{"id":"https://openalex.org/W186013200","doi":null,"title":"Anal squamous intraepithelial lesions in human immunodeficiency virus-positive men and women.","display_name":"Anal squamous intraepithelial lesions in human immunodeficiency virus-positive men and women.","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W186013200","mag":"186013200","pmid":"https://pubmed.ncbi.nlm.nih.gov/10950374"},"language":"en","primary_location":{"id":"pmid:10950374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10950374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079764395","display_name":"Joel Michael Palefsky","orcid":"https://orcid.org/0000-0002-5097-3818","observed_orcids":["https://orcid.org/0000-0002-5097-3818"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J M Palefsky","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079764395"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":4.0666,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.93510519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"27","issue":"4","first_page":"471","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.08780000358819962,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anal-squamous-intraepithelial-lesions","display_name":"anal squamous intraepithelial lesions","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.8939999938011169},{"id":"https://openalex.org/keywords/anal-cancer","display_name":"anal cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9300000071525574},{"id":"https://openalex.org/keywords/anal-cancer-screening","display_name":"anal cancer screening","score":0.7300000190734863},{"id":"https://openalex.org/keywords/anal-cytology","display_name":"anal cytology","score":0.9509999752044678},{"id":"https://openalex.org/keywords/anal-cancer-incidence","display_name":"anal cancer incidence","score":0.4880000054836273},{"id":"https://openalex.org/keywords/hiv-positive-men","display_name":"HIV-positive men","score":0.5600000023841858},{"id":"https://openalex.org/keywords/women-living-with-hiv","display_name":"women living with HIV","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cost-effectiveness-of-screening","display_name":"cost-effectiveness of screening","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2779840525","wikidata":"https://www.wikidata.org/wiki/Q484827","display_name":"Anal cancer","level":3,"score":0.9570074081420898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8654124736785889},{"id":"https://openalex.org/C2775924586","wikidata":"https://www.wikidata.org/wiki/Q7581955","display_name":"Squamous intraepithelial lesion","level":5,"score":0.8000034093856812},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5761454105377197},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.570117712020874},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4861147403717041},{"id":"https://openalex.org/C2776939746","wikidata":"https://www.wikidata.org/wiki/Q853451","display_name":"Men who have sex with men","level":4,"score":0.44625407457351685},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4430431127548218},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40342798829078674},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4006701409816742},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.35691189765930176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3389437198638916},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33241748809814453},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.14170923829078674},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001005","descriptor_name":"Anus Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001005","descriptor_name":"Anus Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001005","descriptor_name":"Anus Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003581","descriptor_name":"Cytodiagnosis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10950374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10950374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},{"id":"mag:186013200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10950374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2589614255","display_name":"NATURAL HISTORY OF ANAL NEOPLASIA IN HIV INFECTED MEN","funder_award_id":"R01CA054053","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G431906986","display_name":"ANAL NEOPLASIA IN HIV POSITIVE AND HIV NEGATIVE WOMEN","funder_award_id":"R01CA063933","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G849458189","display_name":"General Clinical Research Center","funder_award_id":"5m01rr000079-42","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2460494606","https://openalex.org/W2316970556","https://openalex.org/W2147519428","https://openalex.org/W2332799841","https://openalex.org/W2040431926","https://openalex.org/W1976245963","https://openalex.org/W7096442067","https://openalex.org/W7095780536","https://openalex.org/W2059787835","https://openalex.org/W2153551627"],"abstract_inverted_index":{"Studies":[0,75],"from":[1],"the":[2,6,17,55,61,126,146,156,199,271,277],"era":[3],"prior":[4],"to":[5,42,118,136,176,190,198,207,226,257,263,268],"introduction":[7],"of":[8,19,57,76,85,91,115,140,148,170,184,228,233,242,249,253,274],"highly":[9],"active":[10],"antiretroviral":[11],"therapy":[12],"(HAART)":[13],"have":[14],"shown":[15],"that":[16,54,100,169,214],"prevalence":[18,90],"anal":[20,26,92,102,116,120,141,150,178,185,195,215],"human":[21,35],"papillomavirus":[22],"(HPV)":[23],"infection":[24,94],"and":[25,41,72,79,95,164,182,247,251,267],"squamous":[27],"intraepithelial":[28],"lesions":[29,104],"(ASIL)":[30],"was":[31,67],"very":[32],"high":[33,68,83,89],"among":[34,46,69,160],"immunodeficiency":[36],"virus":[37],"(HIV)-positive":[38],"homosexual":[39,48],"men,":[40,163],"a":[43,88,188,235],"lesser":[44],"extent,":[45],"HIV-negative":[47,73,80,171],"men.":[49,74,173,223],"Prospective":[50],"data":[51,98],"also":[52],"show":[53,87],"incidence":[56,147],"high-grade":[58],"ASIL":[59,275],"(HSIL),":[60],"putative":[62],"invasive":[63,119,149],"cancer":[64,121,151,179],"precursor":[65],"lesion,":[66],"both":[70],"HIV-positive":[71,77,161,222],"women":[78,81],"at":[82],"risk":[84,139],"HIV":[86],"HPV":[93],"ASIL.":[96],"Early":[97],"suggest":[99],"most":[101],"HSIL":[103,117,186,250],"do":[105],"not":[106],"regress":[107],"after":[108],"an":[109,137,239],"individual":[110],"begins":[111],"HAART.":[112],"Since":[113],"progression":[114],"may":[122,133],"require":[123],"several":[124],"years,":[125],"improvement":[127],"in":[128,221,245,276],"survival":[129],"associated":[130],"with":[131,144,194],"HAART":[132,278],"paradoxically":[134],"lead":[135],"increased":[138],"cancer.":[142,210],"Consistent":[143],"this,":[145],"has":[152],"been":[153],"increasing":[154],"over":[155],"last":[157],"few":[158],"years":[159],"gay":[162,172],"is":[165],"now":[166],"approximately":[167],"twice":[168],"The":[174],"potential":[175],"prevent":[177,208],"through":[180],"detection":[181],"treatment":[183,248],"suggests":[187],"need":[189],"screen":[191],"high-risk":[192],"individuals":[193],"cytology,":[196],"similar":[197],"longstanding":[200],"cervical":[201,209],"cytology":[202],"screening":[203,216,229],"program":[204],"currently":[205],"used":[206],"Cost-effectiveness":[211],"analyses":[212],"indicate":[213],"programs":[217],"should":[218],"be":[219],"cost-effective":[220],"However,":[224],"barriers":[225],"implementation":[227,232],"preclude":[230],"near-term":[231],"such":[234],"program.":[236],"These":[237],"include":[238],"inadequate":[240],"number":[241],"clinicians":[243],"skilled":[244],"diagnosis":[246],"lack":[252],"effective":[254],"medical":[255],"alternatives":[256],"surgical":[258],"excision.":[259],"Efforts":[260],"are":[261],"underway":[262],"address":[264],"these":[265],"issues":[266],"better":[269],"understand":[270],"natural":[272],"history":[273],"era.":[279]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
