{"id":"https://openalex.org/W186006459","doi":null,"title":"Effects of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in postmenopausal women: a randomized clinical trial in Beijing.","display_name":"Effects of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in postmenopausal women: a randomized clinical trial in Beijing.","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W186006459","mag":"186006459","pmid":"https://pubmed.ncbi.nlm.nih.gov/12935394"},"language":"en","primary_location":{"id":"pmid:12935394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12935394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shurong Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shurong Zheng","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing 100034, China. cyzh@public.fhnet.cn.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing 100034, China. cyzh@public.fhnet.cn.net","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100848944","display_name":"Yiyong Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiyong Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083234461","display_name":"Zhonglan Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhonglan Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070505748","display_name":"Ying Hua Hui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Hui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051180946","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0003-3139-3524","observed_orcids":["https://orcid.org/0000-0003-3139-3524","https://orcid.org/0009-0001-0640-2356","https://orcid.org/0009-0008-8454-8618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shuling Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuling Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106613849","display_name":"Wenhui Deng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenhui Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008568396","display_name":"Abie Ekangaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abie Ekangaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111402136","display_name":"Jodie M. Stocks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jodie Stocks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045969194","display_name":"Kristine D. Harper","orcid":"https://orcid.org/0000-0001-8490-7520","observed_orcids":["https://orcid.org/0000-0001-8490-7520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristine Harper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jianli Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianli Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1591,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.54650197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"116","issue":"8","first_page":"1127","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raloxifene-hydrochloride","display_name":"raloxifene hydrochloride","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8180000185966492},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.781000018119812},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.902999997138977},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9819999933242798},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.7549999952316284},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.8399999737739563},{"id":"https://openalex.org/keywords/c-terminal-telopeptide","display_name":"C-terminal telopeptide","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hip-bone-mineral-density","display_name":"hip bone density","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.734000027179718},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5669999718666077},{"id":"https://openalex.org/keywords/china","display_name":"China","score":0.45100000500679016},{"id":"https://openalex.org/keywords/beijing","display_name":"Beijing","score":0.6050000190734863},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7777401804924011},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.714270830154419},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6691697835922241},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6625508666038513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6525249481201172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.643433690071106},{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.6358996629714966},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5274059176445007},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.47419339418411255},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.47120946645736694},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.4230450391769409},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3164297044277191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2057652473449707},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.11155924201011658},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020849","descriptor_name":"Raloxifene Hydrochloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12935394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12935394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Clinical Trial"},{"id":"mag:186006459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12935394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3140918175","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/200308/9693523.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2357950799","https://openalex.org/W2352816967","https://openalex.org/W2373688669","https://openalex.org/W2358323640","https://openalex.org/W2112233548","https://openalex.org/W2086570453","https://openalex.org/W2018437777","https://openalex.org/W2390538124","https://openalex.org/W3090905828","https://openalex.org/W2012619076"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3,104,202,238,253,259,272,289],"effects":[4,270],"of":[5,38,120,151,280],"raloxifene":[6],"hydrochloride":[7],"(RLX)":[8],"on":[9,271,288],"bone":[10,14,76,152,281],"mineral":[11],"density":[12],"(BMD),":[13],"metabolism":[15],"markers":[16,77,150,279],"and":[17,48,75,81,99,139,156,162,175,190,199,214,256,276,283],"serum":[18,73,154,291],"lipids":[19],"in":[20,24,35,94,109,164,169,201,207,252,258,294,297],"healthy":[21,40],"postmenopausal":[22,41,295],"women":[23,42,296],"Beijing.":[25],"METHODS:":[26],"A":[27],"multicenter,":[28],"randomized,":[29],"double-blind,":[30],"placebo-controlled":[31],"study":[32,264],"was":[33,112],"conducted":[34],"a":[36,91,118,134,140,172,176,211,215,285],"total":[37,96,100,110,130,188],"204":[39],"(age":[43],"59.5":[44],"+/-":[45,51],"5.0":[46],"years":[47],"weight":[49],"62.8":[50],"8.7":[52],"kg)":[53],"treated":[54],"with":[55,87,114,117,122,181,220],"either":[56],"RLX":[57,89,115,138,254,267],"60":[58],"mg":[59],"(n":[60,65],"=":[61,66,146],"102)":[62,67],"or":[63,234],"placebo":[64,123,144,170,260],"daily":[68],"for":[69,129,137,143,230],"12":[70],"months.":[71],"BMD,":[72],"lipids,":[74],"were":[78,133,160,171,197,210,228],"measured":[79],"before":[80],"after":[82],"drug":[83],"administration.":[84],"RESULTS:":[85],"Compared":[86],"placebo,":[88,182,221],"produced":[90],"significant":[92],"increase":[93,108,136,142,178,213],"both":[95,183,222],"lumbar":[97,105],"spine":[98],"hip":[101,131],"BMD.":[102],"For":[103,148,187],"spine,":[106],"percentage":[107,158,195],"BMD":[111,132,275],"2.3%":[113],"compared":[116,180,219],"decrease":[119,174,217],"0.1%":[121],"(P":[124,145],"<":[125,185,224],"0.001).":[126,186,225],"Corresponding":[127,167,205],"values":[128,168,206],"2.5%":[135],"1.1%":[141],"0.011).":[147],"biochemical":[149,278],"metabolism,":[153,282],"osteocalcin":[155],"C-telopeptide,":[157],"decreases":[159,196],"27.65%":[161],"24.02%":[163],"RLX-treated":[165,203],"subjects.":[166],"10.64%":[173],"15.75%":[177],"(RLX":[179,218],"P":[184,223],"cholesterol":[189,193,233],"low-density":[191],"lipoprotein":[192,232],"levels,":[194],"6.44%":[198],"34.58%":[200],"group.":[204],"placebo-treated":[208],"patients":[209],"1.44%":[212],"19.07%":[216],"No":[226],"differences":[227],"found":[229],"high-density":[231],"triglyceride":[235],"levels":[236],"between":[237],"two":[239],"groups.":[240],"Only":[241],"5":[242],"subjects":[243],"discontinued":[244],"early":[245],"owing":[246],"to":[247],"an":[248],"adverse":[249],"event":[250],"(3":[251],"group":[255],"2":[257],"group).":[261],"CONCLUSIONS:":[262],"This":[263],"confirms":[265],"that":[266],"exerts":[268],"positive":[269,286],"skeleton,":[273],"increasing":[274],"decreasing":[277],"has":[284],"effect":[287],"overall":[290],"lipid":[292],"profile":[293],"China.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
