{"id":"https://openalex.org/W18749199","doi":null,"title":"[Clinical or subclinical hypothyroidism and thyroid autoantibody before 20 weeks pregnancy and risk of preterm birth: a systematic review].","display_name":"[Clinical or subclinical hypothyroidism and thyroid autoantibody before 20 weeks pregnancy and risk of preterm birth: a systematic review].","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W18749199","mag":"18749199","pmid":"https://pubmed.ncbi.nlm.nih.gov/25603905"},"language":"zh","primary_location":{"id":"pmid:25603905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25603905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100664825","display_name":"Shaowei Wang","orcid":"https://orcid.org/0000-0002-1267-9554","observed_orcids":["https://orcid.org/0000-0002-1267-9554"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaowei Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China. Email: w-sw999@sohu.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China. Email: w-sw999@sohu.com","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086170038","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-7724-6514","observed_orcids":["https://orcid.org/0000-0002-7724-6514"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048799511","display_name":"Defa Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Defa Chu","raw_affiliation_strings":["Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051797488","display_name":"Lin Liang","orcid":"https://orcid.org/0000-0002-2654-8360","observed_orcids":["https://orcid.org/0000-0002-2654-8360"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Liang","raw_affiliation_strings":["Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632220","display_name":"Xiaodong Zhao","orcid":"https://orcid.org/0000-0002-2630-7161","observed_orcids":["https://orcid.org/0000-0002-2630-7161"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Zhao","raw_affiliation_strings":["Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"last","author":{"id":null,"display_name":"Junrong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junrong Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology,Beijing Hospital, Beijing 100730, China","institution_ids":["https://openalex.org/I4210119648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210119648"],"apc_list":null,"apc_paid":null,"fwci":0.436,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63994817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"49","issue":"11","first_page":"816","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":0.9440000057220459},{"id":"https://openalex.org/keywords/overt-hypothyroidism","display_name":"overt hypothyroidism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/thyroid-autoantibodies","display_name":"thyroid autoantibodies","score":0.9879999756813049},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6010000109672546},{"id":"https://openalex.org/keywords/thyroid-dysfunction-in-pregnancy","display_name":"thyroid dysfunction in pregnancy","score":0.5},{"id":"https://openalex.org/keywords/preterm-labor","display_name":"preterm labor","score":0.5320000052452087},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.5910000205039978},{"id":"https://openalex.org/keywords/neonatal-hypothyroidism","display_name":"neonatal hypothyroidism","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8907120227813721},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.8271715641021729},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6863287687301636},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.602766215801239},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.5552769899368286},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5117478370666504},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.46181097626686096},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.42836323380470276},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.41134387254714966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25782620906829834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007230","descriptor_name":"Infant, Low Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007752","descriptor_name":"Obstetric Labor, Premature","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007752","descriptor_name":"Obstetric Labor, Premature","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007752","descriptor_name":"Obstetric Labor, Premature","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047928","descriptor_name":"Premature Birth","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25603905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25603905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"Journal Article"},{"id":"mag:18749199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25603905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2416571335","https://openalex.org/W2440710589","https://openalex.org/W4289993926"],"related_works":["https://openalex.org/W2927071435","https://openalex.org/W2765742526","https://openalex.org/W2969751565","https://openalex.org/W2754279543","https://openalex.org/W2091951281","https://openalex.org/W2463659694","https://openalex.org/W4224979490","https://openalex.org/W3029016968","https://openalex.org/W2408302860","https://openalex.org/W2097361009"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3],"relationship":[4,130],"between":[5,131],"clinical":[6,76,92,132,203,220],"or":[7,93,133,149,375],"subclinical":[8,60,94,134,260,277,376],"hypothyroidism":[9,95,135,185,204,221,242,261,278,377],"and":[10,18,40,75,96,100,136,140,205,262,322,378],"positive":[11,97,137,301,321,337,379],"thyroid":[12,63,98,138,318,338,345,380],"autoantibody":[13,139,339,346,381],"before":[14],"20":[15],"weeks":[16],"pregnancy":[17],"risk":[19,141,212,269,329,386],"of":[20,142,160,164,213,270,330,388],"preterm":[21,65,67,103,143,165,214,271,331,389],"birth.":[22,104,390],"METHODS:":[23],"Literature":[24],"search":[25,56],"was":[26,91,102,124,145,222,279,340,369],"done":[27],"in":[28,175,186,216,229,243,273,283,302,333,347,382],"PubMed,":[29],"EMBASE,":[30],"Wanfang":[31],"Medical":[32],"Database,":[33],"China":[34,41],"Academic":[35],"Journal":[36],"Network":[37],"Publishing":[38],"Database":[39],"Biology":[42],"Medicine":[43],"disc":[44],"databases":[45],"from":[46],"January":[47],"1st,":[48],"1980":[49],"to":[50],"December":[51],"31th,":[52],"2013.":[53],"The":[54,106,129,173,211,268,328,360],"following":[55],"terms":[57],"were":[58,78,88,109,118,156,178,190,247,305],"used:hypothyroidism,":[59],"hypothyroidism,":[61],"hypothyroxinnism,":[62],"antibody,":[64],"labor,":[66],"birth,":[68],"etc.":[69],"(1)":[70,152],"Criteria":[71],"for":[72],"inclusion:cohort":[73],"studies":[74,77,155,177,189,246,304],"included;":[79],"only":[80],"articles":[81,110],"that":[82,111,367],"described":[83,112],"at":[84],"least":[85],"10":[86,115],"patients":[87],"eligible;the":[89],"exposure":[90],"autoantihody,":[99],"outcome":[101],"(2)":[105,183],"excluded":[107],"subjects":[108],"less":[113],"than":[114,224,281,342],"patients;":[116],"controls":[117,174],"pregnant":[119,171,179,197,209,217,227,254,266,274,312,326,334,383],"women":[120,180,198,201,218,228,255,258,275,313,316,335,384],"without":[121],"eurothyrodisim.":[122,182],"Meta-analysis":[123],"performed":[125],"by":[126,147,286],"RevMan":[127],"5.":[128],"birth":[144,166,215,272,332],"evaluated":[146],"OR":[148],"RR.":[150],"RESULTS:":[151],"Twenty":[153],"cohort":[154],"enrolled.":[157],"A":[158],"total":[159],"39":[161],"596":[162],"cases":[163],"occurred":[167],"among":[168],"498":[169],"418":[170,196],"women.":[172],"these":[176],"with":[181,202,219,259,276,317,336],"Clinical":[184,374],"pregnancy:":[187,244],"eight":[188],"included,":[191,248,306],"reported":[192,249,307],"data":[193,250,308],"on":[194,251,309],"478":[195],"(5":[199,256],"473":[200],"472":[206],"945":[207],"euthyroid":[208,265,325],"women).":[210,267,327],"higher":[223,280,341],"those":[225,282,343],"eurothyroid":[226],"control":[230,284,348],"group":[231,285,349],"(OR":[232,290,350],"=":[233,291,351],"1.25,":[234,292],"95%":[235,293,353],"CI:1.15-1.36,":[236],"P":[237,295,357],"<":[238,296,358],"0.01).":[239,297,359],"(3)":[240],"Subclinical":[241],"ten":[245],"277":[252],"531":[253],"257":[257],"272":[263],"274":[264],"random":[287],"effects":[288],"analysis":[289],"CI:1.14-1.36,":[294],"(4)":[298],"Thyroid":[299],"autoantibodys":[300],"pregnancy:eleven":[303],"28":[310],"781":[311],"(3":[314],"036":[315],"autoanti":[319],"body":[320],"25":[323],"745":[324],"negative":[344],"1.47,":[352],"CI:":[354],"1.27-":[355],"1.70,":[356],"funnel":[361],"plots":[362],"presented":[363],"symmetrical":[364],"graphics,":[365],"indicating":[366],"there":[368],"no":[370],"publication":[371],"bias.":[372],"CONCLUSION:":[373],"is":[385],"factors":[387]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}