{"id":"https://openalex.org/W1866639487","doi":null,"title":"Oxidative impairment of plasma and skeletal muscle sarcoplasmic reticulum in rats with adjuvant arthritis - effects of pyridoindole antioxidants.","display_name":"Oxidative impairment of plasma and skeletal muscle sarcoplasmic reticulum in rats with adjuvant arthritis - effects of pyridoindole antioxidants.","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W1866639487","mag":"1866639487","pmid":"https://pubmed.ncbi.nlm.nih.gov/18987589"},"language":"en","primary_location":{"id":"pmid:18987589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18987589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087267996","display_name":"Miriam \u0160trosov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Miriam Strosova","raw_affiliation_strings":["Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020240913","display_name":"Iveta Tomaskova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iveta Tomaskova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068413199","display_name":"Silvester Poni\u0161t","orcid":"https://orcid.org/0000-0001-9672-5441","observed_orcids":["https://orcid.org/0000-0001-9672-5441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvester Ponist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081005362","display_name":"Katar\u00edna Bauerov\u00e1","orcid":"https://orcid.org/0000-0002-7863-2142","observed_orcids":["https://orcid.org/0000-0002-7863-2142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarina Bauerova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091576645","display_name":"Janka Karlovsk\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Janka Karlovska","raw_affiliation_strings":["Univerzita Komensk\u00e9ho v Bratislave"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univerzita Komensk\u00e9ho v Bratislave","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064011950","display_name":"Corinne Michelle Spickett","orcid":"https://orcid.org/0000-0003-4054-9279","observed_orcids":["https://orcid.org/0000-0003-4054-9279"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Corinne M Spickett","raw_affiliation_strings":["University of Strathclyde"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Strathclyde","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002742557","display_name":"\u013dubica Hor\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0003-0229-5888","observed_orcids":["https://orcid.org/0000-0003-0229-5888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lubica Horakova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8856,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68202654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"29","issue":"5","first_page":"706","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.04410000145435333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adjuvant-induced-arthritis","display_name":"adjuvant-induced arthritis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.781000018119812},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9520000219345093},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7860000133514404},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":1.0},{"id":"https://openalex.org/keywords/stobadine","display_name":"stobadine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tryptophan-fluorescence","display_name":"tryptophan fluorescence","score":0.9300000071525574},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8805220127105713},{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.8221439123153687},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.8128874897956848},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5293591618537903},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.5205829739570618},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.481931209564209},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.45042502880096436},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.415299654006958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40869662165641785},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3874571919441223},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.3392561674118042},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.286309152841568},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08038309216499329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06450769305229187}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050050","descriptor_name":"Protein Carbonylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18987589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18987589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:1866639487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18987589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996479055","https://openalex.org/W2170222601","https://openalex.org/W7216628615","https://openalex.org/W2150979246","https://openalex.org/W2088679036","https://openalex.org/W2093940460","https://openalex.org/W4248234318","https://openalex.org/W3049269845","https://openalex.org/W2043910792","https://openalex.org/W2411818657"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"study":[2,212],"possible":[3],"oxidation":[4,136],"of":[5,23,36,71,89,99,119,125,131,161,167,213,222],"proteins":[6,179],"and":[7,11,18,32,52,65,92,107,155,171,180,217],"lipids":[8,181],"in":[9,26,50,97,116,142,165,185,226],"plasma":[10,51,98,126],"sarcoplasmic":[12],"reticulum":[13],"(SR)":[14],"from":[15,39,144,149],"skeletal":[16],"muscles":[17],"to":[19,33,83,195],"assess":[20],"the":[21],"effects":[22],"pyridoindole":[24,132],"antioxidants":[25,189],"rats":[27,100,151,169,186],"with":[28,101,187,193,237],"adjuvant":[29,102],"arthritis":[30],"(AA)":[31],"analyze":[34,84],"modulation":[35],"Ca-ATPase":[37],"activity":[38,70,148,200],"SR":[40,43,53,143,166],"(SERCA).":[41],"METHODS:":[42],"was":[44,60,73,81,95,121,127,140,172,201],"isolated":[45],"by":[46,56,62,66,75,175,205,211],"ultracentrifugation,":[47],"protein":[48,90,113,135],"carbonyls":[49,91],"were":[54,182],"determined":[55],"ELISA.":[57],"Lipid":[58,123],"peroxidation":[59,94,124,139],"analyzed":[61],"TBARS":[63],"determination":[64],"mass":[67],"spectrometry.":[68],"ATPase":[69],"SERCA":[72,147,199,223],"measured":[74],"NADH-coupled":[76],"enzyme":[77,158],"assay.":[78],"Tryptophan":[79],"fluorescence":[80,163],"used":[82],"conformational":[85,207,234],"alterations.":[86],"RESULTS:":[87],"Increase":[88],"lipid":[93,138],"observed":[96],"arthritis.":[103],"Pyridoindole":[104],"antioxidant":[105],"stobadine":[106,120,154],"its":[108,206],"methylated":[109],"derivative":[110],"SMe1":[111,156,218],"decreased":[112],"carbonyl":[114],"formation":[115],"plasma,":[117],"effect":[118,130],"significant.":[122],"without":[128],"any":[129],"derivatives.":[133],"Neither":[134],"nor":[137],"identified":[141],"AA":[145,150,168,227],"rats.":[146],"increased":[152,170],"significantly,":[153],"diminished":[157],"activity.":[159],"Ratio":[160],"tryptophan":[162,214,238],"intensity":[164],"not":[173,232],"influenced":[174],"antioxidants.":[176],"CONCLUSION:":[177],"Plasma":[178],"oxidatively":[183],"injured":[184],"AA;":[188],"exerted":[190],"protection":[191],"only":[192],"respect":[194],"proteins.":[196],"In":[197],"SR,":[198],"altered,":[202],"apparently":[203],"induced":[204,219],"changes,":[208],"as":[209],"supported":[210],"fluorescence.":[215,239],"Stobadine":[216],"a":[220],"decrease":[221],"activity,":[224],"elevated":[225],"rats,":[228],"but":[229],"they":[230],"did":[231],"affect":[233],"changes":[235],"associated":[236]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
