{"id":"https://openalex.org/W1859017","doi":null,"title":"Natural Killer cell-dependent and non-dependent anti-viral activity of 2-Cys Peroxiredoxin against HIV.","display_name":"Natural Killer cell-dependent and non-dependent anti-viral activity of 2-Cys Peroxiredoxin against HIV.","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1859017","mag":"1859017","pmid":"https://pubmed.ncbi.nlm.nih.gov/24244928","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3826819"},"language":"en","primary_location":{"id":"pmid:24244928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24244928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International trends in immunity","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3826819","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055726573","display_name":"Mohammed Asmal","orcid":"https://orcid.org/0009-0002-9834-1286","observed_orcids":["https://orcid.org/0009-0002-9834-1286"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Asmal","raw_affiliation_strings":["Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108363333","display_name":"Norman L. Letvin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norman L Letvin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011032016","display_name":"Ralf Geiben-Lynn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralf Geiben-Lynn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2419,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.48716216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1","issue":"4","first_page":"69","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-cys-peroxiredoxin","display_name":"2-Cys peroxiredoxin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hiv-1-replication-inhibition","display_name":"HIV-1 replication inhibition","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.847000002861023},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ciap1","display_name":"cIAP1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9900000095367432},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.640999972820282},{"id":"https://openalex.org/keywords/gene-expression-networks","display_name":"gene expression networks","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6034414768218994},{"id":"https://openalex.org/C2780416994","wikidata":"https://www.wikidata.org/wiki/Q419462","display_name":"Peroxiredoxin","level":4,"score":0.522160530090332},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.44764870405197144},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4450421631336212},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4153153896331787},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41295385360717773},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39125579595565796},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3581077456474304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3172145187854767},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.23161134123802185},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1972980797290802},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13776522874832153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08496832847595215},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:24244928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24244928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International trends in immunity","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2814337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3826819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3826819","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3826819/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int Trends Immun","raw_type":"Text"},{"id":"mag:1859017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24244928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2814337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3826819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G70189922","display_name":"In Vitro Antiviral Screening Program","funder_award_id":"n01ai30049-9-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G726617035","display_name":"In Vitro Antiviral Screening Program","funder_award_id":"n01ai30048-10-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1484482345","https://openalex.org/W1823200218","https://openalex.org/W1974966731","https://openalex.org/W1980385765","https://openalex.org/W1985169370","https://openalex.org/W1998354673","https://openalex.org/W2002123191","https://openalex.org/W2011054328","https://openalex.org/W2024396222","https://openalex.org/W2030872095","https://openalex.org/W2041769972","https://openalex.org/W2046714652","https://openalex.org/W2056037428","https://openalex.org/W2059129711","https://openalex.org/W2075584603","https://openalex.org/W2088814252","https://openalex.org/W2089605310","https://openalex.org/W2092986570","https://openalex.org/W2099967110","https://openalex.org/W2105352387","https://openalex.org/W2106364045","https://openalex.org/W2106695232","https://openalex.org/W2110096570","https://openalex.org/W2117586443","https://openalex.org/W2121738391","https://openalex.org/W2122707868","https://openalex.org/W2125585170","https://openalex.org/W2128009957","https://openalex.org/W2134087536","https://openalex.org/W2158402737","https://openalex.org/W2158498221","https://openalex.org/W2168539374","https://openalex.org/W2265065426","https://openalex.org/W2315916518","https://openalex.org/W2408230628"],"related_works":["https://openalex.org/W2106364045","https://openalex.org/W2108432057","https://openalex.org/W2231489492","https://openalex.org/W7098416576","https://openalex.org/W2156034405","https://openalex.org/W2017265125","https://openalex.org/W7154895395","https://openalex.org/W7096857979","https://openalex.org/W7164842894","https://openalex.org/W2139234129"],"abstract_inverted_index":{"2-cys":[0],"peroxiredoxins":[1],"(Prx),":[2],"a":[3,59,132,146],"group":[4],"of":[5,22,28,64,73,95,119,134,148,161],"anti-oxidative":[6],"enzyme":[7],"proteins,":[8],"act":[9],"directly":[10],"on":[11,75,171],"virally-infected":[12],"cells":[13,25],"to":[14],"inhibit":[15],"HIV-1":[16,78,115],"replication,":[17],"and":[18,79,152,174,188],"indirectly":[19],"through":[20,185],"destruction":[21],"HIV":[23,86,183],"infected":[24],"by":[26],"stimulation":[27],"Natural":[29],"Killer":[30],"(NK)":[31],"cell-mediated":[32],"immune":[33],"responses.":[34],"We":[35,51,68,82,165],"assayed":[36],"for":[37],"antibody-dependent":[38],"NK":[39,65,76,105,186,189],"cell":[40,66,106],"mediated":[41],"viral":[42,96],"inhibition":[43],"(ADCVI)":[44],"using":[45],"plasma":[46],"from":[47],"SIV-infected":[48],"rhesus":[49],"macaques.":[50],"found":[52,83,110],"that":[53,84,111,180],"Prx-1":[54,74,112,138,181],"strongly":[55],"increased":[56],"ADCVI":[57],"in":[58],"dose-dependent":[60],"manner,":[61],"suggesting":[62],"augmentation":[63],"killing.":[67],"also":[69],"investigated":[70],"the":[71,114,135,149,162,172],"effect":[72],"cell-independent":[77,190],"HIV-2":[80],"inhibition.":[81],"primary":[85],"isolates":[87],"were":[88],"potently":[89],"inhibited":[90],"at":[91],"nM":[92],"concentrations,":[93],"regardless":[94],"clade,":[97],"receptor":[98],"usage":[99],"or":[100],"anti-retroviral":[101],"drug":[102],"resistance.":[103],"During":[104],"independent":[107],"inhibition,":[108],"we":[109],"reversed":[113],"induced":[116],"gene":[117,147,160],"expression":[118],"Heat":[120],"shock":[121],"protein":[122,133],"90":[123],"kDa":[124],"alpha":[125],"(cystolic),":[126],"class":[127],"A":[128],"member":[129],"2,":[130],"(HSP90),":[131],"stress":[136],"pathway.":[137,164],"highly":[139,169],"activated":[140],"Cyclin-dependent":[141],"kinase":[142],"inhibitor":[143],"2B":[144],"(CDKN2B),":[145],"TGF-\u03b2":[150],"pathway,":[151],"Baculoviral":[153],"IAP":[154],"repeat-containing":[155],"2":[156],"(Birc-2),":[157],"an":[158],"anti-apoptotic":[159],"NF-\u03baB":[163],"identified":[166],"gene-expression":[167],"networks":[168],"dependent":[170],"NF\u03baB":[173],"ERK1/2":[175],"pathways.":[176],"Our":[177],"findings":[178],"demonstrate":[179],"inhibits":[182],"replication":[184],"cell-dependent":[187],"mechanisms.":[191]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}