{"id":"https://openalex.org/W1863636479","doi":"https://doi.org/10.1242/dev.121.11.3861","title":"The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis","display_name":"The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W1863636479","doi":"https://doi.org/10.1242/dev.121.11.3861","mag":"1863636479","pmid":"https://pubmed.ncbi.nlm.nih.gov/8582295"},"language":"en","primary_location":{"id":"doi:10.1242/dev.121.11.3861","doi":"https://doi.org/10.1242/dev.121.11.3861","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.121.11.3861","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109908300","display_name":"Josef G. Heuer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josef G. Heuer","raw_affiliation_strings":["Indiana University Howard Hughes Medical Institute, and Department of Biology , , Bloomington, IN 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Howard Hughes Medical Institute, and Department of Biology , , Bloomington, IN 47405, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013340880","display_name":"Kaijun Li","orcid":"https://orcid.org/0000-0002-2422-5437","observed_orcids":["https://orcid.org/0000-0002-2422-5437","https://orcid.org/0009-0000-5677-5129"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaijun Li","raw_affiliation_strings":["Indiana University Howard Hughes Medical Institute, and Department of Biology , , Bloomington, IN 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Howard Hughes Medical Institute, and Department of Biology , , Bloomington, IN 47405, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037744823","display_name":"Thomas C. Kaufman","orcid":"https://orcid.org/0000-0003-1406-7671","observed_orcids":["https://orcid.org/0000-0003-1406-7671"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas C. Kaufman","raw_affiliation_strings":["Indiana University Howard Hughes Medical Institute, and Department of Biology , , Bloomington, IN 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Howard Hughes Medical Institute, and Department of Biology , , Bloomington, IN 47405, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3584,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.89451731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"121","issue":"11","first_page":"3861","last_page":"3876"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrosomin","display_name":"centrosomin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/homeotic-genes","display_name":"homeotic genes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/antennapedia","display_name":"Antennapedia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/centrosome","display_name":"centrosome","score":0.8999999761581421},{"id":"https://openalex.org/keywords/leucine-zipper","display_name":"leucine zipper","score":0.8339999914169312},{"id":"https://openalex.org/keywords/coiled-coil-domain","display_name":"coiled-coil domain","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ultrabithorax","display_name":"Ultrabithorax","score":0.7929999828338623},{"id":"https://openalex.org/keywords/abdominal-a","display_name":"abdominal-A","score":0.984000027179718},{"id":"https://openalex.org/keywords/visceral-mesoderm","display_name":"visceral mesoderm","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mitotic-spindle-assembly","display_name":"mitotic spindle assembly","score":0.7160000205039978},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drosophila-embryo","display_name":"Drosophila embryo","score":0.5830000042915344},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C46751350","wikidata":"https://www.wikidata.org/wiki/Q1939530","display_name":"Homeotic gene","level":4,"score":0.9122788906097412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9022315740585327},{"id":"https://openalex.org/C197564579","wikidata":"https://www.wikidata.org/wiki/Q2019281","display_name":"Ultrabithorax","level":5,"score":0.8833385705947876},{"id":"https://openalex.org/C2780172944","wikidata":"https://www.wikidata.org/wiki/Q1075029","display_name":"Antennapedia","level":5,"score":0.7555925846099854},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.6147750616073608},{"id":"https://openalex.org/C156860981","wikidata":"https://www.wikidata.org/wiki/Q2565229","display_name":"Leucine zipper","level":4,"score":0.6038271188735962},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5488378405570984},{"id":"https://openalex.org/C184937244","wikidata":"https://www.wikidata.org/wiki/Q410820","display_name":"Gap gene","level":4,"score":0.45713600516319275},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.4421805739402771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43810638785362244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4307264983654022},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3533961772918701},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2647497057914734},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.07456877827644348}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005801","descriptor_name":"Genes, Homeobox","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016350","descriptor_name":"Leucine Zippers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051943","descriptor_name":"Antennapedia Homeodomain Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.121.11.3861","doi":"https://doi.org/10.1242/dev.121.11.3861","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.121.11.3861","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:8582295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8582295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:develop:121/11/3861","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/121/11/3861","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W57133674","https://openalex.org/W146513923","https://openalex.org/W569951484","https://openalex.org/W1135216113","https://openalex.org/W1535427487","https://openalex.org/W1565800544","https://openalex.org/W1605923556","https://openalex.org/W1850470395","https://openalex.org/W1852889371","https://openalex.org/W1867994916","https://openalex.org/W1927398280","https://openalex.org/W1928879384","https://openalex.org/W1969112687","https://openalex.org/W1970271670","https://openalex.org/W1971943731","https://openalex.org/W1990137409","https://openalex.org/W1993019988","https://openalex.org/W1995112067","https://openalex.org/W1999702908","https://openalex.org/W1999932376","https://openalex.org/W2000977514","https://openalex.org/W2005393972","https://openalex.org/W2006609702","https://openalex.org/W2006788765","https://openalex.org/W2009017737","https://openalex.org/W2013683245","https://openalex.org/W2014908429","https://openalex.org/W2015913211","https://openalex.org/W2022236187","https://openalex.org/W2024645073","https://openalex.org/W2025303794","https://openalex.org/W2031781345","https://openalex.org/W2033777731","https://openalex.org/W2036725844","https://openalex.org/W2042351695","https://openalex.org/W2049780277","https://openalex.org/W2054964020","https://openalex.org/W2055290772","https://openalex.org/W2057653339","https://openalex.org/W2064251573","https://openalex.org/W2072293838","https://openalex.org/W2079628834","https://openalex.org/W2083602338","https://openalex.org/W2085610641","https://openalex.org/W2086842568","https://openalex.org/W2089545402","https://openalex.org/W2094100752","https://openalex.org/W2096867567","https://openalex.org/W2105501493","https://openalex.org/W2110643873","https://openalex.org/W2111202552","https://openalex.org/W2126892094","https://openalex.org/W2138270253","https://openalex.org/W2144634347","https://openalex.org/W2160620008","https://openalex.org/W2174019304","https://openalex.org/W2188162909","https://openalex.org/W2402353156","https://openalex.org/W2411745245","https://openalex.org/W2728956820","https://openalex.org/W2886962912","https://openalex.org/W4300448772"],"related_works":["https://openalex.org/W2058036227","https://openalex.org/W2347163430","https://openalex.org/W2205530970","https://openalex.org/W2171906885","https://openalex.org/W2151815913","https://openalex.org/W7073534930","https://openalex.org/W2028630904","https://openalex.org/W7096912642","https://openalex.org/W1971667392","https://openalex.org/W1967734956"],"abstract_inverted_index":{"The":[0,73,234],"products":[1],"of":[2,22,51,61,65,78,88,97,146,172,200,209,221,229,237,242,260],"the":[3,19,23,27,52,59,66,79,83,89,92,106,115,131,169,178,185,188,194,207,210,214,218,227,230,240,258],"homeotic":[4,31,100,112],"genes":[5,29,50,68],"in":[6,82,213,223,244,253],"Drosophila":[7],"are":[8,12,38],"transcription":[9],"factors":[10],"that":[11,33,108,177,206,224,248],"necessary":[13],"to":[14,47,168,184,193],"impose":[15],"regional":[16],"identity":[17],"along":[18],"anterior-posterior":[20],"axis":[21],"developing":[24,84],"embryo.":[25],"However,":[26],"target":[28,49,67],"under":[30],"regulation":[32],"control":[34],"this":[35,71,249],"developmental":[36],"process":[37],"largely":[39],"unknown.":[40],"We":[41,56],"have":[42],"utilized":[43],"an":[44,263],"immunopurification":[45],"method":[46],"clone":[48],"Antennapedia":[53],"protein":[54,155,181,250],"(ANTP).":[55],"present":[57],"here":[58],"characterization":[60],"centrosomin":[62],"(cnn),":[63],"one":[64],"isolated":[69],"using":[70],"approach.":[72],"spatial":[74],"and":[75,91,99,118,139,143,161,187,196,239,257],"temporal":[76],"expression":[77,208],"cnn":[80,109,133,179,211],"gene":[81,212],"visceral":[85],"mesoderm":[86],"(VM)":[87],"midgut":[90,232,245],"central":[93],"nervous":[94],"system":[95],"(CNS)":[96],"wild-type":[98],"mutant":[101],"embryos":[102],"is":[103,110,134,182,191],"consistent":[104],"with":[105,156,217,265],"idea":[107],"a":[111,147,152],"target.":[113],"In":[114,130,202],"VM,":[116],"Antp":[117,138],"abdominal-A":[119],"(abd-A)":[120],"negatively":[121,140],"regulate":[122],"cnn,":[123],"while":[124],"Ultrabithorax":[125],"(Ubx)":[126],"shows":[127],"positive":[128],"regulation.":[129],"CNS,":[132],"regulated":[135],"positively":[136],"by":[137,141],"Ubx":[142,222],"abd-A.":[144],"Characterization":[145],"cDNA":[148],"encoding":[149],"CNN":[150,238],"predicts":[151],"novel":[153],"structural":[154],"three":[157],"leucine":[158],"zipper":[159],"motifs":[160],"several":[162],"coiled-coil":[163],"domains":[164],"exhibiting":[165],"limited":[166],"homology":[167],"rod":[170],"portion":[171],"myosin.":[173],"Immunocytochemical":[174],"results":[175],"demonstrate":[176],"encoded":[180],"localized":[183],"centrosome":[186,197],"accumulation":[189],"pattern":[190],"coupled":[192],"nuclear":[195],"duplication":[198],"cycles":[199],"cleavage.":[201],"addition,":[203],"evidence":[204],"suggests":[205],"VM":[215],"correlates":[216],"morphogenetic":[219],"function":[220],"tissue,":[225],"i.e.,":[226],"formation":[228],"second":[231],"construction.":[233],"centrosomal":[235],"localization":[236],"involvement":[241],"microtubules":[243],"morphogenesis":[246,261],"suggest":[247],"may":[251],"participate":[252],"mitotic":[254],"spindle":[255],"assembly":[256],"mechanics":[259],"through":[262],"interaction":[264],"microtubules,":[266],"either":[267],"directly":[268],"or":[269],"indirectly.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}