{"id":"https://openalex.org/W1869716043","doi":"https://doi.org/10.4049/jimmunol.175.1.270","title":"The CD3\u03b5 Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function","display_name":"The CD3\u03b5 Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W1869716043","doi":"https://doi.org/10.4049/jimmunol.175.1.270","mag":"1869716043","pmid":"https://pubmed.ncbi.nlm.nih.gov/15972658"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.175.1.270","doi":"https://doi.org/10.4049/jimmunol.175.1.270","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.1.270","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066869434","display_name":"Andrea L. Szymczak-Workman","orcid":"https://orcid.org/0000-0002-9776-049X","observed_orcids":["https://orcid.org/0000-0002-9776-049X","https://orcid.org/0000-0002-9757-3432"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Andrea L Szymczak","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008106149","display_name":"Creg J. Workman","orcid":"https://orcid.org/0000-0002-9964-9509","observed_orcids":["https://orcid.org/0000-0002-9964-9509"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Creg J Workman","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028331931","display_name":"Diana Gil","orcid":"https://orcid.org/0000-0003-1744-3484","observed_orcids":["https://orcid.org/0000-0003-1744-3484"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Diana Gil","raw_affiliation_strings":["Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel , Basel ,","Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105","\u2020Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel , Basel ,","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"\u2020Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049798545","display_name":"Smaroula Dilioglou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Smaroula Dilioglou","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109595575","display_name":"Kate M. Vignali","orcid":"https://orcid.org/0000-0001-8564-3301","observed_orcids":["https://orcid.org/0000-0001-8564-3301"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Kate M Vignali","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109871338","display_name":"Ed Palmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Ed Palmer","raw_affiliation_strings":["Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel , Basel ,","Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105","\u2020Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel , Basel ,","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"\u2020Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001000053","display_name":"Dario A.A. Vignali","orcid":"https://orcid.org/0000-0002-2771-5992","observed_orcids":["https://orcid.org/0000-0002-2771-5992"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Dario A A Vignali","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"*Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.1057,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.92082879,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"175","issue":"1","first_page":"270","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd3e","display_name":"CD3\u03b5","score":0.8090000152587891},{"id":"https://openalex.org/keywords/proline-rich-sequences","display_name":"proline-rich sequences","score":0.996999979019165},{"id":"https://openalex.org/keywords/nck","display_name":"Nck","score":0.9850000143051147},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.6880000233650208},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9369999766349792},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.699999988079071},{"id":"https://openalex.org/keywords/thymocyte-selection","display_name":"thymic selection","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8512876033782959},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6265740990638733},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.5918649435043335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5849853754043579},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.4899429678916931},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.42170950770378113},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42049920558929443},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41581061482429504},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35856008529663086},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33006155490875244},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.32033777236938477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17509272694587708},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1669749617576599},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.08682966232299805}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.175.1.270","doi":"https://doi.org/10.4049/jimmunol.175.1.270","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.1.270","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15972658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15972658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6023481052","display_name":null,"funder_award_id":"AI52199","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G609259107","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W45421301","https://openalex.org/W191171710","https://openalex.org/W1557290263","https://openalex.org/W1576944993","https://openalex.org/W1662447390","https://openalex.org/W1750539994","https://openalex.org/W1863617934","https://openalex.org/W1944221029","https://openalex.org/W1968109986","https://openalex.org/W1980953046","https://openalex.org/W1984473379","https://openalex.org/W1987889377","https://openalex.org/W1989987282","https://openalex.org/W1999298531","https://openalex.org/W2016253390","https://openalex.org/W2019872000","https://openalex.org/W2022204362","https://openalex.org/W2032359283","https://openalex.org/W2038173050","https://openalex.org/W2042704418","https://openalex.org/W2044374752","https://openalex.org/W2047301480","https://openalex.org/W2049058314","https://openalex.org/W2051248831","https://openalex.org/W2059257370","https://openalex.org/W2072515487","https://openalex.org/W2075723649","https://openalex.org/W2086788811","https://openalex.org/W2087159097","https://openalex.org/W2096234619","https://openalex.org/W2111528051","https://openalex.org/W2128377922","https://openalex.org/W2134855648","https://openalex.org/W2138197182","https://openalex.org/W2148330408","https://openalex.org/W2151206902","https://openalex.org/W2152093499","https://openalex.org/W2156031506","https://openalex.org/W2159189324","https://openalex.org/W2161718684","https://openalex.org/W2161977998","https://openalex.org/W2164845999","https://openalex.org/W2164909338","https://openalex.org/W2171893470","https://openalex.org/W2185196628","https://openalex.org/W4313333869"],"related_works":["https://openalex.org/W1573257970","https://openalex.org/W2091769111","https://openalex.org/W2138489609","https://openalex.org/W2022204362","https://openalex.org/W2148112693","https://openalex.org/W2040302674","https://openalex.org/W1958617503","https://openalex.org/W7202151609","https://openalex.org/W1569609488","https://openalex.org/W4313333869"],"abstract_inverted_index":{"The":[0],"CD3epsilon":[1,39,61,137],"proline-rich":[2],"sequence":[3],"(PRS)":[4],"binds":[5],"to":[6,57,59,109],"the":[7,34,38,53,60,77,86,102,133,136],"cytosolic":[8],"adaptor":[9],"molecule":[10],"Nck":[11,56],"after":[12,68],"TCR":[13,69,118],"ligation.":[14,70],"It":[15],"has":[16],"been":[17],"proposed":[18],"that":[19,45,132],"this":[20,47],"interaction":[21,134],"is":[22,149],"essential":[23,151],"for":[24,152],"immunological":[25],"synapse":[26],"formation":[27],"and":[28,79,88,90,113,123,139,156],"T":[29,82,107,153],"cell":[30,83,154],"activation.":[31],"To":[32],"assess":[33],"physiological":[35],"importance":[36],"of":[37,55,81,105],"PRS,":[40],"we":[41],"have":[42],"generated":[43],"mice":[44,67],"lack":[46],"motif":[48],"(CD3epsilon.PRS(M)).":[49],"Pull-down":[50],"experiments":[51],"demonstrated":[52],"inability":[54],"bind":[58],"PRS":[62,138],"in":[63,76,85,96],"thymocytes":[64],"from":[65],"mutant":[66],"Surprisingly,":[71],"no":[72,93],"differences":[73],"were":[74,126],"observed":[75],"number":[78],"percentage":[80],"subsets":[84],"thymus":[87],"spleen,":[89],"there":[91],"was":[92,116],"apparent":[94],"defect":[95],"positive":[97],"or":[98,141],"negative":[99],"selection.":[100],"Furthermore,":[101],"proliferative":[103],"response":[104],"CD3epsilon.PRS(M)":[106],"cells":[108],"staphylococcal":[110],"enterotoxin":[111],"B":[112],"anti-CD3":[114],"Ab":[115],"normal.":[117,128],"surface":[119],"expression,":[120],"constitutive":[121],"internalization,":[122],"Ag-induced":[124],"down-modulation":[125],"also":[127],"These":[129],"data":[130],"suggest":[131],"between":[135],"Nck,":[140],"any":[142],"other":[143],"Src":[144],"homology":[145],"3":[146],"domain-containing":[147],"molecule,":[148],"not":[150],"development":[155],"function.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
