{"id":"https://openalex.org/W18657166","doi":null,"title":"Naltrexone long-acting formulation in the treatment of alcohol dependence.","display_name":"Naltrexone long-acting formulation in the treatment of alcohol dependence.","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W18657166","mag":"18657166","pmid":"https://pubmed.ncbi.nlm.nih.gov/18472999","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2376083"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2376083","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2376083/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2376083/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Clin Risk Manag","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2376083/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032742542","display_name":"Bankole A. Johnson","orcid":"https://orcid.org/0000-0002-8901-6177","observed_orcids":["https://orcid.org/0000-0002-8901-6177"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bankole A Johnson","raw_affiliation_strings":["Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032742542"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":1.014,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.7615529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"5","first_page":"741","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.9879999756813049},{"id":"https://openalex.org/keywords/long-acting-injectables","display_name":"long-acting injectables","score":0.875},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9639999866485596},{"id":"https://openalex.org/keywords/vivitrol","display_name":"Vivitrol","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6639999747276306},{"id":"https://openalex.org/keywords/alcohol-abstinence","display_name":"alcohol abstinence","score":0.6190000176429749},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.9490000009536743},{"id":"https://openalex.org/keywords/heavy-drinking","display_name":"heavy drinking","score":0.6449999809265137},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7160000205039978},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.9843552112579346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8692652583122253},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.7068926095962524},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6354491114616394},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6315210461616516},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.5934256315231323},{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.5722494125366211},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49429917335510254},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4648629128932953},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4568305015563965},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39645010232925415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.364688515663147},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.22458094358444214},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.17370805144309998},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2376083","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2376083/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2376083/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Clin Risk Manag","raw_type":"Text"},{"id":"pmid:18472999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18472999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutics and clinical risk management","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.274.8778","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.8778","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d2/1d/Ther_Clin_Risk_Manag_2007_Oct_3(5)_741-749.tar.gz","raw_type":"text"},{"id":"mag:18657166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18472999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2376083","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2376083/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2376083/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Clin Risk Manag","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1729993911","display_name":"Pharmacologic Treatments in Emerging Adults","funder_award_id":"R01AA010522","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4408192742","display_name":"Combining Medication Treatments for Alcoholism","funder_award_id":"R01AA013964","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5531328711","display_name":"General Clinical Research Center","funder_award_id":"M01RR000847","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G580993508","display_name":"New Medications to Treat Alcohol Dependence","funder_award_id":"R01AA014628","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6908319169","display_name":"Joint Behavior/Pharmacologic Treatment of Alcoholism","funder_award_id":"U10AA011776","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G8867474288","display_name":"COMBINED PHARMACOTHERAPIES FOR ALCOHOLISM","funder_award_id":"R01AA012964","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W18657166.pdf","grobid_xml":"https://content.openalex.org/works/W18657166.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W111370587","https://openalex.org/W1518632134","https://openalex.org/W1554927263","https://openalex.org/W1635084872","https://openalex.org/W1949610657","https://openalex.org/W1964623442","https://openalex.org/W1969966959","https://openalex.org/W1975907845","https://openalex.org/W1985094131","https://openalex.org/W1986130864","https://openalex.org/W1987988504","https://openalex.org/W2016562568","https://openalex.org/W2031172625","https://openalex.org/W2033122986","https://openalex.org/W2045782183","https://openalex.org/W2052360330","https://openalex.org/W2063044913","https://openalex.org/W2074406420","https://openalex.org/W2076078537","https://openalex.org/W2079074743","https://openalex.org/W2084200679","https://openalex.org/W2093559862","https://openalex.org/W2104008263","https://openalex.org/W2104538950","https://openalex.org/W2107970821","https://openalex.org/W2108173576","https://openalex.org/W2110140436","https://openalex.org/W2112996216","https://openalex.org/W2118229177","https://openalex.org/W2121496050","https://openalex.org/W2122592499","https://openalex.org/W2138742021","https://openalex.org/W2141757671","https://openalex.org/W2147784083","https://openalex.org/W2157113531"],"related_works":["https://openalex.org/W7096996634","https://openalex.org/W2104008263","https://openalex.org/W2034538711","https://openalex.org/W1515337023","https://openalex.org/W1966070495","https://openalex.org/W2147784083","https://openalex.org/W2076078537","https://openalex.org/W4238989061","https://openalex.org/W1554927263","https://openalex.org/W2152347083"],"abstract_inverted_index":{"While":[0],"oral":[1,97],"naltrexone":[2,33,72],"has":[3,13,100],"a":[4,18,130],"demonstrated":[5,101],"ability":[6],"to":[7,57,64,90,112],"decrease":[8,116],"alcohol":[9,84],"reinforcement,":[10],"it":[11],"also":[12],"pharmacotherapeutic":[14],"limitations,":[15],"such":[16],"as":[17,79],"small":[19],"treatment":[20],"effect":[21],"size,":[22],"adverse":[23],"events,":[24],"and":[25,48,68,115],"plasma":[26,50],"level":[27],"fluctuations.":[28],"The":[29,127],"pharmacokinetic":[30],"profile":[31],"of":[32,96,119,124,143],"could":[34],"be":[35,91],"enhanced":[36],"by":[37],"intramuscular":[38],"administration,":[39],"which":[40],"would":[41],"sustain":[42],"its":[43],"release":[44],"over":[45],"several":[46],"weeks":[47],"keep":[49],"levels":[51],"relatively":[52],"constant,":[53],"ie,":[54],"low":[55],"enough":[56,63],"minimize":[58],"side":[59],"effects":[60],"but":[61],"high":[62],"reduce":[65],"drinking.":[66],"Vivitrex((R))/Vivitrol((R))":[67,99],"Naltrel((R))":[69,110],"are":[70,134],"injectable":[71],"depot":[73],"formulations":[74,139],"that":[75,95],"have":[76],"been":[77],"tested":[78],"possible":[80],"medications":[81],"for":[82],"treating":[83],"dependence.":[85],"Their":[86],"adverse-event":[87],"profiles":[88],"appear":[89],"less":[92],"severe":[93],"than":[94],"naltrexone.":[98],"efficacy":[102],"at":[103],"decreasing":[104],"heavy":[105],"drinking":[106],"among":[107],"alcohol-dependent":[108,125],"males.":[109],"helped":[111],"promote":[113],"abstinence":[114],"the":[117],"incidence":[118],"relapse":[120],"in":[121],"two":[122],"samples":[123],"subjects.":[126],"data":[128],"on":[129],"third":[131],"formulation,":[132],"Depotrex((R)),":[133],"still":[135],"limited.":[136],"All":[137],"three":[138],"require":[140],"further":[141],"study":[142],"their":[144],"efficacy.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}