{"id":"https://openalex.org/W18744606","doi":"https://doi.org/10.3233/ch-2012-1575","title":"Role molecular signaling pathways in changes of red blood cell deformability","display_name":"Role molecular signaling pathways in changes of red blood cell deformability","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W18744606","doi":"https://doi.org/10.3233/ch-2012-1575","mag":"18744606","pmid":"https://pubmed.ncbi.nlm.nih.gov/22951624"},"language":"en","primary_location":{"id":"doi:10.3233/ch-2012-1575","doi":"https://doi.org/10.3233/ch-2012-1575","is_oa":false,"landing_page_url":"https://doi.org/10.3233/ch-2012-1575","pdf_url":null,"source":{"id":"https://openalex.org/S74293116","display_name":"Clinical Hemorheology and Microcirculation","issn_l":"1386-0291","issn":["1386-0291","1875-8622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Hemorheology and Microcirculation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055925178","display_name":"Alexei V. Muravyov","orcid":"https://orcid.org/0000-0002-5502-9164","observed_orcids":["https://orcid.org/0000-0002-5502-9164"]},"institutions":[{"id":"https://openalex.org/I4210121576","display_name":"Yaroslavl State Pedagogical University","ror":"https://ror.org/02n3d5p55","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210121576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexei V. Muravyov","raw_affiliation_strings":["State Pedagogical University, Yaroslavl, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Pedagogical University, Yaroslavl, Russia","institution_ids":["https://openalex.org/I4210121576"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053274972","display_name":"Irina A. Tikhomirova","orcid":"https://orcid.org/0000-0001-9521-4017","observed_orcids":["https://orcid.org/0000-0001-9521-4017"]},"institutions":[{"id":"https://openalex.org/I4210121576","display_name":"Yaroslavl State Pedagogical University","ror":"https://ror.org/02n3d5p55","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210121576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina A. Tikhomirova","raw_affiliation_strings":["State Pedagogical University, Yaroslavl, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Pedagogical University, Yaroslavl, Russia","institution_ids":["https://openalex.org/I4210121576"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210121576"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.8416,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.92940034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"1-2","first_page":"45","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.9940000176429749},{"id":"https://openalex.org/keywords/molecular-pathways","display_name":"molecular pathways","score":0.8109999895095825},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.7269999980926514},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/phosphodiesterase-inhibitors","display_name":"phosphodiesterase inhibitors","score":0.75},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7839999794960022},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.722000002861023},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/membrane-protein-phosphorylation","display_name":"membrane protein phosphorylation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.7609999775886536},{"id":"https://openalex.org/keywords/microrheology","display_name":"microrheology","score":0.7049999833106995},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.8199999928474426},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2776185378","wikidata":"https://www.wikidata.org/wiki/Q5396464","display_name":"Erythrocyte deformability","level":3,"score":0.7583166360855103},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.7012199759483337},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.7011995911598206},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.614920973777771},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5722256302833557},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.5656687617301941},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5513861775398254},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5254434943199158},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4985983371734619},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49087053537368774},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.45595553517341614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44879546761512756},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41178151965141296},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3707196116447449},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35613059997558594},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3401522636413574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33682680130004883}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/ch-2012-1575","doi":"https://doi.org/10.3233/ch-2012-1575","is_oa":false,"landing_page_url":"https://doi.org/10.3233/ch-2012-1575","pdf_url":null,"source":{"id":"https://openalex.org/S74293116","display_name":"Clinical Hemorheology and Microcirculation","issn_l":"1386-0291","issn":["1386-0291","1875-8622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Hemorheology and Microcirculation","raw_type":"journal-article"},{"id":"pmid:22951624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22951624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W7430747","https://openalex.org/W8899386","https://openalex.org/W14343090","https://openalex.org/W94407003","https://openalex.org/W112316798","https://openalex.org/W139423649","https://openalex.org/W152546199","https://openalex.org/W949575744","https://openalex.org/W1503697962","https://openalex.org/W1515879533","https://openalex.org/W1540067706","https://openalex.org/W1551636999","https://openalex.org/W1571775208","https://openalex.org/W1576821632","https://openalex.org/W1634451056","https://openalex.org/W1702133486","https://openalex.org/W1711838248","https://openalex.org/W1716855656","https://openalex.org/W1959350518","https://openalex.org/W1968023205","https://openalex.org/W1968506904","https://openalex.org/W1972530107","https://openalex.org/W1981610263","https://openalex.org/W1986140188","https://openalex.org/W1991486039","https://openalex.org/W1992205563","https://openalex.org/W2004778528","https://openalex.org/W2006724189","https://openalex.org/W2010955648","https://openalex.org/W2016334410","https://openalex.org/W2017210380","https://openalex.org/W2022066534","https://openalex.org/W2023777343","https://openalex.org/W2025195837","https://openalex.org/W2026924145","https://openalex.org/W2028758117","https://openalex.org/W2037535094","https://openalex.org/W2041000554","https://openalex.org/W2041178998","https://openalex.org/W2047177892","https://openalex.org/W2048809551","https://openalex.org/W2051442934","https://openalex.org/W2056477864","https://openalex.org/W2058573283","https://openalex.org/W2061275657","https://openalex.org/W2063423031","https://openalex.org/W2064021058","https://openalex.org/W2065002635","https://openalex.org/W2072680860","https://openalex.org/W2083112746","https://openalex.org/W2093025457","https://openalex.org/W2105539899","https://openalex.org/W2108914956","https://openalex.org/W2113728300","https://openalex.org/W2136753018","https://openalex.org/W2144884598","https://openalex.org/W2155154942","https://openalex.org/W2156215631","https://openalex.org/W2163878933","https://openalex.org/W2163969168","https://openalex.org/W2165474821","https://openalex.org/W2168617162","https://openalex.org/W2232553440","https://openalex.org/W2276150117","https://openalex.org/W2307195668","https://openalex.org/W2313272249","https://openalex.org/W2374261122","https://openalex.org/W2403019844","https://openalex.org/W2403985131","https://openalex.org/W2410947778","https://openalex.org/W2412174089","https://openalex.org/W2412508128","https://openalex.org/W2413409407","https://openalex.org/W2422166536","https://openalex.org/W2469100339","https://openalex.org/W2507997887"],"related_works":["https://openalex.org/W1634547101","https://openalex.org/W949575744","https://openalex.org/W2051118473","https://openalex.org/W1992429370","https://openalex.org/W1169855942","https://openalex.org/W4223467373","https://openalex.org/W1556083772","https://openalex.org/W2959794987","https://openalex.org/W4389008224","https://openalex.org/W4392213222"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,49,57,114,164,181,203],"designed":[3],"to":[4,28,31,34,51,141,272],"investigate":[5],"the":[6,9,38,54,87,92,102,124,148,151,156,198,210,223,244,246,252,286],"dependency":[7],"of":[8,16,23,45,72,86,94,101,120,128,147,150,189,201,209,213,225,227,261,285,292],"red":[10,24,77,95,103,157,214,253,275],"blood":[11,25,96,104,158,215,276],"cell":[12,78,97,105,159,216,254,277],"deformability":[13,56,62,143,160,255,278],"upon":[14],"activation":[15,170,226,260,284],"extra-":[17,228],"and":[18,30,229,265,289],"intracellular":[19,230,266],"signaling":[20,89,232,267],"pathways.":[21,268],"Exposures":[22],"cells":[26],"(RBCs)":[27],"catecholamines":[29],"insulin":[32],"led":[33,140],"positive":[35],"change":[36],"in":[37,91],"RBC":[39,52,55,66,121,132,195],"deformability.":[40,79,98,122],"When":[41],"forskolin,":[42],"a":[43,83,117,182],"stimulator":[44],"adenylyl":[46],"cyclase":[47],"(AC),":[48],"added":[50],"suspension,":[53],"increased.":[58],"Somewhat":[59],"more":[60,166],"significant":[61,142,187],"rise":[63,100],"appeared":[64],"after":[65],"incubation":[67],"with":[68,259,283,290],"dB-AMP.":[69],"The":[70,99,145,207,220],"inhibitors":[71],"phosphodiesterase":[73],"(PDE)":[74],"activity":[75],"increased":[76],"These":[80],"results":[81],"revealed":[82],"considerable":[84,167],"role":[85],"AC-cAMP":[88],"system":[90],"regulation":[93,212],"Ca(2+)":[106,129,136,293],"influx,":[107],"stimulated":[108],"by":[109,116,133,138,171,176],"mechanical":[110],"loading":[111],"or":[112,135,173],"A23187":[113],"accompanied":[115],"marked":[118],"lowering":[119],"At":[123],"same":[125],"time":[126],"blocking":[127],"entry":[130,294],"into":[131,295],"verapamil":[134],"chelating":[137],"EGTA":[139],"rise.":[144],"comparison":[146],"effect":[149,188,200],"different":[152,262],"protein":[153,178,191,241],"kinases":[154],"on":[155,194],"showed":[161],"that":[162,251,274],"it":[163],"altered":[165],"under":[168],"PKA":[169],"forskolin":[172],"dB-cAMP":[174],"than":[175],"other":[177],"kinases.":[179],"There":[180],"lesser":[183],"but":[184],"quite":[185],"statistically":[186],"tyrosine":[190],"kinase":[192],"(TPK)":[193],"microrheology.":[196],"Whereas":[197],"microrheological":[199],"PKC":[202],"not":[204],"so":[205],"considerable.":[206],"problem":[208],"short-term":[211],"microrheology":[217],"is":[218],"examined.":[219],"latter":[221],"includes:":[222],"modes":[224],"molecular":[231],"pathways,":[233],"ligand":[234],"-":[235,264],"receptor":[236],"interaction,":[237],"second":[238],"messengers,":[239],"membrane":[240],"phosphorylation.":[242],"On":[243],"whole":[245],"total":[247],"data":[248],"clearly":[249],"show":[250],"changes":[256,279],"are":[257],"connected":[258],"extra":[263],"It":[269],"seems":[270],"reasonable":[271],"suppose":[273],"were":[280],"mainly":[281],"associated":[282],"AC-cAMP-PKA":[287],"pathway,":[288],"decrease":[291],"cells.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
