{"id":"https://openalex.org/W185924985","doi":null,"title":"Methylenedioxymethamphetamine-induced neurotoxicity: The role of hepatic enzymes cytochrome p450 2d6 and catechol-o-methyltransferase and contribution of microglia","display_name":"Methylenedioxymethamphetamine-induced neurotoxicity: The role of hepatic enzymes cytochrome p450 2d6 and catechol-o-methyltransferase and contribution of microglia","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W185924985","mag":"185924985"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/306920","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/306920","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031605226","display_name":"Joseph M. Herndon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph M. Herndon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031605226"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ecstasy","display_name":"ecstasy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cyp2d1","display_name":"CYP2D1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6320000290870667},{"id":"https://openalex.org/keywords/serotonin-depletion","display_name":"serotonin depletion","score":0.7379999756813049},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8100000023841858},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.6949999928474426},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7509999871253967},{"id":"https://openalex.org/keywords/individual-susceptibility","display_name":"individual susceptibility","score":0.4269999861717224},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.4909999966621399},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.3720000088214874},{"id":"https://openalex.org/keywords/parietal-cortex","display_name":"parietal cortex","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7657378911972046},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6446590423583984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5599046349525452},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5553398728370667},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5339433550834656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4706128239631653},{"id":"https://openalex.org/C2777713698","wikidata":"https://www.wikidata.org/wiki/Q282440","display_name":"Catechol","level":2,"score":0.42412734031677246},{"id":"https://openalex.org/C185361966","wikidata":"https://www.wikidata.org/wiki/Q94291140","display_name":"Catechol-O-methyl transferase","level":4,"score":0.42288535833358765},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41956180334091187},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.410258948802948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24956616759300232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24291908740997314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22938397526741028},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1822693943977356},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.08508747816085815},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0772416889667511},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07264518737792969},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/306920","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/306920","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:185924985","doi":null,"is_oa":false,"landing_page_url":"https://arizona.openrepository.com/handle/10150/306920","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":330,"referenced_works":["https://openalex.org/W14602739","https://openalex.org/W51589336","https://openalex.org/W150246076","https://openalex.org/W156099876","https://openalex.org/W174864995","https://openalex.org/W185250218","https://openalex.org/W235859955","https://openalex.org/W1479855792","https://openalex.org/W1487335348","https://openalex.org/W1513552488","https://openalex.org/W1514135333","https://openalex.org/W1531892057","https://openalex.org/W1533321987","https://openalex.org/W1555375083","https://openalex.org/W1562529961","https://openalex.org/W1565127991","https://openalex.org/W1581024190","https://openalex.org/W1581194755","https://openalex.org/W1584069397","https://openalex.org/W1588570886","https://openalex.org/W1638542732","https://openalex.org/W1651376769","https://openalex.org/W1683600212","https://openalex.org/W1693348571","https://openalex.org/W1837126245","https://openalex.org/W1847256235","https://openalex.org/W1885853127","https://openalex.org/W1894300836","https://openalex.org/W1900109421","https://openalex.org/W1916392066","https://openalex.org/W1932356664","https://openalex.org/W1949070403","https://openalex.org/W1960526592","https://openalex.org/W1963719599","https://openalex.org/W1965557712","https://openalex.org/W1967306755","https://openalex.org/W1967567964","https://openalex.org/W1969800514","https://openalex.org/W1971191340","https://openalex.org/W1972490292","https://openalex.org/W1972491768","https://openalex.org/W1973126788","https://openalex.org/W1973234849","https://openalex.org/W1973256378","https://openalex.org/W1973550821","https://openalex.org/W1973743872","https://openalex.org/W1974518872","https://openalex.org/W1974766709","https://openalex.org/W1975513214","https://openalex.org/W1976342621","https://openalex.org/W1976355699","https://openalex.org/W1978363134","https://openalex.org/W1980341424","https://openalex.org/W1981713105","https://openalex.org/W1982558653","https://openalex.org/W1982988839","https://openalex.org/W1984131408","https://openalex.org/W1984280476","https://openalex.org/W1985612870","https://openalex.org/W1986449836","https://openalex.org/W1986462418","https://openalex.org/W1989038222","https://openalex.org/W1989118896","https://openalex.org/W1990551987","https://openalex.org/W1990635104","https://openalex.org/W1990692265","https://openalex.org/W1991809846","https://openalex.org/W1993036354","https://openalex.org/W1993455459","https://openalex.org/W1994082731","https://openalex.org/W1994094794","https://openalex.org/W1994244927","https://openalex.org/W1995859810","https://openalex.org/W1997306238","https://openalex.org/W1998129912","https://openalex.org/W1998225973","https://openalex.org/W2000397914","https://openalex.org/W2000469157","https://openalex.org/W2001333277","https://openalex.org/W2002920339","https://openalex.org/W2002956985","https://openalex.org/W2003069133","https://openalex.org/W2003616879","https://openalex.org/W2003674452","https://openalex.org/W2004349171","https://openalex.org/W2005416260","https://openalex.org/W2006073621","https://openalex.org/W2006643658","https://openalex.org/W2007173542","https://openalex.org/W2007383758","https://openalex.org/W2007549333","https://openalex.org/W2007649442","https://openalex.org/W2008186920","https://openalex.org/W2009457246","https://openalex.org/W2010875415","https://openalex.org/W2011248808","https://openalex.org/W2011428797","https://openalex.org/W2011827250","https://openalex.org/W2012252010","https://openalex.org/W2013923425","https://openalex.org/W2014157816","https://openalex.org/W2014591574","https://openalex.org/W2015086898","https://openalex.org/W2015928428","https://openalex.org/W2016532705","https://openalex.org/W2016902306","https://openalex.org/W2017447972","https://openalex.org/W2017621114","https://openalex.org/W2020142342","https://openalex.org/W2020337411","https://openalex.org/W2020897170","https://openalex.org/W2021041549","https://openalex.org/W2022056885","https://openalex.org/W2025216803","https://openalex.org/W2025239832","https://openalex.org/W2025655040","https://openalex.org/W2026781905","https://openalex.org/W2027011037","https://openalex.org/W2027687342","https://openalex.org/W2028163847","https://openalex.org/W2029777052","https://openalex.org/W2030040543","https://openalex.org/W2031965067","https://openalex.org/W2032639288","https://openalex.org/W2032748840","https://openalex.org/W2033243193","https://openalex.org/W2034008127","https://openalex.org/W2035055624","https://openalex.org/W2035295533","https://openalex.org/W2035759859","https://openalex.org/W2036570302","https://openalex.org/W2036629661","https://openalex.org/W2036982675","https://openalex.org/W2038629990","https://openalex.org/W2038890629","https://openalex.org/W2039265593","https://openalex.org/W2039465457","https://openalex.org/W2039753838","https://openalex.org/W2039758887","https://openalex.org/W2039803572","https://openalex.org/W2039997415","https://openalex.org/W2040494232","https://openalex.org/W2041365749","https://openalex.org/W2041610229","https://openalex.org/W2042201688","https://openalex.org/W2043143222","https://openalex.org/W2043246427","https://openalex.org/W2043576655","https://openalex.org/W2044165548","https://openalex.org/W2045279684","https://openalex.org/W2048055615","https://openalex.org/W2050063162","https://openalex.org/W2053938649","https://openalex.org/W2054217820","https://openalex.org/W2054856852","https://openalex.org/W2055750901","https://openalex.org/W2057484845","https://openalex.org/W2057528351","https://openalex.org/W2058008096","https://openalex.org/W2058365449","https://openalex.org/W2058524677","https://openalex.org/W2058609816","https://openalex.org/W2059002674","https://openalex.org/W2060188319","https://openalex.org/W2060519440","https://openalex.org/W2062337275","https://openalex.org/W2063603694","https://openalex.org/W2064004368","https://openalex.org/W2064496574","https://openalex.org/W2064576666","https://openalex.org/W2064734152","https://openalex.org/W2065619339","https://openalex.org/W2065850862","https://openalex.org/W2066750823","https://openalex.org/W2067055946","https://openalex.org/W2068549596","https://openalex.org/W2068769189","https://openalex.org/W2069800617","https://openalex.org/W2070435252","https://openalex.org/W2070730444","https://openalex.org/W2070953022","https://openalex.org/W2071369096","https://openalex.org/W2071419870","https://openalex.org/W2071694134","https://openalex.org/W2073494415","https://openalex.org/W2077344396","https://openalex.org/W2079537717","https://openalex.org/W2080043971","https://openalex.org/W2081349320","https://openalex.org/W2082609266","https://openalex.org/W2082669257","https://openalex.org/W2082832315","https://openalex.org/W2082986500","https://openalex.org/W2085243884","https://openalex.org/W2085562256","https://openalex.org/W2086332600","https://openalex.org/W2088737294","https://openalex.org/W2089143133","https://openalex.org/W2089155165","https://openalex.org/W2089262318","https://openalex.org/W2090183075","https://openalex.org/W2090826913","https://openalex.org/W2090990681","https://openalex.org/W2091064440","https://openalex.org/W2091073665","https://openalex.org/W2091075456","https://openalex.org/W2091385849","https://openalex.org/W2092476585","https://openalex.org/W2093419170","https://openalex.org/W2093897431","https://openalex.org/W2094072306","https://openalex.org/W2095031720","https://openalex.org/W2095188030","https://openalex.org/W2095195769","https://openalex.org/W2096542780","https://openalex.org/W2096557101","https://openalex.org/W2098139332","https://openalex.org/W2100180911","https://openalex.org/W2100352065","https://openalex.org/W2100507133","https://openalex.org/W2101207155","https://openalex.org/W2101277151","https://openalex.org/W2101367564","https://openalex.org/W2102393059","https://openalex.org/W2103607451","https://openalex.org/W2103745296","https://openalex.org/W2105342126","https://openalex.org/W2105625596","https://openalex.org/W2105878845","https://openalex.org/W2106566412","https://openalex.org/W2109188786","https://openalex.org/W2110552269","https://openalex.org/W2111112265","https://openalex.org/W2111329465","https://openalex.org/W2113121748","https://openalex.org/W2113363590","https://openalex.org/W2114937850","https://openalex.org/W2115241864","https://openalex.org/W2115290225","https://openalex.org/W2115752255","https://openalex.org/W2116536917","https://openalex.org/W2116808683","https://openalex.org/W2116910569","https://openalex.org/W2117224038","https://openalex.org/W2117517043","https://openalex.org/W2119283923","https://openalex.org/W2120113858","https://openalex.org/W2120534405","https://openalex.org/W2120611477","https://openalex.org/W2121108165","https://openalex.org/W2121872553","https://openalex.org/W2122464153","https://openalex.org/W2126087777","https://openalex.org/W2126906152","https://openalex.org/W2127654449","https://openalex.org/W2128008585","https://openalex.org/W2128322193","https://openalex.org/W2128698693","https://openalex.org/W2128828064","https://openalex.org/W2128951033","https://openalex.org/W2129695646","https://openalex.org/W2131278093","https://openalex.org/W2131721815","https://openalex.org/W2132011757","https://openalex.org/W2133377406","https://openalex.org/W2133409052","https://openalex.org/W2133416128","https://openalex.org/W2135538008","https://openalex.org/W2137174865","https://openalex.org/W2137229007","https://openalex.org/W2138700431","https://openalex.org/W2138939084","https://openalex.org/W2140634520","https://openalex.org/W2141190015","https://openalex.org/W2141692973","https://openalex.org/W2142291145","https://openalex.org/W2143437320","https://openalex.org/W2144193551","https://openalex.org/W2144919948","https://openalex.org/W2146714987","https://openalex.org/W2146889361","https://openalex.org/W2147623733","https://openalex.org/W2148562084","https://openalex.org/W2148726772","https://openalex.org/W2149537152","https://openalex.org/W2149675018","https://openalex.org/W2150159755","https://openalex.org/W2150184757","https://openalex.org/W2150792870","https://openalex.org/W2151283331","https://openalex.org/W2151818435","https://openalex.org/W2152165298","https://openalex.org/W2152846519","https://openalex.org/W2154210087","https://openalex.org/W2154549928","https://openalex.org/W2154971988","https://openalex.org/W2155591011","https://openalex.org/W2155849144","https://openalex.org/W2157478055","https://openalex.org/W2158635723","https://openalex.org/W2158719307","https://openalex.org/W2159633740","https://openalex.org/W2159815442","https://openalex.org/W2160588949","https://openalex.org/W2160935383","https://openalex.org/W2161284294","https://openalex.org/W2161821412","https://openalex.org/W2161950360","https://openalex.org/W2163091881","https://openalex.org/W2163815564","https://openalex.org/W2164191009","https://openalex.org/W2165440826","https://openalex.org/W2166148255","https://openalex.org/W2166469175","https://openalex.org/W2166933801","https://openalex.org/W2168757036","https://openalex.org/W2169132085","https://openalex.org/W2169872401","https://openalex.org/W2170485551","https://openalex.org/W2218120369","https://openalex.org/W2252930795","https://openalex.org/W2253242458","https://openalex.org/W2315182483","https://openalex.org/W2399478936","https://openalex.org/W2400165548","https://openalex.org/W2400189451","https://openalex.org/W2400995186","https://openalex.org/W2419612826","https://openalex.org/W4247088117","https://openalex.org/W4323874097"],"related_works":["https://openalex.org/W2121687021","https://openalex.org/W7043077317","https://openalex.org/W2152846519","https://openalex.org/W3020543541","https://openalex.org/W2043246427","https://openalex.org/W7096972010","https://openalex.org/W2022418335","https://openalex.org/W2048841731","https://openalex.org/W1512465094","https://openalex.org/W2090590927"],"abstract_inverted_index":{"3,4-(\u00b1)-Methylenedioxymethamphetamine":[0],"(MDMA,":[1],"ecstasy)":[2],"is":[3,13,68,239,289],"a":[4,17,129,133,167,212,249,266],"widely":[5],"abused":[6],"amphetamine":[7],"derivative.":[8],"The":[9,280],"metabolism":[10,80,288],"of":[11,20,26,33,46,58,73,81,104,108,112,122,136,150,163,170,184,193,198,206,219,242,255,263,275,327,331],"MDMA":[12,27,53,158,238,247,269,317],"thought":[14],"to":[15,36,63,145,188],"be":[16,335],"necessary":[18],"component":[19],"MDMA-induced":[21,66,164,292,328],"neurotoxicity,":[22,329],"as":[23,93,95,295],"direct":[24],"administration":[25,45],"into":[28],"the":[29,38,71,79,96,102,110,116,152,157,189,196,203,217,226,253,260,272,278,285,303,325],"central":[30],"nervous":[31],"system":[32],"rats":[34,173,264],"failed":[35],"reproduce":[37],"hallmark":[39],"serotonin":[40,139,177],"deficits":[41,140,178],"seen":[42],"following":[43,125,316],"systemic":[44],"MDMA.":[47,207],"Mechanistic":[48],"questions":[49],"remain":[50],"regarding":[51],"how":[52,65],"elicits":[54],"this":[55,59,105,199],"neurotoxicity.":[56,106,165,293],"Work":[57],"thesis":[60],"was":[61],"undertaken":[62],"examine":[64],"neurotoxicity":[67,124],"affected":[69],"by":[70,232,237],"activity":[72,274],"two":[74],"polymorphic":[75,301],"enzymes":[76],"involved":[77],"in":[78,101,115,119,156,161,201,225,252,259,277,291,302],"MDMA,":[82,194],"namely":[83],"cytochrome":[84],"P450":[85],"family":[86],"member":[87],"2D6":[88],"(CYP2D6)":[89],"and":[90,132,222,298],"catechol-O-methyltransferase":[91],"(COMT),":[92],"well":[94],"potential":[97,218],"role":[98],"microglia":[99,229,276,321],"play":[100],"facilitation":[103],"Inhibition":[107,149],"CYP2D1,":[109],"homolog":[111],"human":[113,304],"CYP2D6":[114,297],"rat,":[117],"resulted":[118,160],"an":[120,240],"attenuation":[121],"serotonergic":[123,314],"MDMA-administration.":[126],"In":[127,166],"both":[128,220,296],"pharmacological":[130,168],"model":[131,135,169],"genetic":[134],"CYP2D1":[137,147],"inhibition,":[138,172],"were":[141],"alleviated":[142],"when":[143],"compared":[144],"normal-activity":[146],"counterparts.":[148],"COMT,":[151],"primary":[153],"detoxication":[154],"enzyme":[155,200],"pathway,":[159],"potentiation":[162],"COMT":[171,180,185,299],"displayed":[174],"greater":[175],"long-term":[176],"after":[179],"inhibition.":[181],"Mice":[182],"devoid":[183],"proved":[186],"sensitive":[187],"lethal":[190],"hyperthermic":[191],"effects":[192],"illustrating":[195],"importance":[197],"preventing":[202],"acute":[204],"toxicity":[205,315],"Brain":[208],"lesions":[209],"often":[210],"elicit":[211],"microglial":[213,256],"response.":[214],"Microglia":[215],"have":[216],"beneficial":[221],"deleterious":[223],"actions":[224],"brain.":[227],"Whether":[228],"are":[230,300,308,322],"activated":[231],"nerve":[233],"terminal":[234],"degeneration":[235],"produced":[236],"area":[241],"ongoing":[243],"debate.":[244],"Systemically":[245],"delivered":[246],"produces":[248],"modest":[250],"increase":[251],"amount":[254],"cells":[257,333],"present":[258],"parietal":[261],"cortex":[262],"over":[265],"one-week":[267],"period.":[268],"also":[270],"increased":[271],"phagocytic":[273],"cortex.":[279],"studies":[281],"described":[282],"herein":[283],"support":[284],"hypothesis":[286],"that":[287],"critical":[290],"Furthermore,":[294],"population,":[305],"certain":[306],"individuals":[307],"more":[309],"at":[310],"risk":[311],"for":[312],"severe":[313],"administration.":[318],"Finally,":[319],"while":[320],"likely":[323],"not":[324],"cause":[326],"contributions":[330],"these":[332],"cannot":[334],"dismissed.":[336]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}