{"id":"https://openalex.org/W187562889","doi":null,"title":"Brain tumor as a prototype of severe brain lesion in patients with \"low T3 syndrome\".","display_name":"Brain tumor as a prototype of severe brain lesion in patients with \"low T3 syndrome\".","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W187562889","mag":"187562889","pmid":"https://pubmed.ncbi.nlm.nih.gov/23115945"},"language":"en","primary_location":{"id":"pmid:23115945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23115945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta clinica Croatica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hrcak.srce.hr/file/156352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052081034","display_name":"Miljenko Solter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Miljenko Solter","raw_affiliation_strings":["University Department of Endocrinology, Sestre milosrdnice University Hospital Center, School of Medicine, University of Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Endocrinology, Sestre milosrdnice University Hospital Center, School of Medicine, University of Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732","https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019146710","display_name":"Darko Katalini\u0107","orcid":"https://orcid.org/0000-0002-4433-338X","observed_orcids":["https://orcid.org/0000-0002-4433-338X"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Darko Katalini\u0107","raw_affiliation_strings":["University Hospital Centre Zagreb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Centre Zagreb","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088458619","display_name":"Vesna Vargek-Solter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vesna Vargek-Solter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034429838","display_name":"Karolina Dobrovi\u0107","orcid":"https://orcid.org/0000-0001-5396-2770","observed_orcids":["https://orcid.org/0000-0001-5396-2770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karolina Dobrovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111002205","display_name":"A Mari\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreja Mari\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078034511","display_name":"Ljubica Posavec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ljubica Posavec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Darko Solter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darko Solter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051612903","display_name":"Stjepko Ple\u0161tina","orcid":"https://orcid.org/0000-0002-8212-7763","observed_orcids":["https://orcid.org/0000-0002-8212-7763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stjepko Plestina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"51","issue":"2","first_page":"215","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-thyroidal-illness","display_name":"low T3 syndrome","score":0.8569999933242798},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8849999904632568},{"id":"https://openalex.org/keywords/reverse-t3","display_name":"reverse T3","score":0.8920000195503235},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.7549999952316284},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.8830000162124634},{"id":"https://openalex.org/keywords/thyroid-hormone-metabolism","display_name":"thyroid hormone metabolism","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.7572953701019287},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6966210007667542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6910813450813293},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.642279326915741},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6320129632949829},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.619030773639679},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5831915140151978},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5301704406738281},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5287957787513733},{"id":"https://openalex.org/C2780486670","wikidata":"https://www.wikidata.org/wiki/Q7318276","display_name":"Reverse triiodothyronine","level":4,"score":0.48682039976119995},{"id":"https://openalex.org/C2779571634","wikidata":"https://www.wikidata.org/wiki/Q422106","display_name":"Thyroid hormones","level":3,"score":0.45137137174606323},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30407437682151794}],"mesh":[{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005067","descriptor_name":"Euthyroid Sick Syndromes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005067","descriptor_name":"Euthyroid Sick Syndromes","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005067","descriptor_name":"Euthyroid Sick Syndromes","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:23115945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23115945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta clinica Croatica","raw_type":"Journal Article"},{"id":"pmh:oai:hrcak.srce.hr:106163","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/106163","pdf_url":"http://hrcak.srce.hr/file/156352","source":{"id":"https://openalex.org/S4306400677","display_name":"Hr\u010dak Portal of scientific journals of Croatia (University Computing Centre)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104502","host_organization_name":"United Nations University","host_organization_lineage":["https://openalex.org/I4210104502"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta clinica Croatica","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1827154455","doi":null,"is_oa":true,"landing_page_url":"https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=156351&lang=en","pdf_url":null,"source":{"id":"https://openalex.org/S60988351","display_name":"Acta Clinica Croatica","issn_l":"0353-9466","issn":["0353-9466","0353-9474","1333-9451"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314831","host_organization_name":"Croatian Dairy Union","host_organization_lineage":["https://openalex.org/P4310314831"],"host_organization_lineage_names":["Croatian Dairy Union"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta Clinica Croatica","raw_type":null},{"id":"mag:187562889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23115945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:hrcak.srce.hr:106163","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/106163","pdf_url":"http://hrcak.srce.hr/file/156352","source":{"id":"https://openalex.org/S4306400677","display_name":"Hr\u010dak Portal of scientific journals of Croatia (University Computing Centre)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104502","host_organization_name":"United Nations University","host_organization_lineage":["https://openalex.org/I4210104502"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta clinica Croatica","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W187562889.pdf","grobid_xml":"https://content.openalex.org/works/W187562889.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W118019771","https://openalex.org/W937597592","https://openalex.org/W1555250162","https://openalex.org/W1903607752","https://openalex.org/W1989023227","https://openalex.org/W1993358990","https://openalex.org/W1994921108","https://openalex.org/W2002197081","https://openalex.org/W2014444795","https://openalex.org/W2019562533","https://openalex.org/W2027461774","https://openalex.org/W2039380871","https://openalex.org/W2045662648","https://openalex.org/W2048540725","https://openalex.org/W2064550235","https://openalex.org/W2079525748","https://openalex.org/W2107724883","https://openalex.org/W2152059169","https://openalex.org/W2161338375","https://openalex.org/W2164180269","https://openalex.org/W2175175849"],"related_works":["https://openalex.org/W1903607752","https://openalex.org/W2327456062","https://openalex.org/W2121395222","https://openalex.org/W2013139186","https://openalex.org/W3023899481","https://openalex.org/W1518675200","https://openalex.org/W2107724883","https://openalex.org/W1981268339","https://openalex.org/W2155854266","https://openalex.org/W2045662648"],"abstract_inverted_index":{"The":[0,120],"purpose":[1],"of":[2,11,23,36,54,84,104,110,129,147,175,190],"our":[3],"study":[4],"was":[5,123],"to":[6,8,32,184],"contribute":[7],"better":[9],"understanding":[10],"cerebrospinal":[12],"fluid":[13],"(CSF)":[14],"as":[15],"a":[16,99,134],"valuable":[17],"biological":[18],"material":[19],"in":[20,39,44,73,82,106,125,151,160,178],"the":[21,27,34,40,52,91,148,161,191],"research":[22],"brain":[24,87,111,130,152],"tumors":[25],"within":[26],"\"low":[28,192],"T3":[29,165,193],"syndrome\",":[30,166],"and":[31,70,75,79,89,108,127],"discuss":[33],"role":[35],"thyroid":[37],"hormones":[38],"central":[41],"nervous":[42],"system":[43],"subjects":[45],"with":[46,86,93],"severe":[47,179],"cerebral":[48,180],"lesions.":[49],"We":[50,155],"studied":[51],"levels":[53,81],"total":[55,58],"triiodothyronine":[56,62,68],"(tT3),":[57],"thyroxine":[59,65],"(tT4),":[60],"free":[61,64],"(fT3),":[63],"(fT4),":[66],"reverse":[67],"(rT3)":[69],"thyrotropin":[71],"(TSH)":[72],"serum,":[74],"fT3,":[76],"fT4,":[77],"rT3":[78,105,186],"TSH":[80],"CSF":[83,109,126],"patients":[85,113],"tumor,":[88],"compared":[90],"results":[92,97,142],"control":[94,115],"group.":[95],"Study":[96],"indicated":[98],"statistically":[100,135],"significantly":[101],"higher":[102,145],"level":[103],"serum":[107,128],"tumor":[112,131,153],"vs.":[114],"group":[116],"(p":[117,138],"<":[118,139],"0.05).":[119,140],"rT3/fT3":[121],"ratio":[122],"highest":[124],"patients,":[132],"yielding":[133],"significant":[136],"difference":[137],"These":[141],"could":[143],"suggest":[144],"permeability":[146],"blood-brain":[149],"barrier":[150],"patients.":[154],"also":[156,168],"assume":[157],"that":[158],"rT3,":[159],"framework":[162],"of\"cerebral":[163],"low":[164],"is":[167],"generated":[169],"through":[170],"local":[171],"intracerebral":[172],"conversion.":[173],"Disruption":[174],"this":[176],"process":[177],"lesion":[181],"can":[182],"lead":[183],"increased":[185],"concentrations,":[187],"i.e.":[188],"development":[189],"syndrome\".":[194]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
