{"id":"https://openalex.org/W1861853271","doi":null,"title":"The potential pathogenicity of Dolosigranulum pigrum in multiple sclerosis, and the occurrence of the organism in the upper respiratory tract","display_name":"The potential pathogenicity of Dolosigranulum pigrum in multiple sclerosis, and the occurrence of the organism in the upper respiratory tract","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1861853271","mag":"1861853271"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:33034","doi":null,"is_oa":false,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049764905","display_name":"Francis Mark Jorge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Francis Mark Jorge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049764905"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dolosigranulum-pigrum","display_name":"Dolosigranulum pigrum","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/upper-respiratory-tract","display_name":"upper respiratory tract","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nasopharynx","display_name":"nasopharynx","score":0.8180000185966492},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.43799999356269836},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pathogenicity","display_name":"pathogenicity","score":0.5210000276565552},{"id":"https://openalex.org/keywords/pcr-detection","display_name":"PCR detection","score":0.4830000102519989},{"id":"https://openalex.org/keywords/elisa","display_name":"ELISA","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8753496408462524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5777180194854736},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5500643253326416},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.5357068777084351},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4711757302284241},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4315834939479828},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3166542053222656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.304101824760437},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08634424209594727}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:33034","doi":null,"is_oa":false,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/33034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:1861853271","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617934","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":228,"referenced_works":["https://openalex.org/W52273774","https://openalex.org/W111436969","https://openalex.org/W397168879","https://openalex.org/W1485179699","https://openalex.org/W1526603781","https://openalex.org/W1549162736","https://openalex.org/W1551091299","https://openalex.org/W1581145233","https://openalex.org/W1583234779","https://openalex.org/W1590438197","https://openalex.org/W1596760026","https://openalex.org/W1611703640","https://openalex.org/W1775175557","https://openalex.org/W1781678203","https://openalex.org/W1890407939","https://openalex.org/W1894225655","https://openalex.org/W1896670249","https://openalex.org/W1904815041","https://openalex.org/W1936737016","https://openalex.org/W1954174443","https://openalex.org/W1964260826","https://openalex.org/W1968456700","https://openalex.org/W1968618666","https://openalex.org/W1972120975","https://openalex.org/W1972594723","https://openalex.org/W1974533768","https://openalex.org/W1975434091","https://openalex.org/W1975538431","https://openalex.org/W1975812849","https://openalex.org/W1979349368","https://openalex.org/W1980921054","https://openalex.org/W1981489624","https://openalex.org/W1981522055","https://openalex.org/W1982029510","https://openalex.org/W1987057401","https://openalex.org/W1989932903","https://openalex.org/W1990120347","https://openalex.org/W1990227775","https://openalex.org/W1990923564","https://openalex.org/W1991204721","https://openalex.org/W1991594214","https://openalex.org/W1994362998","https://openalex.org/W1994469616","https://openalex.org/W1994712122","https://openalex.org/W1998145603","https://openalex.org/W1998258994","https://openalex.org/W1998436005","https://openalex.org/W1998556087","https://openalex.org/W2000485891","https://openalex.org/W2002265763","https://openalex.org/W2003541887","https://openalex.org/W2003670088","https://openalex.org/W2006859741","https://openalex.org/W2007785782","https://openalex.org/W2010256293","https://openalex.org/W2011198421","https://openalex.org/W2012398968","https://openalex.org/W2013808146","https://openalex.org/W2014427579","https://openalex.org/W2016381472","https://openalex.org/W2017702837","https://openalex.org/W2018027744","https://openalex.org/W2018104302","https://openalex.org/W2018938372","https://openalex.org/W2021493191","https://openalex.org/W2030095751","https://openalex.org/W2030667631","https://openalex.org/W2031267349","https://openalex.org/W2031656722","https://openalex.org/W2032009229","https://openalex.org/W2032515410","https://openalex.org/W2034491265","https://openalex.org/W2035103102","https://openalex.org/W2035744157","https://openalex.org/W2037341192","https://openalex.org/W2037939989","https://openalex.org/W2039479870","https://openalex.org/W2041053334","https://openalex.org/W2041535834","https://openalex.org/W2041929026","https://openalex.org/W2042871262","https://openalex.org/W2043204993","https://openalex.org/W2043214444","https://openalex.org/W2047316494","https://openalex.org/W2048269796","https://openalex.org/W2048285059","https://openalex.org/W2048479283","https://openalex.org/W2049548074","https://openalex.org/W2050167321","https://openalex.org/W2051004675","https://openalex.org/W2052026518","https://openalex.org/W2053019087","https://openalex.org/W2053816424","https://openalex.org/W2055553707","https://openalex.org/W2055789745","https://openalex.org/W2055912129","https://openalex.org/W2055995510","https://openalex.org/W2056010835","https://openalex.org/W2056356293","https://openalex.org/W2058065040","https://openalex.org/W2058576452","https://openalex.org/W2059079850","https://openalex.org/W2059266047","https://openalex.org/W2060123690","https://openalex.org/W2061213993","https://openalex.org/W2062658585","https://openalex.org/W2065375309","https://openalex.org/W2066040421","https://openalex.org/W2067633002","https://openalex.org/W2068418613","https://openalex.org/W2070123947","https://openalex.org/W2072214162","https://openalex.org/W2073162546","https://openalex.org/W2073669156","https://openalex.org/W2075112416","https://openalex.org/W2077720065","https://openalex.org/W2079580539","https://openalex.org/W2080123065","https://openalex.org/W2080855922","https://openalex.org/W2081210074","https://openalex.org/W2081632246","https://openalex.org/W2082950857","https://openalex.org/W2085106089","https://openalex.org/W2085412596","https://openalex.org/W2085937163","https://openalex.org/W2087635386","https://openalex.org/W2090297349","https://openalex.org/W2090856267","https://openalex.org/W2092404255","https://openalex.org/W2093240670","https://openalex.org/W2093439715","https://openalex.org/W2093632199","https://openalex.org/W2093942918","https://openalex.org/W2094336084","https://openalex.org/W2096511107","https://openalex.org/W2097232765","https://openalex.org/W2098519100","https://openalex.org/W2100845224","https://openalex.org/W2103279952","https://openalex.org/W2103406482","https://openalex.org/W2104369359","https://openalex.org/W2105139740","https://openalex.org/W2105421015","https://openalex.org/W2105442968","https://openalex.org/W2106326935","https://openalex.org/W2107356037","https://openalex.org/W2107426014","https://openalex.org/W2108059723","https://openalex.org/W2108291169","https://openalex.org/W2108957625","https://openalex.org/W2109684840","https://openalex.org/W2111113492","https://openalex.org/W2111700032","https://openalex.org/W2111891338","https://openalex.org/W2113716753","https://openalex.org/W2114955576","https://openalex.org/W2115773278","https://openalex.org/W2118913849","https://openalex.org/W2120238028","https://openalex.org/W2125883938","https://openalex.org/W2125996621","https://openalex.org/W2126643108","https://openalex.org/W2127413215","https://openalex.org/W2127570658","https://openalex.org/W2127820117","https://openalex.org/W2128220462","https://openalex.org/W2129812336","https://openalex.org/W2130183563","https://openalex.org/W2131784472","https://openalex.org/W2132456042","https://openalex.org/W2133489776","https://openalex.org/W2133911870","https://openalex.org/W2135149767","https://openalex.org/W2135564638","https://openalex.org/W2137086934","https://openalex.org/W2137295250","https://openalex.org/W2137350492","https://openalex.org/W2142760583","https://openalex.org/W2143107875","https://openalex.org/W2143706002","https://openalex.org/W2143782983","https://openalex.org/W2144106665","https://openalex.org/W2145553005","https://openalex.org/W2146802311","https://openalex.org/W2147062889","https://openalex.org/W2148014160","https://openalex.org/W2148670577","https://openalex.org/W2148959055","https://openalex.org/W2151311876","https://openalex.org/W2151363203","https://openalex.org/W2151469181","https://openalex.org/W2152289084","https://openalex.org/W2152919759","https://openalex.org/W2154114156","https://openalex.org/W2155957284","https://openalex.org/W2156481229","https://openalex.org/W2157339124","https://openalex.org/W2158611477","https://openalex.org/W2160943182","https://openalex.org/W2161618867","https://openalex.org/W2161929126","https://openalex.org/W2163277460","https://openalex.org/W2166785990","https://openalex.org/W2170663446","https://openalex.org/W2186343893","https://openalex.org/W2262524567","https://openalex.org/W2268715814","https://openalex.org/W2288234740","https://openalex.org/W2292698209","https://openalex.org/W2313550510","https://openalex.org/W2322278951","https://openalex.org/W2333915866","https://openalex.org/W2335501583","https://openalex.org/W2335836975","https://openalex.org/W2411140402","https://openalex.org/W2411682561","https://openalex.org/W2413950438","https://openalex.org/W2414773468","https://openalex.org/W2416244342","https://openalex.org/W2416476156","https://openalex.org/W2506537925","https://openalex.org/W2552733521","https://openalex.org/W2590687738","https://openalex.org/W2767905780","https://openalex.org/W2946843107","https://openalex.org/W2952388773","https://openalex.org/W3022172768","https://openalex.org/W3166935891"],"related_works":["https://openalex.org/W2806826091","https://openalex.org/W1702382615","https://openalex.org/W4237102572","https://openalex.org/W2124850757","https://openalex.org/W6980193255","https://openalex.org/W2017655996","https://openalex.org/W2128732666","https://openalex.org/W152470852","https://openalex.org/W2098519100","https://openalex.org/W2415419433"],"abstract_inverted_index":{"The":[0,172,226],"bacterial":[1,9,243,292],"toxins":[2,10],"hypothesis":[3],"in":[4,23,31,46,67,222,259],"multiple":[5,33,59,68,154,173,190],"sclerosis":[6,34,60,69,155,174,191],"postulates":[7],"that":[8,217],"from":[11,124,246],"the":[12,16,24,42,52,65,182,189,223,247,251,260,269,276,295,300],"human":[13,47],"nasopharynx":[14],"access":[15],"central":[17,252,277,296],"nervous":[18,253,278,297],"system":[19,279,298],"and":[20,50,58,71,84,91,143,157,193],"are":[21],"implicated":[22],"disease.":[25],"Dolosigranulum":[26,55,98,100,137,149,211,218],"pigrum":[27,56,89,101,164,219,235],"was":[28,102],"originally":[29],"found":[30,45,221,231],"acute":[32],"tissues.":[35],"This":[36],"study":[37,215],"seeks":[38],"to":[39,64,127,181,210,232],"determine":[40],"if":[41],"organism":[43],"is":[44,220,263],"nasal":[48,224,248,261,270],"tracts":[49],"explores":[51],"relationship":[53],"between":[54],"infection":[57],"by":[61,280,290],"measuring":[62],"antibody":[63],"bacterium":[66],"patients":[70],"matched":[72,136,158],"controls.":[73],"\\n":[74,151,213],"\\nEighty":[75],"eight":[76],"clinical":[77],"specimens":[78],"were":[79,131,160,195,199,229],"cultured":[80],"onto":[81],"blood":[82,301],"agar":[83],"analysed":[85],"using":[86,105,165],"rabbit":[87,206],"anti-Dolosigranulum":[88,163,234],"sera,":[90],"fluorescein":[92],"isothiocyanate.":[93],"None":[94],"tested":[95,114,161],"positive":[96],"for":[97,104,133,162],"pigrum.":[99,150,212],"looked":[103],"a":[106,166,288],"novel":[107,167],"polymerase":[108],"chain":[109],"reaction":[110],"test.":[111],"Thirty":[112],"samples":[113],"positive,":[115],"17":[116],"male,":[117],"13":[118],"female,":[119],"with":[120,205,272],"an":[121],"age":[122],"range":[123],"8":[125],"days":[126],"74":[128],"years.":[129],"Twelve":[130],"sent":[132],"sequencing,":[134],"seven":[135],"pigrum,":[138],"two":[139],"showed":[140,176],"mixed":[141],"amplicons":[142],"three":[144],"produced":[145],"signals":[146],"not":[147,230],"matching":[148],"\\nSixty":[152],"five":[153],"sera":[156,192,207],"controls":[159,194],"enzyme":[168],"linked":[169],"immunosorbant":[170],"assay.":[171],"group":[175],"raised":[177],"antibodies,":[178],"significantly":[179],"different":[180],"controls,":[183],"p":[184],"\u2264":[185],"0.001.":[186],"Fifteen":[187],"of":[188,242,266,287],"Western":[196],"blotted.":[197],"There":[198],"no":[200],"common":[201],"bands":[202],"when":[203],"compared":[204],"containing":[208],"antibodies":[209,228],"\\nThis":[214],"shows":[216],"tract.":[225],"elevated":[227],"be":[233,240],"but":[236],"their":[237],"presence":[238],"may":[239],"suggestive":[241],"products":[244],"leaking":[245],"tract":[249,262],"into":[250,257,268,275],"system.":[254],"Further":[255],"research":[256],"bacteria":[258],"indicated.":[264],"Introduction":[265],"markers":[267],"passages":[271],"subsequent":[273],"tracking":[274],"magnetic":[281],"resonance":[282],"imaging":[283],"could":[284],"provide":[285],"evidence":[286],"route":[289],"which":[291],"molecules":[293],"enter":[294],"\u201ebehind\u201f":[299],"brain":[302],"barrier.":[303]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}