{"id":"https://openalex.org/W187102695","doi":"https://doi.org/10.1182/blood.v122.21.1673.1673","title":"SPD602 Is a Selective Iron Chelator Which Is Able To Mobilise The Non-Transferrin-Bound Iron Pool","display_name":"SPD602 Is a Selective Iron Chelator Which Is Able To Mobilise The Non-Transferrin-Bound Iron Pool","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W187102695","doi":"https://doi.org/10.1182/blood.v122.21.1673.1673","mag":"187102695"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.1673.1673","doi":"https://doi.org/10.1182/blood.v122.21.1673.1673","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.1673.1673","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020843793","display_name":"Robert C. Hider","orcid":"https://orcid.org/0000-0003-1330-5797","observed_orcids":["https://orcid.org/0000-0003-1330-5797"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Robert Hider","raw_affiliation_strings":["Institute of Pharmaceutical Science, King\u2019s College, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Science, King\u2019s College, London, United Kingdom,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110207752","display_name":"Xiaole Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Xiaole Kong","raw_affiliation_strings":["Institute of Pharmaceutical Science, King\u2019s College, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Science, King\u2019s College, London, United Kingdom,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026898037","display_name":"Tim J. Luker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155342","display_name":"Shire (United Kingdom)","ror":"https://ror.org/0547dck29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210147578","https://openalex.org/I4387155342","https://openalex.org/I44892455"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tim Luker","raw_affiliation_strings":["Exploratory Projects, Shire, Basingstoke, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Projects, Shire, Basingstoke, United Kingdom,","institution_ids":["https://openalex.org/I4387155342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027945805","display_name":"Kelly M. Conlon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155342","display_name":"Shire (United Kingdom)","ror":"https://ror.org/0547dck29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210147578","https://openalex.org/I4387155342","https://openalex.org/I44892455"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kelly Conlon","raw_affiliation_strings":["Biosciences, Shire, Basingstoke, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosciences, Shire, Basingstoke, United Kingdom","institution_ids":["https://openalex.org/I4387155342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085080328","display_name":"Rachel Harland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155342","display_name":"Shire (United Kingdom)","ror":"https://ror.org/0547dck29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210147578","https://openalex.org/I4387155342","https://openalex.org/I44892455"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rachel Harland","raw_affiliation_strings":["Biosciences, Shire, Basingstoke, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosciences, Shire, Basingstoke, United Kingdom","institution_ids":["https://openalex.org/I4387155342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020843793","https://openalex.org/A5026898037","https://openalex.org/A5027945805","https://openalex.org/A5085080328","https://openalex.org/A5110207752"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4387155342"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"1673","last_page":"1673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-chelators","display_name":"iron chelators","score":0.9309999942779541},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.7200000286102295},{"id":"https://openalex.org/keywords/deferiprone","display_name":"deferiprone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":1.0},{"id":"https://openalex.org/keywords/non-transferrin-bound-iron","display_name":"non-transferrin-bound iron","score":0.8880000114440918},{"id":"https://openalex.org/keywords/iron-mobilization","display_name":"iron mobilization","score":0.5879999995231628},{"id":"https://openalex.org/keywords/redox-cycling","display_name":"redox cycling","score":0.6669999957084656},{"id":"https://openalex.org/keywords/iron-binding-affinity","display_name":"iron binding affinity","score":0.43799999356269836},{"id":"https://openalex.org/keywords/oral-iron-chelation","display_name":"oral iron chelation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.9912272691726685},{"id":"https://openalex.org/C2776517179","wikidata":"https://www.wikidata.org/wiki/Q749664","display_name":"Deferiprone","level":3,"score":0.9820587635040283},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.9320769309997559},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6788028478622437},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.6136282682418823},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.4886815845966339},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.4195733964443207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36474862694740295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2543749213218689},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25077444314956665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22843173146247864},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.17833441495895386}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.1673.1673","doi":"https://doi.org/10.1182/blood.v122.21.1673.1673","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.1673.1673","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038047990","https://openalex.org/W833954827","https://openalex.org/W121203478","https://openalex.org/W1984614605","https://openalex.org/W4238687358","https://openalex.org/W2167980905","https://openalex.org/W2015708072","https://openalex.org/W4232329567","https://openalex.org/W2147801584","https://openalex.org/W4416504185"],"abstract_inverted_index":{"Abstract":[0],"Currently":[1],"there":[2],"are":[3,34,137,277,383,409,452,477,551],"three":[4],"iron":[5,55,329,345,350,353,361,371,406,503,543],"chelators":[6],"in":[7,57,66,120,227,244,400,405,411,449,459,464,486],"clinical":[8,58,70,209,398,444,529,562],"use,":[9],"deferoxamine,":[10,88,192],"deferiprone":[11,21,186],"and":[12,18,22,96,98,135,146,214,232,250,335,358,375,379,422,429,472,519,521],"deferasirox.":[13,533],"Each":[14],"has":[15,61,112,196,215,397,522],"its":[16],"limitations":[17],"although":[19],"both":[20,33,100,373,468],"deferasirox":[23,97,213,276,423,432,476],"have":[24,253],"the":[25,202,208,255,260,266,270,293,352,387,402,412,436,457,465,469,490,528],"advantage":[26],"over":[27,510],"deferoxamine":[28],"of":[29,39,64,82,180,246,269,349,356,390,416,446,475,536,561],"being":[30],"orally":[31,53],"active,":[32],"associated":[35,138],"with":[36,139,344,505],"a":[37,51,67,80,89,93,129,140,148,216],"range":[38],"side":[40],"effects":[41],"(Neufeld,":[42],"Blood":[43,75],"2006;107:3436).":[44],"SPD602":[45,174,195,235,296,366,396,417,439,488,500,538],"(formerly":[46],"known":[47],"as":[48,207,265,435,517,527],"FBS0701)":[49],"is":[50,175,363,367,433,440,461,463,493,501],"tridentate,":[52],"administered":[54],"chelator":[56,95,330,504],"development":[59],"that":[60,179,184,194,395,558],"shown":[62],"evidence":[63],"effect":[65],"phase":[68],"2":[69],"trial":[71],"(Neufeld":[72],"et":[73,155,284],"al.":[74,156,285],"2012;119:3263).":[76],"Here,":[77],"we":[78,252],"present":[79],"comparison":[81,108],"clinically":[83],"relevant":[84,204,340,513,546],"physicochemical":[85,450],"data":[86,332,393],"for":[87,132,173,185,191,201,219,234,275,301,338,508,525],"hexadentate":[90],"chelator,":[91],"deferiprone,":[92],"bidentate":[94],"SPD602,":[99],"tridentate":[101,262],"chelators,":[102,110],"using":[103],"techniques":[104],"to":[105,118,151,178,238,259,280,385,481,553],"allow":[106],"direct":[107],"between":[109,230],"which":[111,382],"not":[113],"previously":[114],"been":[115],"possible":[116],"due":[117,279],"differences":[119,410],"experimental":[121],"methodology.":[122],"Broadly":[123],"speaking,":[124],"all":[125],"four":[126],"compounds":[127],"possess":[128],"high":[130],"selectivity":[131,507],"iron(III)":[133,206,233,377,509,526],"(Table)":[134,264],"thereby":[136],"strongly":[141],"negative":[142],"ligand\u2013iron":[143],"oxidation":[144],"potential":[145,218],"thus":[147],"low":[149,217],"tendency":[150],"redox":[152,222],"cycle":[153],"(Ma":[154],"Curr":[157],"Med":[158],"Chem":[159,287],"2012;19:2816).":[160],"The":[161,225,443],"pFe3+":[162,336],"value":[163],"(1":[164],"\u00b5M":[165,168],"Fe3+;":[166],"10":[167],"Ligand":[169],"(L);":[170],"pH":[171],"7.4)":[172],"very":[176],"close":[177],"deferasirox,":[181],"larger":[182],"than":[183,189,305],"but":[187],"smaller":[188],"found":[190],"suggesting":[193],"at":[197,369,541],"least":[198],"equivalent":[199],"affinity":[200,300,524],"physiologically":[203,339,512,545],"form":[205],"1st":[210,530],"line":[211,531],"treatment":[212],"cell":[220],"damaging":[221],"cycling":[223],"activity.":[224],"separation":[226],"binding":[228,299,354],"affinities":[229],"iron(II)":[231],"was":[236,539],"determined":[237],"be":[239,386,560],"approximately":[240],"14":[241],"log":[242],"units":[243],"favour":[245],"iron(III).":[247],"For":[248],"zinc(II)":[249,518],"copper(II)":[251],"compared":[254],"logK1":[256,294],"values":[257,268,274],"corresponding":[258,272],"two":[261,271,303],"ligands":[263],"reported":[267],"logK2":[273],"unreliable":[278],"polymer":[281],"formation":[282],"(Heinz":[283],"Angew":[286],"Int":[288],"Ed":[289],"1999;38:2568).":[290],"Based":[291],"on":[292],"values,":[295],"showed":[297],"lower":[298],"these":[302],"metals":[304,341],"deferasirox.Fe3+pFe3+Mg2+Ca2+Cu2+Zn2+Deferoxamine28.3":[306],"(logK1)26.54.3":[307],"(logK1)2.4":[308],"(logK1)7.9":[309],"(logK1)5.4":[310],"(logK1)Deferasirox36.9":[311],"(log\u03b22)22.57.6":[312],"(logK1)5.5":[313],"(logK1)18.8":[314],"(logK1)13.3":[315],"(logK1)SPD60233.1":[316],"(log\u03b22)22.36.0":[317],"(logK1)4.5":[318],"(logK1)14.8":[319],"(logK1)9.6":[320],"(logK1)Deferiprone37.0":[321],"(log\u03b23)20.59.1":[322],"(logK1)2.0":[323],"(logK1)19.1":[324],"(log\u03b22)13.5":[325],"(log\u03b22)":[326],"Table":[327],"shows":[328],"metal-binding":[331],"(stability":[333],"constants":[334],"values)":[337],"In":[342,498,534],"patients":[343],"overload":[346],"disorders,":[347],"levels":[348],"exceed":[351],"capacity":[355],"transferrin,":[357],"non-transferrin":[359],"bound":[360,480,494],"(NTBI)":[362],"evident.":[364],"Pre-clinically,":[365],"efficient":[368],"mobilising":[370,401,542],"from":[372],"mononuclear":[374],"oligonuclear":[376],"citrate":[378],"albumin-bound":[380],"iron(III),":[381],"believed":[384],"major":[388],"components":[389],"NTBI.":[391],"These":[392],"suggest":[394],"utility":[399],"NTBI":[403],"pool":[404],"overload.":[407],"There":[408],"partition":[413],"coefficients":[414],"(logD7.4)":[415],"(L,":[418,424],"-1.3;":[419],"FeL2,":[420,426],"-2.7)":[421],"1.1;":[425],"<":[427],"-3.0)":[428],"so":[430],"whereas":[431],"hydrophobic":[434],"free":[437,470,491],"ligand,":[438],"relatively":[441],"hydrophilic.":[442],"implications":[445],"this":[447],"difference":[448,458],"properties":[451],"unknown.":[453],"One":[454],"area":[455],"where":[456],"hydrophobicity":[460],"reflected":[462],"albumin-binding":[466],"properties:":[467],"ligand":[471],"FeL2":[473],"complex":[474],"almost":[478],"completely":[479],"albumin":[482],"(>":[483],"99%)":[484],"whereas,":[485],"contrast,":[487],"(as":[489],"ligand)":[492],"less":[495],"extensively":[496],"(85.5%).":[497],"summary,":[499],"an":[502],"good":[506],"other":[511],"metal":[514],"ions,":[515],"such":[516],"copper(II),":[520],"identical":[523],"treatment,":[532],"models":[535],"NTBI,":[537],"effective":[540],"under":[544],"conditions.":[547],"Further":[548],"pre-clinical":[549],"studies":[550],"warranted":[552],"elucidate":[554],"additional":[555],"mechanistic":[556],"features":[557],"may":[559],"importance.":[563],"Disclosures:":[564],"Hider:":[565],"Shire:":[566],"Consultancy,":[567],"Research":[568,571],"Funding.":[569,572],"Kong:Shire:":[570],"Luker:Shire:":[573],"Employment.":[574,576,578],"Conlon:Shire:":[575],"Harland:Shire:":[577]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
