{"id":"https://openalex.org/W1864679293","doi":"https://doi.org/10.1517/14728222.2015.1067684","title":"Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy","display_name":"Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy","publication_year":2015,"publication_date":"2015-08-17","ids":{"openalex":"https://openalex.org/W1864679293","doi":"https://doi.org/10.1517/14728222.2015.1067684","mag":"1864679293","pmid":"https://pubmed.ncbi.nlm.nih.gov/26294111","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4640938"},"language":"en","primary_location":{"id":"doi:10.1517/14728222.2015.1067684","doi":"https://doi.org/10.1517/14728222.2015.1067684","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2015.1067684","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4640938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109069165","display_name":"Sajjadh M. J. Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sajjadh MJ Ali","raw_affiliation_strings":["a Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery , Boston, MA, USA +1 617 525 8530 ; +1 617 264 5124 ; raouf_khalil@hms.harvard.edu","+1 617 264 5124","Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery, Boston, MA, USA +1 617 525 8530"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery , Boston, MA, USA +1 617 525 8530 ; +1 617 264 5124 ; raouf_khalil@hms.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"+1 617 264 5124","institution_ids":[]},{"raw_affiliation_string":"Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery, Boston, MA, USA +1 617 525 8530","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063840461","display_name":"Raouf A. Khalil","orcid":"https://orcid.org/0000-0002-7374-1956","observed_orcids":["https://orcid.org/0000-0002-7374-1956"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raouf A Khalil","raw_affiliation_strings":["a Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery , Boston, MA, USA +1 617 525 8530 ; +1 617 264 5124 ; raouf_khalil@hms.harvard.edu","+1 617 264 5124","Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery, Boston, MA, USA +1 617 525 8530"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery , Boston, MA, USA +1 617 525 8530 ; +1 617 264 5124 ; raouf_khalil@hms.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"+1 617 264 5124","institution_ids":[]},{"raw_affiliation_string":"Brigham and Women's Hospital, Vascular Surgery Research Laboratory, Harvard Medical School, Division of Vascular and Endovascular Surgery, Boston, MA, USA +1 617 525 8530","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0177,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.69433962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"11","first_page":"1495","last_page":"1515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":1.0},{"id":"https://openalex.org/keywords/hypertension-in-pregnancy","display_name":"hypertension in pregnancy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/spiral-artery-remodeling","display_name":"spiral artery remodeling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cytotrophoblast-invasion","display_name":"cytotrophoblast invasion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/placental-ischemia","display_name":"placental ischemia","score":0.7670000195503235},{"id":"https://openalex.org/keywords/antiangiogenic-factors","display_name":"anti-angiogenic factors","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6710000038146973},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.902999997138977},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hellp-syndrome","display_name":"HELLP syndrome","score":0.7879999876022339},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.777999997138977},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/endothelium-derived-hyperpolarizing-factor","display_name":"endothelium-derived hyperpolarizing factor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8740000128746033},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.8379999995231628},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9490000009536743},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9589999914169312},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8080000281333923},{"id":"https://openalex.org/keywords/maternal-immune-response","display_name":"maternal immune response","score":0.890999972820282},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6062125563621521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5897472500801086},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5823627710342407},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5693333745002747},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5249685645103455},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.522010862827301},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.45955976843833923},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.44047489762306213},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.43423518538475037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.229261577129364},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20068204402923584},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08382049202919006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07668513059616089},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017359","descriptor_name":"HELLP Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017359","descriptor_name":"HELLP Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D046110","descriptor_name":"Hypertension, Pregnancy-Induced","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046110","descriptor_name":"Hypertension, Pregnancy-Induced","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1517/14728222.2015.1067684","doi":"https://doi.org/10.1517/14728222.2015.1067684","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2015.1067684","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},{"id":"pmid:26294111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26294111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic targets","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4640938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4640938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Opin Ther Targets","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4640938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4640938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Opin Ther Targets","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3515968036","display_name":"Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy","funder_award_id":"R03HD060702","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3554097583","display_name":"Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency","funder_award_id":"R21HL111775","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G404125967","display_name":"Role of Endothelin B Receptor in Vascular Protection in Females","funder_award_id":"R21HL098724","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8229038284","display_name":"Vascular Mechanisms in Pregnancy-Induced Hypertension","funder_award_id":"R01HL065998","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W136917416","https://openalex.org/W1732025351","https://openalex.org/W1965325969","https://openalex.org/W1965604913","https://openalex.org/W1965712768","https://openalex.org/W1966503539","https://openalex.org/W1967204365","https://openalex.org/W1968036856","https://openalex.org/W1972456226","https://openalex.org/W1982623110","https://openalex.org/W1983388032","https://openalex.org/W1984026715","https://openalex.org/W1987649372","https://openalex.org/W1993234237","https://openalex.org/W1993289582","https://openalex.org/W1995016085","https://openalex.org/W1997292511","https://openalex.org/W1998811486","https://openalex.org/W2002107019","https://openalex.org/W2002533528","https://openalex.org/W2004877730","https://openalex.org/W2005588487","https://openalex.org/W2007810215","https://openalex.org/W2013430295","https://openalex.org/W2013784872","https://openalex.org/W2013951540","https://openalex.org/W2014388753","https://openalex.org/W2020264961","https://openalex.org/W2021920246","https://openalex.org/W2023549854","https://openalex.org/W2024678567","https://openalex.org/W2028031291","https://openalex.org/W2035504487","https://openalex.org/W2035575290","https://openalex.org/W2036283983","https://openalex.org/W2039892095","https://openalex.org/W2041999129","https://openalex.org/W2042141097","https://openalex.org/W2044551154","https://openalex.org/W2047852779","https://openalex.org/W2047868879","https://openalex.org/W2051945870","https://openalex.org/W2052018751","https://openalex.org/W2053510985","https://openalex.org/W2054065836","https://openalex.org/W2056519432","https://openalex.org/W2059297577","https://openalex.org/W2064655257","https://openalex.org/W2066278927","https://openalex.org/W2070116321","https://openalex.org/W2070511288","https://openalex.org/W2075035710","https://openalex.org/W2075067207","https://openalex.org/W2087563770","https://openalex.org/W2089221056","https://openalex.org/W2091890651","https://openalex.org/W2097292741","https://openalex.org/W2102939691","https://openalex.org/W2104378956","https://openalex.org/W2105517621","https://openalex.org/W2105632053","https://openalex.org/W2106849785","https://openalex.org/W2109102843","https://openalex.org/W2116119379","https://openalex.org/W2116806083","https://openalex.org/W2119882510","https://openalex.org/W2122436530","https://openalex.org/W2123125959","https://openalex.org/W2129206669","https://openalex.org/W2131528943","https://openalex.org/W2132961242","https://openalex.org/W2133010496","https://openalex.org/W2133562580","https://openalex.org/W2134236464","https://openalex.org/W2134634254","https://openalex.org/W2135137874","https://openalex.org/W2136003807","https://openalex.org/W2138038413","https://openalex.org/W2139903829","https://openalex.org/W2140124730","https://openalex.org/W2140748581","https://openalex.org/W2142551707","https://openalex.org/W2142738186","https://openalex.org/W2143180984","https://openalex.org/W2143438629","https://openalex.org/W2144351575","https://openalex.org/W2144833935","https://openalex.org/W2145038821","https://openalex.org/W2145729033","https://openalex.org/W2146371213","https://openalex.org/W2146403616","https://openalex.org/W2147834765","https://openalex.org/W2151966945","https://openalex.org/W2153523244","https://openalex.org/W2154156678","https://openalex.org/W2158141547","https://openalex.org/W2159570527","https://openalex.org/W2159621826","https://openalex.org/W2160230584","https://openalex.org/W2164443274","https://openalex.org/W2164608636","https://openalex.org/W2165937399","https://openalex.org/W2166952082","https://openalex.org/W2190434307","https://openalex.org/W2230944006","https://openalex.org/W4211054086","https://openalex.org/W4236182870","https://openalex.org/W4244433662","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1972251421","https://openalex.org/W3048084405","https://openalex.org/W2119682545","https://openalex.org/W2035504487","https://openalex.org/W1967661660","https://openalex.org/W2499431560","https://openalex.org/W2132961242","https://openalex.org/W1964399903","https://openalex.org/W2897721164","https://openalex.org/W2040119916"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Preeclampsia":[1],"(PE)":[2],"is":[3],"a":[4,57,151],"major":[5],"complication":[6],"of":[7,22,36,53,65,85,144,180,211,238],"pregnancy":[8],"that":[9],"could":[10,108,222],"lead":[11],"to":[12,33,71,141],"maternal":[13,46],"and":[14,17,44,77,100,113,119,132,135,161,174,177,192,199,205,215,230,236],"fetal":[15],"morbidity":[16],"mortality.":[18],"The":[19],"pathophysiological":[20],"mechanisms":[21,179],"PE":[23],"are":[24],"not":[25],"completely":[26],"understood,":[27],"but":[28],"recent":[29],"research":[30],"has":[31],"begun":[32],"unravel":[34],"some":[35],"the":[37,54,68,83,142,212],"potential":[38,58,232],"mechanisms.":[39],"AREAS":[40],"COVERED:":[41],"Genetic":[42],"polymorphisms":[43],"altered":[45],"immune":[47,214],"response":[48],"may":[49,139],"cause":[50,109,202],"impaired":[51],"remodeling":[52,204],"spiral":[55],"arteries;":[56],"early":[59,228],"defect":[60],"in":[61,116,153,167,195,219],"PE.":[62,239],"Inadequate":[63],"invasion":[64],"cytotrophoblasts":[66],"into":[67],"decidua":[69],"leads":[70],"reduced":[72],"uteroplacental":[73],"perfusion":[74],"pressure":[75],"(RUPP)":[76],"placental":[78],"ischemia/hypoxia.":[79],"Placental":[80],"ischemia":[81],"causes":[82,150],"release":[84],"biologically":[86],"active":[87],"factors":[88,107,217],"such":[89,156,169,185],"as":[90,157,170,186,225,231],"anti-angiogenic":[91],"factors,":[92,99],"inflammatory":[93],"cytokines,":[94],"reactive":[95],"oxygen":[96],"species,":[97],"hypoxia-inducible":[98],"angiotensin":[101,172],"II":[102,173],"receptor":[103],"autoantibodies.":[104],"These":[105],"vasoactive":[106,216],"systemic":[110],"vascular":[111,117,148,181,203,220],"endotheliosis":[112,123,127,149,221],"consequent":[114],"increase":[115,166],"resistance":[118],"blood":[120],"pressure,":[121],"glomerular":[122],"causing":[124,128],"proteinuria,":[125],"cerebrovascular":[126],"cerebral":[129],"edema,":[130],"seizures":[131],"visual":[133],"disturbances,":[134],"hepatic":[136],"endotheliosis,":[137],"which":[138],"contribute":[140],"manifestations":[143],"HELLP":[145],"syndrome.":[146],"PE-associated":[147],"decrease":[152],"vasodilator":[154],"mediators":[155],"nitric":[158],"oxide,":[159],"prostacyclin":[160],"endothelium-derived":[162],"hyperpolarizing":[163],"factor,":[164],"an":[165],"vasoconstrictors":[168],"endothelin-1,":[171],"thromboxane":[175],"A2,":[176],"enhanced":[178],"smooth":[182],"muscle":[183],"contraction":[184],"intracellular":[187],"Ca(2+),":[188],"protein":[189],"kinase":[190],"C":[191],"Rho-kinase.":[193],"Changes":[194],"matrix":[196,201],"metalloproteinase":[197],"activity":[198],"extracellular":[200],"further":[206],"vasoconstriction.":[207],"EXPERT":[208],"OPINION:":[209],"Some":[210],"genetic,":[213],"involved":[218],"be":[223],"used":[224],"biomarkers":[226],"for":[227,234],"detection,":[229],"targets":[233],"prevention":[235],"treatment":[237]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}