{"id":"https://openalex.org/W1875423180","doi":null,"title":"Allopurinol improves myocardial reperfusion injury in a xanthine oxidase-free model.","display_name":"Allopurinol improves myocardial reperfusion injury in a xanthine oxidase-free model.","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W1875423180","mag":"1875423180","pmid":"https://pubmed.ncbi.nlm.nih.gov/7636893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2607862"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2607862","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2607862","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Natl Med Assoc","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2607862","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056381420","display_name":"Steven B. Hopson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Hopson","raw_affiliation_strings":["Department of Surgery, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007744549","display_name":"Robert M. Lust","orcid":"https://orcid.org/0000-0001-5816-0005","observed_orcids":["https://orcid.org/0000-0001-5816-0005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Lust","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y S Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y S Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080461534","display_name":"Richard S. Zeri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R S Zeri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031501022","display_name":"Ron F. Morrison","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R F Morrison","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Otaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Otaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109505071","display_name":"Walter Randolph Chitwood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W R Chitwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.304,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.58678898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"87","issue":"7","first_page":"480","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":1.0},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9950000047683716},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.7799999713897705},{"id":"https://openalex.org/keywords/regional-myocardial-perfusion","display_name":"regional myocardial blood flow","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hyperemia","display_name":"hyperemia","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.7089999914169312},{"id":"https://openalex.org/keywords/sonomicrometry","display_name":"sonomicrometry","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.9250087141990662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7897790670394897},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.6855164170265198},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5927985310554504},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5249481201171875},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4917738735675812},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.46122556924819946},{"id":"https://openalex.org/C2780393670","wikidata":"https://www.wikidata.org/wiki/Q5172192","display_name":"Coronary occlusion","level":3,"score":0.4499087929725647},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.4431875944137573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34506672620773315},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3401413559913635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11640185117721558},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07113009691238403},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000493","descriptor_name":"Allopurinol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000493","descriptor_name":"Allopurinol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006940","descriptor_name":"Hyperemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D017725","descriptor_name":"Ventricular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2607862","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2607862","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Natl Med Assoc","raw_type":"Text"},{"id":"pmid:7636893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7636893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Medical Association","raw_type":"Journal Article"},{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/3275","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/3275","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:1875423180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7636893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2607862","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2607862","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Natl Med Assoc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1965748372","https://openalex.org/W1992595604","https://openalex.org/W2017411482","https://openalex.org/W2034228138","https://openalex.org/W2034683799","https://openalex.org/W2055907674","https://openalex.org/W2078683430","https://openalex.org/W2416878118","https://openalex.org/W2474617437"],"related_works":["https://openalex.org/W1970328928","https://openalex.org/W71941236","https://openalex.org/W2471756400","https://openalex.org/W2093511210","https://openalex.org/W2055907674","https://openalex.org/W2059029275","https://openalex.org/W2004153771","https://openalex.org/W1999816148","https://openalex.org/W1994008059","https://openalex.org/W2108402806"],"abstract_inverted_index":{"The":[0,143],"ability":[1],"of":[2,29,36,58,181,196,209],"allopurinol":[3,37,74,217],"to":[4,16,53,162],"protect":[5],"against":[6],"reperfusion":[7,67],"injury":[8],"in":[9,38,231],"the":[10,34,59,111,134,172,207,216,226,232],"heart":[11],"has":[12,25],"usually":[13],"been":[14],"attributed":[15],"its":[17],"xanthine":[18],"oxidase":[19],"(XO)-inhibiting":[20],"properties.":[21],"Human":[22],"myocardium":[23],"however,":[24],"exhibited":[26,146],"low":[27],"levels":[28,164,198],"XO":[30],"activity.":[31],"To":[32],"investigate":[33],"effects":[35],"an":[39,212],"XO-free":[40],"model":[41],"and":[42,84,99,103,121,124,167,201],"determine":[43],"whether":[44],"pretreatment":[45],"is":[46],"necessary,":[47],"12":[48],"domestic":[49],"pigs":[50],"(15":[51],"kg":[52],"20":[54],"kg)":[55],"underwent":[56],"occlusion":[57,80],"left":[60],"circumflex":[61],"for":[62,68,206],"8":[63],"minutes":[64,83,126,153,187],"followed":[65],"by":[66,137],"4":[69],"hours.":[70],"One":[71],"group":[72,87,145,174,218,234],"received":[73,91],"infusion":[75,94],"(5":[76],"mg/kg":[77],"IV)":[78],"at":[79,133,151,165,185,194,199,235],"over":[81],"45":[82],"a":[85,92,147],"control":[86,163,173,197,233],"(n":[88],"=":[89],"6)":[90],"saline":[93],"(same":[95],"volume).":[96],"Left":[97],"ventricular":[98],"aortic":[100],"pressure,":[101],"electrocardiograms,":[102],"regional":[104],"wall":[105],"motion":[106],"(sonomicrometry)":[107],"were":[108,117],"monitored":[109],"throughout":[110],"process.":[112],"Regional":[113],"blood":[114,183],"flow":[115,132,184],"(microspheres)":[116],"obtained":[118],"before,":[119],"during,":[120],"5,":[122],"10,":[123],"30":[125,168,202],"after":[127],"ischemia.":[128],"Occlusion":[129],"decreased":[130],"transmural":[131],"midpapillary":[135],"level":[136],"75%":[138],"(0.28":[139],"versus":[140,157,189],"1.10":[141,158,190],"mL/minute/g).":[142],"allopurinol-treated":[144],"mild,":[148],"generalized":[149],"hyperemia":[150],"5":[152,186],"(ischemic":[154],"zone:":[155],"1.44":[156],"mL/min/g,":[159],"which":[160,192],"returned":[161],"10":[166,200],"minutes.":[169,203],"In":[170],"contrast,":[171],"was":[175],"associated":[176],"with":[177,225],"only":[178],"80%":[179],"restoration":[180],"resting":[182],"(0.84":[188],"mL/min/g),":[191],"stabilized":[193],"63%":[195],"When":[204],"evaluated":[205],"propensity":[208],"arrhythmias":[210],"using":[211],"arbitrary":[213],"arrhythmia":[214],"score,":[215],"demonstrated":[219],"no":[220],"myocardial":[221],"ectopy":[222,228],"when":[223],"compared":[224],"focal":[227],"routinely":[229],"encountered":[230],"all":[236],"time":[237],"intervals.(ABSTRACT":[238],"TRUNCATED":[239],"AT":[240],"250":[241],"WORDS)":[242]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
