{"id":"https://openalex.org/W1864637814","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.830.31","title":"Grape pomace bioactivity from Brazilian wine industry: toxicity and antioxidant properties in human hepatocarcinoma cells (830.31)","display_name":"Grape pomace bioactivity from Brazilian wine industry: toxicity and antioxidant properties in human hepatocarcinoma cells (830.31)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1864637814","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.830.31","mag":"1864637814"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.830.31","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.830.31","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.830.31","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017428835","display_name":"Tatiana El\u2010Bacha","orcid":"https://orcid.org/0000-0003-0809-0218","observed_orcids":["https://orcid.org/0000-0003-0809-0218"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tatiana El Bacha","raw_affiliation_strings":["Instituto DE Nutricao Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","3Instituto de Nutricao Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto DE Nutricao Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"3Instituto de Nutricao Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015832903","display_name":"Nathalia Sales","orcid":"https://orcid.org/0000-0003-2121-6866","observed_orcids":["https://orcid.org/0000-0003-2121-6866"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nathalia Sales","raw_affiliation_strings":["Laboratorio DE Bioquimica Nutricional e DE Alimentos Instituto DE Quimica Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","4Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio DE Bioquimica Nutricional e DE Alimentos Instituto DE Quimica Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"4Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056317500","display_name":"Daniela Alves Minuzzo","orcid":"https://orcid.org/0000-0003-2771-5914","observed_orcids":["https://orcid.org/0000-0003-2771-5914"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniela Minuzzo","raw_affiliation_strings":["Coordenacao DE Nutricao Faculdade Arthur Sa Earp Neto Rio DE Janeiro Brazil","Instituto DE Nutricao Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","3Instituto de Nutricao Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coordenacao DE Nutricao Faculdade Arthur Sa Earp Neto Rio DE Janeiro Brazil","institution_ids":[]},{"raw_affiliation_string":"Instituto DE Nutricao Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"3Instituto de Nutricao Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058337664","display_name":"Ana Paula Gil Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I199691007","display_name":"Embrapa","ror":"https://ror.org/0482b5b22","country_code":"BR","type":"government","lineage":["https://openalex.org/I199691007"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Paula Cruz","raw_affiliation_strings":["Ctaa Empresa Brasil eira DE Pesquisa Agropecuaria Rio DE Janeiro Brazil","Laboratorio DE Bioquimica Nutricional e DE Alimentos Instituto DE Quimica Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","1Ctaa Empresa Brasileira de Pesquisa Agropecuaria Rio de Janeiro Brazil","4Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ctaa Empresa Brasil eira DE Pesquisa Agropecuaria Rio DE Janeiro Brazil","institution_ids":["https://openalex.org/I199691007"]},{"raw_affiliation_string":"Laboratorio DE Bioquimica Nutricional e DE Alimentos Instituto DE Quimica Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"1Ctaa Empresa Brasileira de Pesquisa Agropecuaria Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I199691007"]},{"raw_affiliation_string":"4Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108671590","display_name":"Lourdes M.C. Cabral","orcid":"https://orcid.org/0000-0003-2513-0381","observed_orcids":["https://orcid.org/0000-0003-2513-0381"]},"institutions":[{"id":"https://openalex.org/I199691007","display_name":"Embrapa","ror":"https://ror.org/0482b5b22","country_code":"BR","type":"government","lineage":["https://openalex.org/I199691007"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lourdes Cabral","raw_affiliation_strings":["Ctaa Empresa Brasil eira DE Pesquisa Agropecuaria Rio DE Janeiro Brazil","1Ctaa Empresa Brasileira de Pesquisa Agropecuaria Rio de Janeiro Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ctaa Empresa Brasil eira DE Pesquisa Agropecuaria Rio DE Janeiro Brazil","institution_ids":["https://openalex.org/I199691007"]},{"raw_affiliation_string":"1Ctaa Empresa Brasileira de Pesquisa Agropecuaria Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I199691007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101990956","display_name":"Alexandre Guedes Torres","orcid":"https://orcid.org/0000-0002-7376-4939","observed_orcids":["https://orcid.org/0000-0002-7376-4939"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alexandre Torres","raw_affiliation_strings":["Laboratorio DE Bioquimica Nutricional e DE Alimentos Instituto DE Quimica Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","4Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio DE Bioquimica Nutricional e DE Alimentos Instituto DE Quimica Universidade Federal do Rio DE Janeiro Rio DE Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"4Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10750","display_name":"Fermentation and Sensory Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grape-pomace","display_name":"grape pomace","score":0.9940000176429749},{"id":"https://openalex.org/keywords/winemaking-by-products","display_name":"winemaking by-products","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma-cells","display_name":"hepatocellular carcinoma cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7300000190734863},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/selective-anticancer-activity","display_name":"selective anticancer activity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C35421065","wikidata":"https://www.wikidata.org/wiki/Q927202","display_name":"Pomace","level":2,"score":0.8846094012260437},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7311773896217346},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.7306644320487976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7217763662338257},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.7216930389404297},{"id":"https://openalex.org/C2781031786","wikidata":"https://www.wikidata.org/wiki/Q287582","display_name":"ABTS","level":4,"score":0.7014097571372986},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6822453141212463},{"id":"https://openalex.org/C2779964046","wikidata":"https://www.wikidata.org/wiki/Q209286","display_name":"Dichlorofluorescein","level":3,"score":0.6659647226333618},{"id":"https://openalex.org/C55952523","wikidata":"https://www.wikidata.org/wiki/Q3014419","display_name":"Wine","level":2,"score":0.5641083121299744},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5316216349601746},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5258063673973083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4216371774673462},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.2001839280128479},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14239507913589478}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.830.31","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.830.31","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.830.31","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321675","display_name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria","ror":"https://ror.org/0482b5b22"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2739019858","https://openalex.org/W2021415085","https://openalex.org/W2793316741","https://openalex.org/W646255267","https://openalex.org/W231616007","https://openalex.org/W2982037346","https://openalex.org/W7025277634","https://openalex.org/W2884392393","https://openalex.org/W3133782638","https://openalex.org/W4407059779"],"abstract_inverted_index":{"Wine":[0],"industry":[1,36,191],"produces":[2],"large":[3],"quantities":[4],"of":[5,29,44,49,101,163],"by\u2010products":[6,192],"rich":[7],"in":[8,37,128,152,175],"bioactive":[9,45],"compounds":[10,46],"from":[11,33],"grapes,":[12],"which":[13],"could":[14],"be":[15],"utilized":[16],"for":[17],"nutraceutical":[18],"purposes.":[19],"We":[20],"aim":[21],"to":[22,184],"evaluate":[23],"antioxidant":[24,83,195],"activity":[25,196],"(AC)":[26],"and":[27,47,60,68,81,92,99,112,131,141,148,165,197,201],"bioactivity":[28],"grape":[30],"pomace":[31],"extract":[32],"Brazilian":[34],"wine":[35,190],"human":[38,71],"hepatocarcinoma":[39],"cells":[40],"(HepG2).":[41],"The":[42],"content":[43],"AC":[48,117],"extracts":[50,102],"were":[51],"determined":[52],"by":[53,78,86,159,212],"ORAC,":[54],"TEAC":[55],"(ABTS":[56],"\u2022":[57],"\u2010":[58],")":[59],"TRAP":[61],"assays.":[62],"Bioactivity":[63],"was":[64,76,118,156],"assessed":[65],"on":[66,69,204],"HepG2":[67,125,176,186,205],"normal":[70],"fibroblasts":[72],"(BEAS).":[73],"Cellular":[74],"viability":[75,126,155],"accessed":[77],"MTT":[79],"reduction":[80,151],"cellular":[82],"capacity":[84],"(CAC)":[85],"dichlorofluorescein":[87],"oxidation,":[88],"under":[89],"short\u2010,":[90],"medium\u2010,":[91],"long\u2010term":[93,142],"incubation":[94,135,143,170],"periods.":[95],"Total":[96],"phenolics,":[97],"flavonoids":[98],"anthocyanins":[100],"where,":[103],"respectively,":[104,145],"(mean\u00b1SD)":[105],"473.8\u00b152.4":[106],"mg":[107,110,114],"GAE/100g,":[108],"147.5\u00b12.77":[109],"CE/100g":[111],"105.5\u00b17.27":[113],"cyanidin3\u2010glycoside/100g.":[115],"Extract":[116],"(mean\u00b1SD;":[119],"\u00b5mol":[120],"TE/g)":[121],"27.1\u00b10.33,":[122],"9.33\u00b16.74,":[123],"122.2\u00b12.40.":[124],"reduced":[127],"a":[129,146,149,172],"time\u2010":[130],"dose\u2010dependent":[132],"manner.":[133],"Short\u2010term":[134],"had":[136],"no":[137],"effect":[138],"whereas":[139],"medium\u2010":[140],"induced,":[144],"37%":[147],"75%":[150],"viability.":[153],"BEAS":[154],"not":[157],"affected":[158],"the":[160],"extract,":[161],"regardless":[162],"time":[164],"concentration":[166],"used.":[167],"Interestingly,":[168],"short\u2010term":[169],"promoted":[171],"dose\u2010response":[173],"increase":[174],"CAC,":[177],"suggesting":[178],"that":[179],"decreased":[180],"oxidative":[181],"stress":[182],"signals":[183],"decrease":[185],"proliferation.":[187],"Taken":[188],"together,":[189],"present":[193],"important":[194],"potential":[198],"selective":[199],"anticancer":[200],"antiproliferative":[202],"effects":[203],"cells.":[206],"Grant":[207],"Funding":[208],"Source":[209],":":[210],"Supported":[211],"FAPERJ,":[213],"CNPq,":[214],"CAPES,":[215],"EMBRAPA":[216],"(Brazil)":[217]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
