{"id":"https://openalex.org/W186575205","doi":null,"title":"Ciblage th\u00e9rapeutique des tumeurs osseuses primitives par transfert de g\u00e8ne","display_name":"Ciblage th\u00e9rapeutique des tumeurs osseuses primitives par transfert de g\u00e8ne","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W186575205","mag":"186575205"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/822305","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/822305","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011209723","display_name":"Fran\u00e7ois Lamoureux","orcid":"https://orcid.org/0000-0002-2738-0758","observed_orcids":["https://orcid.org/0000-0002-2738-0758"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois Lamoureux","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2738-0758","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011209723"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.41110000014305115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-bone-tumors","display_name":"primary bone tumors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.6510000228881836},{"id":"https://openalex.org/keywords/rank-rankl-opg-pathway","display_name":"RANK/RANKL/OPG pathway","score":0.75},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8230000138282776},{"id":"https://openalex.org/keywords/antiresorptive-therapy","display_name":"antiresorptive therapy","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6654841899871826},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.4691036641597748},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3337162733078003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3161354064941406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2609791159629822}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/822305","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/822305","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:186575205","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2008NANT32VS","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":344,"referenced_works":["https://openalex.org/W63968789","https://openalex.org/W66681832","https://openalex.org/W126874934","https://openalex.org/W184127349","https://openalex.org/W1168761028","https://openalex.org/W1480416633","https://openalex.org/W1491950503","https://openalex.org/W1495009998","https://openalex.org/W1495140191","https://openalex.org/W1503052062","https://openalex.org/W1511075257","https://openalex.org/W1534645474","https://openalex.org/W1535201509","https://openalex.org/W1545561369","https://openalex.org/W1573010771","https://openalex.org/W1573495239","https://openalex.org/W1577265851","https://openalex.org/W1577577364","https://openalex.org/W1624294703","https://openalex.org/W1639934123","https://openalex.org/W1650001464","https://openalex.org/W1672290086","https://openalex.org/W1789272384","https://openalex.org/W1797236870","https://openalex.org/W1839671168","https://openalex.org/W1842425533","https://openalex.org/W1893341441","https://openalex.org/W1954845453","https://openalex.org/W1964066819","https://openalex.org/W1964914796","https://openalex.org/W1966970126","https://openalex.org/W1967615426","https://openalex.org/W1968152282","https://openalex.org/W1968195674","https://openalex.org/W1968321554","https://openalex.org/W1968898308","https://openalex.org/W1969834700","https://openalex.org/W1970856815","https://openalex.org/W1970864109","https://openalex.org/W1971017689","https://openalex.org/W1971127908","https://openalex.org/W1971387567","https://openalex.org/W1971456299","https://openalex.org/W1971720206","https://openalex.org/W1972704451","https://openalex.org/W1973011134","https://openalex.org/W1973311536","https://openalex.org/W1973773144","https://openalex.org/W1974029074","https://openalex.org/W1974659965","https://openalex.org/W1975510007","https://openalex.org/W1977013832","https://openalex.org/W1977387775","https://openalex.org/W1977753585","https://openalex.org/W1978122265","https://openalex.org/W1978614581","https://openalex.org/W1980418071","https://openalex.org/W1980786892","https://openalex.org/W1981285854","https://openalex.org/W1982926533","https://openalex.org/W1983185770","https://openalex.org/W1983589855","https://openalex.org/W1985148995","https://openalex.org/W1985962986","https://openalex.org/W1986310612","https://openalex.org/W1988807967","https://openalex.org/W1989051889","https://openalex.org/W1989526399","https://openalex.org/W1990119475","https://openalex.org/W1990306722","https://openalex.org/W1991388845","https://openalex.org/W1992767687","https://openalex.org/W1993192911","https://openalex.org/W1993300838","https://openalex.org/W1995616953","https://openalex.org/W1996964527","https://openalex.org/W1997286496","https://openalex.org/W1997461030","https://openalex.org/W1998024723","https://openalex.org/W1998666925","https://openalex.org/W1999077925","https://openalex.org/W1999205738","https://openalex.org/W2000647744","https://openalex.org/W2000736649","https://openalex.org/W2001049190","https://openalex.org/W2001630588","https://openalex.org/W2002445145","https://openalex.org/W2003089270","https://openalex.org/W2003090246","https://openalex.org/W2003865675","https://openalex.org/W2004061849","https://openalex.org/W2004254194","https://openalex.org/W2004897012","https://openalex.org/W2005360870","https://openalex.org/W2006825597","https://openalex.org/W2007270178","https://openalex.org/W2007415750","https://openalex.org/W2009273763","https://openalex.org/W2009566132","https://openalex.org/W2011387218","https://openalex.org/W2012511365","https://openalex.org/W2013571231","https://openalex.org/W2016384953","https://openalex.org/W2017237496","https://openalex.org/W2018450202","https://openalex.org/W2018602999","https://openalex.org/W2019480285","https://openalex.org/W2020911631","https://openalex.org/W2021467798","https://openalex.org/W2023188086","https://openalex.org/W2023245305","https://openalex.org/W2024896951","https://openalex.org/W2025989401","https://openalex.org/W2026828263","https://openalex.org/W2028268979","https://openalex.org/W2029176649","https://openalex.org/W2030204681","https://openalex.org/W2030504185","https://openalex.org/W2031486735","https://openalex.org/W2032855363","https://openalex.org/W2035658521","https://openalex.org/W2036289981","https://openalex.org/W2036679520","https://openalex.org/W2036760454","https://openalex.org/W2037753229","https://openalex.org/W2037760271","https://openalex.org/W2038995854","https://openalex.org/W2039192289","https://openalex.org/W2039719308","https://openalex.org/W2039912051","https://openalex.org/W2041345827","https://openalex.org/W2043390906","https://openalex.org/W2043553082","https://openalex.org/W2043992170","https://openalex.org/W2044482752","https://openalex.org/W2044614528","https://openalex.org/W2046945256","https://openalex.org/W2047425473","https://openalex.org/W2047721737","https://openalex.org/W2047924366","https://openalex.org/W2048299560","https://openalex.org/W2049362047","https://openalex.org/W2049891971","https://openalex.org/W2050104200","https://openalex.org/W2051130290","https://openalex.org/W2051255001","https://openalex.org/W2051320963","https://openalex.org/W2052194344","https://openalex.org/W2052512461","https://openalex.org/W2052577034","https://openalex.org/W2052801322","https://openalex.org/W2053428586","https://openalex.org/W2054383673","https://openalex.org/W2054703329","https://openalex.org/W2054919644","https://openalex.org/W2055763817","https://openalex.org/W2055916341","https://openalex.org/W2056621404","https://openalex.org/W2057484433","https://openalex.org/W2058708997","https://openalex.org/W2059571444","https://openalex.org/W2059776314","https://openalex.org/W2060298346","https://openalex.org/W2060482009","https://openalex.org/W2060529002","https://openalex.org/W2063048904","https://openalex.org/W2063654089","https://openalex.org/W2064040661","https://openalex.org/W2064732266","https://openalex.org/W2064942973","https://openalex.org/W2065184790","https://openalex.org/W2065297127","https://openalex.org/W2065371374","https://openalex.org/W2066000727","https://openalex.org/W2066639236","https://openalex.org/W2067076724","https://openalex.org/W2068963825","https://openalex.org/W2069622785","https://openalex.org/W2070013317","https://openalex.org/W2072250933","https://openalex.org/W2072315137","https://openalex.org/W2072738451","https://openalex.org/W2072789990","https://openalex.org/W2073112480","https://openalex.org/W2073807010","https://openalex.org/W2074040545","https://openalex.org/W2074152898","https://openalex.org/W2074494405","https://openalex.org/W2074776278","https://openalex.org/W2075261011","https://openalex.org/W2076458531","https://openalex.org/W2076788883","https://openalex.org/W2078325464","https://openalex.org/W2080007472","https://openalex.org/W2080998316","https://openalex.org/W2082179591","https://openalex.org/W2082457193","https://openalex.org/W2082675827","https://openalex.org/W2082784075","https://openalex.org/W2082990291","https://openalex.org/W2083019332","https://openalex.org/W2083392027","https://openalex.org/W2084102864","https://openalex.org/W2084557652","https://openalex.org/W2086008590","https://openalex.org/W2086174019","https://openalex.org/W2086491566","https://openalex.org/W2087122528","https://openalex.org/W2087324367","https://openalex.org/W2088535641","https://openalex.org/W2090603283","https://openalex.org/W2092751827","https://openalex.org/W2093252878","https://openalex.org/W2093349314","https://openalex.org/W2093571282","https://openalex.org/W2094374305","https://openalex.org/W2095031099","https://openalex.org/W2095546640","https://openalex.org/W2097037712","https://openalex.org/W2097465717","https://openalex.org/W2099516468","https://openalex.org/W2101103980","https://openalex.org/W2102070943","https://openalex.org/W2102460328","https://openalex.org/W2102969047","https://openalex.org/W2103405666","https://openalex.org/W2104953667","https://openalex.org/W2105010528","https://openalex.org/W2105856491","https://openalex.org/W2106751714","https://openalex.org/W2106766464","https://openalex.org/W2108779942","https://openalex.org/W2109608328","https://openalex.org/W2111967805","https://openalex.org/W2112558234","https://openalex.org/W2114394594","https://openalex.org/W2115871403","https://openalex.org/W2115922516","https://openalex.org/W2116271160","https://openalex.org/W2116281705","https://openalex.org/W2117963070","https://openalex.org/W2119843976","https://openalex.org/W2120240705","https://openalex.org/W2120788367","https://openalex.org/W2120837197","https://openalex.org/W2121570978","https://openalex.org/W2122306511","https://openalex.org/W2122390343","https://openalex.org/W2124036292","https://openalex.org/W2127114138","https://openalex.org/W2127360580","https://openalex.org/W2128271300","https://openalex.org/W2128843508","https://openalex.org/W2129651548","https://openalex.org/W2129864520","https://openalex.org/W2129873319","https://openalex.org/W2130728604","https://openalex.org/W2131155074","https://openalex.org/W2131424836","https://openalex.org/W2132258320","https://openalex.org/W2133172137","https://openalex.org/W2133260436","https://openalex.org/W2133916339","https://openalex.org/W2135117001","https://openalex.org/W2135686124","https://openalex.org/W2136257629","https://openalex.org/W2136547055","https://openalex.org/W2137083298","https://openalex.org/W2137376744","https://openalex.org/W2137537720","https://openalex.org/W2137676632","https://openalex.org/W2138220544","https://openalex.org/W2139055941","https://openalex.org/W2139090888","https://openalex.org/W2139996507","https://openalex.org/W2140353133","https://openalex.org/W2141070796","https://openalex.org/W2141348613","https://openalex.org/W2141591906","https://openalex.org/W2141877739","https://openalex.org/W2142136189","https://openalex.org/W2142304480","https://openalex.org/W2142335737","https://openalex.org/W2144630934","https://openalex.org/W2144816848","https://openalex.org/W2145026015","https://openalex.org/W2146115158","https://openalex.org/W2146143139","https://openalex.org/W2148300353","https://openalex.org/W2148489270","https://openalex.org/W2150072015","https://openalex.org/W2150436360","https://openalex.org/W2150531719","https://openalex.org/W2150892304","https://openalex.org/W2151444534","https://openalex.org/W2154211764","https://openalex.org/W2156467557","https://openalex.org/W2156764890","https://openalex.org/W2156854226","https://openalex.org/W2157573016","https://openalex.org/W2157573351","https://openalex.org/W2159885083","https://openalex.org/W2159999899","https://openalex.org/W2160491669","https://openalex.org/W2160527120","https://openalex.org/W2160592082","https://openalex.org/W2163208284","https://openalex.org/W2163592418","https://openalex.org/W2164071805","https://openalex.org/W2164174012","https://openalex.org/W2164650822","https://openalex.org/W2164838111","https://openalex.org/W2165678358","https://openalex.org/W2166227856","https://openalex.org/W2166781825","https://openalex.org/W2167227856","https://openalex.org/W2167886526","https://openalex.org/W2168730134","https://openalex.org/W2169278972","https://openalex.org/W2169802771","https://openalex.org/W2169829977","https://openalex.org/W2183857785","https://openalex.org/W2184993925","https://openalex.org/W2199761800","https://openalex.org/W2239005142","https://openalex.org/W2246578212","https://openalex.org/W2253720089","https://openalex.org/W2291260831","https://openalex.org/W2323447227","https://openalex.org/W2325060315","https://openalex.org/W2329218644","https://openalex.org/W2330598934","https://openalex.org/W2341456905","https://openalex.org/W2396324133","https://openalex.org/W2396392270","https://openalex.org/W2400280624","https://openalex.org/W2414017360","https://openalex.org/W2416426790","https://openalex.org/W2416479825","https://openalex.org/W2416774637","https://openalex.org/W2417402918","https://openalex.org/W2464643803","https://openalex.org/W2985087204","https://openalex.org/W4297631159"],"related_works":["https://openalex.org/W7033277393","https://openalex.org/W564655678","https://openalex.org/W7058577192","https://openalex.org/W136003169","https://openalex.org/W2453499","https://openalex.org/W7042287396","https://openalex.org/W2058261339","https://openalex.org/W1970546801","https://openalex.org/W2194557575","https://openalex.org/W2111967805"],"abstract_inverted_index":{"L'ost\u00e9osarcome":[0],"est":[1,80],"la":[2,22,25,35,56,60,65,84,87],"plus":[3],"fr\u00e9quente":[4],"des":[5,27,119],"tumeurs":[6],"osseuses":[7],"primitives":[8],"affectant":[9],"principalement":[10],"une":[11,102],"population":[12],"jeune.":[13],"Bien":[14],"que":[15],"les":[16],"traitements":[17],"actuels":[18],"aient":[19],"contribu\u00e9":[20],"\u00e0":[21],"progression":[23],"de":[24,37,39,44,86,97,107,112,114,124,132,135,143,148,150,154,158],"survie":[26],"patients,":[28],"ils":[29],"montrent":[30],"d\u00e9sormais":[31],"leurs":[32],"limites":[33],"d'o\u00f9":[34],"n\u00e9cessit\u00e9":[36],"d\u00e9velopper":[38,113],"nouvelles":[40,115],"th\u00e9rapies.":[41],"L'hypoth\u00e8se":[42],"biologique":[43],"l":[45,95,98,155],"ost\u00e9osarcome":[46],"repose":[47],"sur":[48],"l'existence":[49],"d":[50],"un":[51],"cercle":[52,127],"vicieux":[53],"s'instaurant":[54],"entre":[55],"prolif\u00e9ration":[57],"tumorale":[58],"et":[59,90,157],"r\u00e9sorption":[61,88],"osseuse.":[62],"R\u00e9cemment":[63],"d\u00e9couverte,":[64],"triade":[66],"mol\u00e9culaire":[67],"Receptor":[68],"Activator":[69],"of":[70],"NF":[71],"B":[72],"(RANK)":[73],"/":[74,77],"RANK":[75],"ligand":[76],"Ost\u00e9oprot\u00e9g\u00e9rine":[78],"(RANK/RANKL/OPG)":[79],"fortement":[81],"impliqu\u00e9e":[82],"dans":[83,118,160],"r\u00e9gulation":[85],"osseuse":[89],"du":[91],"d\u00e9veloppement":[92],"tumoral,":[93],"ainsi":[94],"inhibition":[96],"interaction":[99],"RANK/RANKL":[100],"repr\u00e9sente":[101],"cible":[103],"th\u00e9rapeutique":[104],"majeure.":[105],"L'objectif":[106],"cette":[108],"th\u00e8se":[109],"a":[110],"\u00e9t\u00e9":[111],"approches":[116],"th\u00e9rapeutiques":[117],"mod\u00e8les":[120],"exp\u00e9rimentaux":[121],"d'ost\u00e9osarcomes":[122],"afin":[123],"rompre":[125],"ce":[126],"vicieux,":[128],"notamment":[129],"par":[130,141],"l'utilisation":[131],"l'OPG":[133],"ou":[134],"RANK-Fc,":[136],"mol\u00e9cules":[137],"anti-r\u00e9sorption":[138],"osseuse,":[139],"lib\u00e9r\u00e9s":[140],"transfert":[142],"g\u00e8ne":[144],"non":[145],"viral,":[146],"puis":[147],"tenter":[149],"comprendre":[151],"le":[152,161],"r\u00f4le":[153],"OPG":[156],"RANKL":[159],"microenvironnement":[162],"tumoral":[163],"osseux.":[164]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}