{"id":"https://openalex.org/W1860601694","doi":"https://doi.org/10.1242/dev.104.2.331","title":"Heat shock causes repeated segmental anomalies in the chick embryo","display_name":"Heat shock causes repeated segmental anomalies in the chick embryo","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W1860601694","doi":"https://doi.org/10.1242/dev.104.2.331","mag":"1860601694","pmid":"https://pubmed.ncbi.nlm.nih.gov/3254821"},"language":"en","primary_location":{"id":"doi:10.1242/dev.104.2.331","doi":"https://doi.org/10.1242/dev.104.2.331","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.104.2.331","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109942249","display_name":"Dennis R. N. Primmett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. R. N. Primmett","raw_affiliation_strings":["1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041431345","display_name":"Claudio D. Stern","orcid":"https://orcid.org/0000-0002-9907-889X","observed_orcids":["https://orcid.org/0000-0002-9907-889X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. D. Stern","raw_affiliation_strings":["1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Human Anatomy, South Parks Road, Oxford 0X1 3QX, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042802022","display_name":"Roger J. Keynes","orcid":"https://orcid.org/0000-0002-1557-7684","observed_orcids":["https://orcid.org/0000-0002-1557-7684"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. J. Keynes","raw_affiliation_strings":["2 Department of Anatomy, Downing Street, Cambridge CB2 3 DY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Anatomy, Downing Street, Cambridge CB2 3 DY, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0238,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.74555309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"104","issue":"2","first_page":"331","last_page":"339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.8769999742507935},{"id":"https://openalex.org/keywords/somite-segmentation","display_name":"somite segmentation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/clock-and-wavefront-model","display_name":"clock and wavefront model","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cellular-clock","display_name":"cellular clock","score":0.8970000147819519},{"id":"https://openalex.org/keywords/sclerotome","display_name":"sclerotome","score":0.7620000243186951},{"id":"https://openalex.org/keywords/somite-patterning","display_name":"somite patterning","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9323292970657349},{"id":"https://openalex.org/C2779018604","wikidata":"https://www.wikidata.org/wiki/Q1427600","display_name":"Somite","level":4,"score":0.8543258905410767},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6123012900352478},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5841356515884399},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5482507348060608},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.47134822607040405},{"id":"https://openalex.org/C16693951","wikidata":"https://www.wikidata.org/wiki/Q3489847","display_name":"Somitogenesis","level":5,"score":0.45049065351486206},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42019107937812805},{"id":"https://openalex.org/C2781012678","wikidata":"https://www.wikidata.org/wiki/Q482853","display_name":"Vertebral column","level":2,"score":0.41648048162460327},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2562706470489502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12147429585456848},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.104.2.331","doi":"https://doi.org/10.1242/dev.104.2.331","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.104.2.331","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:3254821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3254821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1366813","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1366813/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DEVELOPMENT , 104 (2) pp. 331-339. (1988)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W55610903","https://openalex.org/W149327803","https://openalex.org/W191290898","https://openalex.org/W191342842","https://openalex.org/W977114565","https://openalex.org/W1807957656","https://openalex.org/W1867413792","https://openalex.org/W1919944832","https://openalex.org/W1978556012","https://openalex.org/W2026211608","https://openalex.org/W2030835301","https://openalex.org/W2034334214","https://openalex.org/W2043684972","https://openalex.org/W2063853340","https://openalex.org/W2091445050","https://openalex.org/W2092480877","https://openalex.org/W2098841171","https://openalex.org/W2126139029","https://openalex.org/W2140034535","https://openalex.org/W2145655068","https://openalex.org/W2184954420","https://openalex.org/W2186005865","https://openalex.org/W2260755944","https://openalex.org/W2324386099","https://openalex.org/W2343816916","https://openalex.org/W2402486108","https://openalex.org/W2408744261","https://openalex.org/W2414721774"],"related_works":["https://openalex.org/W2400124582","https://openalex.org/W2047307058","https://openalex.org/W2343816916","https://openalex.org/W7100651417","https://openalex.org/W2994519566","https://openalex.org/W1488436678","https://openalex.org/W2343243839","https://openalex.org/W2254185136","https://openalex.org/W4244467466","https://openalex.org/W2186005865"],"abstract_inverted_index":{"A":[0],"single":[1,78],"heat":[2],"shock,":[3],"given":[4],"to":[5,24,84],"2-day-old":[6],"chick":[7],"embryos,":[8],"can":[9],"generate":[10],"multiple":[11,50],"but":[12],"discrete":[13],"somite":[14],"and":[15,60,94],"skeletal":[16],"anomalies.":[17],"Each":[18],"of":[19,43,51,68,96,104,115,132],"these":[20],"anomalies":[21,34],"is":[22],"restricted":[23],"one,":[25],"or":[26,46,48],"at":[27],"the":[28,58,66,92,101,105,112,128,133],"most":[29],"two,":[30],"consecutive":[31],"segments.":[32],"The":[33,107],"are":[35,73,109],"separated":[36],"from":[37],"each":[38,86],"other":[39],"by":[40],"a":[41,49,69,77],"distance":[42],"6-7":[44],"somites":[45],"vertebrae,":[47],"this":[52],"distance.":[53],"These":[54],"results":[55,108],"argue":[56],"against":[57],"'clock":[59],"wavefront'":[61],"model;":[62],"while":[63],"they":[64,72],"support":[65],"idea":[67],"cellular":[70],"clock,":[71],"not":[74],"consistent":[75,110],"with":[76,111],"propagating":[79],"wave":[80],"gating":[81],"cells":[82,117],"destined":[83],"form":[85],"segment.":[87],"Heat":[88],"shock":[89],"also":[90],"alters":[91],"size":[93],"number":[95],"segments,":[97],"as":[98,100],"well":[99],"rostrocaudal":[102,113],"proportions":[103],"sclerotome.":[106],"fate":[114],"sclerotome":[116],"being":[118],"determined":[119],"during":[120],"segmentation.":[121],"From":[122],"our":[123],"observations,":[124],"we":[125],"speculate":[126],"on":[127],"implications":[129],"for":[130],"regionalization":[131],"vertebral":[134],"column.":[135]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}