{"id":"https://openalex.org/W1871019207","doi":"https://doi.org/10.1017/cbo9780511544699.003","title":"The \u2018developmental origins\u2019 hypothesis: epidemiology","display_name":"The \u2018developmental origins\u2019 hypothesis: epidemiology","publication_year":2006,"publication_date":"2006-04-20","ids":{"openalex":"https://openalex.org/W1871019207","doi":"https://doi.org/10.1017/cbo9780511544699.003","mag":"1871019207"},"language":"en","primary_location":{"id":"doi:10.1017/cbo9780511544699.003","doi":"https://doi.org/10.1017/cbo9780511544699.003","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511544699.003","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Origins of Health and Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1420275956","display_name":"Developmental Origins of Health and Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031184713","display_name":"Keith M. Godfrey","orcid":"https://orcid.org/0000-0002-4643-0618","observed_orcids":["https://orcid.org/0000-0002-4643-0618"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Keith Godfrey","raw_affiliation_strings":["University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031184713"],"corresponding_institution_ids":["https://openalex.org/I43439940"],"apc_list":null,"apc_paid":null,"fwci":89.5824,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.99898888,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"6","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/developmental-origins-of-health-and-disease","display_name":"developmental origins of health and disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/fetal-origins-of-disease","display_name":"fetal origins of disease","score":0.6259999871253967},{"id":"https://openalex.org/keywords/infant-size","display_name":"infant size","score":0.4729999899864197},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.7200000286102295},{"id":"https://openalex.org/keywords/childhood-weight-gain","display_name":"child weight gain","score":0.5870000123977661},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9700000286102295},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/obstructive-airway-disease","display_name":"obstructive airway disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mental-health","display_name":"mental health","score":0.8579999804496765},{"id":"https://openalex.org/keywords/maternal-diet-during-pregnancy","display_name":"maternal diet during pregnancy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/fetal-programming","display_name":"fetal programming","score":0.6209999918937683},{"id":"https://openalex.org/keywords/developmental-plasticity","display_name":"developmental plasticity","score":0.906000018119812},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7300000190734863},{"id":"https://openalex.org/keywords/glucose-insulin-metabolism","display_name":"glucose-insulin metabolism","score":0.8270000219345093},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8076528310775757},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6710022687911987},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6568255424499512},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.582211971282959},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.568959653377533},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5375333428382874},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.534771740436554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.502079963684082},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4451267123222351},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.43780189752578735},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.432953804731369},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.42271244525909424},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.36082595586776733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.285090833902359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2583601474761963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2049030065536499},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/cbo9780511544699.003","doi":"https://doi.org/10.1017/cbo9780511544699.003","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511544699.003","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Origins of Health and Disease","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":173,"referenced_works":["https://openalex.org/W34792663","https://openalex.org/W1518743262","https://openalex.org/W1527151119","https://openalex.org/W1602975631","https://openalex.org/W1633496227","https://openalex.org/W1832572159","https://openalex.org/W1836621098","https://openalex.org/W1894533129","https://openalex.org/W1964007647","https://openalex.org/W1966621757","https://openalex.org/W1967188184","https://openalex.org/W1969733084","https://openalex.org/W1970763946","https://openalex.org/W1972822085","https://openalex.org/W1974735770","https://openalex.org/W1974959407","https://openalex.org/W1975718971","https://openalex.org/W1976466322","https://openalex.org/W1981005576","https://openalex.org/W1982249713","https://openalex.org/W1983374783","https://openalex.org/W1984191137","https://openalex.org/W1984832774","https://openalex.org/W1986296227","https://openalex.org/W1988168615","https://openalex.org/W1989736577","https://openalex.org/W1990738464","https://openalex.org/W1990759351","https://openalex.org/W1993206740","https://openalex.org/W2001012384","https://openalex.org/W2001656238","https://openalex.org/W2001723434","https://openalex.org/W2002835550","https://openalex.org/W2004311396","https://openalex.org/W2009185558","https://openalex.org/W2009936399","https://openalex.org/W2010379253","https://openalex.org/W2015065436","https://openalex.org/W2015470285","https://openalex.org/W2015838103","https://openalex.org/W2016881008","https://openalex.org/W2018983090","https://openalex.org/W2019205491","https://openalex.org/W2021708142","https://openalex.org/W2023178118","https://openalex.org/W2024706817","https://openalex.org/W2024967609","https://openalex.org/W2027075831","https://openalex.org/W2027670788","https://openalex.org/W2029978093","https://openalex.org/W2030419068","https://openalex.org/W2030728911","https://openalex.org/W2030729694","https://openalex.org/W2031792984","https://openalex.org/W2034559806","https://openalex.org/W2035240733","https://openalex.org/W2035616843","https://openalex.org/W2038894275","https://openalex.org/W2039246535","https://openalex.org/W2040950220","https://openalex.org/W2040957117","https://openalex.org/W2042533820","https://openalex.org/W2045927998","https://openalex.org/W2046301895","https://openalex.org/W2046844809","https://openalex.org/W2048013543","https://openalex.org/W2048776230","https://openalex.org/W2052173775","https://openalex.org/W2052867915","https://openalex.org/W2055042591","https://openalex.org/W2057565196","https://openalex.org/W2058995902","https://openalex.org/W2059125731","https://openalex.org/W2059631901","https://openalex.org/W2060921297","https://openalex.org/W2061451259","https://openalex.org/W2063058707","https://openalex.org/W2065006096","https://openalex.org/W2065072159","https://openalex.org/W2065579032","https://openalex.org/W2067412184","https://openalex.org/W2067509268","https://openalex.org/W2068603371","https://openalex.org/W2069074157","https://openalex.org/W2070889093","https://openalex.org/W2071680557","https://openalex.org/W2075137969","https://openalex.org/W2075153512","https://openalex.org/W2076257244","https://openalex.org/W2082311069","https://openalex.org/W2083687156","https://openalex.org/W2084339428","https://openalex.org/W2086132445","https://openalex.org/W2086641067","https://openalex.org/W2087695778","https://openalex.org/W2087829034","https://openalex.org/W2088037656","https://openalex.org/W2088346988","https://openalex.org/W2090628703","https://openalex.org/W2090862723","https://openalex.org/W2092941844","https://openalex.org/W2093559962","https://openalex.org/W2094551470","https://openalex.org/W2095865232","https://openalex.org/W2096308395","https://openalex.org/W2096601431","https://openalex.org/W2101153618","https://openalex.org/W2101189704","https://openalex.org/W2106735268","https://openalex.org/W2108021565","https://openalex.org/W2108105399","https://openalex.org/W2109183846","https://openalex.org/W2110321302","https://openalex.org/W2110491410","https://openalex.org/W2110684580","https://openalex.org/W2110952210","https://openalex.org/W2112526870","https://openalex.org/W2113607955","https://openalex.org/W2115116599","https://openalex.org/W2117234503","https://openalex.org/W2118723878","https://openalex.org/W2119437828","https://openalex.org/W2120789686","https://openalex.org/W2121804122","https://openalex.org/W2121917420","https://openalex.org/W2121960810","https://openalex.org/W2122611189","https://openalex.org/W2123349198","https://openalex.org/W2125089843","https://openalex.org/W2126179885","https://openalex.org/W2126288906","https://openalex.org/W2126384545","https://openalex.org/W2127054925","https://openalex.org/W2129311416","https://openalex.org/W2130583716","https://openalex.org/W2131165622","https://openalex.org/W2131351862","https://openalex.org/W2132308960","https://openalex.org/W2132877813","https://openalex.org/W2133167114","https://openalex.org/W2133629205","https://openalex.org/W2135171274","https://openalex.org/W2135550286","https://openalex.org/W2136732031","https://openalex.org/W2137966772","https://openalex.org/W2139986991","https://openalex.org/W2140511860","https://openalex.org/W2142783026","https://openalex.org/W2151172803","https://openalex.org/W2153510380","https://openalex.org/W2158914718","https://openalex.org/W2159735990","https://openalex.org/W2160087042","https://openalex.org/W2162499454","https://openalex.org/W2164404896","https://openalex.org/W2166194564","https://openalex.org/W2166444468","https://openalex.org/W2168972047","https://openalex.org/W2170505333","https://openalex.org/W2172149859","https://openalex.org/W2312397711","https://openalex.org/W2316054685","https://openalex.org/W2317295129","https://openalex.org/W2321245768","https://openalex.org/W2411945829","https://openalex.org/W2418091973","https://openalex.org/W2503234566","https://openalex.org/W2793935305","https://openalex.org/W3128996862","https://openalex.org/W3134173180","https://openalex.org/W4248832213","https://openalex.org/W4256098581","https://openalex.org/W6657098810"],"related_works":["https://openalex.org/W2041800172","https://openalex.org/W2043139108","https://openalex.org/W1967832563","https://openalex.org/W2143230895","https://openalex.org/W7037503055","https://openalex.org/W7037679253","https://openalex.org/W2101153618","https://openalex.org/W1964304628","https://openalex.org/W4255886428","https://openalex.org/W7097738439"],"abstract_inverted_index":{"Introduction":[0],"Research":[1],"worldwide":[2],"has":[3],"established":[4],"that":[5,108,148,161,189,224],"people":[6],"who":[7],"were":[8],"small":[9],"at":[10,123],"birth":[11],"and":[12,27,67,77,84,103,112,133,137,167,173,196,209],"had":[13],"poor":[14,68],"growth":[15,48],"in":[16,53,95,140,178],"infancy":[17],"have":[18,106,118,184],"an":[19,78],"increased":[20,37,79],"risk":[21,80],"of":[22,81,92,213,216],"adult":[23,85,142,180],"coronary":[24],"heart":[25],"disease":[26,86,172,199],"type":[28,192],"2":[29,193],"diabetes,":[30,194],"particularly":[31],"if":[32],"this":[33],"is":[34,42,145],"followed":[35],"by":[36,206],"childhood":[38],"weight":[39],"gain.":[40],"There":[41],"also":[43],"evidence":[44],"linking":[45],"impaired":[46],"early":[47],"with":[49,129],"other":[50],"degenerative":[51],"disorders":[52],"later":[54],"life,":[55],"including":[56],"stroke,":[57],"hypertension,":[58],"obesity,":[59],"osteoporosis,":[60],"obstructive":[61,197],"airways":[62,198],"disease,":[63,191],"reduced":[64],"cognitive":[65],"function":[66],"mental":[69],"health.":[70],"The":[71,182],"relations":[72],"between":[73,163],"smaller":[74],"infant":[75,93,210],"size":[76,94,122],"ill":[82],"health":[83],"extend":[87],"across":[88],"the":[89,141,149,158,164,168,179,187,207,217],"normal":[90],"range":[91],"a":[96,214],"graded":[97],"manner.":[98],"Moreover,":[99],"recent":[100],"animal":[101],"studies":[102],"epidemiological":[104],"data":[105],"demonstrated":[107],"while":[109],"maternal":[110],"thinness":[111],"unbalanced":[113],"diet":[114],"during":[115],"pregnancy":[116],"may":[117],"modest":[119],"effects":[120],"on":[121],"birth,":[124],"they":[125],"are":[126],"nonetheless":[127],"associated":[128],"raised":[130],"blood":[131],"pressure":[132],"altered":[134],"glucose\u2013insulin":[135],"metabolism":[136],"stress":[138],"responsiveness":[139],"offspring.":[143],"It":[144],"now":[146],"clear":[147],"associations":[150],"do":[151],"not":[152],"simply":[153],"reflect":[154],"genetic":[155,165],"influences;":[156],"rather":[157],"findings":[159],"indicate":[160],"interactions":[162],"influences":[166,177],"early-life":[169],"environment":[170,219],"determine":[171],"susceptibility":[174],"to":[175,186,220],"adverse":[176],"environment.":[181],"observations":[183],"led":[185],"hypothesis":[188],"cardiovascular":[190],"osteoporosis":[195],"originate":[200],"through":[201],"developmental":[202],"plastic":[203],"responses":[204],"made":[205],"fetus":[208],"as":[211],"part":[212],"prediction":[215],"subsequent":[218],"which":[221],"it":[222,225],"anticipates":[223],"will":[226],"be":[227],"exposed.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}