{"id":"https://openalex.org/W1868683020","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a124180","title":"Novel Members of the Two-Component Signal Transduction Genes in Escherichia coli1","display_name":"Novel Members of the Two-Component Signal Transduction Genes in Escherichia coli1","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W1868683020","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a124180","mag":"1868683020","pmid":"https://pubmed.ncbi.nlm.nih.gov/8282725"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a124180","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a124180","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a124180","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008812110","display_name":"S. Nagasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinobu Nagasawa","raw_affiliation_strings":["Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Aichi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Aichi","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020417622","display_name":"Kazuya Ishige","orcid":"https://orcid.org/0009-0001-9620-8775","observed_orcids":["https://orcid.org/0009-0001-9620-8775"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Ishige","raw_affiliation_strings":["Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University Chikusa-ku, Nagoya, Aichi 464"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University Chikusa-ku, Nagoya, Aichi 464","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110038776","display_name":"Takeshi Mizuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takeshi Mizuno","raw_affiliation_strings":["Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University Chikusa-ku, Nagoya, Aichi 464"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University Chikusa-ku, Nagoya, Aichi 464","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110038776"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":2.8078,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.90734455,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"114","issue":"3","first_page":"350","last_page":"357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/two-component-signal-transduction","display_name":"two-component signal transduction","score":0.9229999780654907},{"id":"https://openalex.org/keywords/response-regulator","display_name":"response regulator","score":0.9629999995231628},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9459999799728394},{"id":"https://openalex.org/keywords/phosphotransfer","display_name":"phosphotransfer","score":0.6729999780654907},{"id":"https://openalex.org/keywords/envz","display_name":"EnvZ","score":0.5139999985694885},{"id":"https://openalex.org/keywords/adaptive-response","display_name":"adaptive response","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.8241367936134338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7676702737808228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.738090991973877},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.7338107824325562},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6470766067504883},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6385339498519897},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5726399421691895},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5656080842018127},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.514365553855896},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4330388009548187},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4201608896255493},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35335826873779297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08134418725967407},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.06777599453926086}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a124180","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a124180","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a124180","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:8282725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8282725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142193549","https://openalex.org/W2414168425","https://openalex.org/W149843209","https://openalex.org/W2118862241","https://openalex.org/W6999397442","https://openalex.org/W2083093593","https://openalex.org/W2081929574","https://openalex.org/W3003820224","https://openalex.org/W2147333841","https://openalex.org/W1988270388"],"abstract_inverted_index":{"A":[0],"variety":[1],"of":[2,14,27,49,60,68,104,137,153,165,183,190],"adaptive":[3],"response":[4],"systems":[5],"in":[6,40,90,176,180],"prokaryotes":[7],"often":[8],"involve":[9],"two":[10,80,123,144,151],"families":[11],"(two":[12],"components)":[13],"signal":[15],"transduction":[16],"proteins,":[17],"namely,":[18],"sensory":[19],"kinases":[20],"and":[21,64,84,127,148,193],"response-regulators.":[22],"To":[23],"extend":[24],"the":[25,62,75,98,105,116,138,166,175,181,191],"list":[26],"such":[28],"sensor/regulator":[29,106,167],"genes":[30],"for":[31],"Escherichia":[32],"coli,":[33],"we":[34,45],"adopted":[35],"a":[36,47,71,188],"random":[37],"screening":[38],"method":[39],"this":[41],"study.":[42],"In":[43],"particular,":[44],"isolated":[46],"series":[48],"recombinant":[50,76],"plasmids":[51,77],"that":[52,121,141,185],"are":[53],"able":[54],"phenotypically":[55],"to":[56,88,96,160,162,173],"suppress":[57],"mutational":[58],"lesions":[59],"both":[61],"envZ":[63],"phoR/creC":[65],"genes,":[66],"each":[67],"which":[69],"encodes":[70],"well-characterized":[72],"sensory-kinase.":[73],"Among":[74],"thus":[78,155],"isolated,":[79],"clones":[81],"(named":[82],"pSN11":[83],"pSN25)":[85],"were":[86,158,171],"subjected":[87],"characterization":[89],"detail.":[91],"These":[92,150],"analyses":[93],"allowed":[94],"us":[95],"identify":[97],"genetic":[99,119,139],"loci":[100],"specifying":[101],"novel":[102],"members":[103,164],"families.":[107,168],"One":[108],"(pSN11)":[109],"is":[110,132,186],"located":[111,133],"around":[112,134],"45":[113],"min":[114,136],"on":[115],"E.":[117],"coli":[118],"map,":[120,140],"contains":[122],"adjacent":[124,145],"coding-sequences":[125,146],"(baeS":[126],"baeR).":[128],"The":[129],"other":[130],"(pSN25)":[131],"93":[135],"also":[142,187],"comprises":[143],"(basS":[147],"basR).":[149],"pairs":[152],"gene-products,":[154],"newly":[156],"identified,":[157],"revealed":[159],"belong":[161],"typical":[163],"Furthermore,":[169],"they":[170],"demonstrated":[172],"exhibit":[174],"vitro":[177],"phosphotransfer":[178],"reaction":[179],"presence":[182],"ATP,":[184],"characteristic":[189],"sensory-kinase":[192],"response-regulator":[194],"proteins.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}