{"id":"https://openalex.org/W1870397453","doi":"https://doi.org/10.7490/f1000research.324.1","title":"Experimental design for genome-wide association studies","display_name":"Experimental design for genome-wide association studies","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W1870397453","doi":"https://doi.org/10.7490/f1000research.324.1","mag":"1870397453"},"language":"en","primary_location":{"id":"pmh:oai:pure.mpg.de:item_3012180","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0002-9F9B-D","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"F1000Posters","raw_type":"info:eu-repo/semantics/other"},"volume":null,"type":"other","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074204533","display_name":"Christoph Lippert","orcid":"https://orcid.org/0000-0001-6363-2556","observed_orcids":["https://orcid.org/0000-0001-6363-2556"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Lippert","raw_affiliation_strings":["Max Planck Institute for Biological Cybernetics, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0001-6363-2556","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biological Cybernetics, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091002491","display_name":"Oliver Stegle","orcid":"https://orcid.org/0000-0002-8818-7193","observed_orcids":["https://orcid.org/0000-0002-8818-7193"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Stegle","raw_affiliation_strings":["Max Planck Institute for Biological Cybernetics, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0002-8818-7193","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biological Cybernetics, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041524969","display_name":"Hannes Nickisch","orcid":"https://orcid.org/0000-0003-1604-6647","observed_orcids":["https://orcid.org/0000-0003-1604-6647"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannes Nickisch","raw_affiliation_strings":["Max Planck Institute for Biological Cybernetics, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0003-1604-6647","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biological Cybernetics, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074540538","display_name":"Karsten Michael Borgwardt","orcid":"https://orcid.org/0000-0001-7221-2393","observed_orcids":["https://orcid.org/0000-0001-7221-2393"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karsten Borgwardt","raw_affiliation_strings":["Max Planck Institute for Biological Cybernetics, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0001-7221-2393","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biological Cybernetics, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003440649","display_name":"Detlef Weigel","orcid":"https://orcid.org/0000-0002-2114-7963","observed_orcids":["https://orcid.org/0000-0002-2114-7963"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Detlef Weigel","raw_affiliation_strings":["Max Planck Institute for Developmental Biology, Max Planck Society"],"raw_orcid":"https://orcid.org/0000-0002-2114-7963","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Developmental Biology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"324","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.19859999418258667,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.08900000154972076,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9139999747276306},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.9509999752044678},{"id":"https://openalex.org/keywords/study-design","display_name":"research design","score":0.3889999985694885},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2983643791","wikidata":"https://www.wikidata.org/wiki/Q1999993","display_name":"Open peer review","level":3,"score":0.8946970701217651},{"id":"https://openalex.org/C2992936677","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Plant biology","level":2,"score":0.8160524368286133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5334848165512085},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5254572629928589},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.479867160320282},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4796893298625946},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.47630178928375244},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.44275131821632385},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37464457750320435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34475380182266235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2604531943798065},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16350296139717102},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10629847645759583},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.09476003050804138},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.07372185587882996},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.05160447955131531},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pure.mpg.de:item_3012180","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0002-9F9B-D","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"F1000Posters","raw_type":"info:eu-repo/semantics/other"},{"id":"mag:1870397453","doi":"https://doi.org/10.7490/f1000research.324.1","is_oa":false,"landing_page_url":"https://f1000research.com/posters/324","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"F1000Research","raw_type":null},{"id":"mag:2909842092","doi":null,"is_oa":false,"landing_page_url":"https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_3012180","pdf_url":null,"source":{"id":"https://openalex.org/S4306418945","display_name":"Intelligent Systems in Molecular Biology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Intelligent Systems in Molecular Biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2767785164","https://openalex.org/W1977511407","https://openalex.org/W7098829312","https://openalex.org/W2035763284","https://openalex.org/W4412523304","https://openalex.org/W7149981096","https://openalex.org/W1509374256","https://openalex.org/W7112848109","https://openalex.org/W2099495260","https://openalex.org/W4286843333"],"abstract_inverted_index":{"Background":[0],"/":[1],"Purpose:":[2],"Genetic":[3],"association":[4,143],"studies":[5],"have":[6],"become":[7],"an":[8],"integral":[9],"tool":[10],"to":[11,32,44,67,80,86,180],"understand":[12],"how":[13],"genetic":[14],"variation":[15],"effects":[16],"a":[17,108,115,120,146,150],"growing":[18],"selection":[19,100,157,177,182],"of":[20,41,57,97,124,127,138,201],"phenotypes.":[21],"These":[22],"may":[23],"range":[24],"from":[25],"molecular":[26],"phenotypes,":[27],"such":[28,35],"as":[29,36],"gene":[30],"expression,":[31],"global":[33],"phenotypes":[34,72],"growth":[37],"rate":[38],"or":[39,65,89],"floweringtime":[40],"plants.":[42],"Thanks":[43],"recent":[45],"advances":[46],"in":[47,141],"sequencing":[48],"technology,":[49],"large-scale":[50],"genotype":[51],"information":[52,110],"for":[53,171],"hundreds,":[54],"soon":[55,66],"thousands":[56],"humans,":[58],"plants":[59],"and":[60,88,103,154,175],"animals":[61],"are":[62,73],"now":[63],"available":[64],"be":[68],"released.":[69],"If":[70],"new":[71],"being":[74],"studied,":[75],"it":[76],"is":[77],"rarely":[78],"feasible":[79],"phenotype":[81],"all":[82],"the":[83,136,172,184,191,194],"individuals,":[84],"due":[85],"cost":[87],"time":[90],"constraints.":[91],"To":[92],"solve":[93],"this":[94],"emerging":[95],"problem":[96],"appropriate":[98],"sample":[99],"we":[101,134],"propose":[102],"investigate":[104],"experimental":[105,139],"design":[106,140,169],"by":[107],"principled":[109],"criterion.":[111],"Main":[112],"conclusion:":[113],"In":[114],"retrospective":[116],"real-data":[117],"study":[118,123,152],"on":[119,161,164,183],"flowering-time":[121,187],"QTL":[122],"166":[125],"individuals":[126],"A.":[128,185],"thaliana":[129,186],"(Atwell":[130],"et":[131],"al":[132],"2010),":[133],"demonstrate":[135],"viability":[137],"genome-wide":[142],"studies,":[144],"achieving":[145],"significant":[147],"improvement":[148],"over":[149],"non-optimised":[151],"layout":[153],"simple":[155],"baseline":[156],"criteria.":[158],"(See":[159],"figure":[160],"poster:":[162],"\u201cRMSE":[163],"independent":[165],"test":[166],"set\u201d:":[167],"Experimental":[168],"curves":[170],"Bayesian":[173],"Lasso":[174],"various":[176],"criteria":[178],"compared":[179],"random":[181],"dataset.":[188],"ALC":[189],"denotes":[190],"area":[192],"under":[193],"learning":[195],"curve.)":[196],"Disclosures:":[197],"No":[198],"relevant":[199],"conflicts":[200],"interest":[202],"declared.":[203]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
