464523","https://openalex.org/W2062613923","https://openalex.org/W2063557216","https://openalex.org/W2064168698","https://openalex.org/W2064428081","https://openalex.org/W2064706357","https://openalex.org/W2064920472","https://openalex.org/W2065475067","https://openalex.org/W2065966578","https://openalex.org/W2066013797","https://openalex.org/W2066960417","https://openalex.org/W2068032204","https://openalex.org/W2068441417","https://openalex.org/W2068890283","https://openalex.org/W2069015362","https://openalex.org/W2071742554","https://openalex.org/W2071871975","https://openalex.org/W2072045194","https://openalex.org/W2072404428","https://openalex.org/W2072419473","https://openalex.org/W2072493871","https://openalex.org/W2072696221","https://openalex.org/W2073026109","https://openalex.org/W2073299113","https://openalex.org/W2073310925","https://openalex.org/W2073573249","https://openalex.org/W2073920144","https://openalex.org/W2074396094","https://openalex.org/W2074562836","https://openalex.org/W2074604431","https://openalex.org/W2075809552","https://openalex.org/W2075977076","https://openalex.org/W2076106140","https://openalex.org/W2076466010","https://openalex.org/W2076711139","https://openalex.org/W2077147012","https://openalex.org/W2077169231","https://openalex.org/W2077686810","https://openalex.org/W2078197336","https://openalex.org/W2078427292","https://openalex.org/W2078827912","https://openalex.org/W2078917040","https://openalex.org/W2079118456","https://openalex.org/W2079136653","https://openalex.org/W2079212864","https://openalex.org/W2079911327","https://openalex.org/W2080757497","https://openalex.org/W2080933544","https://openalex.org/W2081265652","https://openalex.org/W2081288466","https://openalex.org/W2081513802","https://openalex.org/W2081561748","https://openalex.org/W2082134864","https://openalex.org/W2083008638","https://openalex.org/W2083189901","https://openalex.org/W2083920899","https://openalex.org/W2084292672","https://openalex.org/W2084998643","https://openalex.org/W2085191451","https://openalex.org/W2085452545","https://openalex.org/W2085478834","https://openalex.org/W2085818294","https://openalex.org/W2086001247","https://openalex.org/W2086135567","https://openalex.org/W2086770363","https://openalex.org/W2087171945","https://openalex.org/W2087877138","https://openalex.org/W2088095172","https://openalex.org/W2088364215","https://openalex.org/W2088571368","https://openalex.org/W2089684997","https://openalex.org/W2089892946","https://openalex.org/W2090048090","https://openalex.org/W2091493364","https://openalex.org/W2091880298","https://openalex.org/W2093118025","https://openalex.org/W2093485788","https://openalex.org/W2093591730","https://openalex.org/W2094201721","https://openalex.org/W2094409655","https://openalex.org/W2094522719","https://openalex.org/W2094570524","https://openalex.org/W2094981409","https://openalex.org/W2095022409","https://openalex.org/W2095048746","https://openalex.org/W2095220820","https://openalex.org/W2095224412","https://openalex.org/W2096002454","https://openalex.org/W2096119021","https://openalex.org/W2096398040","https://openalex.org/W2096625946","https://openalex.org/W2096788770","https://openalex.org/W2097074641","https://openalex.org/W2097916072","https://openalex.org/W2098073152","https://openalex.org/W2098100504","https://openalex.org/W2098290847","https://openalex.org/W2098439946","https://openalex.org/W2098677755","https://openalex.org/W2098983864","https://openalex.org/W2100677570","https://openalex.org/W2101249156","https://openalex.org/W2102537478","https://openalex.org/W2102683915","https://openalex.org/W2102689053","https://openalex.org/W2103097932","https://openalex.org/W2103390588","https://openalex.org/W2104205504","https://openalex.org/W2104952141","https://openalex.org/W2105248948","https://openalex.org/W2105533119","https://openalex.org/W2105878567","https://openalex.org/W2106655707","https://openalex.org/W2107516467","https://openalex.org/W2108114104","https://openalex.org/W2108308200","https://openalex.org/W2108782816","https://openalex.org/W2109206382","https://openalex.org/W2109721791","https://openalex.org/W2109876118","https://openalex.org/W2109923945","https://openalex.org/W2110392390","https://openalex.org/W2110561490","https://openalex.org/W2111441225","https://openalex.org/W2112179844","https://openalex.org/W2112736971","https://openalex.org/W2113007586","https://openalex.org/W2113164415","https://openalex.org/W2113259730","https://openalex.org/W2113313714","https://openalex.org/W2114163044","https://openalex.org/W2114216374","https://openalex.org/W2114964602","https://openalex.org/W2115293825","https://openalex.org/W2115674896","https://openalex.org/W2115684094","https://openalex.org/W2115767710","https://openalex.org/W2116171543","https://openalex.org/W2116460444","https://openalex.org/W2117313288","https://openalex.org/W2118124078","https://openalex.org/W2118447882","https://openalex.org/W2119800239","https://openalex.org/W2119939110","https://openalex.org/W2120010406","https://openalex.org/W2121033861","https://openalex.org/W2121626779","https://openalex.org/W2122042627","https://openalex.org/W2122414959","https://openalex.org/W2122541507","https://openalex.org/W2123151135","https://openalex.org/W2124097265","https://openalex.org/W2124992697","https://openalex.org/W2125170171","https://openalex.org/W2125913713","https://openalex.org/W2125988618","https://openalex.org/W2126639777","https://openalex.org/W2126665111","https://openalex.org/W2127468351","https://openalex.org/W2128101943","https://openalex.org/W2128680377","https://openalex.org/W2128692203","https://openalex.org/W2129607888","https://openalex.org/W2130443831","https://openalex.org/W2132358441","https://openalex.org/W2132929600","https://openalex.org/W2133669258","https://openalex.org/W2134257413","https://openalex.org/W2134768631","https://openalex.org/W2135808990","https://openalex.org/W2136509222","https://openalex.org/W2136958926","https://openalex.org/W2137074525","https://openalex.org/W2137538026","https://openalex.org/W2137889895","https://openalex.org/W2138961639","https://openalex.org/W2139014493","https://openalex.org/W2139694919","https://openalex.org/W2139789471","https://openalex.org/W2140366271","https://openalex.org/W2140397231","https://openalex.org/W2140712673","https://openalex.org/W2140885797","https://openalex.org/W2141355322","https://openalex.org/W2141612652","https://openalex.org/W2141778744","https://openalex.org/W2142490613","https://openalex.org/W2142598717","https://openalex.org/W2142600437","https://openalex.org/W2143023706","https://openalex.org/W2143652083","https://openalex.org/W2143998429","https://openalex.org/W2144037068","https://openalex.org/W2144891041","https://openalex.org/W2145679164","https://openalex.org/W2145777525","https://openalex.org/W2145779541","https://openalex.org/W2147209945","https://openalex.org/W2147350757","https://openalex.org/W2148461908","https://openalex.org/W2149177848","https://openalex.org/W2149260641","https://openalex.org/W2149312162","https://openalex.org/W2150123812","https://openalex.org/W2150334825","https://openalex.org/W2150373615","https://openalex.org/W2150437482","https://openalex.org/W2150632173","https://openalex.org/W2150678612","https://openalex.org/W2151384979","https://openalex.org/W2151666328","https://openalex.org/W2152596295","https://openalex.org/W2152765064","https://openalex.org/W2153148807","https://openalex.org/W2153505850","https://openalex.org/W2153522966","https://openalex.org/W2153942882","https://openalex.org/W2154042421","https://openalex.org/W2155274259","https://openalex.org/W2155917076","https://openalex.org/W2156091997","https://openalex.org/W2156104527","https://openalex.org/W2156106286","https://openalex.org/W2156277550","https://openalex.org/W2156978579","https://openalex.org/W2157518949","https://openalex.org/W2157579823","https://openalex.org/W2158319766","https://openalex.org/W2158514490","https://openalex.org/W2159312193","https://openalex.org/W2159633294","https://openalex.org/W2159830797","https://openalex.org/W2160048269","https://openalex.org/W2160276388","https://openalex.org/W2160566717","https://openalex.org/W2160592660","https://openalex.org/W2161257907","https://openalex.org/W2161354474","https://openalex.org/W2162168470","https://openalex.org/W2162344035","https://openalex.org/W2162418942","https://openalex.org/W2162450383","https://openalex.org/W2162646039","https://openalex.org/W2164296948","https://openalex.org/W2164772840","https://openalex.org/W2165491538","https://openalex.org/W2166070294","https://openalex.org/W2166970460","https://openalex.org/W2167686417","https://openalex.org/W2167787789","https://openalex.org/W2168539521","https://openalex.org/W2168747001","https://openalex.org/W2168888631","https://openalex.org/W2169069665","https://openalex.org/W2169101531","https://openalex.org/W2169626634","https://openalex.org/W2170069789","https://openalex.org/W2170678234","https://openalex.org/W2171445183","https://openalex.org/W2171709048","https://openalex.org/W2173218561","https://openalex.org/W2176650786","https://openalex.org/W2271226922","https://openalex.org/W2287739879","https://openalex.org/W2314138926","https://openalex.org/W2316183230","https://openalex.org/W2319415808","https://openalex.org/W2319486658","https://openalex.org/W2320870975","https://openalex.org/W2321641613","https://openalex.org/W2326266120","https://openalex.org/W2326401583","https://openalex.org/W2326425416","https://openalex.org/W2327522594","https://openalex.org/W2328514608","https://openalex.org/W2329506722","https://openalex.org/W2329952317","https://openalex.org/W2330923897","https://openalex.org/W2334968498","https://openalex.org/W2337432642","https://openalex.org/W2396391211","https://openalex.org/W2400817683","https://openalex.org/W2401904549","https://openalex.org/W2402827688","https://openalex.org/W2403235609","https://openalex.org/W2407844270","https://openalex.org/W2409573685","https://openalex.org/W2409593897","https://openalex.org/W2410140846","https://openalex.org/W2411082393","https://openalex.org/W2412436821","https://openalex.org/W2417799216","https://openalex.org/W2418886529","https://openalex.org/W2419078497","https://openalex.org/W2421190366","https://openalex.org/W2421638702","https://openalex.org/W2472581739","https://openalex.org/W2783142245","https://openalex.org/W2791218690","https://openalex.org/W2793859699","https://openalex.org/W4313347964"],"related_works":["https://openalex.org/W1950823605","https://openalex.org/W2025941802","https://openalex.org/W1996329986","https://openalex.org/W2158514490","https://openalex.org/W3204351611","https://openalex.org/W4231719821","https://openalex.org/W2007105300","https://openalex.org/W3160413453","https://openalex.org/W7140712616","https://openalex.org/W4415123793"],"abstract_inverted_index":{"Neuroblastoma":[0],"(NB)":[1],"is":[2],"the":[3,14,54,58,68,74,77,88,92,97,100,105,117,144,154,187,232,239,242,250,271,283,293,300,322,328,388,406,468,489,504,518,529,532,550],"most":[4],"common":[5],"solid":[6],"extracranial":[7],"tumor":[8,106,310,385,533],"in\\nchildren.":[9],"Despite":[10],"intensive":[11],"multimodal":[12],"treatment,":[13],"prognosis":[15],"for\\nhigh-risk":[16],"NB":[17,36,157,167,223,253,331,377,400,459,478,514,555],"patients":[18,539],"remains":[19],"poor":[20],"and":[21,57,109,215,236,248,260,275,476,512,548],"therefore":[22],"new":[23],"treatment":[24,202,284],"modalities\\nare":[25],"needed.":[26],"The":[27],"main":[28],"aim":[29],"of":[30,70,76,99,126,141,146,156,174,210,222,234,244,252,273,285,295,299,327,373,392,408,470,483,491,508,531,554,567],"my":[31],"studies":[32,188,290],"was":[33,449],"to":[34,119,152,224,255,387,493],"assess":[35],"as":[37,82,84,135,137,208,217,219,333,335,418,420,451,485,487],"a":[38,124,138,201,381,439,536],"target":[39,89],"for\\ncytotoxic":[40],"T":[41],"lymphocyte":[42],"(CTL)-mediated":[43],"immunotherapy.":[44],"CTLs":[45,313,393,397,413,448,502,527,542],"induce":[46,297],"target\\ncell":[47],"death":[48,59,93,433,494],"through":[49,67],"two":[50,363],"major":[51],"pathways,":[52],"namely":[53],"cytotoxic":[55],"granule\\nexocytosis-":[56],"receptor-mediated":[60,495],"pathway.":[61],"While":[62],"an":[63,111,178,279,354,370,403,452],"efficient":[64,355],"T\\ncell-mediated":[65],"lysis":[66,265],"release":[69],"perforin/granzyme-containing\\ncytotoxic":[71],"granules":[72],"requires":[73,110],"expression":[75,140,233,372],"relevant":[78],"HLA":[79,132,211,245,257,261,343],"class":[80,133,212,246,262,344],"I\\ncomplexes":[81],"well":[83,136,218,334,419,486],"adhesion":[85],"molecules":[86,473],"on":[87,308,336,346,376,415],"cells,":[90,378],"killing\\nthrough":[91],"receptor":[94],"pathway":[95],"involves":[96],"binding":[98],"ligands":[101],"to\\ndeath":[102],"receptors":[103],"in":[104,177,186,190,199,305,330,402,436,438,443,521,538],"cell":[107,121,432,460,471,479],"membrane,":[108],"intact\\nintracellular":[112],"molecular":[113],"machinery":[114,303],"that":[115,194,270,525,559],"conveys":[116],"signal":[118],"execute\\ntumor":[120],"death.":[122],"However,":[123],"number":[125],"features":[127],"including":[128],"low":[129],"or":[130],"absent\\nsurface":[131],"I":[134,263,345],"defective":[139],"caspase-8,":[142,484],"may\\nhamper":[143],"development":[145],"immunotherapeutic":[147],"modalities":[148],"for":[149,164,204,282,366],"NB.\\nNevertheless,":[150],"strategies":[151],"enhance":[153],"immunogenicity":[155],"cells":[158,168,254,332,386,401,515],"could\\nrender":[159],"them":[160],"into":[161,353,528],"good":[162],"targets":[163],"CTL-mediated":[165,225,560],"immunotherapy.\\nAlternatively,":[166],"can":[169],"be":[170,278,563],"targeted":[171],"by":[172,312,359,465,500],"means":[173],"bystander":[175,440],"activated\\nCTLs":[176,466],"HLA-independent":[179,477],"fashion.":[180],"Both":[181],"these":[182,425],"approaches":[183],"have":[184,291,535],"been\\ninvestigated":[185],"presented":[189,520],"this":[191,348,367,522],"thesis.\\n\\nWe":[192],"demonstrated":[193,292],"retinoids,":[195],"differentiating":[196],"agents":[197],"currently":[198],"use\\nas":[200],"modality":[203],"high-risk":[205],"NB,":[206,306],"act":[207],"enhancers":[209],"I\\nantigen":[213],"processing":[214,302],"presentation":[216],"increase":[220,356],"the\\nsusceptibility":[221],"effector":[226,454],"mechanisms.":[227],"We":[228,361,427],"found":[229],"that\\nretinoids":[230],"induced":[231,341,435,481],"proteolytic":[235],"regulatory":[237],"subunits\\nof":[238],"immunoproteasome,":[240],"increased":[241,488],"half-life":[243],"I\\ncomplexes,":[247],"enhanced":[249],"sensitivity":[251],"both":[256,429],"class\\nI-restricted":[258],"peptide-specific":[259],"non-restricted":[264],"by\\nCTLs.":[266],"Our":[267],"data":[268],"suggest":[269,362,524,558],"application":[272],"retinoids":[274],"CTL-based\\nimmunotherapy":[276],"may":[277,398,534,543],"effective":[280],"combination":[281],"NB\\n(Paper":[286],"I).":[287],"Though":[288],"numerous":[289],"ability":[294],"IFN\u03b3\\nto":[296],"components":[298,326],"antigen":[301],"(APM)":[304],"the\\nimpact":[307],"subsequent":[309],"recognition":[311],"has":[314],"not":[315,351],"been":[316],"investigated\\nin":[317],"detail.":[318],"Therefore,":[319],"we":[320,410],"investigated":[321],"IFN\u03b3-induced":[323,371],"effects":[324],"on\\nselected":[325],"APM":[329],"CTL":[337],"recognition.\\nAlthough":[338],"IFN\u03b3-treatment":[339],"efficiently":[340],"surface":[342,472,505],"NB\\ncells,":[347],"effect":[349],"did":[350],"translate":[352],"in\\nHLA-restricted":[357,475],"killing":[358],"CTLs.":[360,426],"possible":[364],"molecular\\nexplanations":[365],"phenomenon;":[368],"(i)":[369],"the\\ninhibitory":[374],"HLA-E":[375],"and/or":[379],"(ii)":[380],"decreased":[382],"susceptibility":[383,490],"of\\nIFN\u03b3-treated":[384],"cytolytic":[389],"granule":[390],"content":[391],"(Paper\\nIII).\\n\\nTo":[394],"investigate":[395],"whether":[396],"eliminate":[399],"HLA-independent\\nmanner":[404],"without":[405],"involvement":[407],"perforin/granzyme-mediated\\ncytotoxicity,":[409],"used":[411],"NB-non-specific":[412],"activated":[414,501],"third":[416],"party\\ntargets":[417],"soluble":[421,462,498],"factors":[422,463],"released":[423,446,464],"from":[424],"found\\nthat":[428],"caspasedependent":[430],"and-independent":[431],"were":[434],"NB\\ncells":[437,492],"manner,":[441],"and,":[442],"addition,":[444],"TNF\u03b1":[445],"from\\nactivated":[447],"defined":[450],"important":[453],"molecule":[455],"(Paper":[456,516],"II).\\nBesides":[457],"inducing":[458],"death,":[461],"modulated":[467],"levels":[469],"implicated":[474],"recognition,":[480],"the\\nexpression":[482],"killing.":[496],"Importantly,":[497],"factors\\nreleased":[499],"skewed":[503],"immune":[506,552],"phenotype":[507,553],"both\\nlong":[509],"term":[510],"cultured":[511],"primary":[513],"IV).\\n\\nAltogether,":[517],"results":[519],"thesis":[523],"recruiting\\nactivated":[526],"proximity":[530],"therapeutic\\neffect":[537],"with":[540,565],"NB.":[541,568],"simultaneously":[544],"activate":[545],"different\\ndeath":[546],"pathways":[547],"override":[549],"\u201csilent\u201d":[551],"cells.":[556],"We\\nalso":[557],"therapy":[561],"could":[562],"combined":[564],"retinoid\\ntreatment":[566]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}