{"id":"https://openalex.org/W1870088907","doi":null,"title":"[Rho GTPases as therapeutic targets in cancer and other human diseases].","display_name":"[Rho GTPases as therapeutic targets in cancer and other human diseases].","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1870088907","mag":"1870088907","pmid":"https://pubmed.ncbi.nlm.nih.gov/21163747"},"language":"es","primary_location":{"id":"pmid:21163747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21163747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112304782","display_name":"Pablo Lorenzano Menna","orcid":"https://orcid.org/0000-0002-5635-4487","observed_orcids":["https://orcid.org/0000-0002-5635-4487"]},"institutions":[{"id":"https://openalex.org/I138504249","display_name":"National University of Quilmes","ror":"https://ror.org/01r53hz59","country_code":"AR","type":"education","lineage":["https://openalex.org/I138504249"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Pablo Lorenzano Menna","raw_affiliation_strings":["Laboratorio de Oncolog\u00eda Molecular, Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Oncolog\u00eda Molecular, Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes","institution_ids":["https://openalex.org/I138504249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111842093","display_name":"Georgina Alexandra Cardama","orcid":"https://orcid.org/0000-0003-4751-5485","observed_orcids":["https://orcid.org/0000-0003-4751-5485","https://orcid.org/0000-0002-5042-8051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgina A Cardama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068605061","display_name":"Maria Julieta Comin","orcid":"https://orcid.org/0000-0003-2187-1932","observed_orcids":["https://orcid.org/0000-0003-2187-1932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda J Comin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053775464","display_name":"Daniel F. Alonso","orcid":"https://orcid.org/0000-0002-0601-613X","observed_orcids":["https://orcid.org/0000-0002-0601-613X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel F Alonso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012774649","display_name":"Daniel Eduardo Gomez","orcid":"https://orcid.org/0000-0002-8629-0787","observed_orcids":["https://orcid.org/0000-0002-8629-0787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel E G\u00f3mez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4248,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.54396565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"70","issue":"6","first_page":"555","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":1.0},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6000000238418579},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9350000023841858},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.640999972820282},{"id":"https://openalex.org/keywords/cell-function","display_name":"cell function","score":0.5270000100135803},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.7836568355560303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5204232335090637},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.45105117559432983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38953906297683716},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33261775970458984}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21163747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21163747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"English Abstract"},{"id":"pmh:oai:doaj.org/article:4734c0d389e647e4b43c7e5df1ac5a48","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4734c0d389e647e4b43c7e5df1ac5a48","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina (Buenos Aires), Vol 70, Iss 6, Pp 555-564 (2010)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W25707239","https://openalex.org/W106628407","https://openalex.org/W141200506","https://openalex.org/W300178483","https://openalex.org/W1527426559","https://openalex.org/W1790645982","https://openalex.org/W1839381104","https://openalex.org/W1965136295","https://openalex.org/W1966310390","https://openalex.org/W1967114494","https://openalex.org/W1969200465","https://openalex.org/W1969292147","https://openalex.org/W1972004676","https://openalex.org/W1972024414","https://openalex.org/W1978359080","https://openalex.org/W1980674137","https://openalex.org/W1980814667","https://openalex.org/W1987452783","https://openalex.org/W1988224167","https://openalex.org/W1996245793","https://openalex.org/W1999871489","https://openalex.org/W2003322119","https://openalex.org/W2003563101","https://openalex.org/W2004220006","https://openalex.org/W2004732764","https://openalex.org/W2009262775","https://openalex.org/W2015015957","https://openalex.org/W2016970095","https://openalex.org/W2021437057","https://openalex.org/W2031951506","https://openalex.org/W2033741397","https://openalex.org/W2035643930","https://openalex.org/W2037419556","https://openalex.org/W2039092278","https://openalex.org/W2040443947","https://openalex.org/W2042584344","https://openalex.org/W2044034037","https://openalex.org/W2056698109","https://openalex.org/W2060818768","https://openalex.org/W2066521906","https://openalex.org/W2073363124","https://openalex.org/W2077072914","https://openalex.org/W2079076968","https://openalex.org/W2079517986","https://openalex.org/W2085254603","https://openalex.org/W2093382854","https://openalex.org/W2096255272","https://openalex.org/W2101441879","https://openalex.org/W2102312968","https://openalex.org/W2105280248","https://openalex.org/W2105746559","https://openalex.org/W2111778006","https://openalex.org/W2111897479","https://openalex.org/W2112078762","https://openalex.org/W2115819535","https://openalex.org/W2117839670","https://openalex.org/W2119875542","https://openalex.org/W2122042596","https://openalex.org/W2124054733","https://openalex.org/W2126104879","https://openalex.org/W2126922455","https://openalex.org/W2131137736","https://openalex.org/W2132337295","https://openalex.org/W2136628679","https://openalex.org/W2137405846","https://openalex.org/W2139239806","https://openalex.org/W2142685635","https://openalex.org/W2144323830","https://openalex.org/W2144741986","https://openalex.org/W2146055738","https://openalex.org/W2159976463","https://openalex.org/W2165432808","https://openalex.org/W2166798256","https://openalex.org/W2168091755","https://openalex.org/W2171635900","https://openalex.org/W2182031655","https://openalex.org/W2403197302","https://openalex.org/W2416591944"],"related_works":["https://openalex.org/W7015180424","https://openalex.org/W2743283968","https://openalex.org/W2898304664","https://openalex.org/W4377030269","https://openalex.org/W2384072406","https://openalex.org/W1493430231","https://openalex.org/W3022666250","https://openalex.org/W2004220006","https://openalex.org/W2034266654","https://openalex.org/W2004732764"],"abstract_inverted_index":{"Rho":[0,41,71,91],"GTPases":[1,72,92],"are":[2],"a":[3,32],"key":[4],"protein":[5],"family":[6],"controlling":[7],"the":[8,19,23,37,51,61,68,74],"transduction":[9],"of":[10,25,36,40,45,70,76],"external":[11],"signals":[12],"to":[13,49],"cytoplasmatic":[14],"and":[15,27],"nuclear":[16],"effectors.":[17],"In":[18],"last":[20],"few":[21],"years,":[22],"development":[24,75],"genetic":[26],"pharmacological":[28],"tools":[29],"has":[30],"allowed":[31],"more":[33],"precise":[34],"definition":[35],"specific":[38],"roles":[39],"GTPases.":[42],"The":[43],"aim":[44],"this":[46],"review":[47],"is":[48],"describe":[50,85],"cellular":[52],"functions":[53],"regulated":[54],"by":[55],"these":[56],"proteins":[57],"with":[58,90],"focus":[59],"on":[60],"molecular":[62,94],"mechanism":[63],"involved.":[64],"We":[65],"also":[66],"address":[67],"role":[69],"in":[73],"different":[77,86],"human":[78],"diseases":[79],"such":[80],"as":[81,93],"cancer.":[82],"Finally,":[83],"we":[84],"experimental":[87],"therapeutic":[88],"strategies":[89],"targets.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}