{"id":"https://openalex.org/W1868645210","doi":null,"title":"[Hemostasis alterations in sickle cell syndrome].","display_name":"[Hemostasis alterations in sickle cell syndrome].","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W1868645210","mag":"1868645210","pmid":"https://pubmed.ncbi.nlm.nih.gov/24974633"},"language":"es","primary_location":{"id":"pmid:24974633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24974633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigacion clinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060873251","display_name":"Diego Higuera","orcid":"https://orcid.org/0009-0007-3157-6140","observed_orcids":["https://orcid.org/0009-0007-3157-6140"]},"institutions":[{"id":"https://openalex.org/I191242182","display_name":"Instituto Venezolano de Investigaciones Cient\u00edficas","ror":"https://ror.org/02ntheh91","country_code":"VE","type":"facility","lineage":["https://openalex.org/I191242182"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Diego Higuera","raw_affiliation_strings":["Instituto  Venezolano de Investigaciones Cient\u00edficas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto  Venezolano de Investigaciones Cient\u00edficas","institution_ids":["https://openalex.org/I191242182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110437875","display_name":"Martha Nathaly Alava Bravo","orcid":"https://orcid.org/0009-0007-8477-348X","observed_orcids":["https://orcid.org/0009-0007-8477-348X"]},"institutions":[{"id":"https://openalex.org/I82002896","display_name":"Universidad Central de Venezuela","ror":"https://ror.org/05kacnm89","country_code":"VE","type":"education","lineage":["https://openalex.org/I82002896"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Martha Bravo","raw_affiliation_strings":["Universidad Central de Venezuela, Caracas, Venezuela;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Central de Venezuela, Caracas, Venezuela;","institution_ids":["https://openalex.org/I82002896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079147730","display_name":"Belsy Guerrero","orcid":"https://orcid.org/0000-0001-8702-3579","observed_orcids":["https://orcid.org/0000-0001-8702-3579"]},"institutions":[{"id":"https://openalex.org/I191242182","display_name":"Instituto Venezolano de Investigaciones Cient\u00edficas","ror":"https://ror.org/02ntheh91","country_code":"VE","type":"facility","lineage":["https://openalex.org/I191242182"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Belsy Guerrero","raw_affiliation_strings":["Instituto  Venezolano de Investigaciones Cient\u00edficas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto  Venezolano de Investigaciones Cient\u00edficas","institution_ids":["https://openalex.org/I191242182"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2532,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53186097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"55","issue":"2","first_page":"173","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9290000200271606},{"id":"https://openalex.org/keywords/thrombotic-complications","display_name":"thrombotic complications","score":0.875},{"id":"https://openalex.org/keywords/hemoglobin-s","display_name":"hemoglobin S","score":0.6990000009536743},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.8610000014305115},{"id":"https://openalex.org/keywords/prothrombin-fragment-1-2","display_name":"prothrombin fragment 1+2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9879999756813049},{"id":"https://openalex.org/keywords/avascular-necrosis","display_name":"avascular necrosis","score":0.6850000023841858},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5640000104904175},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.7599999904632568},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8378864526748657},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.8299500942230225},{"id":"https://openalex.org/C2780976302","wikidata":"https://www.wikidata.org/wiki/Q4677915","display_name":"Acute chest syndrome","level":4,"score":0.5548221468925476},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5133959054946899},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5112228393554688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4731636643409729},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4680235981941223},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.45687735080718994},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.42954879999160767},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39719220995903015},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.39163699746131897},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36626362800598145},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.3200925588607788},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071120","descriptor_name":"ADAMTS13 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000979","descriptor_name":"alpha-2-Antiplasmin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006487","descriptor_name":"Hemostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24974633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24974633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigacion clinica","raw_type":"Journal Article"},{"id":"mag:1868645210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24974633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W98872757","https://openalex.org/W145216157","https://openalex.org/W187221286","https://openalex.org/W1735133062","https://openalex.org/W1964235253","https://openalex.org/W1977320652","https://openalex.org/W1977902516","https://openalex.org/W1980573671","https://openalex.org/W1981340903","https://openalex.org/W1981361161","https://openalex.org/W1985557909","https://openalex.org/W1986547098","https://openalex.org/W1988936178","https://openalex.org/W1990033742","https://openalex.org/W1992577724","https://openalex.org/W1993539946","https://openalex.org/W1995891872","https://openalex.org/W1996924061","https://openalex.org/W1997122596","https://openalex.org/W2000893933","https://openalex.org/W2007223732","https://openalex.org/W2007684714","https://openalex.org/W2011654721","https://openalex.org/W2012329069","https://openalex.org/W2025960306","https://openalex.org/W2028158781","https://openalex.org/W2031020699","https://openalex.org/W2031188411","https://openalex.org/W2042544679","https://openalex.org/W2050611373","https://openalex.org/W2051990009","https://openalex.org/W2054224182","https://openalex.org/W2065251351","https://openalex.org/W2068218670","https://openalex.org/W2073806240","https://openalex.org/W2078992248","https://openalex.org/W2088787533","https://openalex.org/W2093499369","https://openalex.org/W2098847286","https://openalex.org/W2108644172","https://openalex.org/W2111857020","https://openalex.org/W2112375947","https://openalex.org/W2112693834","https://openalex.org/W2114234859","https://openalex.org/W2116791780","https://openalex.org/W2123458472","https://openalex.org/W2137081005","https://openalex.org/W2142385132","https://openalex.org/W2155751726","https://openalex.org/W2160219813","https://openalex.org/W2170077226","https://openalex.org/W2260881586","https://openalex.org/W3144957394"],"related_works":["https://openalex.org/W2483697364","https://openalex.org/W2501546854","https://openalex.org/W2121478912","https://openalex.org/W2215583678","https://openalex.org/W2000893933","https://openalex.org/W3188585582","https://openalex.org/W2170077226","https://openalex.org/W2732958242","https://openalex.org/W2139906185","https://openalex.org/W2794838774"],"abstract_inverted_index":{"Sickle":[0],"cell":[1,35,104,190],"syndrome":[2,36,58],"(SCS)":[3],"includes":[4],"a":[5,64,160],"group":[6],"of":[7,15,28,47,54,73,81,114,127,133,145,170,175,178,201,204,208],"congenital":[8],"hemolytic":[9],"anemias":[10],"associated":[11,62,95],"to":[12,63,222],"the":[13,82,115,134,168,176,180,194,202,205,209],"presence":[14],"hemoglobin":[16],"S,":[17],"which":[18,163],"is":[19],"characterized":[20],"by":[21,68],"acute":[22,56],"pain":[23],"episodes":[24],"and":[25,59,87,137,147,150,198,218],"progressive":[26],"damage":[27],"different":[29,71,181,206],"organs.":[30],"Some":[31],"patients":[32,107,187],"with":[33,41,96,188],"sickle":[34,103,189],"have":[37,108,153],"shown,":[38],"when":[39],"compared":[40],"healthy":[42],"individuals,":[43],"an":[44,109,215],"increased":[45,138,148],"risk":[46],"presenting":[48],"stroke,":[49],"pulmonary":[50],"hypertension,":[51],"avascular":[52],"necrosis":[53],"joints,":[55],"chest":[57],"pregnancy":[60],"complications,":[61],"hypercoagulable":[65,161],"state":[66],"induced":[67],"alterations":[69,158,213],"in":[70,102,111,186,196],"components":[72,207],"hemostasis,":[74],"such":[75,118],"as":[76,119],"changes":[77],"that":[78,183],"include":[79],"activation":[80,112,132],"endothelium,":[83],"platelet":[84,151],"activity,":[85],"coagulation":[86,116],"fibrinolytic":[88,135],"systems.":[89],"This":[90],"paper":[91],"compiles":[92],"hemostasis":[93],"disorders,":[94],"thrombotic":[97,171,224],"manifestations,":[98],"reported":[99],"until":[100],"now":[101],"syndrom.":[105],"These":[106],"increase":[110],"markers":[113],"system,":[117,211],"prothrombin":[120],"fragment":[121],"1.2,":[122],"thrombin-antithrombin":[123],"complex,":[124],"etc.,":[125],"depletion":[126],"natural":[128],"anticoagulant":[129],"proteins,":[130],"abnormal":[131,143],"system":[136],"tissue":[139],"factor":[140],"expression.":[141],"Similarly,":[142],"expression":[144],"glycoproteins":[146],"adhesion":[149],"aggregation":[152],"been":[154],"reported.":[155],"All":[156],"these":[157],"produce":[159],"state,":[162],"induces,":[164],"among":[165],"other":[166],"things,":[167],"appearance":[169],"complications.":[172,225],"In":[173],"view":[174],"importance":[177],"controlling":[179],"complications":[182],"can":[184],"occur":[185],"syndrome,":[191],"we":[192],"recommend":[193],"implementation,":[195],"diagnosis":[197],"monitoring":[199],"studies,":[200],"evaluation":[203],"hemostatic":[210],"identifying":[212],"at":[214],"early":[216],"stage":[217],"applying":[219],"effective":[220],"treatments":[221],"prevent":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}