{"id":"https://openalex.org/W1867732273","doi":"https://doi.org/10.1161/atvb.34.suppl_1.648","title":"Abstract 648: Visualizing the Genesis of Microcalcifications via Matrix Vesicle Aggregation: Novel Implications for Plaque Vulnerability","display_name":"Abstract 648: Visualizing the Genesis of Microcalcifications via Matrix Vesicle Aggregation: Novel Implications for Plaque Vulnerability","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1867732273","doi":"https://doi.org/10.1161/atvb.34.suppl_1.648","mag":"1867732273"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.34.suppl_1.648","doi":"https://doi.org/10.1161/atvb.34.suppl_1.648","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.34.suppl_1.648","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091530626","display_name":"Joshua D. Hutcheson","orcid":"https://orcid.org/0000-0002-8383-4435","observed_orcids":["https://orcid.org/0000-0002-8383-4435"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D Hutcheson","raw_affiliation_strings":["Medicine, Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006481103","display_name":"Claudia Goettsch","orcid":"https://orcid.org/0000-0002-7973-1329","observed_orcids":["https://orcid.org/0000-0002-7973-1329"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Goettsch","raw_affiliation_strings":["Medicine, Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013701219","display_name":"Piero Ricchiuto","orcid":"https://orcid.org/0000-0002-8525-6624","observed_orcids":["https://orcid.org/0000-0002-8525-6624"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piero Ricchiuto","raw_affiliation_strings":["Medicine, Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009432106","display_name":"S\u00e9rgio Bertazzo","orcid":"https://orcid.org/0000-0003-4889-8190","observed_orcids":["https://orcid.org/0000-0003-4889-8190"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sergio Bertazzo","raw_affiliation_strings":["Dept of Materials, Imperial College London, London, United Kingdom","Department of Materials, Imperial College, London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Materials, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Materials, Imperial College, London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000818819","display_name":"Natalia Maldonado","orcid":"https://orcid.org/0009-0009-7522-3966","observed_orcids":["https://orcid.org/0009-0009-7522-3966","https://orcid.org/0009-0009-9281-2084"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia M Maldonado","raw_affiliation_strings":["Medicine, Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064861833","display_name":"Masanori Aikawa","orcid":"https://orcid.org/0000-0002-9275-2079","observed_orcids":["https://orcid.org/0000-0002-9275-2079"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Aikawa","raw_affiliation_strings":["Medicine, Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015707475","display_name":"Sasha A. Singh","orcid":"https://orcid.org/0000-0003-0929-3164","observed_orcids":["https://orcid.org/0000-0003-0929-3164"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasha Singh","raw_affiliation_strings":["Medicine, Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064521237","display_name":"Elena A\u00efkawa","orcid":"https://orcid.org/0000-0001-7835-2135","observed_orcids":["https://orcid.org/0000-0001-7835-2135"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Aikawa","raw_affiliation_strings":["Medicine, Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.38839998841285706,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.38839998841285706,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.1712999939918518,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.12559999525547028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcalcifications","display_name":"microcalcifications","score":0.8759999871253967},{"id":"https://openalex.org/keywords/matrix-vesicles","display_name":"matrix vesicles","score":0.9190000295639038},{"id":"https://openalex.org/keywords/unstable-plaque","display_name":"plaque vulnerability","score":0.7429999709129333},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-rupture","display_name":"atherosclerotic plaque rupture","score":0.843999981880188},{"id":"https://openalex.org/keywords/coronary-artery-smooth-muscle-cells","display_name":"coronary artery smooth muscle cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/calcium-phosphate-mineralization","display_name":"calcium phosphate mineralization","score":0.8970000147819519},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8040000200271606},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.7162531018257141},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6057425737380981},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.5787309408187866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5589171648025513},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.549725353717804},{"id":"https://openalex.org/C2779318932","wikidata":"https://www.wikidata.org/wiki/Q1058276","display_name":"Atheroma","level":2,"score":0.5286824107170105},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.4841471314430237},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.4626999497413635},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4230266511440277},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3585052490234375},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27457278966903687},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2098425030708313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16821187734603882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12859895825386047},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.12529242038726807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1214560866355896},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.34.suppl_1.648","doi":"https://doi.org/10.1161/atvb.34.suppl_1.648","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.34.suppl_1.648","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2257022282","https://openalex.org/W7166253842","https://openalex.org/W200787065","https://openalex.org/W2202768967","https://openalex.org/W2417643138","https://openalex.org/W4387190601","https://openalex.org/W4251327626","https://openalex.org/W7162136084","https://openalex.org/W4412119357","https://openalex.org/W4413363310"],"abstract_inverted_index":{"Background:":[0],"Microcalcifications":[1],"in":[2,30,60,111,173,194],"the":[3,23,45,81,120,148,169,184,205,222,229],"cap":[4,219],"of":[5,36,47,53,62,69,119,150,171,192,207,213,224],"vulnerable":[6],"plaques":[7,56],"contribute":[8],"to":[9,22,25,44,79,97,129,168,186,203,221],"plaque":[10],"rupture.":[11],"The":[12],"mechanism":[13],"by":[14,133],"which":[15,226],"microcalcifications":[16,104,131,208],"form":[17,130],"is":[18,165],"poorly":[19],"understood":[20],"due":[21],"inability":[24],"monitor":[26],"initiating":[27],"calcification":[28,163,191],"events":[29],"vivo.":[31],"We":[32],"hypothesized":[33],"that":[34],"aggregation":[35,68,161,189],"cellular-derived":[37],"matrix":[38],"vesicles":[39],"(MV)":[40],"within":[41,154,215],"atheroma":[42],"lead":[43],"formation":[46,223],"microcalcifications.":[48],"Results:":[49],"Transmission":[50],"electron":[51,141],"microscopy":[52,101,118,142],"ApoE-/-":[54],"mouse":[55],"reveals":[57,102],"MVs":[58,125,193,214],"aggregating":[59,126],"regions":[61],"disrupted":[63],"collagen":[64,76,98,121,172],"(A).":[65],"To":[66,179],"image":[67],"calcifying":[70],"MVs,":[71],"we":[72,182],"created":[73],"a":[74,134,200,216],"3D":[75,175],"hydrogel":[77],"system":[78],"simulate":[80],"atherosclerotic":[82],"fibrous":[83,218],"cap.":[84,230],"Conditioned":[85],"media":[86],"from":[87,209],"calcific":[88],"human":[89,112],"coronary":[90],"artery":[91],"smooth":[92],"muscle":[93],"cells":[94],"was":[95],"added":[96],"hydrogels.":[99],"Confocal":[100],"spherical":[103],"(B,":[105],"arrows)":[106,128],"resembling":[107],"those":[108],"previously":[109],"reported":[110],"plaques.":[113],"Super-resolution":[114],"(<":[115],"200":[116],"nm)":[117],"hydrogels":[122],"shows":[123],"individual":[124],"(C,":[127],"shown":[132],"near-infrared":[135],"calcium":[136,151],"phosphate":[137,152],"tracer":[138],"(D).":[139],"Scanning":[140],"combined":[143],"with":[144],"x-ray":[145],"spectroscopy":[146],"confirms":[147],"presence":[149],"mineral":[153],"MV":[155,160],"aggregates":[156],"(E,":[157],"orange":[158],"color).":[159],"and":[162,190],"size":[164],"inversely":[166],"related":[167],"amount":[170],"our":[174,180],"model":[176],"(p<0.05).":[177],"Conclusion:":[178],"knowledge,":[181],"are":[183],"first":[185],"directly":[187],"visualize":[188],"real":[195],"time.":[196],"This":[197],"approach":[198],"presents":[199],"powerful":[201],"tool":[202],"understand":[204],"genesis":[206],"nucleating":[210],"events.":[211],"Aggregation":[212],"thinning":[217],"leads":[220],"microcalcifications,":[225],"further":[227],"destabilize":[228]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
