{"id":"https://openalex.org/W186019757","doi":null,"title":"Exploring the Interactions between Mesenchymal Stem Cells and Endothelial Cells in Engineered Perivascular Niches.","display_name":"Exploring the Interactions between Mesenchymal Stem Cells and Endothelial Cells in Engineered Perivascular Niches.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W186019757","mag":"186019757"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/97927","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/97927","pdf_url":"https://hdl.handle.net/2027.42/97927","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/97927","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029583218","display_name":"Bita Carrion","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bita Carrion","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029583218"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.7979999780654907},{"id":"https://openalex.org/keywords/perivascular-niche","display_name":"perivascular niche","score":0.7799999713897705},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fibrin-matrix","display_name":"fibrin matrix","score":0.8149999976158142},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.7570000290870667},{"id":"https://openalex.org/keywords/capillary-morphogenesis","display_name":"capillary morphogenesis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.800000011920929},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7760000228881836},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.6570000052452087},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5289999842643738},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7160000205039978},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.840277910232544},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.5338842272758484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5076619386672974},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5040108561515808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4267979562282562},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0691886842250824}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/97927","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/97927","pdf_url":"https://hdl.handle.net/2027.42/97927","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:186019757","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/97927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/97927","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/97927","pdf_url":"https://hdl.handle.net/2027.42/97927","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W186019757.pdf","grobid_xml":"https://content.openalex.org/works/W186019757.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W220964935","https://openalex.org/W1653639829","https://openalex.org/W1977887541","https://openalex.org/W1978969115","https://openalex.org/W1979704965","https://openalex.org/W1980441719","https://openalex.org/W1989085371","https://openalex.org/W1990574061","https://openalex.org/W2004727527","https://openalex.org/W2008021821","https://openalex.org/W2030956730","https://openalex.org/W2037932372","https://openalex.org/W2041426549","https://openalex.org/W2049385358","https://openalex.org/W2051771541","https://openalex.org/W2068450796","https://openalex.org/W2070306500","https://openalex.org/W2071628173","https://openalex.org/W2071895235","https://openalex.org/W2077723969","https://openalex.org/W2084436684","https://openalex.org/W2088704132","https://openalex.org/W2092721126","https://openalex.org/W2102056525","https://openalex.org/W2103692236","https://openalex.org/W2107503723","https://openalex.org/W2112940666","https://openalex.org/W2115368694","https://openalex.org/W2119308535","https://openalex.org/W2131739064","https://openalex.org/W2134257943","https://openalex.org/W2140786981","https://openalex.org/W2143022774","https://openalex.org/W2147164277","https://openalex.org/W2150951349"],"related_works":["https://openalex.org/W2054330160","https://openalex.org/W4239727261","https://openalex.org/W2044134230","https://openalex.org/W2103692236","https://openalex.org/W2026575398","https://openalex.org/W1983444416","https://openalex.org/W2142746463","https://openalex.org/W2898365858","https://openalex.org/W2332910308","https://openalex.org/W2010423489"],"abstract_inverted_index":{"Therapeutic":[0],"approaches":[1],"to":[2,16,56,127,135,189,246,272,288],"induce":[3],"neovascularization":[4,40],"comprise":[5],"cell-based":[6],"therapies":[7],"using":[8],"endothelial":[9],"cells":[10,15,34,75,90,129,275,287,315],"(ECs)":[11],"co-cultured":[12,221],"with":[13,149,158,167,193,222,248,258],"stromal":[14,33,74,89,128,314],"form":[17],"long":[18],"lasting":[19],"functional":[20],"blood":[21,96,250],"vessels.":[22,251],"This":[23],"dissertation":[24,328],"investigates":[25],"the":[26,37,46,62,92,124,159,175,199,256,284,302,317],"role":[27],"of":[28,39,45,86,94,178,211,286,304,320],"cross-talk":[29],"between":[30,61,308],"ECs":[31,87,117,160,215],"and":[32,77,88,142,155,242,312,336],"in":[35,41,50,103,123,208,213,237,293,326],"governing":[36],"processes":[38],"fibrin":[42,120,226],"matrices,":[43],"representative":[44],"wound":[47],"healing":[48],"environment":[49],"vivo.":[51],"Special":[52],"attention":[53],"was":[54],"paid":[55],"a":[57,114,131,138,145,225,267],"specific":[58],"molecular":[59],"interaction":[60,192],"alpha":[63,182,200,260],"6":[64,183,201,261],"beta":[65,184],"1":[66,185],"integrin":[67,186,235,262],"adhesion":[68],"receptor":[69],"on":[70,217],"bone":[71],"marrow":[72],"derived":[73],"(BMSCs)":[76],"EC-deposited":[78,194,309],"laminin.":[79,195],"Prior":[80],"studies":[81],"have":[82,330],"shown":[83],"that":[84,174,233,255],"co-delivery":[85],"supports":[91],"formation":[93],"robust":[95,146],"vessel":[97,321],"networks.":[98],"To":[99,196],"validate":[100],"this":[101,291,327],"phenomenon":[102],"vitro,":[104],"we":[105,205,231,253],"utilized":[106],"an":[107,191,207],"established":[108],"three":[109],"dimensional":[110],"microfluidic":[111],"device":[112,125],"as":[113],"model":[115,210],"system.":[116],"suspended":[118],"within":[119,224],"gels":[121],"patterned":[122],"adjacent":[126],"executed":[130],"morphogenetic":[132],"process":[133,319],"akin":[134],"vasculogenesis,":[136],"forming":[137],"primitive":[139],"vascular":[140],"plexus":[141],"maturing":[143],"into":[144],"capillary":[147,165,240],"network":[148],"hollow":[150],"well-defined":[151],"lumens.":[152],"Both":[153],"BMSCs":[154,179,223,238,257],"fibroblasts":[156],"associated":[157],"like":[161],"pericytes,":[162],"but":[163],"promoted":[164],"morphogenesis":[166],"distinct":[168],"kinetics.":[169],"Furthermore,":[170,252],"biochemical":[171],"assays":[172],"revealed":[173],"perivascular":[176],"association":[177],"required":[180],"their":[181,244],"receptor,":[187],"presumably":[188],"mediate":[190],"further":[197],"investigate":[198],"beta1":[202],"integrin-laminin":[203],"interactions,":[204],"used":[206],"vitro":[209],"angiogenesis":[212],"which":[214],"coated":[216],"microcarrier":[218],"beads":[219],"were":[220],"matrix.":[227],"Using":[228],"RNA":[229],"interference,":[230],"demonstrated":[232,254],"\u03b16":[234],"inhibition":[236],"reduced":[239],"sprouting,":[241],"blocked":[243],"ability":[245],"associate":[247],"nascent":[249],"attenuated":[259],"expression":[263],"levels":[264],"proliferate":[265],"at":[266],"significantly":[268],"lower":[269],"rate":[270],"relative":[271],"either":[273],"control":[274],"expressing":[276],"non-targeting":[277],"shRNA":[278],"or":[279],"wild":[280],"type":[281],"BMSCs.":[282],"Despite":[283],"addition":[285],"compensate":[289],"for":[290,333],"deficit":[292],"proliferation,":[294],"deficient":[295],"sprouting":[296],"persists.":[297],"These":[298],"data":[299],"collectively":[300],"underscore":[301],"importance":[303],"understanding":[305],"integrin-mediated":[306],"interactions":[307],"basement":[310],"membranes":[311],"supporting":[313],"during":[316],"complex":[318],"formation.":[322],"The":[323],"results":[324],"presented":[325],"could":[329],"significant":[331],"implications":[332],"both":[334],"physiological":[335],"pathological":[337],"neovascularization.":[338]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
