{"id":"https://openalex.org/W1865619950","doi":"https://doi.org/10.1128/mcb.18.6.3509","title":"Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase","display_name":"Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W1865619950","doi":"https://doi.org/10.1128/mcb.18.6.3509","mag":"1865619950","pmid":"https://pubmed.ncbi.nlm.nih.gov/9584191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/108932"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.18.6.3509","doi":"https://doi.org/10.1128/mcb.18.6.3509","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.18.6.3509","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC108932","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rakesh K. Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh K. Srivastava","raw_affiliation_strings":["1Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823","Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001464738","display_name":"Aparna R. Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292069884","display_name":"Greater Baltimore Medical Center","ror":"https://ror.org/0077fnc39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1292069884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aparna R. Srivastava","raw_affiliation_strings":["2Greater Baltimore Medical Center, Baltimore, Maryland 21204","#N#Greater Baltimore Medical Center, Baltimore, Maryland 21204#N#2#N#;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Greater Baltimore Medical Center, Baltimore, Maryland 21204","institution_ids":["https://openalex.org/I1292069884"]},{"raw_affiliation_string":"#N#Greater Baltimore Medical Center, Baltimore, Maryland 21204#N#2#N#;","institution_ids":["https://openalex.org/I1292069884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109113107","display_name":"Stanley J. Korsmeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley J. Korsmeyer","raw_affiliation_strings":["3Washington University School of Medicine, St. Louis, Missouri 63110","#N#Washington University School of Medicine, St. Louis, Missouri 63110#N#3#N#; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"#N#Washington University School of Medicine, St. Louis, Missouri 63110#N#3#N#; and","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064644423","display_name":"Maria Nesterova","orcid":"https://orcid.org/0000-0001-5784-4704","observed_orcids":["https://orcid.org/0000-0001-5784-4704"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Nesterova","raw_affiliation_strings":["4National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892","National Cancer Institute, National Institutes of Health, Bethesda, Maryland 208924"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, Maryland 208924","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111545178","display_name":"Yoon S. Cho\u2010Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoon S. Cho-Chung","raw_affiliation_strings":["4National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892","National Cancer Institute, National Institutes of Health, Bethesda, Maryland 208924"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, Maryland 208924","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039707350","display_name":"Dan L. Longo","orcid":"https://orcid.org/0000-0002-5850-5998","observed_orcids":["https://orcid.org/0000-0002-5850-5998"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan L. Longo","raw_affiliation_strings":["1Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823","#N#Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823#N#1#N#;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"#N#Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6823#N#1#N#;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.3191,"has_fulltext":false,"cited_by_count":365,"citation_normalized_percentile":{"value":0.9929538,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"6","first_page":"3509","last_page":"3517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl-2-phosphorylation","display_name":"Bcl-2 phosphorylation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9179999828338623},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.921999990940094},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":1.0},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7269999980926514},{"id":"https://openalex.org/keywords/p53-independent-apoptosis","display_name":"p53-independent apoptosis","score":0.875},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8569999933242798},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.8650000095367432},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cytoskeleton-disruption","display_name":"cytoskeleton disruption","score":0.7039999961853027},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.8407450914382935},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6762905120849609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6269121170043945},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5629739761352539},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5372818112373352},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5295187830924988},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5107870101928711},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5011744499206543},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4677441418170929},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.446557879447937},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4359615445137024},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42219191789627075},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3362027108669281},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2503221035003662},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14373856782913208},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.10135474801063538},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0595339834690094},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.18.6.3509","doi":"https://doi.org/10.1128/mcb.18.6.3509","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.18.6.3509","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:134913","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC108932","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:108932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/108932","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:9584191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9584191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:134913","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC108932","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W35060329","https://openalex.org/W1527321128","https://openalex.org/W1547132539","https://openalex.org/W1570441204","https://openalex.org/W1603530183","https://openalex.org/W1861097978","https://openalex.org/W1900014550","https://openalex.org/W1911989431","https://openalex.org/W1916777863","https://openalex.org/W1962741441","https://openalex.org/W1970834072","https://openalex.org/W1970839214","https://openalex.org/W1981056903","https://openalex.org/W1982502422","https://openalex.org/W1991865867","https://openalex.org/W1992045438","https://openalex.org/W1994818689","https://openalex.org/W1996180957","https://openalex.org/W1996522179","https://openalex.org/W1998564425","https://openalex.org/W2007689766","https://openalex.org/W2010298858","https://openalex.org/W2010820226","https://openalex.org/W2020721942","https://openalex.org/W2031647568","https://openalex.org/W2041466047","https://openalex.org/W2048596513","https://openalex.org/W2049377259","https://openalex.org/W2051219590","https://openalex.org/W2057713336","https://openalex.org/W2058591356","https://openalex.org/W2063176993","https://openalex.org/W2070862399","https://openalex.org/W2072894284","https://openalex.org/W2078001244","https://openalex.org/W2081145901","https://openalex.org/W2093467508","https://openalex.org/W2114265064","https://openalex.org/W2118873545","https://openalex.org/W2122664645","https://openalex.org/W2122978471","https://openalex.org/W2128016549","https://openalex.org/W2134979684","https://openalex.org/W2143051140","https://openalex.org/W2164998638","https://openalex.org/W2182207230","https://openalex.org/W2412318818","https://openalex.org/W4300472050"],"related_works":["https://openalex.org/W1547132539","https://openalex.org/W2043061492","https://openalex.org/W2080155235","https://openalex.org/W2026199302","https://openalex.org/W2022458822","https://openalex.org/W2022273982","https://openalex.org/W2028679472","https://openalex.org/W2314828225","https://openalex.org/W2622371525","https://openalex.org/W1911989431"],"abstract_inverted_index":{"The":[0],"Bcl2":[1,24,48,79,111,143,163,185],"family":[2],"of":[3,11,43,47,56,59,68,92,100,115,126,142,149,175,180,184],"proteins":[4],"plays":[5],"a":[6,194],"significant":[7],"role":[8],"in":[9,28,49,110,123],"regulation":[10],"apoptosis.":[12,116],"In":[13,62],"this":[14],"study,":[15],"the":[16,54,87,127,147,153,204,225],"microtubule-damaging":[17,118],"drugs":[18,119,155],"paclitaxel,":[19],"vincristine,":[20],"and":[21,26,30,33,65,81,113,130,144,157,178,221],"vinblastine":[22],"induced":[23,40,78,166,173,197],"hyperphosphorylation":[25,80,112,139,164],"apoptosis":[27,145],"MCF-7":[29],"MDA-MB-231":[31],"cells":[32],"reduced":[34],"Bcl2-Bax":[35],"dimerization.":[36],"Paclitaxel":[37],"or":[38,171,202],"vincristine":[39,172],"increased":[41],"expression":[42],"Bax,":[44],"while":[45],"overexpression":[46],"these":[50,60],"cell":[51,128],"lines":[52],"counteracted":[53],"effects":[55],"low":[57],"doses":[58],"drugs.":[61],"addition,":[63],"paclitaxel-":[64],"vincristine-induced":[66],"activation":[67,99,174,220],"cyclic":[69],"AMP":[70],"(cAMP)-dependent":[71],"protein":[72],"kinase":[73,75,219],"(protein":[74],"A":[76],"[PKA])":[77],"apoptosis,":[82],"which":[83],"were":[84],"blocked":[85],"by":[86,198],"PKA":[88,101],"inhibitor":[89],"Rp":[90],"diastereomers":[91],"cAMP":[93],"(Rp-cAMP).":[94],"This":[95],"finding":[96],"suggests":[97],"that":[98,138,190,200,206],"due":[102],"to":[103,216,223,228],"microtubule":[104],"damage":[105,203],"is":[106,207],"an":[107],"important":[108],"event":[109],"induction":[114],"These":[117,187],"caused":[120],"growth":[121],"arrest":[122],"G2-M":[124],"phase":[125],"cycle":[129],"had":[131,159],"no":[132,160],"effect":[133,161],"on":[134,162],"p53":[135,167,211],"induction,":[136],"suggesting":[137],"mediated":[140],"inactivation":[141],"without":[146],"involvement":[148],"p53.":[150],"By":[151],"comparison,":[152],"DNA-damaging":[154],"methotrexate":[156],"doxorubicin":[158],"but":[165,213],"expression.":[168],"Interestingly,":[169],"paclitaxel":[170],"caspase":[176],"3":[177],"cleavage":[179],"poly(ADP-ribose)":[181],"polymerase":[182],"downstream":[183],"hyperphosphorylation.":[186],"data":[188],"suggest":[189],"there":[191],"may":[192],"be":[193],"signaling":[195],"cascade":[196],"agents":[199],"disrupt":[201],"cytoskeleton":[205],"distinct":[208],"from":[209],"(i.e.,":[210,217],"independent),":[212],"perhaps":[214],"related":[215],"involves":[218],"leads":[222],"apoptosis),":[224],"cellular":[226],"response":[227],"DNA":[229],"damage.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
