{"id":"https://openalex.org/W1868202024","doi":null,"title":"Defining New Treatment Approaches for KRAS-Mutant Lung Cancer","display_name":"Defining New Treatment Approaches for KRAS-Mutant Lung Cancer","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1868202024","mag":"1868202024"},"language":"en","primary_location":{"id":"mag:1868202024","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a621643.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035793503","display_name":"Eric Andrew Collisson","orcid":"https://orcid.org/0000-0001-8037-9388","observed_orcids":["https://orcid.org/0000-0001-8037-9388","https://orcid.org/0000-0002-2829-355X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eric A. Collisson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8037-9388","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035793503"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06115675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.18729999661445618,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.9390000104904175},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cellular-cofactors","display_name":"cellular cofactors","score":0.6859999895095825},{"id":"https://openalex.org/keywords/shrna-screen","display_name":"shRNA screen","score":0.7149999737739563},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.5379999876022339},{"id":"https://openalex.org/keywords/kras-inhibition","display_name":"KRAS inhibition","score":0.5590000152587891},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.9791147708892822},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.7254047393798828},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7252957224845886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6047659516334534},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5824993848800659},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5560401082038879},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4937795102596283},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4453585147857666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43870699405670166},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4295780062675476},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42653223872184753},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.41645753383636475},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3182451128959656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30781155824661255},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2702966034412384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2657972574234009},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.2395113706588745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1696285903453827},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.14714094996452332},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0665503442287445}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1868202024","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a621643.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982760226","https://openalex.org/W2762379094","https://openalex.org/W2314396321","https://openalex.org/W2810382969","https://openalex.org/W2336774614","https://openalex.org/W3002487670","https://openalex.org/W1924891172","https://openalex.org/W7057624201","https://openalex.org/W2029446677","https://openalex.org/W245303997"],"abstract_inverted_index":{"Abstract":[0],":":[1,48,158],"Lung":[2],"cancer":[3],"is":[4,15,103,110],"a":[5,21,36,74,133],"deadly":[6],"malignancy.":[7],"The":[8],"most":[9],"commonly":[10],"mutated":[11],"oncogene":[12],"we":[13,71,130],"know":[14],"KRAS.":[16],"We":[17,34],"do":[18],"not":[19],"have":[20,31],"drug":[22],"to":[23,39,43],"inhibit":[24,44],"KRAS":[25,55,109,115],",":[26],"and":[27,98,105],"medicinal":[28],"chemistry":[29],"approaches":[30],"exhausted":[32],"leads.":[33],"need":[35],"new":[37,41],"approach":[38],"find":[40],"ways":[42],"this":[45],"oncogene.":[46],"Objective":[47],"To":[49,62,123],"identify":[50,63],"cellular":[51],"cofactors":[52],"required":[53],"for":[54,68,83,145],"G12D":[56],"-driven":[57],"NSCLC.":[58],"Specific":[59,120],"Aim":[60,102,121,154,164,173],"1:":[61],"gene":[64],"products":[65],"specifically":[66],"essential":[67,112],"KRAS-driven":[69],"NSCLC,":[70],"will":[72,131],"perform":[73],"shRNA":[75,161,167],"screen":[76,162],"of":[77,79,135],"thousands":[78],"mouse":[80,117],"genes,":[81],"looking":[82],"essentiality":[84],"in":[85,113,127,153,163,169,172],"multiple":[86],"independent":[87],"cell":[88,118,138],"lines":[89,139,171],"derived":[90],"from":[91],"two":[92],"NSCLC":[93,129,137],"GEMMs:":[94],"one":[95,99],"RAF-":[96],"dependent":[97],"RAS-dependent.":[100],"This":[101],"underway":[104],"has":[106],"verified":[107],"that":[108],"indeed":[111],"the":[114,149],"mutant":[116],"lines.":[119],"2:":[122],"validate":[124],"our":[125],"findings":[126],"human":[128,136,170],"test":[132],"panel":[134],"with":[140],"known":[141],"dependence":[142,147],"on":[143,148],"RAS":[144],"their":[146],"elements":[150],"(hits)":[151],"identified":[152],"1.":[155,165],"Study":[156],"Design":[157],"In":[159],"vitro":[160],"Individual":[166],"validation":[168],"2.":[174]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
