{"id":"https://openalex.org/W1861001175","doi":"https://doi.org/10.1007/978-1-4419-1145-2_8","title":"APC and Its Modifiers in Colon Cancer","display_name":"APC and Its Modifiers in Colon Cancer","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1861001175","doi":"https://doi.org/10.1007/978-1-4419-1145-2_8","mag":"1861001175","pmid":"https://pubmed.ncbi.nlm.nih.gov/19928355","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3754875"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4419-1145-2_8","doi":"https://doi.org/10.1007/978-1-4419-1145-2_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4419-1145-2_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4250500390","display_name":"APC Proteins"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3754875","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040776645","display_name":"Lawrence N. Kwong","orcid":"https://orcid.org/0000-0001-8370-1432","observed_orcids":["https://orcid.org/0000-0001-8370-1432"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence N. Kwong","raw_affiliation_strings":["McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066873279","display_name":"William F. Dove","orcid":"https://orcid.org/0000-0002-8666-6895","observed_orcids":["https://orcid.org/0000-0002-8666-6895"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William F. Dove","raw_affiliation_strings":["McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, Wisconsin, 53706, USA","University of Wisconsin \u2013,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, Wisconsin, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin \u2013,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066873279"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":102.055,"has_fulltext":false,"cited_by_count":253,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"656","issue":null,"first_page":"85","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apc-gene","display_name":"APC gene","score":0.9750000238418579},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/modifier-genes","display_name":"genetic modifiers","score":0.8529999852180481},{"id":"https://openalex.org/keywords/colon-carcinogenesis","display_name":"colon carcinogenesis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/gatekeeper-genes","display_name":"gatekeeper genes","score":0.6890000104904175},{"id":"https://openalex.org/keywords/epigenetic-factors","display_name":"epigenetic factors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sporadic-colon-cancer","display_name":"sporadic colon cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.7087175846099854},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6828681230545044},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.670751690864563},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6403945088386536},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6113083362579346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6080577969551086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5619255304336548},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5516324639320374},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5078414082527161},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.5070576667785645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4767897129058838},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4733312726020813},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.44030827283859253},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43824535608291626},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.2209835648536682}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011125","descriptor_name":"Adenomatous Polyposis Coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011125","descriptor_name":"Adenomatous Polyposis Coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/978-1-4419-1145-2_8","doi":"https://doi.org/10.1007/978-1-4419-1145-2_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4419-1145-2_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:19928355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19928355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2745232","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3754875","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3754875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3754875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Exp Med Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.460.4078","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.460.4078","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcardle.wisc.edu/dove/pdfs/Kwong%26Dove.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2745232","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3754875","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G474722314","display_name":"Analyses of Progression to Colon Cancer in a Spectrum of Pathways","funder_award_id":"R01CA063677","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8042123731","display_name":"GENES CONTROLLING NEOPLASIA OF THE INTESTINAL EPITHELIUM","funder_award_id":"R37CA063677","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":175,"referenced_works":["https://openalex.org/W19923603","https://openalex.org/W1483245334","https://openalex.org/W1490298078","https://openalex.org/W1491870867","https://openalex.org/W1502674903","https://openalex.org/W1521791862","https://openalex.org/W1522566189","https://openalex.org/W1540164258","https://openalex.org/W1542104665","https://openalex.org/W1544046482","https://openalex.org/W1547512371","https://openalex.org/W1557349380","https://openalex.org/W1569406536","https://openalex.org/W1573420507","https://openalex.org/W1586223989","https://openalex.org/W1604222256","https://openalex.org/W1795996302","https://openalex.org/W1822129150","https://openalex.org/W1832014025","https://openalex.org/W1846418786","https://openalex.org/W1951715975","https://openalex.org/W1963592300","https://openalex.org/W1963629394","https://openalex.org/W1964589415","https://openalex.org/W1965281877","https://openalex.org/W1967243795","https://openalex.org/W1968407767","https://openalex.org/W1975993620","https://openalex.org/W1976388047","https://openalex.org/W1979618971","https://openalex.org/W1984353621","https://openalex.org/W1987107448","https://openalex.org/W1987952488","https://openalex.org/W1989970624","https://openalex.org/W1989976890","https://openalex.org/W1990557296","https://openalex.org/W1990606472","https://openalex.org/W1993743405","https://openalex.org/W1994418525","https://openalex.org/W1996302902","https://openalex.org/W1996982933","https://openalex.org/W1997937385","https://openalex.org/W1999316583","https://openalex.org/W2000130011","https://openalex.org/W2001949247","https://openalex.org/W2003930763","https://openalex.org/W2003946492","https://openalex.org/W2004499736","https://openalex.org/W2005900617","https://openalex.org/W2006874765","https://openalex.org/W2007364588","https://openalex.org/W2009024472","https://openalex.org/W2009886857","https://openalex.org/W2012385890","https://openalex.org/W2013306879","https://openalex.org/W2016513155","https://openalex.org/W2016634986","https://openalex.org/W2016988907","https://openalex.org/W2017104522","https://openalex.org/W2017937615","https://openalex.org/W2019499262","https://openalex.org/W2021066935","https://openalex.org/W2023321396","https://openalex.org/W2023427658","https://openalex.org/W2023649138","https://openalex.org/W2024349625","https://openalex.org/W2027189086","https://openalex.org/W2029231546","https://openalex.org/W2032067540","https://openalex.org/W2032280075","https://openalex.org/W2040194964","https://openalex.org/W2043944220","https://openalex.org/W2044798039","https://openalex.org/W2045749216","https://openalex.org/W2045927984","https://openalex.org/W2046788126","https://openalex.org/W2047694154","https://openalex.org/W2048988574","https://openalex.org/W2050154250","https://openalex.org/W2051055358","https://openalex.org/W2051931874","https://openalex.org/W2052870426","https://openalex.org/W2057830803","https://openalex.org/W2058043554","https://openalex.org/W2058403714","https://openalex.org/W2058703787","https://openalex.org/W2058743114","https://openalex.org/W2059492365","https://openalex.org/W2059813946","https://openalex.org/W2063197030","https://openalex.org/W2065423665","https://openalex.org/W2070168194","https://openalex.org/W2077269424","https://openalex.org/W2077366285","https://openalex.org/W2079657878","https://openalex.org/W2080506450","https://openalex.org/W2081758458","https://openalex.org/W2081907510","https://openalex.org/W2082387343","https://openalex.org/W2083636455","https://openalex.org/W2086532836","https://openalex.org/W2086990938","https://openalex.org/W2090090000","https://openalex.org/W2090863421","https://openalex.org/W2091747965","https://openalex.org/W2092988685","https://openalex.org/W2093187453","https://openalex.org/W2093570357","https://openalex.org/W2095327320","https://openalex.org/W2098475463","https://openalex.org/W2099005238","https://openalex.org/W2101022917","https://openalex.org/W2101214780","https://openalex.org/W2102085111","https://openalex.org/W2104764813","https://openalex.org/W2105245421","https://openalex.org/W2105473706","https://openalex.org/W2106202652","https://openalex.org/W2106253081","https://openalex.org/W2111567865","https://openalex.org/W2113921159","https://openalex.org/W2114913050","https://openalex.org/W2116431617","https://openalex.org/W2116994536","https://openalex.org/W2120921989","https://openalex.org/W2124387047","https://openalex.org/W2128955543","https://openalex.org/W2132222969","https://openalex.org/W2132349680","https://openalex.org/W2134359750","https://openalex.org/W2135715423","https://openalex.org/W2135854450","https://openalex.org/W2135900256","https://openalex.org/W2136449953","https://openalex.org/W2144066537","https://openalex.org/W2144434262","https://openalex.org/W2146949992","https://openalex.org/W2148018436","https://openalex.org/W2149022033","https://openalex.org/W2149386947","https://openalex.org/W2151150093","https://openalex.org/W2151928111","https://openalex.org/W2151983468","https://openalex.org/W2152515299","https://openalex.org/W2152660706","https://openalex.org/W2153382986","https://openalex.org/W2154387988","https://openalex.org/W2155397038","https://openalex.org/W2156293064","https://openalex.org/W2159084559","https://openalex.org/W2159954049","https://openalex.org/W2160169458","https://openalex.org/W2160267143","https://openalex.org/W2161884297","https://openalex.org/W2162102504","https://openalex.org/W2164139230","https://openalex.org/W2164270033","https://openalex.org/W2165011473","https://openalex.org/W2165257757","https://openalex.org/W2166030420","https://openalex.org/W2167290154","https://openalex.org/W2167650288","https://openalex.org/W2170625681","https://openalex.org/W2170792150","https://openalex.org/W2171971082","https://openalex.org/W2171974881","https://openalex.org/W2186242595","https://openalex.org/W2269922395","https://openalex.org/W2313793103","https://openalex.org/W2320622343","https://openalex.org/W2331426494","https://openalex.org/W2333059281","https://openalex.org/W4235667501","https://openalex.org/W4238842369","https://openalex.org/W7073766583"],"related_works":["https://openalex.org/W2031100160","https://openalex.org/W2031618765","https://openalex.org/W1528159763","https://openalex.org/W2023153607","https://openalex.org/W2081550264","https://openalex.org/W245859475","https://openalex.org/W2037455340","https://openalex.org/W2405946304","https://openalex.org/W2167109216","https://openalex.org/W1579515133"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}