{"id":"https://openalex.org/W1868913231","doi":null,"title":"MicroRNAs: Novel Regulators of the Heart.","display_name":"MicroRNAs: Novel Regulators of the Heart.","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W1868913231","mag":"1868913231","pmid":"https://pubmed.ncbi.nlm.nih.gov/22263016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3256441"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2267784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3256441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3256441","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012318743","display_name":"Junjie Xiao","orcid":"https://orcid.org/0000-0002-9202-0003","observed_orcids":["https://orcid.org/0000-0002-9202-0003"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjie Xiao","raw_affiliation_strings":["Key Laboratory of Arrhythmias, Ministry of Education, China (Tongji University), Shanghai 200065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Arrhythmias, Ministry of Education, China (Tongji University), Shanghai 200065, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101705925","display_name":"Yihan Chen","orcid":"https://orcid.org/0000-0003-1000-1835","observed_orcids":["https://orcid.org/0000-0003-1000-1835","https://orcid.org/0009-0000-7633-4769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Han Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1951,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.53964607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"43","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":1.0},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cardiac-physiology","display_name":"cardiac physiology","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cardiac-pathophysiology","display_name":"cardiac pathophysiology","score":0.9430000185966492},{"id":"https://openalex.org/keywords/heart-disease","display_name":"heart disease","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.6579999923706055},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7269999980926514},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.9049745202064514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5810711979866028},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5121521949768066},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4931289851665497},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4928600788116455},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.484855055809021},{"id":"https://openalex.org/C183683566","wikidata":"https://www.wikidata.org/wiki/Q5038741","display_name":"Cardiovascular physiology","level":2,"score":0.4736408293247223},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42818158864974976},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3444012403488159},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3354033827781677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32940351963043213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3110460042953491},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.25143513083457947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18177387118339539},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16123366355895996}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2267784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3256441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22263016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22263016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thoracic disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3256441","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3256441/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Thorac Dis","raw_type":"Text"},{"id":"mag:1868913231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22263016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2267784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3256441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1500160778","https://openalex.org/W1967686561","https://openalex.org/W1971726501","https://openalex.org/W1972989638","https://openalex.org/W1974068616","https://openalex.org/W1992389076","https://openalex.org/W2009326616","https://openalex.org/W2017718158","https://openalex.org/W2017935902","https://openalex.org/W2039820053","https://openalex.org/W2040851473","https://openalex.org/W2041832370","https://openalex.org/W2046704452","https://openalex.org/W2051319531","https://openalex.org/W2051403674","https://openalex.org/W2051742662","https://openalex.org/W2056556368","https://openalex.org/W2058158664","https://openalex.org/W2060515857","https://openalex.org/W2071925802","https://openalex.org/W2072079310","https://openalex.org/W2080696342","https://openalex.org/W2084087358","https://openalex.org/W2088824478","https://openalex.org/W2092113020","https://openalex.org/W2092310019","https://openalex.org/W2097837136","https://openalex.org/W2107387191","https://openalex.org/W2115093090","https://openalex.org/W2117689702","https://openalex.org/W2118105142","https://openalex.org/W2127367545","https://openalex.org/W2128768066","https://openalex.org/W2134873717","https://openalex.org/W2137132557","https://openalex.org/W2137665434","https://openalex.org/W2146771296","https://openalex.org/W2149146453","https://openalex.org/W2153498428","https://openalex.org/W2155290141","https://openalex.org/W2156554003","https://openalex.org/W2157698700","https://openalex.org/W2161283857","https://openalex.org/W2161693225","https://openalex.org/W2166330589","https://openalex.org/W2166502047","https://openalex.org/W2167494545","https://openalex.org/W2167650832"],"related_works":["https://openalex.org/W2376833809","https://openalex.org/W2055766265","https://openalex.org/W2387243664","https://openalex.org/W2086627977","https://openalex.org/W2109345401","https://openalex.org/W1979355256","https://openalex.org/W2767091594","https://openalex.org/W2047355321","https://openalex.org/W2362750167","https://openalex.org/W1967686561"],"abstract_inverted_index":{"MicroRNAs":[0,18],"are":[1,39],"approximately":[2],"22":[3],"nucleotides":[4],"in":[5,12,20,43,57,76],"length,":[6],"and":[7,31,46,55,73],"they":[8],"play":[9],"central":[10],"roles":[11],"the":[13,49,58],"regulation":[14,50],"of":[15,51,60],"gene":[16],"expression.":[17],"participate":[19],"many":[21],"essential":[22],"biological":[23],"processes,":[24],"such":[25],"as":[26],"cell":[27],"proliferation,":[28],"differentiation,":[29],"apoptosis":[30],"stress.":[32],"Emerging":[33],"evidence":[34],"has":[35],"indicated":[36],"that":[37],"microRNAs":[38,67],"novel":[40],"regulators":[41],"involved":[42],"cardiac":[44,52,61,77],"physiology":[45],"pathophysiology,":[47],"including":[48],"physiological":[53],"function":[54],"participation":[56],"genesis":[59],"diseases.":[62,78],"Although":[63],"several":[64],"challenges":[65],"remain,":[66],"might":[68],"have":[69],"a":[70],"promising":[71],"diagnostic":[72],"therapeutic":[74],"potential":[75]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
