{"id":"https://openalex.org/W1863196444","doi":"https://doi.org/10.20882/adicciones.236","title":"\u00bfExiste envejecimiento precoz entre los consumidores de drogas de abuso?","display_name":"\u00bfExiste envejecimiento precoz entre los consumidores de drogas de abuso?","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W1863196444","doi":"https://doi.org/10.20882/adicciones.236","mag":"1863196444","pmid":"https://pubmed.ncbi.nlm.nih.gov/19578726"},"language":"es","primary_location":{"id":"doi:10.20882/adicciones.236","doi":"https://doi.org/10.20882/adicciones.236","is_oa":true,"landing_page_url":"https://doi.org/10.20882/adicciones.236","pdf_url":"https://www.adicciones.es/index.php/adicciones/article/download/236/227","source":{"id":"https://openalex.org/S174685111","display_name":"Adicciones","issn_l":"0214-4840","issn":["0214-4840","2604-6334"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adicciones","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.adicciones.es/index.php/adicciones/article/download/236/227","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026062012","display_name":"F\u00e9lix Dias Carvalho","orcid":"https://orcid.org/0000-0003-3858-3494","observed_orcids":["https://orcid.org/0000-0003-3858-3494"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"F\u00e9lix Carvalho","raw_affiliation_strings":["REQUIMTE. Departmento de Toxicolog\u00eda. Facultad de Farm\u00e1cia. Universidad de Porto.\r\n\r\nEnviar correspondencia a:\r\n\r\nFelix Carvalho. \r\nREQUIMTE. Departmento de Toxicologia. Facultad de Farm\u00e1cia. Universidad de Porto. Rua An\u00edbal Cunha, 164, 4030-099 Porto, Portugal","Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REQUIMTE. Departmento de Toxicolog\u00eda. Facultad de Farm\u00e1cia. Universidad de Porto.\r\n\r\nEnviar correspondencia a:\r\n\r\nFelix Carvalho. \r\nREQUIMTE. Departmento de Toxicologia. Facultad de Farm\u00e1cia. Universidad de Porto. Rua An\u00edbal Cunha, 164, 4030-099 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]},{"raw_affiliation_string":"Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026062012"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"2","first_page":"99","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.07959999889135361,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.7609999775886536},{"id":"https://openalex.org/keywords/drugs-of-abuse","display_name":"drugs of abuse","score":0.7670000195503235},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mitochondrial-dna-damage","display_name":"mitochondrial DNA damage","score":0.9430000185966492},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lipofuscin-deposition","display_name":"lipofuscin deposition","score":0.8370000123977661},{"id":"https://openalex.org/keywords/stem-and-progenitor-cells","display_name":"stem/progenitor cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ecstasy","display_name":"ecstasy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/opiates","display_name":"opiates","score":0.9490000009536743},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.9190000295639038},{"id":"https://openalex.org/keywords/chronic-alcohol-consumption","display_name":"chronic alcohol consumption","score":0.9350000023841858},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C186198217","wikidata":"https://www.wikidata.org/wiki/Q217740","display_name":"Lipofuscin","level":2,"score":0.7527387142181396},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7317935228347778},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.593123733997345},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5687487125396729},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5620614886283875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5616487264633179},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5526099801063538},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5243573188781738},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4834743142127991},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.464470773935318},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.44934380054473877},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.4272485375404358},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4253704845905304},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3723084032535553},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24074095487594604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2206389605998993},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.20623022317886353},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20170047879219055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19437065720558167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18023738265037537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11247807741165161},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.20882/adicciones.236","doi":"https://doi.org/10.20882/adicciones.236","is_oa":true,"landing_page_url":"https://doi.org/10.20882/adicciones.236","pdf_url":"https://www.adicciones.es/index.php/adicciones/article/download/236/227","source":{"id":"https://openalex.org/S174685111","display_name":"Adicciones","issn_l":"0214-4840","issn":["0214-4840","2604-6334"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adicciones","raw_type":"journal-article"},{"id":"pmid:19578726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19578726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adicciones","raw_type":"Editorial"},{"id":"pmh:oai:redalyc.org:289122894001","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=289122894001","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adicciones (Espa\u00f1a) Num.2 Vol.21","raw_type":"editorial"},{"id":"mag:2335832932","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Felix_Carvalho/publication/28300255_Existe_envejecimiento_precoz_entre_los_consumidores_de_drogas_de_abuso/links/0deec5277c7e50327f000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.20882/adicciones.236","doi":"https://doi.org/10.20882/adicciones.236","is_oa":true,"landing_page_url":"https://doi.org/10.20882/adicciones.236","pdf_url":"https://www.adicciones.es/index.php/adicciones/article/download/236/227","source":{"id":"https://openalex.org/S174685111","display_name":"Adicciones","issn_l":"0214-4840","issn":["0214-4840","2604-6334"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adicciones","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1863196444.pdf","grobid_xml":"https://content.openalex.org/works/W1863196444.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W267892546","https://openalex.org/W1570708643","https://openalex.org/W1929610482","https://openalex.org/W1969080189","https://openalex.org/W1982617903","https://openalex.org/W1989150603","https://openalex.org/W1997829966","https://openalex.org/W2009607822","https://openalex.org/W2022572059","https://openalex.org/W2023896845","https://openalex.org/W2041467474","https://openalex.org/W2043694902","https://openalex.org/W2044795737","https://openalex.org/W2048841731","https://openalex.org/W2052659766","https://openalex.org/W2057484845","https://openalex.org/W2060940195","https://openalex.org/W2062042157","https://openalex.org/W2066630518","https://openalex.org/W2067477189","https://openalex.org/W2073068789","https://openalex.org/W2085396235","https://openalex.org/W2087326566","https://openalex.org/W2113265718","https://openalex.org/W2121686982","https://openalex.org/W2123759970","https://openalex.org/W2139780545","https://openalex.org/W2141636993","https://openalex.org/W2151436477","https://openalex.org/W2153406990","https://openalex.org/W2163320407","https://openalex.org/W2166284137","https://openalex.org/W2166346862","https://openalex.org/W2190831815","https://openalex.org/W2402242772"],"related_works":["https://openalex.org/W1970827931","https://openalex.org/W2298991168","https://openalex.org/W2020131275","https://openalex.org/W7100106256","https://openalex.org/W2006555556","https://openalex.org/W1963672147","https://openalex.org/W2806150111","https://openalex.org/W4283515046","https://openalex.org/W7217490596","https://openalex.org/W2802749243"],"abstract_inverted_index":{"The":[0,67],"aging":[1,77,227],"or":[2],"senescence":[3,125,222],"process":[4],"that":[5,50,150],"follows":[6],"maturation":[7],"is":[8,40,55,92],"characterized":[9],"by":[10,79,164,174],"time-related":[11],"functional":[12],"decline":[13],"due":[14],"to":[15,31,43,75,123,137,231],"genetic,":[16],"biochemical,":[17],"physiological":[18],"and":[19,24,38,65,83,85,133,153,190,211,238],"anatomical":[20],"degeneration":[21],"in":[22,35,57,114,128,140,188,204,245],"tissues":[23],"organ":[25],"systems":[26],"with":[27,62],"time.":[28],"Oxidative":[29],"damage":[30,54],"mitochondrial":[32],"DNA":[33],"(mtDNA)":[34],"the":[36,58,76,93,129,158,162,166,176,199,209,214,232,246],"heart":[37,191],"brain":[39,141,206],"inversely":[41],"related":[42],"maximum":[44],"life":[45],"span":[46],"of":[47,52,69,96,118,161,168,170,179,201,213,216,218,235],"mammals,":[48],"suggesting":[49],"accumulation":[51],"mtDNA":[53],"involved":[56],"various":[59],"disorders":[60],"associated":[61],"aging,":[63],"cancer":[64],"neurodegeneration.":[66],"suppression":[68],"stem/progenitor":[70,144],"cell":[71],"proliferation":[72,169],"also":[73],"contributes":[74],"process,":[78],"reducing":[80,87],"tissue":[81],"regeneration":[82],"repair":[84],"ultimately":[86,109],"longevity.":[88],"Another":[89],"important":[90],"factor":[91],"intracellular":[94],"deposition":[95,187],"lipofuscin":[97,186],"granules":[98],"(age":[99],"pigment),":[100],"a":[101,241],"non-degradable":[102],"polymeric":[103],"material":[104],"accumulated":[105],"within":[106],"lysosomes,":[107],"which":[108],"exacerbate":[110],"oxidative":[111],"stress":[112],"levels":[113],"senescent":[115],"cells.":[116,192],"Drugs":[117],"abuse":[119,219],"can":[120],"strongly":[121],"contribute":[122],"these":[124,202,225],"accelerating":[126,205],"factors":[127],"brain.":[130],"Methylenedioxymethamphetamine":[131],"('ecstasy')":[132],"methamphetamine":[134],"were":[135],"shown":[136,149],"promote":[138],"deletions":[139],"mtDNA.":[142],"Concerning":[143],"cells,":[145],"it":[146],"has":[147],"been":[148],"several":[151],"opiates":[152],"psychostimulants,":[154],"including":[155],"ecstasy,":[156],"decrease":[157],"self-renewal":[159],"capacity":[160],"hippocampus":[163],"diminishing":[165],"rate":[167],"neural":[171,180],"progenitors":[172],"and/or":[173],"impairing":[175],"long-term":[177],"survival":[178],"precursors.":[181],"Chronic":[182],"alcohol":[183],"consumption":[184],"induces":[185],"neurons":[189],"These":[193],"facts":[194],"provide":[195],"interesting":[196],"hints":[197],"on":[198],"potential":[200],"drugs":[203,217],"senescence.":[207],"While":[208],"extent":[210],"severity":[212],"contribution":[215],"for":[220],"accelerated":[221],"remain":[223],"uncertain,":[224],"putative":[226],"effects":[228],"add":[229],"up":[230],"dark":[233],"side":[234],"drug":[236],"addiction":[237],"undoubtedly":[239],"require":[240],"strong":[242],"research":[243],"effort":[244],"near":[247],"future.":[248]},"counts_by_year":[{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
