{"id":"https://openalex.org/W1875761995","doi":"https://doi.org/10.1155/2015/435253","title":"Potentiated Osteoinductivity via Cotransfection with BMP-2 and VEGF Genes in Microencapsulated C2C12 Cells","display_name":"Potentiated Osteoinductivity via Cotransfection with BMP-2 and VEGF Genes in Microencapsulated C2C12 Cells","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1875761995","doi":"https://doi.org/10.1155/2015/435253","mag":"1875761995","pmid":"https://pubmed.ncbi.nlm.nih.gov/26451370","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4588358"},"language":"en","primary_location":{"id":"doi:10.1155/2015/435253","doi":"https://doi.org/10.1155/2015/435253","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/435253","pdf_url":"https://downloads.hindawi.com/journals/bmri/2015/435253.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2015/435253.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017811645","display_name":"Yang Shen","orcid":"https://orcid.org/0000-0002-3312-278X","observed_orcids":["https://orcid.org/0000-0002-3312-278X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Shen","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022898627","display_name":"Han Qiao","orcid":"https://orcid.org/0000-0002-0082-4486","observed_orcids":["https://orcid.org/0000-0002-0082-4486"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Qiao","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111498972","display_name":"Qi\u2010Ming Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiming Fan","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuhong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhong Zhang","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062413297","display_name":"Tingting Tang","orcid":"https://orcid.org/0000-0002-1670-7452","observed_orcids":["https://orcid.org/0000-0002-1670-7452"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Tang","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 20011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":0.8686,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70305886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2015","issue":null,"first_page":"1","last_page":"10"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8519999980926514},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cotransfection","display_name":"cotransfection","score":0.9150000214576721},{"id":"https://openalex.org/keywords/microencapsulation","display_name":"microencapsulation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.9629999995231628},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.5},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.6793289184570312},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6774081587791443},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6535236835479736},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6414778232574463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5674595832824707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49708130955696106},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47263285517692566},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4395088851451874},{"id":"https://openalex.org/C2776872141","wikidata":"https://www.wikidata.org/wiki/Q413006","display_name":"Calcein","level":3,"score":0.4332464933395386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2290821671485901},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2105894684791565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15164855122566223},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10966327786445618},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.08736136555671692},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1155/2015/435253","doi":"https://doi.org/10.1155/2015/435253","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/435253","pdf_url":"https://downloads.hindawi.com/journals/bmri/2015/435253.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3574550","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4588358","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4588358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4588358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Res Int","raw_type":"Text"},{"id":"pmid:26451370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26451370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed research international","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.796.7241","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.796.7241","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7b/c9/BMRI2015-435253.PMC4588358.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6bed04ed4a7f4a65a6a8d8799b26b193","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6bed04ed4a7f4a65a6a8d8799b26b193","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Research International, Vol 2015 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2015/435253","doi":"https://doi.org/10.1155/2015/435253","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/435253","pdf_url":"https://downloads.hindawi.com/journals/bmri/2015/435253.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1126772136","display_name":null,"funder_award_id":"13JC1403900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3225946490","display_name":null,"funder_award_id":"81172549","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G59105983","display_name":null,"funder_award_id":"30772183","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6884743305","display_name":null,"funder_award_id":"13DZ2294000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1875761995.pdf","grobid_xml":"https://content.openalex.org/works/W1875761995.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1484083850","https://openalex.org/W1503109784","https://openalex.org/W1935346479","https://openalex.org/W1951506500","https://openalex.org/W1968730407","https://openalex.org/W1976154397","https://openalex.org/W1976340920","https://openalex.org/W1994461950","https://openalex.org/W2012655169","https://openalex.org/W2012886552","https://openalex.org/W2019777614","https://openalex.org/W2020437028","https://openalex.org/W2022282748","https://openalex.org/W2033016180","https://openalex.org/W2037585512","https://openalex.org/W2043025342","https://openalex.org/W2046467570","https://openalex.org/W2054954212","https://openalex.org/W2091958809","https://openalex.org/W2094085828","https://openalex.org/W2102618636","https://openalex.org/W2107989359","https://openalex.org/W2108371710","https://openalex.org/W2110186943","https://openalex.org/W2111905733","https://openalex.org/W2121551386","https://openalex.org/W2138211958","https://openalex.org/W2145295359","https://openalex.org/W2154025980","https://openalex.org/W2155562094","https://openalex.org/W2161695759","https://openalex.org/W2189475167","https://openalex.org/W2419009448"],"related_works":["https://openalex.org/W7097747804","https://openalex.org/W2011645196","https://openalex.org/W2793108355","https://openalex.org/W3048797648","https://openalex.org/W1881575137","https://openalex.org/W3030308732","https://openalex.org/W2385564399","https://openalex.org/W2124719068","https://openalex.org/W2046467570","https://openalex.org/W1969653325"],"abstract_inverted_index":{"Microcapsules":[0],"with":[1,42],"entrapped":[2],"cells":[3,39,51,92,106,126,145,172],"hold":[4],"great":[5],"promise":[6],"for":[7,57,76,98,132,177,190],"repairing":[8],"bone":[9,181,194],"defects.":[10,195],"Unfortunately,":[11],"the":[12,24,35,71,102,108,136,163,178],"osteoinductivity":[13,36],"of":[14,26,37,70,112,138,165,174,180],"microcapsules":[15],"has":[16],"been":[17],"restricted":[18],"by":[19],"many":[20],"factors,":[21],"among":[22],"which":[23,183],"deficiency":[25],"functional":[27],"proteins":[28],"is":[29,173],"a":[30,147,186],"significant":[31],"priority.":[32],"We":[33],"potentiated":[34],"microencapsulated":[38,87,104,120,143,156,170],"via":[40],"cotransfection":[41,137,164],"BMP-2":[43,58,88,113,121,129,139,166],"and":[44,52,59,114,122,130,140,167],"VEGF":[45,60,90,123,131,141,168],"genes.":[46],"Various":[47],"tissue-derived":[48],"mesenchymal":[49],"stem":[50],"cell":[53,72],"lines":[54],"were":[55],"compared":[56],"cotransfection.":[61],"Ethidium":[62],"bromide":[63],"(EB)/Calcein":[64],"AM":[65],"staining":[66],"revealed":[67],"that":[68,85,119,162],"all":[69,86],"categories":[73],"could":[74,93],"survive":[75],"4":[77,133],"weeks":[78],"after":[79],"microencapsulation.":[80],"An":[81],"ELISA":[82],"assay":[83],"indicated":[84],"or":[89],"transfected":[91],"secrete":[94],"gene":[95],"products":[96],"constitutively":[97],"1":[99],"month.":[100],"Particularly,":[101],"recombinant":[103],"C2C12":[105,125,144,157,171],"released":[107],"most":[109],"desirable":[110],"level":[111],"VEGF.":[115],"Further":[116],"experiments":[117],"demonstrated":[118,161],"cotransfected":[124],"generated":[127],"both":[128],"weeks.":[134],"Additionally,":[135],"in":[142,193],"showed":[146],"stronger":[148],"osteogenic":[149],"induction":[150],"against":[151],"BMSCs":[152],"than":[153],"individual":[154],"BMP-2-transfected":[155],"cells.":[158],"These":[159],"results":[160],"into":[169],"potent":[175],"utility":[176],"potentiation":[179],"regeneration,":[182],"would":[184],"provide":[185],"promising":[187],"clinical":[188],"strategy":[189],"cellular":[191],"therapy":[192]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}