{"id":"https://openalex.org/W185872473","doi":null,"title":"Comparative genomic hybridization: an overview.","display_name":"Comparative genomic hybridization: an overview.","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W185872473","mag":"185872473","pmid":"https://pubmed.ncbi.nlm.nih.gov/7992829","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887496"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1887496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887496","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052154203","display_name":"Jane Houldsworth","orcid":"https://orcid.org/0000-0002-6781-1700","observed_orcids":["https://orcid.org/0000-0002-6781-1700"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Houldsworth","raw_affiliation_strings":["Department of Human Genetics and Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics and Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038450002","display_name":"R. S. K. CHAGANTI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R S Chaganti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9974,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.9422452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"145","issue":"6","first_page":"1253","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comparative-genomic-hybridization","display_name":"comparative genomic hybridization","score":1.0},{"id":"https://openalex.org/keywords/chromosomal-gains-and-losses","display_name":"chromosomal gains and losses","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5879999995231628},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tumor-diagnosis-and-prognosis","display_name":"tumor diagnosis and prognosis","score":0.41499999165534973},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.9342540502548218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7745232582092285},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.696263313293457},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.6226108074188232},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5197463035583496},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5196765065193176},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.5081655979156494},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.4898500144481659},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.44934284687042236},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.440006285905838},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36712002754211426},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3561076521873474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33255571126937866}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1887496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887496","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:7992829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7992829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Comment"},{"id":"mag:185872473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7992829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1887496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887496","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1614769926","https://openalex.org/W1666431833","https://openalex.org/W1818207061","https://openalex.org/W1968046362","https://openalex.org/W1988411119","https://openalex.org/W2024047179","https://openalex.org/W2040316588","https://openalex.org/W2044510046","https://openalex.org/W2051296872","https://openalex.org/W2061206375","https://openalex.org/W2082543658","https://openalex.org/W2139397808","https://openalex.org/W2158006647","https://openalex.org/W2165409131","https://openalex.org/W2170876759","https://openalex.org/W2391575159"],"related_works":["https://openalex.org/W4244620260","https://openalex.org/W2147948918","https://openalex.org/W1965825274","https://openalex.org/W2443734997","https://openalex.org/W2962782625","https://openalex.org/W421448861","https://openalex.org/W261880402","https://openalex.org/W1574871924","https://openalex.org/W2470293156","https://openalex.org/W2019021865"],"abstract_inverted_index":{"Comparative":[0],"genomic":[1,20,36],"hybridization":[2],"(CGH)":[3],"is":[4],"a":[5,19,79,192],"newly":[6],"described":[7],"molecular-cytogenetic":[8],"assay":[9],"that":[10,87,159],"globally":[11],"assays":[12],"for":[13,157],"chromosomal":[14,47,83,200],"gains":[15,84,148],"and":[16,39,70,85,149,165,183,197,205],"losses":[17,86,150],"in":[18,53,102,195,202,206],"complement.":[21],"In":[22],"this":[23],"assay,":[24],"normal":[25],"human":[26],"metaphase":[27],"chromosomes":[28],"are":[29],"competitively":[30],"hybridized":[31],"with":[32,145],"two":[33,58],"differentially":[34],"labeled":[35],"DNAs":[37,64],"(test":[38],"reference),":[40],"which":[41],"upon":[42],"fluorescence":[43],"microscopy,":[44],"reveal":[45],"the":[46,57,127],"locations":[48],"of":[49,61,73,81,151,168,186,199],"copy":[50,104],"number":[51,80],"changes":[52],"DNA":[54,137],"sequences":[55],"between":[56],"complements.":[59],"Application":[60],"CGH":[62,131,169,188],"to":[63,100,170,177],"extracted":[65,138],"from":[66,139],"fresh":[67],"frozen":[68],"specimens":[69,144,158,172],"cell":[71],"lines":[72],"various":[74],"tumor":[75,143,171],"types":[76],"has":[77],"revealed":[78],"recurring":[82],"were":[88,98,115],"undetected":[89],"by":[90,108],"traditional":[91],"cytogenetic":[92],"analysis.":[93],"Few":[94],"previously":[95],"known":[96],"sites":[97],"found":[99],"be":[101,134,155,162,178],"higher":[103],"number,":[105],"or":[106],"lost":[107],"CGH,":[109],"while":[110],"many":[111],"novel":[112],"amplified":[113],"regions":[114,118],"identified.":[116],"These":[117],"warrant":[119],"further":[120],"molecular":[121],"genetic":[122,152],"studies":[123,176],"aimed":[124],"at":[125],"isolating":[126],"perturbed":[128],"genes.":[129],"Since":[130],"can":[132,154],"also":[133,190],"performed":[135],"on":[136],"formalin-fixed":[140],"paraffin-embedded":[141],"archived":[142],"few":[146],"modifications,":[147],"material":[153],"determined":[156],"would":[160,173],"otherwise":[161],"unanalyzable.":[163],"Prospective":[164],"retrospective":[166],"application":[167],"permit":[174],"correlative":[175],"performed,":[179],"possibly":[180],"identifying":[181],"diagnostic":[182],"prognostic":[184],"indicators":[185],"disease.":[187],"may":[189],"have":[191],"future":[193],"role":[194],"detection":[196],"identification":[198],"abnormalities":[201],"prenatal":[203],"diagnosis":[204],"dysmorphic":[207],"anomalies.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
