{"id":"https://openalex.org/W1869558644","doi":"https://doi.org/10.4049/jimmunol.106.1.11","title":"Preventing Antibody Formation to Anti-Lymphocytic Globulin in Man","display_name":"Preventing Antibody Formation to Anti-Lymphocytic Globulin in Man","publication_year":1971,"publication_date":"1971-01-01","ids":{"openalex":"https://openalex.org/W1869558644","doi":"https://doi.org/10.4049/jimmunol.106.1.11","mag":"1869558644","pmid":"https://pubmed.ncbi.nlm.nih.gov/5543702"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.106.1.11","doi":"https://doi.org/10.4049/jimmunol.106.1.11","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.106.1.11","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046816748","display_name":"Roger D. Rossen","orcid":"https://orcid.org/0000-0002-0897-0867","observed_orcids":["https://orcid.org/0000-0002-0897-0867"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger D Rossen","raw_affiliation_strings":["Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113712383","display_name":"William T. Butler","orcid":"https://orcid.org/0000-0003-3366-587X","observed_orcids":["https://orcid.org/0000-0003-3366-587X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T Butler","raw_affiliation_strings":["Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113518386","display_name":"James J. Nora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J Nora","raw_affiliation_strings":["Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113510872","display_name":"Donald J. Fernbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald J Fernbach","raw_affiliation_strings":["Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine and Pediatrics, Baylor College of Medicine and The Methodist, Texas Children's and Veterans Administration Hospitals , Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.5623,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.9347452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"1","first_page":"11","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.7570000290870667},{"id":"https://openalex.org/keywords/allograft-recipients","display_name":"allograft recipients","score":0.7269999980926514},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7369999885559082},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9750000238418579},{"id":"https://openalex.org/keywords/leukemia-patients","display_name":"leukemia patients","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2780762169","wikidata":"https://www.wikidata.org/wiki/Q5905368","display_name":"Horse","level":2,"score":0.8866088390350342},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7794809341430664},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.668750524520874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.637450098991394},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.5900845527648926},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.5647763013839722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4957621991634369},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4422624409198761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3513451814651489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23172813653945923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19724518060684204},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000961","descriptor_name":"Antilymphocyte Serum","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.106.1.11","doi":"https://doi.org/10.4049/jimmunol.106.1.11","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.106.1.11","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:5543702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5543702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1595137903","https://openalex.org/W2016518428","https://openalex.org/W2415787147","https://openalex.org/W2030069009","https://openalex.org/W47168410","https://openalex.org/W2002002177","https://openalex.org/W2063158309","https://openalex.org/W2017332532","https://openalex.org/W1991139020","https://openalex.org/W2052686408"],"abstract_inverted_index":{"Abstract":[0],"One":[1],"or":[2,13,27,106],"more":[3],"doses":[4,121],"of":[5,48,61,70,98,112,122,132,141,167,189,209,214],"equine":[6,16],"IgG":[7,17,53,73,95,174],"either":[8,86],"as":[9],"anti-lymphocytic":[10],"globulin":[11],"(ALG)":[12],"deaggregated":[14],"normal":[15,37],"(DEGG)":[18],"were":[19,82,146],"given":[20,88,116,147],"to":[21,41,51,93,135,159,172,201,222],"73":[22],"individuals":[23],"including":[24],"43":[25],"potential":[26],"actual":[28],"allograft":[29],"recipients,":[30],"10":[31],"patients":[32,55,101,113,143],"with":[33,58,104,114,118,178],"leukemia":[34],"and":[35,74,80,124,206],"20":[36,97],"volunteers":[38],"in":[39,54,96,211],"order":[40],"define":[42],"conditions":[43],"which":[44,217],"would":[45],"prevent":[46],"formation":[47,92,134],"detectable":[49,170],"antibodies":[50,171],"horse":[52,72,94,136,173,191],"being":[56],"treated":[57,103,177],"ALG.":[59,179],"Formation":[60],"antibody":[62,91,133],"was":[63,87],"measured":[64],"by":[65,75,157],"studying":[66],"the":[67,99,107,130,203],"plasma":[68],"clearance":[69],"radioactively-labeled":[71],"an":[76],"immunoadsorbent":[77],"assay.":[78],"DEGG":[79,168],"ALG":[81,115,210],"equally":[83],"immunogenic":[84],"when":[85,175],"alone,":[89],"causing":[90],"27":[100,142],"(74%)":[102],"one":[105],"other":[108],"agent.":[109],"Moreover,":[110],"treatment":[111,150],"along":[117],"maximum":[119],"tolerated":[120],"azathioprine":[123],"methyl":[125],"prednisolone":[126],"did":[127],"not":[128],"reduce":[129],"incidence":[131],"IgG.":[137,192],"In":[138],"contrast,":[139],"8":[140],"(30%)":[144],"who":[145],"chemical":[148],"immunosuppressive":[149],"for":[151],"at":[152],"least":[153],"2":[154,158],"days":[155],"followed":[156],"18":[160],"daily":[161],"intravenous":[162],"injections":[163],"containing":[164],"50":[165],"\u00b5g/Kg":[166],"developed":[169,185],"subsequently":[176],"Of":[180],"these":[181],"8,":[182],"only":[183],"1":[184],"rapid":[186],"immune":[187],"elimination":[188],"labeled":[190],"These":[193],"results":[194],"suggest":[195],"that":[196],"it":[197],"is":[198],"now":[199],"possible":[200],"evaluate":[202],"toxic":[204],"effects":[205],"therapeutic":[207],"efficacy":[208],"man":[212],"free":[213],"those":[215],"manifestations":[216],"might":[218],"otherwise":[219],"be":[220],"ascribed":[221],"allergic":[223],"reactions.":[224]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
