{"id":"https://openalex.org/W1867964494","doi":"https://doi.org/10.1093/genetics/146.3.835","title":"A 140-bp-Long Palindromic Sequence Induces Double-Strand Breaks During Meiosis in the Yeast Saccharomyces cerevisiae","display_name":"A 140-bp-Long Palindromic Sequence Induces Double-Strand Breaks During Meiosis in the Yeast Saccharomyces cerevisiae","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W1867964494","doi":"https://doi.org/10.1093/genetics/146.3.835","mag":"1867964494","pmid":"https://pubmed.ncbi.nlm.nih.gov/9215890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1208054"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/146.3.835","doi":"https://doi.org/10.1093/genetics/146.3.835","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/146.3.835","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1208054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011131070","display_name":"Dilip K. Nag","orcid":"https://orcid.org/0000-0002-9189-2889","observed_orcids":["https://orcid.org/0000-0002-9189-2889"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dilip K Nag","raw_affiliation_strings":["Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, New York 12201","Molecular Genetics Program, Wadsworth Center, Albany, New York 12201-2002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, New York 12201","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]},{"raw_affiliation_string":"Molecular Genetics Program, Wadsworth Center, Albany, New York 12201-2002","institution_ids":["https://openalex.org/I1339417872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000479124","display_name":"Alicia Kurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Kurst","raw_affiliation_strings":["Molecular Genetics Program, Wadsworth Center, Albany, New York 12201-2002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Program, Wadsworth Center, Albany, New York 12201-2002","institution_ids":["https://openalex.org/I1339417872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":2.0148,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.86639464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"146","issue":"3","first_page":"835","last_page":"847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palindromic-dna-sequences","display_name":"palindromic DNA sequences","score":0.890999972820282},{"id":"https://openalex.org/keywords/cruciform-dna-structure","display_name":"cruciform DNA structure","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hairpin-structure","display_name":"hairpin structure","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.828000009059906},{"id":"https://openalex.org/keywords/meiotic-recombination","display_name":"meiotic recombination","score":0.9539999961853027},{"id":"https://openalex.org/keywords/meiotic-recombination-hotspots","display_name":"meiotic recombination hotspots","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.875},{"id":"https://openalex.org/keywords/msh2","display_name":"MSH2","score":0.7639999985694885},{"id":"https://openalex.org/keywords/structure-specific-nucleases","display_name":"structure-specific nucleases","score":0.9340000152587891},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dna-damage-detection","display_name":"DNA damage detection","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7701084017753601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7595347166061401},{"id":"https://openalex.org/C2776086361","wikidata":"https://www.wikidata.org/wiki/Q5189819","display_name":"Cruciform","level":2,"score":0.7020601034164429},{"id":"https://openalex.org/C76557","wikidata":"https://www.wikidata.org/wiki/Q369801","display_name":"Palindromic sequence","level":5,"score":0.7015832662582397},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.5968776941299438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5916386842727661},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.5389021635055542},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4753115773200989},{"id":"https://openalex.org/C74054111","wikidata":"https://www.wikidata.org/wiki/Q5891445","display_name":"Homology directed repair","level":5,"score":0.4126136004924774},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.343636155128479},{"id":"https://openalex.org/C44667518","wikidata":"https://www.wikidata.org/wiki/Q12321","display_name":"Palindrome","level":4,"score":0.341292142868042},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.33502084016799927},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.2755538821220398},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24219828844070435},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1352272629737854},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000619","descriptor_name":"Aminohydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005785","descriptor_name":"Gene Conversion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011755","descriptor_name":"Pyrophosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051718","descriptor_name":"MutS Homolog 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/genetics/146.3.835","doi":"https://doi.org/10.1093/genetics/146.3.835","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/146.3.835","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:321390","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1208054","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:9215890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9215890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:321390","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1208054","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W303825309","https://openalex.org/W1481938713","https://openalex.org/W1547269929","https://openalex.org/W1607454584","https://openalex.org/W1774715425","https://openalex.org/W1833842636","https://openalex.org/W1835569285","https://openalex.org/W1869600472","https://openalex.org/W1887461194","https://openalex.org/W1949150282","https://openalex.org/W1964821658","https://openalex.org/W1973382911","https://openalex.org/W1974141537","https://openalex.org/W1977174919","https://openalex.org/W1984829206","https://openalex.org/W1988875152","https://openalex.org/W1995725495","https://openalex.org/W1999669099","https://openalex.org/W2005563268","https://openalex.org/W2014571977","https://openalex.org/W2025830975","https://openalex.org/W2034252391","https://openalex.org/W2040272632","https://openalex.org/W2041802268","https://openalex.org/W2045349139","https://openalex.org/W2051058497","https://openalex.org/W2051909059","https://openalex.org/W2075504099","https://openalex.org/W2090657834","https://openalex.org/W2108294716","https://openalex.org/W2110627805","https://openalex.org/W2114823800","https://openalex.org/W2117895484","https://openalex.org/W2126969678","https://openalex.org/W2129558265","https://openalex.org/W2134241805","https://openalex.org/W2141798197","https://openalex.org/W2144241955","https://openalex.org/W2148051437","https://openalex.org/W2149049585","https://openalex.org/W2152693329","https://openalex.org/W2166602839","https://openalex.org/W2170472485","https://openalex.org/W2256016482","https://openalex.org/W2260745700","https://openalex.org/W2308684299","https://openalex.org/W2347025710"],"related_works":["https://openalex.org/W2161817820","https://openalex.org/W1480402322","https://openalex.org/W2123553933","https://openalex.org/W2150938260","https://openalex.org/W3150477729","https://openalex.org/W2741646510","https://openalex.org/W1974141537","https://openalex.org/W7096132854","https://openalex.org/W7015828515","https://openalex.org/W2029786576"],"abstract_inverted_index":{"Palindromic":[0],"sequences":[1,125],"have":[2],"the":[3,34,52,67,70,77,89,99,147,165],"potential":[4],"to":[5,27],"form":[6],"hairpin":[7,46,71,167],"or":[8],"cruciform":[9,127,135],"structures,":[10],"which":[11],"are":[12,48,73,83],"putative":[13],"substrates":[14],"for":[15,111,142],"several":[16],"nucleases":[17,144],"and":[18],"mismatch":[19,53],"repair":[20,54,78,163],"enzymes.":[21],"A":[22,94],"genetic":[23],"method":[24,40],"was":[25],"developed":[26],"detect":[28],"such":[29],"structures":[30,47],"in":[31,33,56,66,88,146,155,170],"vivo":[32],"yeast":[35],"Saccharomyces":[36],"cerevisiae.":[37,58],"Using":[38],"this":[39],"we":[41,159],"previously":[42],"showed":[43],"that":[44,62,81,122,161],"short":[45,132,166],"poorly":[49],"repaired":[50],"by":[51,76,107],"system":[55],"S.":[57],"We":[59,120],"show":[60,160],"here":[61],"mismatches,":[63],"when":[64],"present":[65],"stem":[68],"of":[69,117,149,164],"structure,":[72],"not":[74],"processed":[75],"machinery,":[79],"suggesting":[80],"they":[82],"treated":[84],"differently":[85],"than":[86,131],"those":[87],"interstrand":[90],"base-paired":[91],"duplex":[92],"DNA.":[93],"140-bp-long":[95],"palindromic":[96,124],"sequence,":[97],"on":[98],"contrary,":[100],"acts":[101,138],"as":[102,139],"a":[103,109,112,140,150],"meiotic":[104,118],"recombination":[105],"hotspot":[106],"generating":[108],"site":[110],"double-strand":[113,151],"break,":[114],"an":[115,171],"initiator":[116],"recombination.":[119],"suggest":[121],"long":[123],"undergo":[126],"extrusion":[128],"more":[129],"readily":[130],"ones.":[133],"This":[134],"structure":[136,168],"then":[137],"substrate":[141],"structure-specific":[143],"resulting":[145],"formation":[148],"break":[152],"during":[153],"meiosis":[154],"yeast.":[156],"In":[157],"addition,":[158],"residual":[162],"occurs":[169],"MSH2-independent":[172],"pathway.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}